Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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Polθ-IN-7
CAS :<p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>Formule :C28H35F3N6O2Couleur et forme :SolidMasse moléculaire :544.612Cdc7-IN-10
CAS :<p>Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.</p>Formule :C20H22F2N4O2SCouleur et forme :SolidMasse moléculaire :420.48CDK7-IN-33
CAS :<p>CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.</p>Formule :C29H36N6O4SCouleur et forme :SolidMasse moléculaire :564.699DHX9-IN-19
CAS :<p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>Formule :C20H21ClN4O4S2Couleur et forme :SolidMasse moléculaire :480.988IRE1α kinase-IN-5
<p>IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.</p>Formule :C28H30N6O3SCouleur et forme :SolidMasse moléculaire :530.643'-Deoxy-GTP
CAS :<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.</p>Formule :C10H16N5O13P3Couleur et forme :SolidMasse moléculaire :507.1815-Fluorouridine 5'-phosphate
CAS :<p>5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.</p>Formule :C9H12FN2O9PCouleur et forme :SolidMasse moléculaire :342.172Norharmine
CAS :<p>Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.</p>Formule :C12H10N2OCouleur et forme :SolidMasse moléculaire :198.221IXA62
CAS :<p>IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.</p>Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.458HNC-1664
CAS :<p>HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.</p>Formule :C12H13FIN3O3Couleur et forme :SolidMasse moléculaire :393.153CDK1-IN-4
<p>CDK1-IN-4 inhibits CDK1 (IC50: 44.52 nM), CDK2/CDK5 less potently, impacts cell cycle, used in cancer studies.</p>Formule :C26H24ClN5SCouleur et forme :SolidMasse moléculaire :474.02Dyrk1A/α-synuclein-IN-2
<p>Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).</p>Formule :C21H16N4O4SCouleur et forme :SolidMasse moléculaire :420.44LNA-GMP
CAS :<p>LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.</p>Formule :C11H14N5O8PCouleur et forme :SolidMasse moléculaire :375.23CDK2-IN-31
CAS :<p>CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.</p>Formule :C37H52N6O5Couleur et forme :SolidMasse moléculaire :660.85Anticancer agent 29
<p>Compound E/Z-6f, anticancer, IC50: CDK2 (0.054 μM), CDK1 (0.127 μM), CDK4 (0.129 μM), CDK6 (0.396 μM).</p>Formule :C22H15ClFNOCouleur et forme :SolidMasse moléculaire :363.81BET/Aurora kinase-IN-1
CAS :<p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>Formule :C25H30FN7OCouleur et forme :SolidMasse moléculaire :463.55RAD51-IN-6
CAS :<p>RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)</p>Formule :C27H40N3O5PSCouleur et forme :SolidMasse moléculaire :549.66Glycyl H-1152 hydrochloride
CAS :<p>Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.</p>Formule :C18H26Cl2N4O3SCouleur et forme :SolidMasse moléculaire :449.39KI-CDK9d-32
CAS :<p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>Formule :C39H45N9O4Couleur et forme :SolidMasse moléculaire :703.83BBI-355
CAS :<p>BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.</p>Formule :C19H19N7O2Couleur et forme :SolidMasse moléculaire :377.40Haspin-IN-2
CAS :<p>Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).</p>Formule :C12H8N4O3Couleur et forme :SolidMasse moléculaire :256.22Fradafiban
CAS :<p>Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.</p>Formule :C20H21N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.402'-F-UMP
CAS :<p>2'-F-UMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>Formule :C9H12FN2O8PMasse moléculaire :326.176-B345TTQ
CAS :<p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>Formule :C22H20BrNO4Couleur et forme :SolidMasse moléculaire :442.303Galidesivir
CAS :<p>Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.</p>Formule :C11H15N5O3Degré de pureté :96.73% - 99.13%Couleur et forme :SolidMasse moléculaire :265.27Des-ethyl-carafiban
CAS :<p>Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.</p>Formule :C22H23N5O5Couleur et forme :SolidMasse moléculaire :437.4482′-O-MOE-AMP
CAS :<p>2′-O-MOE-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>Formule :C13H20N5O8PCouleur et forme :SolidMasse moléculaire :405.30CDK4/6-IN-13
CAS :<p>Compounds 10B and 10C: potent cdk4/6 inhibitors with low nM activity, great antiproliferative effects, excellent metabolism, and good pharmacokinetics.</p>Formule :C25H29N7OCouleur et forme :SolidMasse moléculaire :443.54Aurora B inhibitor 1
CAS :<p>Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.</p>Formule :C25H26ClF2N7O2Degré de pureté :98.37%Couleur et forme :SolidMasse moléculaire :529.97PD-1/PD-L1-IN-53
CAS :<p>PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.</p>Formule :C31H37N3O4Couleur et forme :SolidMasse moléculaire :515.642'-F-AMP
CAS :<p>2'-F-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>Formule :C10H13FN5O6PMasse moléculaire :349.21CDK2-IN-30
CAS :<p>CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC50 of ≤20 nM, utilized primarily in tumor research.</p>Formule :C18H25N7O3SCouleur et forme :SolidMasse moléculaire :419.50LNA-UTP
CAS :<p>LNA-UTP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>Formule :C10H15N2O15P3Couleur et forme :SolidMasse moléculaire :496.15BWC0977
CAS :<p>BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.</p>Formule :C22H21FN6O5Couleur et forme :SolidMasse moléculaire :468.44DYRK1-IN-1
CAS :<p>DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.</p>Formule :C12H12N6Couleur et forme :SolidMasse moléculaire :240.26GSK3-IN-10
CAS :<p>GSK3-IN-10 (Compound 4) is a multi-target inhibitor primarily affecting GSK3α and GSK3β with IC50 values of 1.0 nM and 2.0 nM, respectively. It inhibits the activation of β-catenin, enhances neuronal survival, and provides protective effects against endoplasmic reticulum stress.</p>Formule :C17H18F2N4O3Couleur et forme :SolidMasse moléculaire :364.347Antitumor agent-74
<p>Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.</p>Formule :C26H23FN6Couleur et forme :SolidMasse moléculaire :438.5Pseudouridine 5'-OTBDPS
CAS :<p>Pseudouridine5'-OTBDPS [5-(5-O-TBDPS-β-D-ribofuranosyl)uracil] is an intermediate of Pseudouridine.</p>Formule :C25H30N2O6SiCouleur et forme :SolidMasse moléculaire :482.60N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine
CAS :<p>N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a nucleoside analog that resembles the natural nucleotide adenosine in structure. It acts as an activator of ribonucleotide reductase, facilitating the conversion of ribonucleotides into deoxyribonucleotides.</p>Formule :C38H35N5O6Couleur et forme :SolidMasse moléculaire :657.714RNAP-σ interaction inhibitor-1
CAS :<p>RNAP-σ interaction inhibitor-1 (compound 5d) acts as an inhibitor of the interaction between RNA polymerase and the sigma factor. It exhibits activity against Streptococci with a minimum inhibitory concentration (MIC) ranging from 1-2 µg/mL.</p>Formule :C19H11Cl3N2O6S2Couleur et forme :SolidMasse moléculaire :533.79BRD4 Inhibitor-40
CAS :<p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>Formule :C27H32N8OCouleur et forme :SolidMasse moléculaire :484.596Aurora inhibitor 1
CAS :<p>Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).</p>Formule :C23H25N9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.57FR-β ligand 1
CAS :<p>FR-β ligand 1 (III) is a ligand that specifically targets folate receptors, exhibiting antitumor activity, high selectivity, and strong affinity.</p>Formule :C22H25N5O6Couleur et forme :SolidMasse moléculaire :455.46DNA Gyrase-IN-16
CAS :<p>DNA Gyrase-IN-16 (Compound 9) is an inhibitor of DNA gyrase, with an IC50 of 1.609 μM. It exhibits antibacterial properties, effectively inhibiting S. aureus and MRSA, with a MIC of 3.125 μM for both.</p>Formule :C17H15N3O3Couleur et forme :SolidMasse moléculaire :309.319MY05
CAS :<p>MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).</p>Formule :C19H11ClN4OCouleur et forme :SolidMasse moléculaire :346.77Anticancer agent 30
<p>Anticancer agent 30 (6f-Z), a 3-arylidene-2-oxindole, selectively inhibits CDK2, showing potent anticancer potential.</p>Formule :C22H15ClFNOCouleur et forme :SolidMasse moléculaire :363.81TA-316
CAS :<p>Agent induces megakaryocytes/platelets from stem cells to treat thrombopenia.</p>Formule :C28H25BrN4O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :641.56CDK4-IN-1
CAS :<p>CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50</p>Formule :C22H29ClN8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.97SGC-CLK-1
CAS :<p>SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.</p>Formule :C19H15F3N6O2Couleur et forme :SolidMasse moléculaire :416.36MTH1 activator-1
CAS :<p>MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.</p>Formule :C29H23F3N4O2Couleur et forme :SolidMasse moléculaire :516.514
