Caspase
Les inhibiteurs de caspases sont des composés qui bloquent l'activité des caspases, une famille de protéases qui jouent un rôle central dans l'exécution de l'apoptose. Les caspases clivent des substrats spécifiques dans la cellule pour déclencher le processus apoptotique, conduisant à la mort cellulaire programmée. Les inhibiteurs de caspases sont utilisés pour étudier les mécanismes de l'apoptose, ainsi que pour prévenir la mort cellulaire indésirable dans divers modèles de recherche. Ces inhibiteurs sont également explorés dans des contextes thérapeutiques pour protéger les cellules de l'apoptose dans des maladies telles que les neurodégénérescences. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de caspases de haute qualité pour soutenir vos recherches sur l'apoptose, la mort cellulaire et les domaines connexes.
157 produits trouvés pour "Caspase".
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VCP/p97 IN-3
VCP/p97 IN-3 is an allosteric inhibitor of VCP/p97. It exhibits inhibitory activity against VCP, with an IC50 of 9 nM, and shows IC50 values of 12 nM (N660K) and 19 nM (V474A/D649A) for mutant VCP proteins. VCP/p97 IN-3 increases the levels of K48 ubiquitination and caspase-3. It activates endoplasmic reticulum stress and the unfolded protein response (UPR). In a subcutaneous xenograft mouse model with RPMI-8226 cells, VCP/p97 IN-3 suppresses tumor growth. This compound is applicable for research in multiple myeloma.Couleur et forme :Odour SolidRoxatidine
CAS :Roxatidine, a metabolite of Roxatidine acetate, is a H2-receptor antagonist that prevents ulcers and has anti-inflammatory properties.Formule :C17H26N2O3Couleur et forme :SolidMasse moléculaire :306.4BOC-D-FMK
CAS :Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).Formule :C11H18FNO5Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :263.26Ref: TM-T10580
1mg50,00€5mg114,00€1mL*10mM (DMSO)132,00€10mg167,00€25mg326,00€50mg462,00€100mg640,00€200mg884,00€Ac-VDQQD-pNA
CAS :Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).Formule :C31H43N9O14Couleur et forme :SolidMasse moléculaire :765.73Ac-AAVALLPAVLLALLAPVAD-CHO TFA
Ac-AAVALLPAVLLALLAPVAD-CHO (TFA) is a complex of Ac-VAD-CHO. It acts as a non-selective caspase inhibitor and features a hydrophobic sequence derived from K-FGF that enables cell penetration.CIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Formule :C28H28N2O6SCouleur et forme :SolidMasse moléculaire :520.6Trehalose-6,6'-dibehenate
CAS :Trehalose-6,6'-dibehenate, a bioactive glycolipid, is applicable for the preparation of vaccine adjuvant [1].Formule :C56H106O13Couleur et forme :SolidMasse moléculaire :987.43Reproxalap
CAS :Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.Formule :C12H13ClN2ODegré de pureté :99.4% - 99.97%Couleur et forme :SolidMasse moléculaire :236.7Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Couleur et forme :Odour SolidRef: TM-L1100
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderTD1092
TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.Formule :C55H70N8O9Couleur et forme :SolidMasse moléculaire :987.19Ac-WEHD-AFC TFA
Ac-WEHD-AFC TFA: a fluorogenic substrate detecting caspase-1 activity, used in tumor and inflammation research.Formule :C40H38F6N8O13Couleur et forme :SolidMasse moléculaire :952.77IRF1-IN-2
CAS :IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.Formule :C18H20N2O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :360.43Ac-AAVALLPAVLLALLAP-YVAD-CHO
CAS :Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].Formule :C97H160N20O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1990.43TNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47Ac-IETD-AFC TFA
Ac-IETD-AFC TFA is a synthetic fluorescent substrate used for the specific detection of Caspase-8 enzyme activity. It contains the fluorescent group AFC (7-amino-4-trifluoromethylcoumarin), which becomes free and emits fluorescence (Ex=~400 nm; Em=~505 nm) when Caspase-8 cleaves the amide bond following the IETD sequence. [INDO 1 pentasodium].Couleur et forme :Odour SolidDiethylnorspermine HCl
CAS :Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectivelyFormule :C13H36Cl4N4Degré de pureté :99.79% - 99.86%Couleur et forme :SolidMasse moléculaire :390.26Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+Formule :C38H44O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.75δ-secretase inhibitor 11
CAS :δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.Formule :C10H12N4O2Degré de pureté :99.84%Couleur et forme :Red SolidMasse moléculaire :220.23Almorexant hydrochloride
CAS :Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.Formule :C29H32ClF3N2O3Degré de pureté :99.85%Couleur et forme :White SolidMasse moléculaire :549.02Tripeptide-32
CAS :Tripeptide-32 is a bioactive peptide recognized for its anti-aging properties, commonly utilized as an ingredient in cosmetics [1].Formule :C12H22N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.33
