Caspase
Les inhibiteurs de caspases sont des composés qui bloquent l'activité des caspases, une famille de protéases qui jouent un rôle central dans l'exécution de l'apoptose. Les caspases clivent des substrats spécifiques dans la cellule pour déclencher le processus apoptotique, conduisant à la mort cellulaire programmée. Les inhibiteurs de caspases sont utilisés pour étudier les mécanismes de l'apoptose, ainsi que pour prévenir la mort cellulaire indésirable dans divers modèles de recherche. Ces inhibiteurs sont également explorés dans des contextes thérapeutiques pour protéger les cellules de l'apoptose dans des maladies telles que les neurodégénérescences. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de caspases de haute qualité pour soutenir vos recherches sur l'apoptose, la mort cellulaire et les domaines connexes.
144 produits trouvés pour "Caspase"
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Ac-DEVD-CHO acetate
Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.Formule :C22H34N4O13Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :562.52BC-1471
CAS :BC-1471 is a STAMBP deubiquitinase inhibitor that blocks NALP7 inflammasome activity.Formule :C27H32N4O4SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :508.63Dehydrocorydaline nitrate
CAS :DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.Formule :C22H24N2O7Degré de pureté :99.79% - 99.92%Couleur et forme :SolidMasse moléculaire :428.44Dehydrotrametenolic acid
CAS :Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation inFormule :C31H48O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.71Limonin glucoside
CAS :Limonin glucoside: a citrus compound, blocks HIV/HTLV-1, triggers cancer cell death, kills Aedes larvae.Formule :C32H42O14Couleur et forme :SolidMasse moléculaire :650.674VRT-043198
CAS :VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.Formule :C22H29ClN4O6Couleur et forme :SolidMasse moléculaire :480.94Tigilanol tiglate
CAS :Tigilanol tiglate (EBC-46) is a PKC/C1 domain activator. Tigilanol tiglate induces immunogenic cell death and tumour regression.Formule :C30H42O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.65QM31
CAS :QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).Formule :C39H38Cl4N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :768.56N1,N11-Diethylnorspermine
CAS :DENSPM: potent anticancer, spurs polyamine breakdown, triggers cytochrome c release and caspase 3, kills GBM via SSAT & H2O2.Formule :C13H32N4Couleur et forme :SolidMasse moléculaire :244.42ZYZ-488
CAS :ZYZ-488 is an Apoptosis protease activating factor-1 (Apaf-1) inhibitor, which suppresses the activation of procaspase-9 and procaspase-3.Formule :C20H29N3O11Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :487.46SDZ 224-015
CAS :SDZ 224-015 is an inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1 with anti-COVID-19 and anti-inflammatory activity.Formule :C30H35Cl2N3O9Degré de pureté :95.49% - 95.49%Couleur et forme :SolidMasse moléculaire :652.52GRI977143
CAS :GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.Formule :C22H17NO4SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :391.44p-nitro-Pifithrin-α
CAS :p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.Formule :C15H16BrN3O3SCouleur et forme :SolidMasse moléculaire :398.27Caspase-9 Inhibitor III
CAS :Caspase-9 Inhibitor III (Ac-LEHD-cmk) blocks caspase-9, protects against ischemic heart damage.Formule :C24H35ClN6O9Couleur et forme :SolidMasse moléculaire :587.02OT-82
CAS :OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.Formule :C26H21FN4ODegré de pureté :98.91% - 99.315%Couleur et forme :SolidMasse moléculaire :424.47Anisperimus
CAS :<p>Anisperimus (LF 15-0195) is an immunosuppressant that prevents CNS autoimmunity by promoting the development of regulatory CD4 T cells expressing Foxp3.</p>Formule :C18H39N7O3Degré de pureté :98.10%Couleur et forme :SolidMasse moléculaire :401.55S1QEL1.1
CAS :S1QEL1.1 (S1QEL) is an electron leakage inhibitor that inhibits O2-induced ROS generation and prevents O2-induced DA closure.Formule :C23H24N4O3SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :436.53ML132
CAS :ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).Formule :C22H28ClN5O5Couleur et forme :SolidMasse moléculaire :477.94Caspase-3-IN-1
CAS :<p>Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).</p>Formule :C26H25N3O6SCouleur et forme :SolidMasse moléculaire :507.562-chloro Palmitic Acid
CAS :2-chloro Palmitic acid triggers NETosis, elevates COX-2, adhesion molecules in HCAECs, and induces apoptosis and caspase-3 in THP-1 cells/monocytes.Formule :C16H31ClO2Couleur et forme :SolidMasse moléculaire :290.87CAY10406
CAS :CAY10406, a trifluoromethyl isatin sulfonamide, selectively targets and inhibits caspase-3 and -7, key in apoptosis, with no data on its inhibition potency.Formule :C27H23F3N2O5SCouleur et forme :SolidMasse moléculaire :544.54AD-2646
CAS :AD-2646 has antidepressant activity and inhibits 2-deoxy-D-glucose (2-DG)-induced gastric acid secretion.Formule :C23H40N2O4Couleur et forme :SolidMasse moléculaire :408.57CZL55
CAS :CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).Formule :C20H22N2O6Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :386.4GDC-2394
CAS :GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.Formule :C20H25N5O4SCouleur et forme :SolidMasse moléculaire :431.51Ac-VAD-CHO
CAS :<p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>Formule :C14H23N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.35Ac-YVAD-pNA
CAS :Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].Formule :C29H36N6O10Couleur et forme :SolidMasse moléculaire :628.639Z-YVAD-CMK
CAS :Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].Formule :C30H37ClN4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :633.09M190S
CAS :M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.Formule :C21H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :375.42CIL62
CAS :<p>CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].</p>Formule :C23H26O5Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :382.45NLRP3 agonist 1
CAS :Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.Formule :C15H16N6Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :280.33EP1013
CAS :EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.Formule :C18H23FN2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.38M867
CAS :M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].Formule :C27H43N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.67N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
CAS :N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.Formule :C14H22Cl2N2O3SMasse moléculaire :369.31NLRP3-IN-81
CAS :NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.Formule :C16H15F3N2O3SCouleur et forme :SolidMasse moléculaire :372.36Z-VA-DL-D-FMK
CAS :Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.Formule :C21H28FN3O7Couleur et forme :SolidMasse moléculaire :453.46Neuroprotective agent 11
CAS :Neuroprotective agent 11 (Compound 1a) is an orally active polyphenolic compound that offers significant protection against cerebral ischemia. Its primary activities include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarct size, and improving behavioral symptoms in mice with cerebral ischemia. The mechanism involves downregulating inflammatory factors (iNOS, COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 is applicable for research in ischemia-related brain diseases, such as ischemic stroke.Formule :C32H30O12Couleur et forme :SolidMasse moléculaire :606.57M826
M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity inFormule :C28H45N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :575.7DeFer-2
CAS :DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.Formule :C44H69N5O5SCouleur et forme :SolidMasse moléculaire :780.11Z-VAD-AMC
CAS :Z-VAD-AMC acts as a substrate specifically for caspase-9.Formule :C30H34N4O9Masse moléculaire :594.61Ac-DMLD-CMK
CAS :Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.Formule :C22H35ClN4O9SCouleur et forme :SolidMasse moléculaire :567.053Caspase-3-IN-2
CAS :Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.Formule :C10H6ClNO5Couleur et forme :SolidMasse moléculaire :255.611ZIF-8
CAS :ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.Formule :C4H6N2ZnCouleur et forme :SolidMasse moléculaire :147.513Ac-Asp-Glu-Val-Asp-pNA
CAS :Ac-Asp-Glu-Val-Asp-pNA is a peptide substrate for caspase-3/7.Formule :C26H34N6O13Masse moléculaire :638.58GlcNAc-MurNAc
CAS :GlcNAc-MurNAc is a disaccharide and mild TLR4 agonist with a Kd of 383 μM for mouse TLR4. It directly binds to TLR4, activating the downstream NF-κB and IRF pathways. Additionally, GlcNAc-MurNAc ameliorates dextran sulfate sodium salt (DSS)-induced colitis in mice through a TLR4-dependent mechanism, making it useful for inflammatory bowel disease research.Formule :C19H32N2O13Couleur et forme :SolidMasse moléculaire :496.46
