LIM Kinase
Les inhibiteurs des kinases LIM ciblent les kinases LIM, une famille d'enzymes impliquées dans la régulation du cytosquelette d'actine et la progression du cycle cellulaire. Les kinases LIM phosphorylent et inactivent la cofiline, une protéine qui désassemble les filaments d'actine, contrôlant ainsi la forme, la motilité et la division des cellules. L'inhibition des kinases LIM peut affecter ces processus, entraînant des dynamiques du cycle cellulaire altérées et une potentielle apoptose. Les inhibiteurs des kinases LIM sont des outils importants dans la recherche sur le cancer et l'étude de la motilité et de l'invasion cellulaires. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs des kinases LIM de haute qualité pour soutenir vos recherches sur la signalisation cellulaire, la dynamique du cytosquelette et l'oncologie.
20 produits trouvés pour "LIM Kinase"
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R-10015
CAS :R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.Formule :C20H19ClN6O2Degré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :410.86Ref: TM-T12609
1mg52,00€5mg118,00€10mg180,00€25mg296,00€50mg393,00€100mg553,00€200mg752,00€1mL*10mM (DMSO)131,00€S3 Fragment
S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinaseFormule :C73H120N18O24S2Couleur et forme :SolidMasse moléculaire :1697.978β,9α-Dihydroxylindan-4(5),7(11)-dien-8α,12-olide
CAS :8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].Formule :C15H18O4Couleur et forme :SolidMasse moléculaire :262.3BMS-3
CAS :BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Formule :C17H12Cl2F2N4OSDegré de pureté :99.31% - 99.81%Couleur et forme :SolidMasse moléculaire :429.27T56-LIMKi
CAS :T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Formule :C19H14F3N3O3Degré de pureté :98.39% - 99.57%Couleur et forme :SolidMasse moléculaire :389.33BMS-5
CAS :BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Formule :C17H14Cl2F2N4OSDegré de pureté :98.01% - 99.88%Couleur et forme :SolidMasse moléculaire :431.29Ref: TM-T4598
1mg40,00€2mg52,00€5mg79,00€10mg116,00€25mg188,00€50mg281,00€100mg420,00€1mL*10mM (DMSO)87,00€LIMK-IN-22j
CAS :LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Formule :C20H21BrN8Degré de pureté :99.165%Couleur et forme :SolidMasse moléculaire :453.34TH-263
CAS :TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.Formule :C21H20N2O3SDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :380.46Ref: TM-T19578
2mg34,00€5mg49,00€10mg75,00€25mg137,00€50mg192,00€100mg281,00€200mg419,00€1mL*10mM (DMSO)54,00€TH-257
CAS :TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Formule :C24H26N2O3SDegré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :422.54LIMK-IN-14
CAS :LIMK-IN-14 is an effective and selective inhibitor of LIMK.Formule :C22H27N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.49CRT-0105446
CAS :CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Formule :C20H18F3N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.44TH470
CAS :TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,Formule :C30H31N5O5S2Couleur et forme :SolidMasse moléculaire :605.73LIMK1 inhibitor BMS-4
CAS :BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Formule :C23H23N7O2SCouleur et forme :SolidMasse moléculaire :461.54SR7826
CAS :SR7826 is a selective LIMK inhibitor.Formule :C22H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43CRT-0105950
CAS :CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Formule :C21H16ClN3OSDegré de pureté :99.78% - 99.86%Couleur et forme :SolidMasse moléculaire :393.89Ref: TM-T23917
1mg65,00€5mg140,00€10mg216,00€25mg439,00€50mg707,00€100mg1.130,00€1mL*10mM (DMSO)156,00€LX7101 hydrochloride
CAS :LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Formule :C23H29N7O3HClCouleur et forme :SolidMasse moléculaire :488LX7101
CAS :LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Formule :C23H29N7O3Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :451.52LIMK-IN-2
CAS :LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].Formule :C28H27N5O2Couleur et forme :SolidMasse moléculaire :465.55LIMK1 inhibitor 1
CAS :LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.Formule :C12H15N3S2Couleur et forme :SolidMasse moléculaire :265.398LIMK1 inhibitor 2
CAS :LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.Formule :C10H11N3OSCouleur et forme :SolidMasse moléculaire :221.279
