PD-1/PD-L1
Les inhibiteurs de PD-1/PD-L1 sont des inhibiteurs de points de contrôle immunitaires qui bloquent l'interaction entre la protéine de mort cellulaire programmée 1 (PD-1) sur les cellules T et son ligand PD-L1 sur les cellules cancéreuses. Cette interaction supprime normalement la réponse immunitaire et permet aux cellules cancéreuses d'échapper à la détection immunitaire. En inhibant PD-1/PD-L1, ces inhibiteurs renforcent la capacité du système immunitaire à reconnaître et à détruire les cellules cancéreuses, induisant l'apoptose et la régression tumorale. Les inhibiteurs de PD-1/PD-L1 sont essentiels dans la recherche en immunothérapie et dans le traitement du cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de PD-1/PD-L1 de haute qualité pour soutenir vos recherches en immuno-oncologie, apoptose et thérapie contre le cancer.
140 produits trouvés pour "PD-1/PD-L1"
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Peresolimab
CAS :Peresolimab is a humanized antibody targeting PD-1, potentially stimulating immune inhibitory pathways for autoimmune disease research.Degré de pureté :95% - 97.8% (SDS-PAGE); 99.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.14 kDaPD-1/PD-L1-IN-20
CAS :PD-1/PD-L1-IN-20 is a small molecule inhibitor of PD-1/PD-L1 protein-protein interaction.Formule :C30H26BrClN2O3Couleur et forme :SolidMasse moléculaire :577.9PD-1-IN-22
CAS :PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).Formule :C25H25N5O4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :459.5Ref: TM-T12379
1mg109,00€2mg163,00€5mg243,00€1mL*10mM (DMSO)284,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€500mg2.035,00€PD-1/PD-L1-IN-NP19
CAS :PD-1/PD-L1-IN-NP19: a PD-1/PD-L1 inhibitor with 12.5 nM IC50, may boost antitumor immunity.Formule :C33H31ClN2O4Degré de pureté :96.70%Couleur et forme :SolidMasse moléculaire :555.06PD-1/PD-L1-IN-26
CAS :PD-1/PD-L1-IN-26 is a strong inhibitor with IC50 of 0.0380 μM that may boost immune response in cancer by aiding CD4+ T cell entry to tumors.Formule :C43H52N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :752.89ASC-69
CAS :ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].Formule :C19H19N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.4PD-L1-IN-2
CAS :PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity.Formule :C33H38N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.68PD-1/PD-L1-IN-33
CAS :PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.Formule :C26H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.53PD-1/PD-L1-IN-34
CAS :PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1Formule :C35H33ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.1PD-1/PD-L1-IN-27
CAS :PD-1/PD-L1-IN-27: potent anti-cancer, IC50 134nM, minimal T cell harm, boosts CD8+ T cells, reduces fatigue.Formule :C44H35NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.75PD-L1-IN-3
CAS :PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.Formule :C19H15ClFN2OSDegré de pureté :99.47%Couleur et forme :SoildMasse moléculaire :373.85LLW-018
CAS :LLW-018 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 2.61 nM. It can disrupt the PD-1/PD-L1 interaction, with a cell-based PD-1/PD-L1 blocking bioassay IC50 value of 0.88 μM. LLW-018 holds potential for research in immune-related diseases.Formule :C35H38Cl2N4O5SMasse moléculaire :697.67PD-1/PD-L1-IN-53
CAS :PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.Formule :C31H37N3O4Couleur et forme :SolidMasse moléculaire :515.64PD-L1-IN-7
CAS :PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.Formule :C46H50N6O7Couleur et forme :SolidMasse moléculaire :798.93Enpp-1-IN-25
CAS :Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.Formule :C15H21N5O4SCouleur et forme :SolidMasse moléculaire :367.423PD-L1/VISTA-IN-1
CAS :PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual inhibitor targeting PD-L1 and VISTA. It effectively hinders the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), leading to the reactivation of T cells. Additionally, PD-L1/VISTA-IN-1 exhibits antitumor activity.Formule :C22H24N4O4Couleur et forme :SolidMasse moléculaire :408.45PD-1/PD-L1-IN-55
CAS :PD-1/PD-L1-IN-55 (compound D6) is a potent PD-1/PD-L1 inhibitor with an IC50 of 4.8 nM. It enhances IFN-γ secretion and decreases the proportion of late apoptosis due to PD-L1.Formule :C25H23ClN2O3Couleur et forme :SolidMasse moléculaire :434.92PD-1-IN-17
CAS :PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.Formule :C13H22N6O7Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :374.35INCB086550
CAS :INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Formule :C41H39N7O4Degré de pureté :98.49%Couleur et forme :SolidMasse moléculaire :693.79PM-8002
PM-8002 is a bispecific antibody that targets PD-L1 and VEGF-A. It is applicable for research on solid tumors.
Couleur et forme :Odour Liquid
