Intégrine
Les inhibiteurs d'intégrines ciblent les intégrines, une famille de récepteurs de surface cellulaire qui jouent un rôle crucial dans l'adhésion cellulaire, la migration et la transduction du signal. Les intégrines sont impliquées dans la régulation du cycle cellulaire, en particulier dans des processus tels que la division et la différenciation cellulaires. Inhiber les intégrines peut perturber ces processus, entraînant un arrêt du cycle cellulaire et l'apoptose, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer et l'étude des métastases. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs d'intégrines de haute qualité pour soutenir vos recherches sur la régulation du cycle cellulaire, la biologie du cancer et le développement thérapeutique.
278 produits trouvés pour "Intégrine"
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αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Formule :C25H32F2N4O3Couleur et forme :SolidMasse moléculaire :474.54Odulimomab
CAS :Odulimomab: anti-LFA-1 antibody, inhibits T cell growth, protects against ischemic injury, used in transplant rejection research.Couleur et forme :LiquidPDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.278R-BC154 acetate
R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.Formule :C56H65N9O14S3Couleur et forme :SolidMasse moléculaire :1184.36EMD527040
CAS :EMD527040 is a potent αvβ6 antagonist with antifibrotic effects, used in carcinoma and liver fibrosis research.Formule :C29H32Cl2N4O5Couleur et forme :SolidMasse moléculaire :587.5BIO5192 hydrate
BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.Couleur et forme :SolidAB-3PRGD2
CAS :AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.Formule :C137H215IN30O45SCouleur et forme :SolidMasse moléculaire :3161.32Ganodermaones B
Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .Formule :C21H26O5Couleur et forme :SolidMasse moléculaire :358.43KGDS
CAS :KGDS is a synthetic peptide that targets the integrin GPIIb-IIIa on the membrane of activated human platelets, with the amino acid sequence Lys-Gly-Asp-Ser [1].Formule :C15H27N5O8Couleur et forme :SolidMasse moléculaire :405.4Lys-Gln-Ala-Gly-Asp-Val
CAS :KQAGDV is a fibrinogen γ-chain cell adhesion peptide, targeting α2bβ3 integrin, and binds SMCs.Formule :C25H44N8O10Couleur et forme :SolidMasse moléculaire :616.66SAN-300
SAN-300 is a human-derived IgG1 monoclonal antibody (mAb) that targets ITGA1/VLA-1. It is utilized in the research of rheumatoid arthritis.Couleur et forme :Odour LiquidGRGDSPK TFA
GRGDSPK TFA is an RGD peptide, competitive inhibitor of integrin-fibronectin, used to research integrins in bone dynamics.Formule :C30H50F3N11O13Couleur et forme :SolidMasse moléculaire :829.78DSPE-PEG5000-cRGD
DSPE-PEG5000-cRGD is a PEG compound composed of DSPE and an αvβ3 targeting peptide (cRGD). The cRGD peptide has the ability to specifically bind to the αvβ3 present on the surfaces of numerous cancer cells and new vascular cells. DSPE-PEG5000-cRGD is useful for drug delivery applications.Couleur et forme :Odour SolidIntegrin Binding Peptide
CAS :Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.Formule :C42H63N15O16SCouleur et forme :SolidMasse moléculaire :1066.12MS133
MS133 is a human bispecific antibody targeting CD133/PROM1 and CD3E. It is used in the study of colon cancer.Couleur et forme :Odour LiquidRTDLDSLRTYTL
CAS :RTDLDSLRTYTL is a high-affinity and specific inhibitor of Alpha (v) beta (6) integrin (avb6). By binding to the avb6 integrin, this peptide sequence activates T cell cytotoxicity and cytokine production, such as interferon-γ. Through the design of chimeric T cell antigen receptors (CAR), RTDLDSLRTYTL enables T cells to be redirected, allowing them to specifically recognize and attack tumor cells. It is used in research for cancer immunotherapy and the development of targeted drugs.Formule :C62H104N18O22Couleur et forme :SolidMasse moléculaire :1453.60HSDVHK-NH2 TFA
HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [Formule :C32H49F3N12O11Couleur et forme :SolidMasse moléculaire :834.8A20FMDV2
CAS :A20FMDV2 is a highly selective αvβ6 integrin inhibitor with an IC 50 of 3 nM, demonstrating 1,000-fold greater selectivity for αvβ6 compared to other RGD-directed integrins like αvβ3, αvβ5, and α5β1. This compound can be derived from the foot-and-mouth disease virus and is suitable for radiolabeling, enabling PET imaging of αvβ6 integrin-positive tumors.Formule :C93H163N31O28Couleur et forme :SolidMasse moléculaire :2163.48PLN-1474
CAS :PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.Formule :C24H37N3O4Degré de pureté :99.92%Couleur et forme :SoildMasse moléculaire :431.57Ref: TM-T60101
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg170,00€25mg289,00€50mg416,00€100mg580,00€ICAM-1988
CAS :ICAM-1988 is a LFA-1 antagonist.Formule :C22H22Cl2N4O6SCouleur et forme :SolidMasse moléculaire :541.4
