LIM Kinase
Les inhibiteurs des kinases LIM ciblent les kinases LIM, une famille d'enzymes impliquées dans la régulation du cytosquelette d'actine et la progression du cycle cellulaire. Les kinases LIM phosphorylent et inactivent la cofiline, une protéine qui désassemble les filaments d'actine, contrôlant ainsi la forme, la motilité et la division des cellules. L'inhibition des kinases LIM peut affecter ces processus, entraînant des dynamiques du cycle cellulaire altérées et une potentielle apoptose. Les inhibiteurs des kinases LIM sont des outils importants dans la recherche sur le cancer et l'étude de la motilité et de l'invasion cellulaires. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs des kinases LIM de haute qualité pour soutenir vos recherches sur la signalisation cellulaire, la dynamique du cytosquelette et l'oncologie.
23 produits trouvés pour "LIM Kinase".
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R-10015
CAS :R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.Formule :C20H19ClN6O2Degré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :410.857MDI-117740
MDI-117740 is a dual LIMK1/2 inhibitor. It demonstrates strong cellular target binding in HEK293 cells, inhibiting LIMK1 (pIC50=6.73) and LIMK2 (pIC50=7.18). In MDA-MB-231 cells, MDI-117740 shows significant anti-migratory activity. This compound is useful for studying diseases associated with LIMK dysregulation, such as cancer and neurodegenerative disorders.SM311
SM311 (Compound 10) is a potent, selective, and irreversible inhibitor of LIMK1, with an EC50 of 0.045 μM and over 30-fold selectivity for LIMK1 over LIMK2. It can inhibit cofilin phosphorylation and actin cytoskeleton regulation. SM311 shows potential for research in neurodegenerative disorders such as Fragile X Syndrome (FXS) and Alzheimer's disease, as well as in tumor invasion.Couleur et forme :Odour SolidS3 Fragment
S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinaseFormule :C73H120N18O24S2Couleur et forme :SolidMasse moléculaire :1697.97LX-7101 hydrochloride
CAS :LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.Formule :C23H29N7O3xHClDegré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :487.99THNAN69
THNAN69 is a potent chemical probe degrader specifically targeting LIMK2, with a DC50 value of 1 nM. This compound is useful for researching diseases driven by LIMK2 overexpression or dysregulation, such as cancer and ophthalmic conditions.BMS-3
CAS :BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Formule :C17H12Cl2F2N4OSDegré de pureté :99.31% - 99.81%Couleur et forme :White SolidMasse moléculaire :429.271TH-257
CAS :TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Formule :C24H26N2O3SDegré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :422.54TH-263
CAS :TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.Formule :C21H20N2O3SDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :380.46BMS-5
CAS :BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Formule :C17H14Cl2F2N4OSDegré de pureté :98.01% - 99.88%Couleur et forme :SolidMasse moléculaire :431.29LIMK-IN-22j
CAS :LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Formule :C20H21BrN8Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :453.338T56-LIMKi
CAS :T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Formule :C19H14F3N3O3Degré de pureté :98.39% - 99.57%Couleur et forme :SolidMasse moléculaire :389.328SR7826
CAS :SR7826 is a selective LIMK inhibitor.Formule :C22H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43CRT-0105446
CAS :CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Formule :C20H18F3N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.44TH470
CAS :TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,Formule :C30H31N5O5S2Couleur et forme :SolidMasse moléculaire :605.73LIMK-IN-14
CAS :LIMK-IN-14 is an effective and selective inhibitor of LIMK.Formule :C22H27N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.49LIMK1 inhibitor BMS-4
CAS :BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Formule :C23H23N7O2SCouleur et forme :SolidMasse moléculaire :461.54CRT-0105950
CAS :CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Formule :C21H16ClN3OSDegré de pureté :99.78% - 99.91%Couleur et forme :SolidMasse moléculaire :393.889LX7101
CAS :LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Formule :C23H29N7O3Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :451.5215LX7101 hydrochloride
CAS :LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Formule :C23H29N7O3HClCouleur et forme :SolidMasse moléculaire :488
