Intégrine
Les inhibiteurs d'intégrines ciblent les intégrines, une famille de récepteurs de surface cellulaire qui jouent un rôle crucial dans l'adhésion cellulaire, la migration et la transduction du signal. Les intégrines sont impliquées dans la régulation du cycle cellulaire, en particulier dans des processus tels que la division et la différenciation cellulaires. Inhiber les intégrines peut perturber ces processus, entraînant un arrêt du cycle cellulaire et l'apoptose, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer et l'étude des métastases. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs d'intégrines de haute qualité pour soutenir vos recherches sur la régulation du cycle cellulaire, la biologie du cancer et le développement thérapeutique.
224 produits trouvés pour "Intégrine"
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RWJ 50271
CAS :<p>RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.</p>Formule :C18H17F3N4O2SDegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :410.41Orbofiban TFA
CAS :<p>Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronary</p>Formule :C19H24F3N5O6Degré de pureté :97.21% - 98.72%Couleur et forme :SolidMasse moléculaire :475.42Elarofiban TFA
CAS :<p>Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.</p>Formule :C26H34F6N4O8Degré de pureté :99.08%Couleur et forme :SoildMasse moléculaire :644.56ATN-161 trifluoroacetate salt
CAS :<p>ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.</p>Formule :C25H36F3N9O10SDegré de pureté :98% - 99.98%Couleur et forme :SolidMasse moléculaire :711.67Abciximab
CAS :<p>Abciximab: chimeric antibody, anti-platelet, blocks glycoprotein IIb/IIIa, vitronectin, Mac-1.</p>Degré de pureté :SDS-PAGE:95.2%;SEC-HPLC:95.9%Couleur et forme :LiquidMasse moléculaire :95.18 kDaVedolizumab
CAS :<p>Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.</p>Degré de pureté :SDS-PAGE:98.4%;SEC-HPLC:99.1%Couleur et forme :LiquidMasse moléculaire :146.80 kDaForalumab
CAS :<p>Foralumab (NI-0401) is a human anti-CD3 monoclonal antibody for the study of COVID-19 infection.</p>Degré de pureté :96.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :LiquidBersanlimab
CAS :<p>Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :144.22 kDaEfalizumab
CAS :<p>Efalizumab: humanized monoclonal antibody CD11a; modulates T cell activation/adhesion; for plaque psoriasis, psoriatic arthritis research.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.77%Couleur et forme :LiquidMasse moléculaire :146.14 kDaAbituzumab
CAS :<p>Abituzumab (DI17E6) is a humanized monoclonal antibody targeting integrin alphaV, exhibiting anti-cancer activity and can be used in prostate cancer research.</p>Degré de pureté :>95%Couleur et forme :LiquidTidutamab
CAS :<p>Tidutamab (XmAb-18087) is a humanized bispecific antibody targeting the growth inhibitory receptor 2 (SSTR2) and T cell binding domain (CD3).</p>Degré de pureté :97.9% (SDS-PAGE); 97.8% (SEC-HPLC) - 97.9% (SDS-PAGE); 97.8% (SEC-HPLC)Couleur et forme :LiquidCibisatamab
CAS :<p>Cibisatamab, a T-cell bispecific antibody, targets CEA on cancer cells and CD3 on T-cells, inducing T-cell-mediated tumor cell killing.</p>Degré de pureté :SDS-PAGE:99.1%;SEC-HPLC:96.5%Couleur et forme :LiquidMasse moléculaire :191.1 kDaOtelixizumab
CAS :<p>Otelixizumab (ChAglyCD3) is a chimeric monoclonal antibody targeting CD3, used in research on Type 1 diabetes and autoimmune diseases.</p>Degré de pureté :>95%Couleur et forme :LiquidTadocizumab
CAS :<p>Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.</p>Degré de pureté :97.1% (SDS-PAGE); 97.2% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.2% (SEC-HPLC)Couleur et forme :LiquidAbrilumab
CAS :<p>Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.</p>Degré de pureté :98.5% (SDS-PAGE); 99% (SEC-HPLC) - 98.5% (SDS-PAGE); 99% (SEC-HPLC)Couleur et forme :LiquidTeplizumab
CAS :<p>Teplizumab (MGA-031) is a humanized monoclonal antibody against CD3 that slows the loss of beta cell function.Teplizumab is used to treat type 1 diabetes.</p>Degré de pureté :SDS-PAGE:95.8%;SEC-HPLC:99.7%Couleur et forme :LiquidMasse moléculaire :145.79 kDaObtustatin triacetate
<p>Obtustatin triacetate, a 41-residue non-RGD disintegrin isolated from the venom of Vipera lebetina obtusa, serves as a potent and selective inhibitor of the</p>Formule :C184H284N52O57S8·3C2H4O2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :4573.21GSK 3008348 hydrochloride
CAS :<p>GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.</p>Formule :C29H37N5O2xHClDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :0BT100
<p>BT100, an aptamer, impedes the interaction of von Willebrand factor (VWF) with platelet glycoprotein GPIb, thus obstructing arterial thrombosis [1].</p>Degré de pureté :98%Couleur et forme :Odour SolidVolociximab
CAS :<p>Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.</p>Degré de pureté :95%Couleur et forme :LiquidDentonin TFA
<p>Dentonin TFA (AC-100 TFA) is a short peptide fragment derived from MEPE. It enhances osteogenesis by promoting the adhesion of osteoprogenitor cells and supports the survival of immature adherent cells. Dentonin TFA does not have a significant effect on mature osteoblasts and can be utilized in studies of phosphate homeostasis and bone metabolism.</p>Formule :C109H161F3N30O44Masse moléculaire :2651.1235ICAM-1988
CAS :<p>ICAM-1988 is a LFA-1 antagonist.</p>Formule :C22H22Cl2N4O6SCouleur et forme :SolidMasse moléculaire :541.4DSPE-PEG1000-cRGD
<p>DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.</p>Couleur et forme :Odour SolidLamifiban trifluoroacetate
CAS :<p>Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa).</p>Formule :C26H29F3N4O8Couleur et forme :SolidMasse moléculaire :582.533Fibronectin CS1 Peptide
CAS :<p>Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.</p>Formule :C38H64N8O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :872.96C16Y
CAS :<p>C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.</p>Formule :C78H115N17O17Couleur et forme :SolidMasse moléculaire :1562.85Ganodermaones B
<p>Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .</p>Formule :C21H26O5Couleur et forme :SolidMasse moléculaire :358.43Catumaxomab
CAS :<p>Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.</p>Degré de pureté :95%Couleur et forme :LiquidLDV-FITC TFA
<p>LDV-FITC TFA is a fluorescent peptide, specifically an FITC-conjugated LDV peptide. This compound binds to the α4β1 integrin with high affinity, displaying a Kd of 0.3 nM in the presence of Mn2+ and 12 nM in its absence, when binding to U937 cells. LDV-FITC TFA is useful for assessing α4β1 integrin affinity.</p>Formule :C69H81N11O17S·xC2HF3O2Azelaoyl PAF
CAS :<p>Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones.promotes the uptake of oxLDL by macrophages by upregulating CD36 expression.</p>Formule :C33H66NO9PCouleur et forme :SolidMasse moléculaire :651.85A20FMDV2
CAS :<p>A20FMDV2 is a highly selective αvβ6 integrin inhibitor with an IC 50 of 3 nM, demonstrating 1,000-fold greater selectivity for αvβ6 compared to other RGD-directed integrins like αvβ3, αvβ5, and α5β1. This compound can be derived from the foot-and-mouth disease virus and is suitable for radiolabeling, enabling PET imaging of αvβ6 integrin-positive tumors.</p>Formule :C93H163N31O28Couleur et forme :SolidMasse moléculaire :2163.48Indatuximab
<p>Indatuximab is a chimeric antibody targeting CD13, used in the synthesis of ADC compound Indatuximab ravtansine.</p>Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :145.5 kDaαvβ6-IN-2
<p>αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.</p>Formule :C25H30F3N3O3Couleur et forme :SolidMasse moléculaire :477.52αVβ8-IN-1
CAS :<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Formule :C25H32ClN5O4Couleur et forme :SolidMasse moléculaire :502.01Risuteganib
CAS :<p>Risuteganib is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide that regulates the functions of multiple integrin isoforms.</p>Formule :C22H39N9O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :637.66HSDVHK-NH2 TFA
<p>HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [</p>Formule :C32H49F3N12O11Couleur et forme :SolidMasse moléculaire :834.8Bimosiamose disodium
CAS :<p>Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.</p>Formule :C46H52Na2O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :906.88GRGDSPK
CAS :<p>GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.</p>Formule :C28H49N11O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :715.76Fradafiban hydrochloride
<p>Fradafiban (BIBU-52) is a nonpeptide GPIIb/IIIa antagonist with Kd 148 nM for human platelets.</p>Formule :C20H22ClN3O4Couleur et forme :SolidMasse moléculaire :403.86αvβ5 integrin-IN-1
CAS :<p>αvβ5 integrin-IN-1, a potent and selective αvβ5 integrin inhibitor, exhibits a high inhibitory potency with a pIC50 value of 8.2.</p>Formule :C25H28F3N3O3Couleur et forme :SolidMasse moléculaire :475.512Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Formule :C25H41N11O8SCouleur et forme :SolidMasse moléculaire :655.727Mumefural
CAS :<p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>Formule :C12H12O9Couleur et forme :SolidMasse moléculaire :300.22TC113
<p>TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.</p>Formule :C37H50F2N12O13Couleur et forme :SolidMasse moléculaire :908.86αvβ6-IN-1
<p>αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.</p>Formule :C25H32F2N4O3Couleur et forme :SolidMasse moléculaire :474.54Anti-GPRC5D Antibody
<p>Anti-GPRC5D Antibody is a humanized IgG1 monoclonal antibody targeting GPRC5D. It serves as the antibody component of the ADC molecule LM-305.</p>Couleur et forme :Odour Liquidc(avb6)-DOTA TFA
<p>c(avb6)-DOTA TFA is a conjugate formed by the coupling of a selective αvβ6 integrin cyclic peptide and a DPTA chelating agent. The Lu (III) complex of c(avb6)-DOTA TFA exhibits considerable affinity for αvβ6 integrin (IC50=0.8 nM), making it suitable for tumor diagnostics.</p>Formule :C69H102F3N17O20Couleur et forme :SolidMasse moléculaire :1546.65Lys-Gln-Ala-Gly-Asp-Val
CAS :<p>KQAGDV is a fibrinogen γ-chain cell adhesion peptide, targeting α2bβ3 integrin, and binds SMCs.</p>Formule :C25H44N8O10Couleur et forme :SolidMasse moléculaire :616.66EMD527040
CAS :<p>EMD527040 is a potent αvβ6 antagonist with antifibrotic effects, used in carcinoma and liver fibrosis research.</p>Formule :C29H32Cl2N4O5Couleur et forme :SolidMasse moléculaire :587.5Odulimomab
CAS :<p>Odulimomab: anti-LFA-1 antibody, inhibits T cell growth, protects against ischemic injury, used in transplant rejection research.</p>Couleur et forme :LiquidBIO5192 hydrate
<p>BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.</p>Couleur et forme :SolidEchistatin TFA
<p>Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.</p>Couleur et forme :Odour SolidDafsolimab
CAS :<p>Dafsolimab (SPV-T3a), an IgG2a murine monoclonal antibody (anti-CD3), induces cell death by modulating and activating the CD3/T cell receptor complex and is</p>Couleur et forme :LiquidIntegrin Binding Peptide
CAS :<p>Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.</p>Formule :C42H63N15O16SCouleur et forme :SolidMasse moléculaire :1066.12Variabilin
CAS :<p>Variabilin is a natural product that can be used as a reference standard. The CAS number of Variabilin is 3187-52-8.</p>Formule :C17H16O5Couleur et forme :SolidMasse moléculaire :300.31LDV FITC
CAS :<p>fluorescent ligand that binds to the α4β1 integrin (VLA-4)</p>Formule :C69H81N11O17SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1368.53Besufetamig
CAS :<p>Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.</p>Couleur et forme :LiquidhuATN-658
<p>huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.</p>Couleur et forme :Odour Liquidc(phg-isoDGR-(NMe)k) TFA
<p>C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].</p>Formule :C29H42F3N9O9Couleur et forme :SolidMasse moléculaire :717.69KGDS
CAS :<p>KGDS is a synthetic peptide that targets the integrin GPIIb-IIIa on the membrane of activated human platelets, with the amino acid sequence Lys-Gly-Asp-Ser [1].</p>Formule :C15H27N5O8Couleur et forme :SolidMasse moléculaire :405.4LDV
CAS :<p>α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.</p>Formule :C48H70N10O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :979.13LXY3
CAS :<p>LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.</p>Formule :C32H43N11O15S2Couleur et forme :SolidMasse moléculaire :885.88DSPE-PEG3000-iRGD
<p>DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.</p>Couleur et forme :Odour SolidMS133
<p>MS133 is a human bispecific antibody targeting CD133/PROM1 and CD3E. It is used in the study of colon cancer.</p>Couleur et forme :Odour LiquidArg-Gly-Glu-Ser
CAS :<p>Arg-Gly-Glu-Ser is a RGD related peptide that is a control for the RGDS activity of fibrinogen binding to activated platelets.</p>Formule :C16H29N7O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :447.44DSPE-PEG5000-cRGD
<p>DSPE-PEG5000-cRGD is a PEG compound composed of DSPE and an αvβ3 targeting peptide (cRGD). The cRGD peptide has the ability to specifically bind to the αvβ3 present on the surfaces of numerous cancer cells and new vascular cells. DSPE-PEG5000-cRGD is useful for drug delivery applications.</p>Couleur et forme :Odour SolidR-BC154 acetate
<p>R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.</p>Formule :C56H65N9O14S3Couleur et forme :SolidMasse moléculaire :1184.36Fuzapladib
CAS :<p>Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.</p>Formule :C15H20F3N3O3SDegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :379.4PLN-1474
CAS :<p>PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.</p>Formule :C24H37N3O4Degré de pureté :99.92%Couleur et forme :SoildMasse moléculaire :431.57RTDLDSLRTYTL
CAS :<p>RTDLDSLRTYTL is a high-affinity and specific inhibitor of Alpha (v) beta (6) integrin (avb6). By binding to the avb6 integrin, this peptide sequence activates T cell cytotoxicity and cytokine production, such as interferon-γ. Through the design of chimeric T cell antigen receptors (CAR), RTDLDSLRTYTL enables T cells to be redirected, allowing them to specifically recognize and attack tumor cells. It is used in research for cancer immunotherapy and the development of targeted drugs.</p>Formule :C62H104N18O22Couleur et forme :SolidMasse moléculaire :1453.60Echistatin
CAS :<p>Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).</p>Formule :C217H341N71O74S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5417.1Obtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Formule :C184H284N52O57S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4393.07GRGDSPK TFA
<p>GRGDSPK TFA is an RGD peptide, competitive inhibitor of integrin-fibronectin, used to research integrins in bone dynamics.</p>Formule :C30H50F3N11O13Couleur et forme :SolidMasse moléculaire :829.78GRGDSP
CAS :<p>Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide.</p>Formule :C22H37N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.58α2β1 Integrin Ligand Peptide TFA
<p>α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is a</p>Formule :C16H23F3N4O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.37PDI-IN-4
<p>PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.</p>Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.278Bimosiamose
CAS :<p>Bimosiamose has anti-inflammatory effects[1].</p>Formule :C46H54O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :862.91Etrolizumab
CAS :<p>MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.</p>Degré de pureté :98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Couleur et forme :LiquidDSPE-PEG1000-iRGD
<p>DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.</p>Couleur et forme :Odour SolidOrbofiban acetate
CAS :<p>Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administered</p>Formule :C19H27N5O6Couleur et forme :SolidMasse moléculaire :421.45STX-100
<p>PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.</p>Degré de pureté :97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :Odour LiquidHSDVHK-NH2
CAS :<p>Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.</p>Formule :C30H48N12O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :720.78AB-3PRGD2
CAS :<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formule :C137H215IN30O45SCouleur et forme :SolidMasse moléculaire :3161.32Gantofiban
CAS :<p>Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.</p>Formule :C21H29N5O6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :447.48P8RI acetate
<p>P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.</p>Formule :C53H81N13O11Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :1076.29Gly-Arg-Gly-Asp-Ser
CAS :<p>Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.</p>Formule :C17H30N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.472-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Formule :C12H24ClNO4Couleur et forme :SolidMasse moléculaire :281.78Anti-EMMPRIN/CD147 Antibody
<p>Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour Liquidα2β1 Integrin Ligand Peptide
CAS :<p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>Formule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.35DSPE-PEG2000-iRGD
<p>DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.</p>Couleur et forme :Odour SolidForimtamig
<p>Forimtamig (RG-6324) is a bispecific antibody that targets GPRC5D and CD3 T cells. It features a 2 + 1 structure, comprising two high-affinity GPRC5D binding segments and one CD3-binding module. Forimtamig is engineered with a P329G LALA mutation in its Fc domain to prevent Fcγ receptor and C1q binding, while maintaining Fc receptor interaction. Its isotype control corresponds to human IgG1 kappa.</p>Couleur et forme :Odour LiquidDSPE-PEG2000-cRGD
<p>DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.</p>Couleur et forme :Odour SolidSMS 121
CAS :<p>SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.</p>Formule :C20H21NO5Degré de pureté :98.29%Couleur et forme :SoildMasse moléculaire :355.38K34c hydrochloride
CAS :<p>K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.</p>Formule :C26H30ClN3O4Degré de pureté :99.76% - 99.89%Couleur et forme :SoildMasse moléculaire :483.99Lifitegrast sodium
CAS :<p>Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.</p>Formule :C29H23Cl2N2NaO7SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :637.46Cilengitide TFA
CAS :<p>Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.</p>Formule :C29H41F3N8O9Couleur et forme :SolidMasse moléculaire :702.68GPRP
CAS :<p>GPRP (Gly-Pro-Arg-Pro) is a fibrin polymerization inhibitor.</p>Formule :C18H31N7O5Couleur et forme :White To Off-White PowderMasse moléculaire :425.48RGD Trifluoroacetate
CAS :<p>RGD Trifluoroacetate is a tripeptide for cell adhesion, effective on 24 integrins, and widely used for synthetic surface binding.</p>Formule :C14H23F3N6O8Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :460.36MK-0429
CAS :<p>MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).</p>Formule :C23H29N5O4Couleur et forme :SolidMasse moléculaire :439.51Anti-Mouse CD3 Antibody (17A2)
<p>Anti-Mouse CD3 Antibody (17A2) is an IgG2b class antibody of murine origin targeting CD3 and can be used to study TCR signaling and antigen recognition.</p>Couleur et forme :Odour LiquidiRGD peptide
CAS :<p>iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.</p>Formule :C35H57N13O14S2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :948.04
