Caspase
Les inhibiteurs de caspases sont des composés qui bloquent l'activité des caspases, une famille de protéases qui jouent un rôle central dans l'exécution de l'apoptose. Les caspases clivent des substrats spécifiques dans la cellule pour déclencher le processus apoptotique, conduisant à la mort cellulaire programmée. Les inhibiteurs de caspases sont utilisés pour étudier les mécanismes de l'apoptose, ainsi que pour prévenir la mort cellulaire indésirable dans divers modèles de recherche. Ces inhibiteurs sont également explorés dans des contextes thérapeutiques pour protéger les cellules de l'apoptose dans des maladies telles que les neurodégénérescences. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de caspases de haute qualité pour soutenir vos recherches sur l'apoptose, la mort cellulaire et les domaines connexes.
125 produits trouvés pour "Caspase"
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p-nitro-Pifithrin-α
CAS :<p>p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.</p>Formule :C15H16BrN3O3SCouleur et forme :SolidMasse moléculaire :398.27SDZ 224-015
CAS :<p>SDZ 224-015 is an inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1 with anti-COVID-19 and anti-inflammatory activity.</p>Formule :C30H35Cl2N3O9Degré de pureté :95.49% - 95.49%Couleur et forme :SolidMasse moléculaire :652.52VRT-043198
CAS :<p>VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.</p>Formule :C22H29ClN4O6Couleur et forme :SolidMasse moléculaire :480.94QM31
CAS :<p>QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).</p>Formule :C39H38Cl4N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :768.56N1,N11-Diethylnorspermine
CAS :<p>DENSPM: potent anticancer, spurs polyamine breakdown, triggers cytochrome c release and caspase 3, kills GBM via SSAT & H2O2.</p>Formule :C13H32N4Couleur et forme :SolidMasse moléculaire :244.42GRI977143
CAS :<p>GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.</p>Formule :C22H17NO4SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :391.44OT-82
CAS :<p>OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.</p>Formule :C26H21FN4ODegré de pureté :98.91% - 99.315%Couleur et forme :SolidMasse moléculaire :424.47ML132
CAS :<p>ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).</p>Formule :C22H28ClN5O5Couleur et forme :SolidMasse moléculaire :477.94CZL55
CAS :<p>CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).</p>Formule :C20H22N2O6Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :386.4NLRP3 agonist 1
CAS :<p>Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.</p>Formule :C15H16N6Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :280.33M190S
CAS :<p>M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.</p>Formule :C21H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :375.42Ac-YVAD-pNA
CAS :<p>Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].</p>Formule :C29H36N6O10Couleur et forme :SolidMasse moléculaire :628.639GDC-2394
CAS :<p>GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.</p>Formule :C20H25N5O4SCouleur et forme :SolidMasse moléculaire :431.51CIL62
CAS :<p>CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].</p>Formule :C23H26O5Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :382.45EP1013
CAS :<p>EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.</p>Formule :C18H23FN2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.38M867
CAS :<p>M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].</p>Formule :C27H43N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.67Ac-VAD-CHO
CAS :<p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>Formule :C14H23N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.35Z-YVAD-CMK
CAS :<p>Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].</p>Formule :C30H37ClN4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :633.09ZIF-8
CAS :<p>ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.</p>Formule :C4H6N2ZnCouleur et forme :SolidMasse moléculaire :147.513Caspase-3-IN-2
CAS :<p>Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.</p>Formule :C10H6ClNO5Couleur et forme :SolidMasse moléculaire :255.611N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
CAS :<p>N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.</p>Formule :C14H22Cl2N2O3SMasse moléculaire :369.31M826
<p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>Formule :C28H45N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :575.7Ac-DMLD-CMK
CAS :<p>Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.</p>Formule :C22H35ClN4O9SCouleur et forme :SolidMasse moléculaire :567.053(2R,3S)-Emricasan
CAS :<p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>Formule :C26H27F4N3O7Couleur et forme :SolidMasse moléculaire :569.5Z-VA-DL-D-FMK
CAS :Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.Formule :C21H28FN3O7Couleur et forme :SolidMasse moléculaire :453.46
