Intégrine
Les inhibiteurs d'intégrines ciblent les intégrines, une famille de récepteurs de surface cellulaire qui jouent un rôle crucial dans l'adhésion cellulaire, la migration et la transduction du signal. Les intégrines sont impliquées dans la régulation du cycle cellulaire, en particulier dans des processus tels que la division et la différenciation cellulaires. Inhiber les intégrines peut perturber ces processus, entraînant un arrêt du cycle cellulaire et l'apoptose, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer et l'étude des métastases. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs d'intégrines de haute qualité pour soutenir vos recherches sur la régulation du cycle cellulaire, la biologie du cancer et le développement thérapeutique.
224 produits trouvés pour "Intégrine"
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HSDVHK-NH2
CAS :<p>Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.</p>Formule :C30H48N12O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :720.78AB-3PRGD2
CAS :<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formule :C137H215IN30O45SCouleur et forme :SolidMasse moléculaire :3161.32Gantofiban
CAS :<p>Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.</p>Formule :C21H29N5O6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :447.48P8RI acetate
<p>P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.</p>Formule :C53H81N13O11Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :1076.29Gly-Arg-Gly-Asp-Ser
CAS :<p>Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.</p>Formule :C17H30N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.472-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Formule :C12H24ClNO4Couleur et forme :SolidMasse moléculaire :281.78Anti-EMMPRIN/CD147 Antibody
<p>Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour Liquidα2β1 Integrin Ligand Peptide
CAS :<p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>Formule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.35DSPE-PEG2000-iRGD
<p>DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.</p>Couleur et forme :Odour SolidForimtamig
<p>Forimtamig (RG-6324) is a bispecific antibody that targets GPRC5D and CD3 T cells. It features a 2 + 1 structure, comprising two high-affinity GPRC5D binding segments and one CD3-binding module. Forimtamig is engineered with a P329G LALA mutation in its Fc domain to prevent Fcγ receptor and C1q binding, while maintaining Fc receptor interaction. Its isotype control corresponds to human IgG1 kappa.</p>Couleur et forme :Odour LiquidDSPE-PEG2000-cRGD
<p>DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.</p>Couleur et forme :Odour SolidSMS 121
CAS :<p>SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.</p>Formule :C20H21NO5Degré de pureté :98.29%Couleur et forme :SoildMasse moléculaire :355.38K34c hydrochloride
CAS :<p>K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.</p>Formule :C26H30ClN3O4Degré de pureté :99.76% - 99.89%Couleur et forme :SoildMasse moléculaire :483.99Lifitegrast sodium
CAS :<p>Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.</p>Formule :C29H23Cl2N2NaO7SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :637.46Cilengitide TFA
CAS :<p>Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.</p>Formule :C29H41F3N8O9Couleur et forme :SolidMasse moléculaire :702.68GPRP
CAS :<p>GPRP (Gly-Pro-Arg-Pro) is a fibrin polymerization inhibitor.</p>Formule :C18H31N7O5Couleur et forme :White To Off-White PowderMasse moléculaire :425.48RGD Trifluoroacetate
CAS :<p>RGD Trifluoroacetate is a tripeptide for cell adhesion, effective on 24 integrins, and widely used for synthetic surface binding.</p>Formule :C14H23F3N6O8Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :460.36MK-0429
CAS :<p>MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).</p>Formule :C23H29N5O4Couleur et forme :SolidMasse moléculaire :439.51Anti-Mouse CD3 Antibody (17A2)
<p>Anti-Mouse CD3 Antibody (17A2) is an IgG2b class antibody of murine origin targeting CD3 and can be used to study TCR signaling and antigen recognition.</p>Couleur et forme :Odour LiquidiRGD peptide
CAS :<p>iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.</p>Formule :C35H57N13O14S2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :948.04
