Intégrine
Les inhibiteurs d'intégrines ciblent les intégrines, une famille de récepteurs de surface cellulaire qui jouent un rôle crucial dans l'adhésion cellulaire, la migration et la transduction du signal. Les intégrines sont impliquées dans la régulation du cycle cellulaire, en particulier dans des processus tels que la division et la différenciation cellulaires. Inhiber les intégrines peut perturber ces processus, entraînant un arrêt du cycle cellulaire et l'apoptose, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer et l'étude des métastases. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs d'intégrines de haute qualité pour soutenir vos recherches sur la régulation du cycle cellulaire, la biologie du cancer et le développement thérapeutique.
224 produits trouvés pour "Intégrine"
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Teplizumab
CAS :<p>Teplizumab (MGA-031) is a humanized monoclonal antibody against CD3 that slows the loss of beta cell function.Teplizumab is used to treat type 1 diabetes.</p>Degré de pureté :SDS-PAGE:95.8%;SEC-HPLC:99.7%Couleur et forme :LiquidMasse moléculaire :145.79 kDaElarofiban TFA
CAS :<p>Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.</p>Formule :C26H34F6N4O8Degré de pureté :99.08%Couleur et forme :SoildMasse moléculaire :644.56Cibisatamab
CAS :<p>Cibisatamab, a T-cell bispecific antibody, targets CEA on cancer cells and CD3 on T-cells, inducing T-cell-mediated tumor cell killing.</p>Degré de pureté :SDS-PAGE:99.1%;SEC-HPLC:96.5%Couleur et forme :LiquidMasse moléculaire :191.1 kDaEfalizumab
CAS :<p>Efalizumab: humanized monoclonal antibody CD11a; modulates T cell activation/adhesion; for plaque psoriasis, psoriatic arthritis research.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.77%Couleur et forme :LiquidMasse moléculaire :146.14 kDaATN-161 trifluoroacetate salt
CAS :<p>ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.</p>Formule :C25H36F3N9O10SDegré de pureté :98% - 99.98%Couleur et forme :SolidMasse moléculaire :711.67Abrilumab
CAS :<p>Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.</p>Degré de pureté :98.5% (SDS-PAGE); 99% (SEC-HPLC) - 98.5% (SDS-PAGE); 99% (SEC-HPLC)Couleur et forme :LiquidAbituzumab
CAS :<p>Abituzumab (DI17E6) is a humanized monoclonal antibody targeting integrin alphaV, exhibiting anti-cancer activity and can be used in prostate cancer research.</p>Degré de pureté :>95%Couleur et forme :LiquidTidutamab
CAS :<p>Tidutamab (XmAb-18087) is a humanized bispecific antibody targeting the growth inhibitory receptor 2 (SSTR2) and T cell binding domain (CD3).</p>Degré de pureté :97.9% (SDS-PAGE); 97.8% (SEC-HPLC) - 97.9% (SDS-PAGE); 97.8% (SEC-HPLC)Couleur et forme :LiquidBersanlimab
CAS :<p>Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :144.22 kDaAbciximab
CAS :<p>Abciximab: chimeric antibody, anti-platelet, blocks glycoprotein IIb/IIIa, vitronectin, Mac-1.</p>Degré de pureté :SDS-PAGE:95.2%;SEC-HPLC:95.9%Couleur et forme :LiquidMasse moléculaire :95.18 kDaTadocizumab
CAS :<p>Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.</p>Degré de pureté :97.1% (SDS-PAGE); 97.2% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.2% (SEC-HPLC)Couleur et forme :LiquidOrbofiban TFA
CAS :<p>Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronary</p>Formule :C19H24F3N5O6Degré de pureté :97.21% - 98.72%Couleur et forme :SolidMasse moléculaire :475.42Vedolizumab
CAS :<p>Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.</p>Degré de pureté :SDS-PAGE:98.4%;SEC-HPLC:99.1%Couleur et forme :LiquidMasse moléculaire :146.80 kDaOtelixizumab
CAS :<p>Otelixizumab (ChAglyCD3) is a chimeric monoclonal antibody targeting CD3, used in research on Type 1 diabetes and autoimmune diseases.</p>Degré de pureté :>95%Couleur et forme :LiquidForalumab
CAS :<p>Foralumab (NI-0401) is a human anti-CD3 monoclonal antibody for the study of COVID-19 infection.</p>Degré de pureté :96.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :LiquidRWJ 50271
CAS :<p>RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.</p>Formule :C18H17F3N4O2SDegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :410.41αvβ5 integrin-IN-1
CAS :<p>αvβ5 integrin-IN-1, a potent and selective αvβ5 integrin inhibitor, exhibits a high inhibitory potency with a pIC50 value of 8.2.</p>Formule :C25H28F3N3O3Couleur et forme :SolidMasse moléculaire :475.512Echistatin
CAS :<p>Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).</p>Formule :C217H341N71O74S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5417.1LDV
CAS :<p>α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.</p>Formule :C48H70N10O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :979.13Fradafiban hydrochloride
<p>Fradafiban (BIBU-52) is a nonpeptide GPIIb/IIIa antagonist with Kd 148 nM for human platelets.</p>Formule :C20H22ClN3O4Couleur et forme :SolidMasse moléculaire :403.86DSPE-PEG1000-cRGD
<p>DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.</p>Couleur et forme :Odour SolidSMS 121
CAS :<p>SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.</p>Formule :C20H21NO5Degré de pureté :98.29%Couleur et forme :SoildMasse moléculaire :355.38LXY3
CAS :<p>LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.</p>Formule :C32H43N11O15S2Couleur et forme :SolidMasse moléculaire :885.88c(phg-isoDGR-(NMe)k) TFA
<p>C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].</p>Formule :C29H42F3N9O9Couleur et forme :SolidMasse moléculaire :717.69Dafsolimab
CAS :<p>Dafsolimab (SPV-T3a), an IgG2a murine monoclonal antibody (anti-CD3), induces cell death by modulating and activating the CD3/T cell receptor complex and is</p>Couleur et forme :LiquidPDI-IN-4
<p>PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.</p>Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.278LDV FITC
CAS :<p>fluorescent ligand that binds to the α4β1 integrin (VLA-4)</p>Formule :C69H81N11O17SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1368.53Catumaxomab
CAS :<p>Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.</p>Degré de pureté :95%Couleur et forme :LiquidDSPE-PEG2000-cRGD
<p>DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.</p>Couleur et forme :Odour SolidBesufetamig
CAS :<p>Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.</p>Couleur et forme :LiquidTC113
<p>TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.</p>Formule :C37H50F2N12O13Couleur et forme :SolidMasse moléculaire :908.86α2β1 Integrin Ligand Peptide
CAS :<p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>Formule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.35Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Formule :C25H41N11O8SCouleur et forme :SolidMasse moléculaire :655.727Obtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Formule :C184H284N52O57S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4393.07Gly-Arg-Gly-Asp-Ser
CAS :<p>Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.</p>Formule :C17H30N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.47Odulimomab
CAS :<p>Odulimomab: anti-LFA-1 antibody, inhibits T cell growth, protects against ischemic injury, used in transplant rejection research.</p>Couleur et forme :LiquidFibronectin CS1 Peptide
CAS :<p>Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.</p>Formule :C38H64N8O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :872.96Bimosiamose
CAS :<p>Bimosiamose has anti-inflammatory effects[1].</p>Formule :C46H54O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :862.91huATN-658
<p>huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.</p>Couleur et forme :Odour LiquidAB-3PRGD2
CAS :<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formule :C137H215IN30O45SCouleur et forme :SolidMasse moléculaire :3161.32GRGDSP
CAS :<p>Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide.</p>Formule :C22H37N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.58Mumefural
CAS :<p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>Formule :C12H12O9Couleur et forme :SolidMasse moléculaire :300.22Anti-EMMPRIN/CD147 Antibody
<p>Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidDSPE-PEG2000-iRGD
<p>DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.</p>Couleur et forme :Odour SolidDSPE-PEG3000-iRGD
<p>DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.</p>Couleur et forme :Odour SolidEtrolizumab
CAS :<p>MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.</p>Degré de pureté :98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Couleur et forme :LiquidSTX-100
<p>PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.</p>Degré de pureté :97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :Odour LiquidαVβ8-IN-1
CAS :<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Formule :C25H32ClN5O4Couleur et forme :SolidMasse moléculaire :502.012-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Formule :C12H24ClNO4Couleur et forme :SolidMasse moléculaire :281.78DSPE-PEG1000-iRGD
<p>DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.</p>Couleur et forme :Odour Solid
