CDK
Les inhibiteurs des kinases dépendantes des cyclines (CDK) sont des composés qui bloquent l'activité des CDK, un groupe de kinases protéiques qui régulent le cycle cellulaire, la transcription et d'autres processus cellulaires. Les CDK sont activées par leur liaison aux cyclines, et leur activité est cruciale pour la progression des cellules à travers les différentes phases du cycle cellulaire. Inhiber les CDK peut arrêter la division cellulaire, entraînant un arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules cancéreuses où les CDK sont souvent dysrégulées. Les inhibiteurs de CDK sont largement utilisés dans la recherche sur le cancer et ont un potentiel thérapeutique dans le traitement de divers cancers. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de CDK de haute qualité pour soutenir vos recherches sur le contrôle du cycle cellulaire, le cancer et le développement thérapeutique.
548 produits trouvés pour "CDK"
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Riviciclib hydrochloride
CAS :Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.Formule :C21H20ClNO5·HClDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :438.3Metralindole HCl
CAS :Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.Formule :C15H18ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :291.78CGP60474
CAS :CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.Formule :C18H18ClN5ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :355.82Ref: TM-T14943
1mg34,00€2mg46,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg92,00€25mg177,00€50mg314,00€100mg518,00€CDK9-IN-15
CAS :CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.Formule :C16H11N3OSDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :293.34Ref: TM-T60619
1mL*10mM (DMSO)44,00€5mg46,00€10mg71,00€25mg126,00€50mg180,00€100mg260,00€200mg364,00€Atuveciclib S-Enantiomer
CAS :Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.Formule :C18H18FN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43CDK2-IN-13
CAS :CDK2-IN-13: Potent CDK2 inhibitor, arrests cell cycle, induces apoptosis, IC50=12 µM, used in cancer research.Formule :C13H12ClN5Couleur et forme :SoildMasse moléculaire :273.72NSC 625987
CAS :NSC 625987, Selective CDK4 inhibitor (IC50=0.2 μM), >500-fold selectivity over CDK2, used for p16-associated tumor studies.Formule :C15H13NO2SDegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :271.33Ref: TM-T23092
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg371,00€50mg595,00€100mg893,00€ARN22089
CAS :ARN22089 is an oral active CDC42 GTPase interaction inhibitor that blocks tumour growth in BRAF mutant mouse melanoma models and PDXs in vivo.Formule :C23H27N5Degré de pureté :98.37%Couleur et forme :SolidMasse moléculaire :373.49Ref: TM-T85727
1mg109,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg385,00€25mg647,00€50mg964,00€100mg1.431,00€200mg1.963,00€Cdc7-IN-4
CAS :Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase.Formule :C22H24F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :479.45BAY-958
CAS :BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.Formule :C17H16FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.4TP1287
CAS :TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.Formule :C21H21ClNO8PCouleur et forme :SolidMasse moléculaire :481.82Aloisine A
CAS :Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.Formule :C16H17N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.33CLK1-IN-2
CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.Formule :C16H12Cl2N2O2SCouleur et forme :SolidMasse moléculaire :367.25CDK4/6-IN-8
CAS :CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).Formule :C18H18N6O5Couleur et forme :SolidMasse moléculaire :398.37NSC 693868
CAS :CDKs and GSK-3 inhibitorFormule :C9H7N5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :185.19(E/Z)-BIO-acetoxime
CAS :(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.Formule :C18H12BrN3O3Couleur et forme :SolidMasse moléculaire :398.21MFH290
CAS :MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.Formule :C26H31N5O3S2Couleur et forme :SolidMasse moléculaire :525.69RP-106
CAS :RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.Formule :C17H19N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :281.35CDK8-IN-10
CAS :CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.Formule :C25H15ClF3N5O3Couleur et forme :SolidMasse moléculaire :525.87CDK4/6-IN-12
CAS :CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.Formule :C12H10N6Couleur et forme :SolidMasse moléculaire :238.25CCT068127
CAS :CCT068127 is a potent CDK2 and CDK9 inhibitor.Formule :C19H27N7OCouleur et forme :SolidMasse moléculaire :369.46(S)-CR8
CAS :(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.Formule :C24H29N7OCouleur et forme :SolidMasse moléculaire :431.53(S)-LY3177833 hydrate
CAS :(S)-LY3177833 ((S)-Example 2) hydrate, an orally active CDC7 kinase inhibitor, exhibits extensive in vitro anticancer efficacy.Formule :C16H14FN5O2Couleur et forme :SolidMasse moléculaire :327.31EGFR/HER2/CDK9-IN-2
CAS :EGFR/HER2/CDK9-IN-2 inhibits EGFR, HER2, CDK9 with IC50s: 145.35, 129.07, 117.13 nM; strong antitumor effects.Formule :C23H20N4O5S2Couleur et forme :SolidMasse moléculaire :496.56Cdc7-IN-9
CAS :Cdc7-IN-9 can be used for the research of cancer which is a potent inhibitor of Cdc7 [1].Formule :C15H17N5OSCouleur et forme :SolidMasse moléculaire :315.39Cdc7-IN-14
CAS :Cdc7-IN-14 (compound 82) is a potent CDC7 inhibitor with an IC50 < 1 nM, promising for cancer research.Formule :C18H20N4O2SCouleur et forme :SolidMasse moléculaire :356.44KH-CB19
CAS :KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).Formule :C15H13Cl2N3O2Couleur et forme :SolidMasse moléculaire :338.19Ref: TM-T15657
2mgÀ demander5mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander1mL*10mM (DMSO)À demanderCDK8-IN-6
CAS :CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers.Formule :C26H37ClN2Couleur et forme :SolidMasse moléculaire :413.04Ipivivint
CAS :Ipivivint: orally active, potent CLK inhibitor; hinders CLK1, CLK2, & CLK3; curbs Wnt signaling & SRSF phosphorylation for cancer research.Formule :C26H21FN8Couleur et forme :SolidMasse moléculaire :464.5FN-1501-propionic acid
CAS :FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.Formule :C25H27N9O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.54Cdc7-IN-3
CAS :Cdc7-IN-3 is a potent inhibitor of Cdc7 kinase.Formule :C20H22N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.41JTK-101
CAS :JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.Formule :C25H23N3O3Couleur et forme :SolidMasse moléculaire :413.47Ulecaciclib
CAS :Ulecaciclib: oral, BBB-permeable CDK inhibitor; favorable pharmacokinetics; ki: 0.62 μM (CDK2/A), 3 nM (CDK6/D3), 0.2 nM (CDK4/D1), 0.63 μM (CDK7/H).Formule :C25H33FN8SCouleur et forme :SolidMasse moléculaire :496.65Cdc7-IN-13
CAS :Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1].Formule :C18H20N4O2SCouleur et forme :SolidMasse moléculaire :356.44CDK4/6-IN-9
CAS :CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.Formule :C22H23FN8Couleur et forme :SolidMasse moléculaire :418.47CDK1-IN-1
CAS :CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.Formule :C27H23N5O3Couleur et forme :SolidMasse moléculaire :465.5Indirubin-5-sulfonate
CAS :Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.Formule :C16H10N2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.33CDK7-IN-8
CAS :CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.Formule :C25H38N8O3Couleur et forme :SolidMasse moléculaire :498.62FLT3/CDK4-IN-1
CAS :FLT3/CDK4-IN-1: Oral FLT3 (7 nM IC50) & CDK4 (11 nM IC50) inhibitor with strong in vivo anti-cancer properties.Formule :C25H28F2N8Couleur et forme :SolidMasse moléculaire :478.54CDK7-IN-20
CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.Formule :C30H26N6O3Couleur et forme :SolidMasse moléculaire :518.57CDK7-IN-13
CAS :CDK7-IN-13 (compound 1) is an effective CDK7 inhibitor for investigating cancers associated with transcriptional dysregulation.Formule :C20H23F3N6OSDegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :452.5Indirubin-3'-monoxime-5-sulphonic acid
CAS :Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.Formule :C16H11N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.34BSJ-01-175
CAS :BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.Formule :C30H33ClN6O2Couleur et forme :SolidMasse moléculaire :545.08MDK6204
CAS :MDK6204 is a selective inhibitor of CLK1 and CLK2.Formule :C20H20N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.41XIE18-6
CAS :XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.Formule :C18H15NO6SDegré de pureté :99.712%Couleur et forme :SolidMasse moléculaire :373.38CDK4/6-IN-14
CAS :CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, >60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.Formule :C24H27ClFN7OCouleur et forme :SolidMasse moléculaire :483.97EGFR/HER2/CDK9-IN-1
CAS :EGFR/HER2/CDK9-IN-1 is a potent inhibitor (IC50: EGFR 90.17 nM, HER2 131.39 nM, CDK9 67.04 nM) with notable anti-tumor activity.Formule :C23H21N3O3S2Couleur et forme :SolidMasse moléculaire :451.56CDK7-IN-2
CAS :CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.Formule :C26H39N7O3Couleur et forme :SolidMasse moléculaire :497.63CDK4/6-IN-7
CAS :CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.Formule :C18H18ClN5O3Couleur et forme :SolidMasse moléculaire :387.82CDK7-IN-12
CAS :CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.Formule :C20H19F3N6Couleur et forme :SolidMasse moléculaire :400.4Crozbaciclib fumarate
CAS :Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.Formule :C32H34F2N6O4Couleur et forme :SolidMasse moléculaire :604.65EGFR/CDK2-IN-1
CAS :EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application inFormule :C19H12BrClO2Couleur et forme :SolidMasse moléculaire :387.65EGFR/HER2/CDK9-IN-3
CAS :EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.Formule :C24H21N3O4S2Couleur et forme :SolidMasse moléculaire :479.57PKC-9
CAS :PKC-9 is a PKC-zeta inhibitor 9.Formule :C25H25N7Couleur et forme :SolidMasse moléculaire :423.51CDK7-IN-15
CAS :CDK7-IN-15 (Compound 8) is an effective CDK7 inhibitor for studying cancers associated with transcriptional dysregulation.Formule :C21H24F4N6OSDegré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :484.51CDK7-IN-10
CAS :CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)Formule :C29H35N7O3Couleur et forme :SolidMasse moléculaire :529.63CDK7-IN-16
CAS :CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.Formule :C19H21F3N6O2SCouleur et forme :SolidMasse moléculaire :454.47CDK9-IN-14
CAS :CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.Formule :C21H23F2N3O4Couleur et forme :SolidMasse moléculaire :419.42Cdc7-IN-17
CAS :Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Formule :C13H15N5OSCouleur et forme :SolidMasse moléculaire :289.36K 00546
CAS :K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).Formule :C15H13F2N7O2S2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :425.44CDK8-IN-7
CAS :CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.Formule :C30H40N2Couleur et forme :SolidMasse moléculaire :428.65Cdc7-IN-15
CAS :Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].Formule :C12H14N4OSCouleur et forme :SolidMasse moléculaire :262.33CP681301
CAS :CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.Formule :C17H22N4OCouleur et forme :SolidMasse moléculaire :298.38P18IN003
CAS :P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion ofFormule :C17H16N2O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :296.32CDK5 inhibitor 20-223
CAS :CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.Formule :C19H19N3OCouleur et forme :SolidMasse moléculaire :305.37SNX2-1-108
CAS :SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.Formule :C21H16N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.38Metralindole
CAS :Metralindole is a reversible inhibitor of monoamine oxidase A (RIMA).Formule :C15H17N3OCouleur et forme :SolidMasse moléculaire :255.32Olomoucine II
CAS :Olomoucine II, a CDK inhibitor effective on Cdk1/2/4/7/9, also inhibits ERK2, ABCB1, and various virus replications, not effective on measles/influenza.Formule :C19H26N6O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :370.45SLM6
CAS :SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.Formule :C12H17N7O4Couleur et forme :SolidMasse moléculaire :323.31CDK9/10/GSK3β-IN-1
CAS :CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50Formule :C29H24ClN3O4SCouleur et forme :SolidMasse moléculaire :546.04SMAPP1
CAS :SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.Formule :C27H25N5O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :563.65SLK/STK10-IN-1
CAS :SLK/STK10-IN-1 is a selective and potent inhibitor of SLK and STK10 with potential antitumor activity.Formule :C17H13ClN2O3Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :328.75GW8510
CAS :GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Formule :C21H15N5O3S2Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :449.51β-catenin-IN-3
CAS :β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces theFormule :C19H20Br2N2OSCouleur et forme :SolidMasse moléculaire :484.25Alsterpaullone, 2-Cyanoethyl
CAS :Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β.Formule :C19H14N4O3Couleur et forme :SolidMasse moléculaire :346.34CDK-IN-10
CAS :CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Formule :C18H18N4O2Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :322.36Zotiraciclib HCl
CAS :Zotiraciclib (TG02/SB1317) is a CDK/JAK2/FLT3 inhibitor potentially treating Myc-overexpressing cancers, including glioblastoma.Formule :C23H26Cl2N4OCouleur et forme :SolidMasse moléculaire :445.388AG-012986
CAS :AG-012986: a selective CDK inhibitor with in vitro and in vivo antitumor effects; low IC50 in 14/18 cancer cell types; CAS# 486414-35-1.Formule :C22H23F2N5O2SCouleur et forme :SolidMasse moléculaire :459.51Aloisine B
CAS :Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.Formule :C15H14ClN3Degré de pureté :95.15%Couleur et forme :SolidMasse moléculaire :271.74Cdc7-IN-5
CAS :Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.Formule :C25H23N3O5Degré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :445.47Ref: TM-T10727
1mg90,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg356,00€25mg587,00€50mg802,00€100mg1.108,00€BS-181
CAS :BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.Formule :C22H32N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.53FN-1501
CAS :FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).Formule :C22H25N9ODegré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :431.49Ref: TM-T15335
1mg87,00€5mg177,00€1mL*10mM (DMSO)203,00€10mg295,00€25mg537,00€50mg807,00€100mg1.099,00€CDK8-IN-4
CAS :CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Formule :C20H18N4OCouleur et forme :SolidMasse moléculaire :330.38CDK12-IN-3
CAS :CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Formule :C23H28F2N8ODegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :470.52Cdc7-IN-1
CAS :Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Formule :C21H16ClN3O4Couleur et forme :SolidMasse moléculaire :409.82CLK1/2-IN-3
CAS :CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.Formule :C21H21N5O2Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :375.42CDK12-IN-E9
CAS :CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.Formule :C24H30N6O2Couleur et forme :SolidMasse moléculaire :434.53AS2863619 free base
CAS :AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.Formule :C16H12N8OCouleur et forme :SolidMasse moléculaire :332.32CLK1-IN-1
CAS :CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).Formule :C24H16FN5OCouleur et forme :SolidMasse moléculaire :409.42THZ1-R
CAS :THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.Formule :C31H30ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.07CDK8/19-IN-51
CAS :CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.Formule :C23H22N6O2Degré de pureté :98.65% - 99.62%Couleur et forme :SoildMasse moléculaire :414.46HTH-01-091
CAS :HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3,Formule :C26H28Cl2N4O2Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :499.43Ref: TM-T24152
1mg266,00€5mg655,00€1mL*10mM (DMSO)735,00€10mg888,00€25mg1.378,00€50mg1.783,00€100mg2.250,00€SJ572403
CAS :SJ572403 inhibits p27 protein, Kd 2.2 mM at D2 subdomain of p27-KID; useful in disordered protein disease research.Formule :C13H17N5O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :275.31Ref: TM-T16889
1mg39,00€5mg86,00€1mL*10mM (DMSO)92,00€10mg119,00€25mg231,00€50mg371,00€100mg537,00€200mg710,00€ML 315
CAS :ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.Formule :C18H13Cl2N3O2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :374.22CDK-IN-2
CAS :CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Formule :C18H19ClFN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :363.81Ref: TM-TQ0078
1mg38,00€2mg51,00€1mL*10mM (DMSO)92,00€5mg96,00€10mg138,00€25mg258,00€50mg376,00€100mg532,00€500mg1.063,00€dCeMM2
CAS :dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.Formule :C16H11ClN6OSDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :370.82Ref: TM-T61477
1mg34,00€5mg74,00€1mL*10mM (DMSO)104,00€10mg113,00€25mg236,00€50mg404,00€100mg600,00€500mg1.279,00€Abemaciclib metabolite M20
CAS :Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。Formule :C27H32F2N8ODegré de pureté :98.1% - 99.08%Couleur et forme :SolidMasse moléculaire :522.59DIF-3
CAS :DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Formule :C13H17ClO4Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :272.72Ref: TM-T60485
1mg96,00€1mL*10mM (DMSO)205,00€5mg222,00€10mg333,00€25mg557,00€50mg795,00€100mg1.071,00€500mg2.187,00€Cdc7-IN-7c
CAS :Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.Formule :C15H17N5OSDegré de pureté :98.19% - 99.22%Couleur et forme :SolidMasse moléculaire :315.39Ref: TM-T23867
1mg315,00€1mL*10mM (DMSO)600,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€SEL120-34A
CAS :SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Formule :C15H18Br2N4Degré de pureté :99.764% - 99.84%Couleur et forme :SolidMasse moléculaire :414.14Ref: TM-T10744
1mg612,00€5mg1.529,00€1mL*10mM (DMSO)1.835,00€10mg1.880,00€25mg2.178,00€50mg2.862,00€100mg3.870,00€
