Kinésine
Les inhibiteurs de kinésine ciblent les protéines motrices kinésines, responsables du transport des cargaisons cellulaires le long des microtubules et jouant un rôle clé dans la division cellulaire, en particulier pendant la mitose. Les kinésines sont impliquées dans le mouvement des chromosomes et d'autres organites pendant la division cellulaire. Inhiber les kinésines peut perturber ces processus, entraînant un arrêt du cycle cellulaire et une mort cellulaire potentielle, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme diversifiée d'inhibiteurs de kinésine de haute qualité pour soutenir vos recherches en biologie cellulaire, mitose et thérapie contre le cancer.
88 produits trouvés pour "Kinésine"
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(R)-Filanesib
CAS :(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).Formule :C20H22F2N4O2SCouleur et forme :SolidMasse moléculaire :420.48Litronesib Racemate
CAS :Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.Formule :C23H37N5O4S2Couleur et forme :SolidMasse moléculaire :511.7Eg5 Inhibitor V, trans-24
CAS :Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Formule :C26H21N3O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :423.46Ref: TM-T11155
1mg96,00€5mg193,00€10mg289,00€25mg469,00€50mg642,00€100mg858,00€200mg1.153,00€1mL*10mM (DMSO)215,00€Mps-BAY2b
CAS :Mps-BAY2b is a novel MPS1 inhibitor.Formule :C20H23N5OCouleur et forme :SolidMasse moléculaire :349.43Mps1-IN-4
CAS :Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.Formule :C26H31F3N6O2Couleur et forme :SolidMasse moléculaire :516.56Syntelin
CAS :Syntelin: a selective CENP-E inhibitor with an IC50 of 160 nM; distinct from GSK923295, effective on resistant mutants.Formule :C21H20N6O2S3Couleur et forme :SolidMasse moléculaire :484.62EMD534085
CAS :EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).Formule :C25H31F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.53HR22C16
CAS :HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.Formule :C23H23N3O3Couleur et forme :SolidMasse moléculaire :389.45KIF18A-IN-4
CAS :KIF18A-IN-4: Non-competitive KIF18A inhibitor, IC50 6.16 μM, targets mitotic kinesins/kinases, anti-tumor.Formule :C22H27N3O3SCouleur et forme :SolidMasse moléculaire :413.53CK0106023
CAS :CK0106023, a KSP inhibitor, shows strong antitumor effects in mice, outperforming paclitaxel, and induces monopolar spindles.Formule :C30H32BrClN4O2Couleur et forme :SolidMasse moléculaire :595.96AM-5308
CAS :AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.Formule :C26H35N5O5SDegré de pureté :98.06% - 99.58%Couleur et forme :SolidMasse moléculaire :529.65SR31527
CAS :SR31527 chloride: potent KIFC1 inhibitor (IC50 6.6 µM), moderately impairs cell viability & colony growth.Formule :C15H14ClN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.81Kif15-IN-1
CAS :Kif15-IN-1 is a Kif15 inhibitor with antiproliferative and potential anticancer activity, which can be used to study gastric cancer.Formule :C20H22N4O5SDegré de pureté :99.39% - 99.39%Couleur et forme :SolidMasse moléculaire :430.48KIF18A-IN-3
CAS :KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Formule :C28H38N4O5S2Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :574.76UMK57
CAS :UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,Formule :C17H17N3SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :295.4KIF18A-IN-7
CAS :KIF18A-IN-7 is an orally active inhibitor targeting KIF18A, demonstrating potent inhibition with an IC50 value of 9.4 nM against the microtubule-dependentFormule :C27H35N3O5S2Couleur et forme :SoildMasse moléculaire :545.71NTRC 0066-0
CAS :NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.Formule :C33H39N7O2Degré de pureté :98.30%Couleur et forme :SolidMasse moléculaire :565.71Mps1-IN-10
CAS :Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects onFormule :C24H27N7O2Couleur et forme :SolidMasse moléculaire :445.52Kif15-IN-2
CAS :Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.Formule :C20H20N6O4SDegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :440.48CCT251455
CAS :CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.
Formule :C26H26ClN7O2Degré de pureté :99.1% - 99.1%Couleur et forme :SolidMasse moléculaire :503.98Litronesib
CAS :Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.Formule :C23H37N5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.7MC-Val-Cit-PAB-Ispinesib
CAS :MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].Formule :C59H71ClN10O10Couleur et forme :SolidMasse moléculaire :1115.71KSP-IA
CAS :KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.Formule :C21H22F2N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.41Luvixasertib hydrochloride
CAS :CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].Formule :C28H31ClN6O3Couleur et forme :SolidMasse moléculaire :535.04CCT-271850
CAS :CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.Formule :C24H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.53PVZB1194
CAS :PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis throughFormule :C13H9F4NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.28SB-743921 free base
CAS :SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).Formule :C31H33ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.06TNH
CAS :TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].Formule :C39H57ClN6O13Couleur et forme :SolidMasse moléculaire :853.36CFI-402257
CAS :CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.Formule :C28H30N6O3Degré de pureté :96.66% - 99.51%Couleur et forme :SolidMasse moléculaire :498.58RMS-07
CAS :RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Formule :C35H40N8O2Couleur et forme :SolidMasse moléculaire :604.74NVP-BQS481
CAS :NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).Formule :C27H33F3N4O2Couleur et forme :SolidMasse moléculaire :502.57Kolavenic acid analog
CAS :KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Formule :C25H38O4Couleur et forme :SolidMasse moléculaire :402.57EX05
CAS :EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.Formule :C26H30F2N4O5SCouleur et forme :SolidMasse moléculaire :548.60Mps1-IN-8
CAS :Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].Formule :C35H47N8O6PCouleur et forme :SolidMasse moléculaire :706.77MKLP2-IN-1
CAS :MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.
Formule :C23H19BrFN3O2Couleur et forme :SolidMasse moléculaire :468.318AM-9022
CAS :AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].Formule :C27H36F2N6O4SCouleur et forme :SolidMasse moléculaire :578.67Terpendole E
CAS :Terpendole E is an atypical L5 site inhibitor.Formule :C28H39NO3Couleur et forme :SolidMasse moléculaire :437.61Mitotic kinesin-IN-1 hydrochloride
CAS :Mitotic kinesin-IN-1 hydrochloride (Example 80) is an inhibitor of mitotic kinesin, which suppresses cell proliferation by hindering mitosis. This compound is applicable in research related to cancer, cardiac hypertrophy, immune and inflammatory diseases, and fungal infections.Formule :C22H26ClF2N3OSCouleur et forme :SolidMasse moléculaire :453.98
