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Cycle cellulaire/point de contrôle

Cycle cellulaire/point de contrôle

Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.

Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"

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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"

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  • CHK1-IN-11
    Targetmol
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    CHK1-IN-11

    CAS :
    <p>CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.</p>
    Formule :C20H22N8O2
    Couleur et forme :Solid
    Masse moléculaire :406.44

    Ref: TM-T207353

  • CDK2 degrader 6
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    CDK2 degrader 6

    CAS :
    <p>CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.</p>
    Formule :C23H22F5N5O3
    Couleur et forme :Solid
    Masse moléculaire :511.44

    Ref: TM-T207287

  • LNA-CTP
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    LNA-CTP

    CAS :
    <p>LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Formule :C10H16N3O14P3
    Couleur et forme :Solid
    Masse moléculaire :495.17

    Ref: TM-TSW-00954

  • RNAP-σ interaction inhibitor-2
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    RNAP-σ interaction inhibitor-2

    CAS :
    <p>RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.</p>
    Formule :C27H19Cl3N2O6S2
    Couleur et forme :Solid
    Masse moléculaire :637.939

    Ref: TM-T206884

  • Antiviral agent 67
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    Antiviral agent 67

    CAS :
    <p>Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.</p>
    Formule :C19H19N3O
    Couleur et forme :Solid
    Masse moléculaire :305.374

    Ref: TM-T206310

  • CD 10899
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    CD 10899

    CAS :
    <p>CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].</p>
    Formule :C34H50N8O4
    Couleur et forme :Solid
    Masse moléculaire :634.81

    Ref: TM-T86023

  • iPAF1C
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    iPAF1C

    CAS :
    <p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>
    Formule :C27H26BrFN4O
    Couleur et forme :Solid
    Masse moléculaire :521.42

    Ref: TM-T86731

  • CDK1-IN-6
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    CDK1-IN-6

    <p>CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.</p>
    Formule :C21H22N4O
    Couleur et forme :Solid
    Masse moléculaire :346.43

    Ref: TM-T201825

  • 2,5-Di-tert-butyl-1,4-benzoquinone
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    2,5-Di-tert-butyl-1,4-benzoquinone

    CAS :
    <p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>
    Formule :C14H20O2
    Couleur et forme :Solid
    Masse moléculaire :220.31

    Ref: TM-T201504

  • Mps1-IN-8
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    Mps1-IN-8

    CAS :
    <p>Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].</p>
    Formule :C35H47N8O6P
    Couleur et forme :Solid
    Masse moléculaire :706.77

    Ref: TM-T86927

  • WRN inhibitor 7
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    WRN inhibitor 7

    CAS :
    <p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>
    Formule :C27H23N3O6
    Couleur et forme :Solid
    Masse moléculaire :485.49

    Ref: TM-T87635

  • N-Nitrosonornicotine
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    N-Nitrosonornicotine

    CAS :
    <p>N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.</p>
    Formule :C9H11N3O
    Couleur et forme :Solid
    Masse moléculaire :177.2

    Ref: TM-T201694

  • DB18
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    DB18

    CAS :
    <p>DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].</p>
    Formule :C24H18ClN7O3
    Couleur et forme :Solid
    Masse moléculaire :487.9

    Ref: TM-T86165

  • VPC-80051
    Targetmol
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    VPC-80051

    CAS :
    <p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>
    Formule :C16H13F2N3O
    Couleur et forme :Solid
    Masse moléculaire :301.291

    Ref: TM-T204737

  • LIMK-IN-2
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    LIMK-IN-2

    CAS :
    <p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>
    Formule :C28H27N5O2
    Couleur et forme :Solid
    Masse moléculaire :465.55

    Ref: TM-T86811

  • 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine
    Targetmol
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    5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine

    CAS :
    <p>5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine is a nucleoside synthesized through oxime ring-opening at the 5' position and methylation at the 2' position. In chemotaxis assays, 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine demonstrates tissue affinity.</p>
    Formule :C36H39N5O8
    Couleur et forme :Solid
    Masse moléculaire :669.724

    Ref: TM-T206273

  • TMX-3013
    Targetmol
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    TMX-3013

    CAS :
    <p>TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, &lt;0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.</p>
    Formule :C17H14BrFN6O3S
    Couleur et forme :Solid
    Masse moléculaire :481.3

    Ref: TM-T201425

  • PKMYT1-IN-2
    Targetmol
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    PKMYT1-IN-2

    CAS :
    <p>PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].</p>
    Formule :C22H19N5O2
    Couleur et forme :Solid
    Masse moléculaire :385.42

    Ref: TM-T87219

  • PLK1-IN-11
    Targetmol
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    PLK1-IN-11

    CAS :
    <p>PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.</p>
    Formule :C12H11N5O
    Couleur et forme :Solid
    Masse moléculaire :241.249

    Ref: TM-T205548

  • 2'-O-MOE-GTP
    Targetmol
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    2'-O-MOE-GTP

    CAS :
    <p>2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Formule :C13H22N5O15P3
    Couleur et forme :Solid
    Masse moléculaire :581.26

    Ref: TM-TSW-00970