TNF
Les inhibiteurs du facteur de nécrose tumorale (TNF) sont des composés qui bloquent l'activité du TNF, une cytokine impliquée dans l'inflammation et la régulation de l'apoptose. Le TNF peut induire l'apoptose dans certains types cellulaires tout en favorisant la survie et l'inflammation dans d'autres. L'inhibition du TNF est cruciale dans le traitement des maladies auto-immunes, des affections inflammatoires chroniques et de certains cancers. Les inhibiteurs de TNF aident à moduler la réponse immunitaire et à réduire les dommages tissulaires causés par une inflammation excessive. Chez CymitQuimica, nous offrons une gamme diversifiée d'inhibiteurs de TNF de haute qualité pour soutenir vos recherches en immunologie, inflammation et apoptose.
92 produits trouvés pour "TNF"
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Nodinitib-1
CAS :<p>Nodinitib-1 (CID-1088438) is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.</p>Formule :C14H13N3O2SDegré de pureté :99.97% - >99.99%Couleur et forme :SolidMasse moléculaire :287.34C25-140
CAS :<p>C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.</p>Formule :C26H31N7ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :457.57(Rac)-Benpyrine
CAS :<p>(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.</p>Formule :C16H16N6ODegré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :308.34Roquinimex
CAS :<p>Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and</p>Formule :C18H16N2O3Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :308.33LASSBio-1135
CAS :<p>LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.</p>Formule :C18H14N4Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :286.33UTL-5g
CAS :<p>UTL-5g is a chemoprotective TNF-α inhibitor reducing cisplatin side effects and toxicity in liver, kidneys, and blood.</p>Formule :C11H8Cl2N2O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :271.1STING-IN-2
CAS :<p>STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. STING-IN-2 can be used for autoinflammatory disease research.</p>Formule :C15H16N2O4Degré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :288.3Tulisokibart
CAS :<p>Tulisokibart (PRA023) is a humanized anti-TNFSF15 monoclonal antibody used to study colon cancer.</p>Degré de pureté :98.38% (SEC-HPLC) - > 95%Couleur et forme :LiquidLicaminlimab
<p>Licaminlimab (OCS-02) is a single-chain antibody fragment targeting TNF alpha, an inflammatory cytokine.</p>Couleur et forme :Odour LiquidToralizumab
CAS :<p>Toralizumab: humanized mAb targeting CD40L to curb T cell signaling and explore SLE treatment.</p>Couleur et forme :LiquidMasse moléculaire :148.43 (kD)Azintuxizumab
CAS :<p>Azintuxizumab, an IgG4 bispecific antibody, targets BCMA, offering dual-action immunotherapy for relapsed/refractory multiple myeloma in preclinical studies.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidInezetamab
CAS :<p>Inezetamab is a bispecific anti- CD40 and anti- MSLN IgG1 monoclonal antibody [1] .</p>Degré de pureté :95% - 95%Couleur et forme :LiquidBleselumab
CAS :<p>Bleselumab (ASKP 1240) is a humanised monoclonal antibody targeting CD40, inhibiting immune responses, organ transplant rejection.</p>Degré de pureté :95%Couleur et forme :LiquidTabalumab
CAS :<p>Tabalumab (LY2127399) is a humanised monoclonal antibody targeting BAFF that neutralises both soluble and membrane-bound forms of BLyS , autoimmune diseases.</p>Degré de pureté :95%Couleur et forme :LiquidIvuxolimab
CAS :<p>Ivuxolimab is a human IgG2 antibody that acts as an OX40 agonist, promoting T cell responses for anti-tumor immunity research.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidCifurtilimab
CAS :<p>Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, anticancer.</p>Degré de pureté :95%Couleur et forme :LiquidAfimkibart
CAS :<p>Afimkibart (PF06480605) is a humanised monoclonal antibody targeting TL1A (TNF-like Ligand 1A), which blocks TL1A-DR3 (death domain receptor 3) signalling on restrictive immune cells and fibroblasts. It can be used for inflammatory bowel disease and ulcerative colitis.</p>Degré de pureté :95% - 95%Couleur et forme :SoildRavagalimab
CAS :<p>Ravagalimab (ABBV-323) is a CD40 antagonist monoclonal antibody, investigated for Crohn’s disease and Sjögren’s syndrome to evaluate immune modulation.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidFrexalimab
CAS :<p>Frexalimab (SAR441344; INX-021), a monoclonal antibody that targets the CD40 ligand (CD40L), shows promise for research in multiple sclerosis [1].</p>Couleur et forme :LiquidAfelimomab
CAS :<p>Afelimomab (MAK 195F), a F(ab')2 fragment of an anti-tumor necrosis factor monoclonal antibody, is utilized in sepsis research [1].</p>Couleur et forme :LiquidTecaginlimab
CAS :<p>Tecaginlimab (BNT-312), an Fc-inert bispecific antibody, targets CD40/4-1BB to boost tumor immunity.</p>Couleur et forme :LiquidAnti-Mouse TNFR2 Antibody (TR75-54.7)
<p>Anti-Mouse TNFR2 Antibody is an Armenian Hamster-derived IgG inhibitor specifically targeting mouse TNFR2.</p>Couleur et forme :Odour LiquidIratumumab
CAS :<p>Iratumumab (MDX-060), a human IgG1κ anti-CD30 monoclonal antibody, halts CD30+ tumor growth, used in HL and ALCL research.</p>Couleur et forme :LiquidIA-14069
CAS :<p>IA-14069 is a TNF-a inhibitor with anti-inflammatory activity and pro-inflammatory cytokine production, and is used in the study of colon cancer.</p>Formule :C20H15ClF2O4Couleur et forme :SoildMasse moléculaire :392.78Cot inhibitor-2
CAS :<p>Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.</p>Formule :C26H25Cl2FN8Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :539.43Selicrelumab
CAS :<p>Selicrelumab (RG-7876) is an antibody targeting CD40 with potential anti-tumor activity for the study of pancreatic cancer.</p>Degré de pureté :98.7% (SDS-PAGE); 95.2% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.2% (SEC-HPLC)Couleur et forme :LiquidVU0285655-1
CAS :<p>VU0285655-1, a PLD2 inhibitor, halts PLD2-deficient cell growth and protects against high glucose-induced cell death. Used in diabetic retinopathy research.</p>Formule :C25H27N5O2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :429.51TNF-α-IN-1
CAS :<p>TNF-α-IN-1 is a TNF-α inhibitor.</p>Formule :C16H14ClN3O5Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :363.75UCB-5307
CAS :<p>UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.</p>Formule :C22H21N3ODegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :343.42Cot inhibitor-1
CAS :<p>Cot inhibitor-1 selectively blocks Tpl2 kinase, reducing TNF-alpha in blood (IC50: 5.7 nM). It may treat arthritis, IBD, and certain cancers.</p>Formule :C27H27Cl2FN8Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :553.46Mitazalimab
CAS :<p>Mitazalimab (ADC-1013/JNJ-64457107) is a CD40 agonist that stimulates T cells to attack tumors and remodels the tumor microenvironment.</p>Degré de pureté :95.1% (SDS-PAGE); 98.7% (SEC-HPLC) - 95.1% (SDS-PAGE); 98.7% (SEC-HPLC)Couleur et forme :LiquidSPD304 dihydrochloride
CAS :<p>SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.</p>Formule :C32H34Cl2F3N3O2Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :620.53GSK2593074A
CAS :<p>GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.</p>Formule :C27H23N5OSDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :465.57BMS-561392
CAS :<p>BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.</p>Formule :C27H32N4O4Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :476.57PK68
CAS :<p>PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.</p>Formule :C22H24N4O3SDegré de pureté :98.09% - 99.64%Couleur et forme :SolidMasse moléculaire :424.52Trovafloxacin mesylate
CAS :<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Formule :C21H19F3N4O6SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :512.46C 87
CAS :<p>C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.</p>Formule :C24H15ClN6O3SDegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :502.93Boserolimab
CAS :<p>Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.</p>Couleur et forme :LiquidCDC801
CAS :<p>CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.</p>Formule :C23H24N2O5Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :408.45TNF-α-IN-2
CAS :<p>TNF-α-IN-2 is orally active TNFα inhibitor that distorts the TNFα trimer, causing abnormal signal transduction when it binds to TNFR1, rheumatoid arthritis.</p>Formule :C25H21ClF2N6ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :494.92TNF-α-IN-14
CAS :<p>TNF-α-IN-14, a potent TNFα inhibitor, exhibits a selective inhibition profile with an IC50 of 1.1 µM and demonstrates antiinflammatory properties (WO2001072735A2; compound 12) [1].</p>Formule :C22H26O6Couleur et forme :SolidMasse moléculaire :386.44TNF-α-IN-12
CAS :<p>TNF-α-IN-12, a TNF-α inhibitor with an IC50 of 0.1 μM, can reduce TNF-α blood levels [1].</p>Formule :C21H22O6Couleur et forme :SolidMasse moléculaire :370.4
