Ferroptose
La ferroptose est une forme de mort cellulaire régulée caractérisée par l'accumulation de peroxydes lipidiques et par le stress oxydatif dépendant du fer. Contrairement à l'apoptose, la ferroptose n'est pas entraînée par les caspases, mais plutôt par l'échec des défenses antioxydantes cellulaires, conduisant à la mort cellulaire. Les inhibiteurs et inducteurs de la ferroptose sont essentiels pour étudier cette voie unique de mort cellulaire, impliquée dans diverses maladies, notamment le cancer, la neurodégénérescence et les lésions d'ischémie-reperfusion. Chez CymitQuimica, nous offrons une large gamme de modulateurs de la ferroptose de haute qualité pour soutenir vos recherches sur les mécanismes de mort cellulaire, le stress oxydatif et la pathologie des maladies.
215 produits trouvés pour "Ferroptose"
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Setanaxib
CAS :<p>Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.</p>Formule :C21H19ClN4O2Degré de pureté :93.468% - 99.31%Couleur et forme :SolidMasse moléculaire :394.85Dp44mT
CAS :<p>Dp44mT, a effective iron chelator, has selective antitumor activity.</p>Formule :C14H15N5SDegré de pureté :99% - 99.02%Couleur et forme :SolidMasse moléculaire :285.37Nordihydroguaiaretic acid
CAS :<p>Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.</p>Formule :C18H22O4Degré de pureté :97.82% - 99.91%Couleur et forme :SolidMasse moléculaire :302.36NADPH tetrasodium salt
CAS :<p>NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety of</p>Formule :C21H26N7Na4O17P3Degré de pureté :97.15% - >99.99%Couleur et forme :SolidMasse moléculaire :833.35Troglitazone
CAS :<p>Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.</p>Formule :C24H27NO5SDegré de pureté :98% - 99.8%Couleur et forme :Yellow SolidMasse moléculaire :441.54SRS16-86
CAS :<p>SRS16-86 is a novel third-generation ferrostatin, is an inhibitor of ferroptosis.</p>Formule :C26H32N4O2Degré de pureté :97.73%Couleur et forme :SolidMasse moléculaire :432.56Pseudolaric Acid B
CAS :<p>Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.</p>Formule :C23H28O8Degré de pureté :98.91% - 99.84%Couleur et forme :SolidMasse moléculaire :432.46Levobupivacaine
CAS :<p>Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.</p>Formule :C18H28N2ODegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :288.43Liproxstatin-1
CAS :<p>Liproxstatin-1 is a potent and selective inhibitor of iron death (IC50=22 nM).</p>Formule :C19H21ClN4Degré de pureté :97.11% - 99.44%Couleur et forme :SolidMasse moléculaire :340.85Rosiglitazone hydrochloride
CAS :<p>Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.</p>Formule :C18H19N3O3S·HClDegré de pureté :99.63% - 99.79%Couleur et forme :SolidMasse moléculaire :393.89SP600125
CAS :<p>SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive</p>Formule :C14H8N2ODegré de pureté :97.63% - 99.82%Couleur et forme :SolidMasse moléculaire :220.23L-Cystine
CAS :<p>L-Cystine (Cystine Acid) is not considered one of the 20 amino acids, L-Cystine (Cystine Acid) is a sulfur-containing derivative obtained from oxidation of</p>Formule :C6H12N2O4S2Degré de pureté :99.59% - 99.85%Couleur et forme :White Solid PowderMasse moléculaire :240.30Rosiglitazone
CAS :<p>Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity.</p>Formule :C18H19N3O3SDegré de pureté :98.61% - 99.87%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :357.43L-Glutamic acid
CAS :<p>L-Glutamic acid is an agonist of glutamate receptors, including metabotropic glutamate receptors (mGluR), AMPA, NMDA, and KA. High-Quality, Low-Cost!</p>Formule :C5H9NO4Degré de pureté :99.14% - 99.55%Couleur et forme :White Solid CrystallineMasse moléculaire :147.13ML385
CAS :<p>ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity.</p>Formule :C29H25N3O4SDegré de pureté :98.08% - >99.99%Couleur et forme :SolidMasse moléculaire :511.59Trigonelline
CAS :<p>Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.</p>Formule :C7H7NO2Degré de pureté :97.585% - 99.49%Couleur et forme :Prisms Aqueous From Alcohol + Water SolidMasse moléculaire :137.14PRIMA-1
CAS :<p>PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.</p>Formule :C9H15NO3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :185.22Atorvastatin hemicalcium salt
CAS :<p>Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.</p>Formule :C33H34FN2O5CaDegré de pureté :99.27% - >99.99%Couleur et forme :White Crystalline PowderMasse moléculaire :577.67Erastin
CAS :<p>Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner, anti-tumor. High-Quality, Low-Cost!</p>Formule :C30H31ClN4O4Degré de pureté :98% - 99.75%Couleur et forme :SolidMasse moléculaire :547.04FIN56
CAS :<p>FIN56 is a specific inducer of ferroptosis.</p>Formule :C25H31N3O5S2Degré de pureté :99.72% - 99.78%Couleur et forme :SolidMasse moléculaire :517.66PD146176
CAS :<p>PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.</p>Formule :C15H11NSDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :237.32Pifithrin-α hydrobromide
CAS :<p>Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.</p>Formule :C16H18N2OS·HBrDegré de pureté :97.71% - >99.99%Couleur et forme :SolidMasse moléculaire :367.3Pifithrin-β hydrobromide
CAS :<p>Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis.</p>Formule :C16H17BrN2SDegré de pureté :99.24% - 99.74%Couleur et forme :SolidMasse moléculaire :349.29Levobupivacaine hydrochloride
CAS :<p>Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.</p>Formule :C18H28N2O·HClDegré de pureté :99.74%Couleur et forme :White Crystalline PowderMasse moléculaire :324.89Ammonium iron(III) citrate
CAS :<p>Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload and iron death.</p>Formule :C24H32Fe3N3O28Degré de pureté :98%Couleur et forme :Ferric Ammonium Citrate Is A Yellowish Brown To Red Solid With A Faint Odor Of AmmoniaMasse moléculaire :978.05U-73122
CAS :<p>U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.</p>Formule :C29H40N2O3Degré de pureté :97.50%Couleur et forme :Solid Off-WhiteMasse moléculaire :464.64UAMC-3203
CAS :<p>UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).</p>Formule :C25H37N5O2SDegré de pureté :97.052% - 99.72%Couleur et forme :SolidMasse moléculaire :471.66FINO2
CAS :<p>FINO2, a strong ferroptosis trigger, blocks GPX4, oxidizes Fe2+, stable in different pH, causes lipid peroxidation.</p>Formule :C15H28O3Degré de pureté :97.27%Couleur et forme :SoildMasse moléculaire :256.38Microtubule inhibitor 8
CAS :<p>Microtubule Inhibitor 8 (MP-HJ-1b) serves as a potent disruptor of microtubule function, inducing cell death via ferroptosis and demonstrating anti-tumor effects [1] [2].</p>Formule :C21H15N3O2SCouleur et forme :SolidMasse moléculaire :373.43Pioglitazone-d4
CAS :<p>Pioglitazone D4 is a deuterium labeled Pioglitazone. Pioglitazone is a agonist of PPARγ .</p>Formule :C19H20N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.46W1131
CAS :<p>W1131 is a potent STAT3 inhibitor and ferroptosis trigger, reducing cancer progression and 5-FU resistance.</p>Formule :C23H19N5O4Couleur et forme :SolidMasse moléculaire :429.43YL-939
<p>YL-939 is a potent inhibitor of ferroptosis, targeting the PHB2/ferritin/iron axis to impede this form of cell death.</p>Formule :C25H26N6OCouleur et forme :SolidMasse moléculaire :426.51Ferroptosis inducer-1
CAS :<p>Ferroptosis inducer-1 is a Ferroptosis inducer with antitumor potential .</p>Formule :C25H21ClN2O5Couleur et forme :SolidMasse moléculaire :464.9CN128 hydrochloride
CAS :<p>CN128 hydrochloride is an oral, selective hydroxypyridone iron chelator for β-thalassemia research.</p>Formule :C15H18ClNO3Couleur et forme :SolidMasse moléculaire :295.76Anticancer agent 147
CAS :<p>Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS</p>Formule :C32H40BrN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :578.58Tubulin inhibitor 30
CAS :<p>Tubulin Inhibitor 30, exhibiting an IC50 value of 0.52 μM, functions as an inhibitor of tubulin assembly. Additionally, it can induce ferroptosis.</p>Formule :C22H19N3O5Couleur et forme :SolidMasse moléculaire :405.4IM-93
CAS :<p>IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 μM for cell death inhibition [1].</p>Formule :C21H28N4O2Couleur et forme :SolidMasse moléculaire :368.47CGP 65015
CAS :<p>CGP 65015 is an oral iron chelator and can mobilize iron deposits.</p>Formule :C14H15NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :261.27FA16
<p>FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16</p>Formule :C22H27F3N4O2SDegré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :468.54Deferitazole
CAS :<p>Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.</p>Formule :C18H25NO7SDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :399.46Erastin2
CAS :<p>Erastin2 is an iron death inducer that induces cell death by binding to the lipophilic free radical trapping antioxidant ferrostatin-1 or the iron chelator DFO.</p>Formule :C36H35ClN4O4Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :623.14HBED
CAS :<p>HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.</p>Formule :C20H24N2O6Degré de pureté :97.35% - 98.58%Couleur et forme :SolidMasse moléculaire :388.41BCP-T.A
CAS :<p>BCP-T.A is an iron death inducer that acts by binding to GPX4.</p>Formule :C23H19Cl2N3OSDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :456.39Lepadin E
CAS :<p>Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway.</p>Formule :C26H47NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.66CP-24879 hydrochloride
CAS :<p>CP-24879 HCl, a Δ5D/Δ6D dual-inhibitor, reduces liver lipid buildup and inflammation.</p>Formule :C11H18ClNODegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :215.72Docebenone
CAS :Docebenone is a selective and orally active inhibitor of 5-LO.Formule :C21H26O3Couleur et forme :SolidMasse moléculaire :326.43Ferroptocide
CAS :<p>Ferroptocide is a thioredoxin inhibitor that induces iron death in cancer cells and can be used in breast cancer research.</p>Formule :C30H36ClN3O7Couleur et forme :SolidMasse moléculaire :586.08Ogremorphin
CAS :<p>Ogremorphin (GPR68-IN-1) is a potent inhibitor of GPR68, exhibiting an EC50 of 170 nM.it is utilized in the study of autoimmune chronic inflammatory diseases [1</p>Formule :C21H17N3OSDegré de pureté :99.65% - 99.65%Couleur et forme :SolidMasse moléculaire :359.44Lepadin H
CAS :<p>Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancing</p>Formule :C26H45NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.64viFSP1
CAS :<p>viFSP1, a species-independent FSP1 inhibitor, effectively induces ferroptosis in FSP1-dependent cells by targeting the highly conserved NAD(P)H binding pocket of FSP1, directly inhibiting its activity. This action results in lipid peroxidation and exhibits anticancer activity [1].</p>Formule :C16H17N3O3SCouleur et forme :SolidMasse moléculaire :331.39
