
p53
Les inhibiteurs de p53 ciblent la protéine p53, un suppresseur de tumeur qui joue un rôle crucial dans la régulation du cycle cellulaire, la réparation de l'ADN et l'apoptose. Bien que p53 soit souvent muté ou inactivé dans les cellules cancéreuses, son inhibition est parfois nécessaire pour protéger les cellules saines de l'apoptose lors de certains traitements. D'autre part, restaurer la fonction de p53 dans les tumeurs peut entraîner l'apoptose des cellules cancéreuses. La recherche sur les inhibiteurs de p53 est complexe et significative pour mieux comprendre les mécanismes du cancer et développer de nouvelles thérapies. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs et de modulateurs de p53 de haute qualité pour soutenir vos recherches en biologie du cancer, apoptose et développement thérapeutique.
62 produits trouvés pour "p53"
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Amifostine
CAS :<p>Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.</p>Formule :C5H15N2O3PSDegré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :214.22NSC-87877
CAS :<p>NSC-87877 inhibits Shp2 (IC50=0.318μM), Shp1 (IC50=0.355μM), and DUSP26 phosphatases.</p>Formule :C19H13N3O7S2Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :459.45Chlorambucil
CAS :<p>Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.</p>Formule :C14H19Cl2NO2Degré de pureté :97.37% - 98.45%Couleur et forme :Off-White Slightly Granular Powder Melting Point 65-69°CMasse moléculaire :304.21Unesbulin
CAS :<p>Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1).</p>Formule :C19H13F5N6Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :420.34Quinacrine dihydrochloride
CAS :<p>Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic</p>Formule :C23H30CLN3O·2HClDegré de pureté :98.24% - 99.80%Couleur et forme :Yellow Crystals Or PowderMasse moléculaire :472.88MT 63-78
CAS :<p>MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM).</p>Formule :C21H14N2O2Degré de pureté :97.11%Couleur et forme :SolidMasse moléculaire :326.35Etoposide
CAS :<p>Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).</p>Formule :C29H32O13Degré de pureté :99.19% - 99.94%Couleur et forme :Crystals From Methanol SolidMasse moléculaire :588.56Transcription Factor-Targeted Compound Library
<p>Well-chosen xnum compounds with unique structures targeting transcription factor;</p>Couleur et forme :Odour SolidTetrofosmin
CAS :<p>Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.</p>Formule :C18H40O4P2Couleur et forme :SolidMasse moléculaire :382.46p53 (17-26)
CAS :<p>Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.</p>Formule :C60H90N12O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1251.43UNC 0631
CAS :<p>UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).</p>Formule :C37H61N7O2Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :635.93BMH-7 HCl
<p>BMH-7 HCl is a p53 activator, showing anti-cancer activity by activating the p53 pathway.</p>Formule :C20H22ClN5ODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :383.88Apoptosis Compound Library
<p>A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;</p>Couleur et forme :Odour SolidHLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi)
<p>p53 is a tumor suppressor protein.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.Anti-p53 Antibody (9D896)
<p>Anti-p53 Antibody (9D896) is an antibody targeting p53. Anti-p53 Antibody (9D896) can be used in ELISA, WB, IHC, IF.</p>Couleur et forme :Odour LiquidAnti-p53 Antibody (2H232)
<p>Anti-p53 Antibody (2H232) is an antibody targeting p53. Anti-p53 Antibody (2H232) can be used in ELISA, IHC.</p>Couleur et forme :Odour LiquidAnti-p53 Antibody (3K688)
<p>Anti-p53 Antibody (3K688) is a Rabbit antibody targeting p53. Anti-p53 Antibody (3K688) can be used in WB,ELISA,IP.</p>Couleur et forme :Odour LiquidAnti-p53 Antibody (9G129)
<p>Anti-p53 Antibody (9G129) is a Rabbit antibody targeting p53. Anti-p53 Antibody (9G129) can be used in IHC-P,ICC/IF.</p>Couleur et forme :Odour LiquidAnti-p53 Antibody (9G324)
<p>Anti-p53 Antibody (9G324) is an antibody targeting p53. Anti-p53 Antibody (9G324) can be used in ELISA, IF.</p>Couleur et forme :Odour LiquidAnti-Phospho-TP53 (Ser392) Antibody (7W136)
<p>Anti-Phospho-TP53 (Ser392) Antibody (7W136) is an antibody targeting Phospho-TP53 (Ser392). Anti-Phospho-TP53 (Ser392) Antibody (7W136) can be used in ELISA, WB.</p>Couleur et forme :Odour LiquidAnti-p53 Antibody (1J151)
<p>Anti-p53 Antibody (1J151) is a Mouse antibody targeting p53. Anti-p53 Antibody (1J151) can be used in ELISA(Cap).</p>Couleur et forme :Odour LiquidAnti-p53 Antibody (8M251)
<p>Anti-p53 Antibody (8M251) is an antibody targeting p53. Anti-p53 Antibody (8M251) can be used in ELISA, WB, IHC, IF.</p>Couleur et forme :Odour LiquidAnti-Phospho-TP53 (Thr55) Antibody (8C690)
<p>Anti-Phospho-TP53 (Thr55) Antibody (8C690) is an antibody targeting Phospho-TP53 (Thr55). Anti-Phospho-TP53 (Thr55) Antibody (8C690) can be used in ELISA, WB, IF.</p>Couleur et forme :Odour LiquidAnti-Phospho-TP53 (Ser33) Antibody (4K787)
<p>Anti-Phospho-TP53 (Ser33) Antibody (4K787) is an antibody targeting Phospho-TP53 (Ser33). Anti-Phospho-TP53 (Ser33) Antibody (4K787) can be used in ELISA, IHC, IF.</p>Couleur et forme :Odour LiquidAnti-p53 Antibody (2V863)
<p>Anti-p53 Antibody (2V863) is a Mouse antibody targeting p53. Anti-p53 Antibody (2V863) can be used in ELISA,ELISA(Det).</p>Couleur et forme :Odour LiquidAnti-Phospho-TP53 (Ser9) Antibody (4M602)
<p>Anti-Phospho-TP53 (Ser9) Antibody (4M602) is an antibody targeting Phospho-TP53 (Ser9). Anti-Phospho-TP53 (Ser9) Antibody (4M602) can be used in ELISA, IF.</p>Couleur et forme :Odour LiquidAnti-p53 Antibody (8C308)
<p>Anti-p53 Antibody (8C308) is an antibody targeting p53. Anti-p53 Antibody (8C308) can be used in ELISA, WB, IF, FCM.</p>Couleur et forme :Odour LiquidMethylstat
CAS :<p>Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability.</p>Formule :C28H31N3O6Degré de pureté :98.34% - 98.34%Couleur et forme :SolidMasse moléculaire :505.56p53 Protein, Cynomolgus, Recombinant
<p>p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :43.7 kDa (predicted); 48 kDa (reducing conditions)HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi), Biotinylated
<p>p53 is a tumor suppressor protein.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi)
<p>p53 is a tumor suppressor protein.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi)
<p>p53 is a tumor suppressor protein.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi), Biotinylated
<p>p53 is a tumor suppressor protein.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
<p>p53 is a tumor suppressor protein.</p>Couleur et forme :Odour Lyophilized PowderHLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi)
<p>p53 is a tumor suppressor protein.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
<p>p53 is a tumor suppressor protein.</p>Couleur et forme :Odour Lyophilized PowderProteasome inhibitor IX
CAS :<p>Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).</p>Formule :C20H21B2NO5Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :377.01LLY-507
CAS :<p>LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.</p>Formule :C36H42N6ODegré de pureté :99.58% - 99.93%Couleur et forme :SolidMasse moléculaire :574.76KCC-07
CAS :<p>KCC-07: Selective, potent, brain-penetrant MBD2 inhibitor with anticancer effects, blocking MBD2-DNA binding and activating BAI1 signaling.</p>Formule :C14H11N3OSDegré de pureté :98.86% - 99.01%Couleur et forme :SolidMasse moléculaire :269.32UNC0646
CAS :<p>UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.</p>Formule :C36H59N7O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :621.9XL177A
CAS :<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Formule :C48H57ClN8O5Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :861.47Schisandrol B
CAS :<p>Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.</p>Formule :C23H28O7Degré de pureté :99.14% - 99.95%Couleur et forme :SolidMasse moléculaire :416.46BIX-01294
CAS :<p>BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).</p>Formule :C28H38N6O2Degré de pureté :98.58% - 99.64%Couleur et forme :SolidMasse moléculaire :490.64NSC-87877 disodium
CAS :<p>NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2. NSC-87877 also inhibits EGF-induced Erk1/2 activation in HEK293 cells.</p>Formule :C19H13N3O7S2·2NaDegré de pureté :97.89%Couleur et forme :SolidMasse moléculaire :503.42NSC 66811
CAS :<p>NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.</p>Formule :C23H20N2ODegré de pureté :96.94%Couleur et forme :SolidMasse moléculaire :340.42(S)-10-Hydroxycamptothecin
CAS :<p>(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.</p>Formule :C20H16N2O5Degré de pureté :99.09% - 99.81%Couleur et forme :SolidMasse moléculaire :364.35NSC348884
CAS :<p>NSC348884, a nucleophosmin inhibitor, disrupts oligomers, induces apoptosis, and inhibits cancer cell growth (IC50: 1.7-4.0 μM).</p>Formule :C38H40N10Degré de pureté :98.69% - 99.91%Couleur et forme :SolidMasse moléculaire :636.79Lumichrome
CAS :<p>Lumichrome, a riboflavin metabolite, influences plant growth, ascidian metamorphosis, bacterial communication, and blocks riboflavin uptake.</p>Formule :C12H10N4O2Degré de pureté :99.69% - 99.93%Couleur et forme :SolidMasse moléculaire :242.23XI-006
CAS :<p>NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.</p>Formule :C11H13N5O4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :279.25cjoc42
CAS :<p>Cjoc42 blocks gankyrin to prevent p53 reduction, aiding cancer prevention and DNA damage response.</p>Formule :C20H21N3O5SDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :415.46

