CDK
Les inhibiteurs des kinases dépendantes des cyclines (CDK) sont des composés qui bloquent l'activité des CDK, un groupe de kinases protéiques qui régulent le cycle cellulaire, la transcription et d'autres processus cellulaires. Les CDK sont activées par leur liaison aux cyclines, et leur activité est cruciale pour la progression des cellules à travers les différentes phases du cycle cellulaire. Inhiber les CDK peut arrêter la division cellulaire, entraînant un arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules cancéreuses où les CDK sont souvent dysrégulées. Les inhibiteurs de CDK sont largement utilisés dans la recherche sur le cancer et ont un potentiel thérapeutique dans le traitement de divers cancers. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de CDK de haute qualité pour soutenir vos recherches sur le contrôle du cycle cellulaire, le cancer et le développement thérapeutique.
548 produits trouvés pour "CDK"
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PS423
CAS :PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.Formule :C25H23F3O9Degré de pureté :98.81% - 99.26%Couleur et forme :SolidMasse moléculaire :524.44Cdk2 Inhibitor II
CAS :Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.Formule :C14H11BrN4O3SDegré de pureté :97.27%Couleur et forme :SolidMasse moléculaire :395.23(S)-PF-06873600
CAS :(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.Formule :C20H27F2N5O4SDegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :471.52BRD7389
CAS :BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.Formule :C24H18N2O2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :366.41CDK8-IN-1
CAS :CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).Formule :C11H8F3N3ODegré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :255.2Ref: TM-T10740
1mg93,00€5mg205,00€1mL*10mM (DMSO)227,00€10mg295,00€25mg497,00€50mg670,00€100mg893,00€Ryuvidine
CAS :Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response, and can be used to study breast cancer and erythroderma.Formule :C15H12N2O2SDegré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :284.33hSMG-1 inhibitor 11e
CAS :hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.Formule :C26H27N7O3SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :517.69-Isopropylolomoucine
CAS :9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.Formule :C17H22N6ODegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :326.4Ref: TM-T23589
1mg315,00€1mL*10mM (DMSO)607,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€SRX3177
CAS :SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.Formule :C31H32N6O4SDegré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :584.69Ref: TM-T69742
1mg70,00€5mg150,00€1mL*10mM (DMSO)178,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€CLK-IN-T3
CAS :CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.Formule :C28H30N6O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :482.58Ref: TM-T14980
1mg47,00€2mg62,00€5mg92,00€10mg160,00€25mg289,00€50mg505,00€100mg787,00€200mg1.063,00€BML-259
CAS :BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Formule :C14H16N2OSDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :260.35Ref: TM-T36964
5mg48,00€1mL*10mM (DMSO)50,00€10mg80,00€25mg160,00€50mg264,00€100mg462,00€500mg982,00€AS-0141
CAS :AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。Formule :C21H22F3N5O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :465.43EHT 1610
CAS :EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.Formule :C18H14FN5O2SDegré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :383.4CDK4/6/1 Inhibitor
CAS :CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).Formule :C28H30F2N6Degré de pureté :97.25% - 99.72%Couleur et forme :SolidMasse moléculaire :488.57CDK9-IN-10
CAS :CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.Formule :C22H16O5Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :360.36CDK4-IN-2
CAS :CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].Formule :C22H26F2N6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.54Nε-(1-Carboxyethyl)-L-lysine
CAS :Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.Formule :C9H18N2O4Couleur et forme :SolidMasse moléculaire :218.25EHT 5372
CAS :EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.Formule :C17H11Cl2N5OSCouleur et forme :SolidMasse moléculaire :404.275-Iodo-indirubin-3'-monoxime
CAS :5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFormule :C16H10IN3O2Couleur et forme :SolidMasse moléculaire :403.17Leucettinib-92
CAS :Leucettinib-92 is a multi-kinase inhibitor of DYRK and CLK families with differential nanomolar activity, supporting studies of kinase signaling regulation.Formule :C21H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.49CDK9-IN-8
CAS :CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).Formule :C31H32FN7O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :569.63Voruciclib hydrochloride
CAS :Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Formule :C22H20Cl2F3NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.3Bisindolylmaleimide X hydrochloride
CAS :Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).Formule :C26H25ClN4O2Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :460.96HQ005
CAS :HQ005, a potent CCNK degrader, exhibits an impressive DC50 value of 0.041 µM and functions as a molecular-glue degrader.Formule :C15H15N5O2S2Couleur et forme :SolidMasse moléculaire :361.44Senexin C
CAS :Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formule :C28H27N5ODegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :449.55CDK4/6-IN-17
CAS :CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Formule :C27H28F4N8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.56CDK9-IN-9
CAS :CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).Formule :C22H23F2N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.51SHP2/CDK4-IN-1
CAS :SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.Formule :C33H35ClF2N10OSCouleur et forme :SolidMasse moléculaire :693.21CDK9-IN-29
CAS :CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.Formule :C29H33F2N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.6(S)-Cdc7-IN-18
CAS :'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'Formule :C19H21N5OSCouleur et forme :SolidMasse moléculaire :367.47CDK/HDAC-IN-3
CAS :CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,Formule :C24H18Cl2N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.34CDK8-IN-3
CAS :CDK8-IN-3 is an inhibitor of CDK8.Formule :C22H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45Xylocydine
CAS :Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.Formule :C12H14BrN5O5Couleur et forme :SolidMasse moléculaire :388.17Cdc7-IN-12
CAS :Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).Formule :C16H14N2O2SCouleur et forme :SolidMasse moléculaire :298.36Senexin A hydrochloride
CAS :Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].Formule :C17H15ClN4Couleur et forme :SolidMasse moléculaire :310.78QR-6401
CAS :QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/Formule :C19H23N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.42CDK4/6-IN-15
CAS :CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.Formule :C21H27FN8SCouleur et forme :SolidMasse moléculaire :442.56Tacaciclib
CAS :Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].Formule :C30H36N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.65PF-6808472
CAS :PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.Formule :C25H27FN8O3SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :538.6LDC3140
CAS :LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).Formule :C23H33N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.55CDK9-IN-19
CAS :CDK9-IN-19: Potent CDK9 inhibitor, anti-cancer, moderate pharmacokinetics, low hERG impact, effective in AML research.Formule :C26H22F2N4O5Couleur et forme :SolidMasse moléculaire :508.47SZ-015268
CAS :SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.Formule :C25H38N8O3Couleur et forme :SolidMasse moléculaire :498.62Mevociclib
CAS :Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Formule :C31H35ClN8O2Degré de pureté :98.02% - 98.02%Couleur et forme :SolidMasse moléculaire :587.11CDK7-IN-14
CAS :CDK7-IN-14 (compound 3) is a pyrimidine-derived CDK7 inhibitor applicable for studying cancers associated with transcriptional dysregulation.Formule :C22H24F3N6OPDegré de pureté :99.24% - 99.48%Couleur et forme :SolidMasse moléculaire :476.43Riviciclib
CAS :Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.Formule :C21H20ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.84ML 315 hydrochloride
CAS :ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].
Formule :C18H14Cl3N3O2Couleur et forme :SolidMasse moléculaire :410.682Lerociclib
CAS :Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.Formule :C26H34N8ODegré de pureté :99%Couleur et forme :SolidMasse moléculaire :474.6CDK7-IN-22
CAS :CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Formule :C22H25F3N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.47Inixaciclib
CAS :Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.Formule :C26H30F2N6OCouleur et forme :SolidMasse moléculaire :480.55CDK-IN-11
CAS :CDK-IN-11, a heterocyclic compound, promotes cardiomyocyte maturation [1].Formule :C25H21BrN4O2Couleur et forme :SolidMasse moléculaire :489.36Palbociclib orotate
CAS :Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.Formule :C29H33N9O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.63KM05382
CAS :KM05382 inhibits CDK9 and the transcription of GAPDH.Formule :C20H19ClN2O3S2Couleur et forme :SolidMasse moléculaire :434.96CDK7-IN-25
CAS :CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].Formule :C33H32N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.65CCT-251921
CAS :CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formule :C21H23ClN6ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :410.9Ref: TM-T14901
1mg90,00€1mL*10mM (DMSO)192,00€5mg210,00€10mg308,00€25mg520,00€50mg745,00€100mg1.018,00€IIIM-290
CAS :IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Formule :C23H21Cl2NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.32Cdc7-IN-7
CAS :Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.
Formule :C21H22N4O5Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :410.42Cdk4 Inhibitor
CAS :PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.Formule :C20H10BrN3O2Couleur et forme :SolidMasse moléculaire :404.2CDK9-IN-23
CAS :CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].Formule :C22H25ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.91(2S,3R)-Voruciclib
CAS :(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.Formule :C22H19ClF3NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.84DCB-3503
CAS :DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.Formule :C24H27NO5Couleur et forme :SolidMasse moléculaire :409.47NU6300
CAS :NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.Formule :C20H23N5O3SDegré de pureté :96.08%Couleur et forme :SolidMasse moléculaire :413.49CDK9-IN-2
CAS :CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formule :C23H25ClFN5Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :425.93Ref: TM-T14918
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg266,00€25mg460,00€50mg668,00€100mg945,00€AZD4573
CAS :AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.Formule :C22H28ClN5O2Degré de pureté :99% - 99.51%Couleur et forme :SolidMasse moléculaire :429.94(R)-Simurosertib
CAS :(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.Formule :C17H19N5OSDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :341.43Debio-0123
CAS :Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.Formule :C26H28Cl2N6ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :511.45XY028-140
CAS :XY028-140 is a selective CDK4/6 inhibitor and degrader, acting via PROTAC with ligands for Cereblon and CDK in cancer cells.Formule :C39H40N10O7Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :760.8CF53
CAS :CF53: potent, selective oral BET inhibitor; Ki <1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.Formule :C24H25N7O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :443.5Ref: TM-T10773
1mg92,00€5mg200,00€1mL*10mM (DMSO)215,00€10mg299,00€25mg484,00€50mg658,00€100mg892,00€Cdk1/2 Inhibitor III
CAS :Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.Formule :C15H13F2N7O2S2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :425.44CDK9-IN-11
CAS :CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].Formule :C20H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.43CDK2-IN-18
CAS :CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].Formule :C21H23N7O2SCouleur et forme :SolidMasse moléculaire :437.52CDK2 degrader 6
CAS :CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.Formule :C23H22F5N5O3Couleur et forme :SolidMasse moléculaire :511.44Tizolemide
CAS :Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Formule :C11H14ClN3O3S2Couleur et forme :SolidMasse moléculaire :335.83INX-315
CAS :INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.Formule :C19H21N7O3SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :427.48CDDD11-8
CAS :CDDD11-8 is an orally administered, highly potent and selective CDK9 and FLT3-ITD inhibitor, with K i values of 8 nM and 13 nM, respectively. It effectively reduces the proliferation of leukemia cell lines, showing particular efficacy against those with the FLT3-ITD mutation [1] [2].Formule :C24H26N6Couleur et forme :SolidMasse moléculaire :398.50Haspin-IN-1
Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.Formule :C12H8N4O2SCouleur et forme :SolidMasse moléculaire :272.28CDK12/13 ligand 1
CAS :ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Formule :C26H26BrN5OCouleur et forme :SolidMasse moléculaire :504.42CDK2-IN-31
CAS :CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.Formule :C37H52N6O5Couleur et forme :SolidMasse moléculaire :660.85SGC-CLK-1
CAS :SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Formule :C19H15F3N6O2Couleur et forme :SolidMasse moléculaire :416.36CDK1-IN-4
CDK1-IN-4 inhibits CDK1 (IC50: 44.52 nM), CDK2/CDK5 less potently, impacts cell cycle, used in cancer studies.Formule :C26H24ClN5SCouleur et forme :SolidMasse moléculaire :474.02CDK8-IN-5
CAS :CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.Formule :C26H22N2O4Couleur et forme :SolidMasse moléculaire :426.46PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) selectively degrades CDK12/13 at nanomolar potency, targeting breast cancer.Couleur et forme :SolidCDK8-IN-11 hydrochloride
CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.Formule :C19H16ClF3N4O2Couleur et forme :SolidMasse moléculaire :424.8CDK9-IN-34
CAS :CDK9-IN-34 (Compound 1b) is an inhibitor of CDK9 with an IC50 of 0.25 μM. It exhibits cytotoxicity against cancer cell lines HCT116, MCF7, and K652, with IC50 values of 1.43 μM, 3.01 μM, and 50.27 μM, respectively. Additionally, CDK9-IN-34 demonstrates antiviral activity against coronavirus 229E with an IC50 of 145.92 μM.Formule :C18H20N4Couleur et forme :SolidMasse moléculaire :292.38CDK8-IN-11
CAS :CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.Formule :C19H15F3N4O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :388.34Ref: TM-T61742
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg178,00€25mg409,00€50mg708,00€100mg982,00€RGB-286638
CAS :RGB-286638 inhibits multiple CDKs and GSK-3β, TAK1, Jak2, MEK1 with IC50s as low as 1-54 nM.Formule :C29H37Cl2N7O4Couleur et forme :SolidMasse moléculaire :618.55Cdc7-IN-10
CAS :Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.Formule :C20H22F2N4O2SCouleur et forme :SolidMasse moléculaire :420.48Haspin-IN-2
CAS :Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).Formule :C12H8N4O3Couleur et forme :SolidMasse moléculaire :256.22Cdc7-IN-8
CAS :Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)Formule :C19H21N5O2Couleur et forme :SolidMasse moléculaire :351.40CDK7-IN-17
CAS :CDK7-IN-17 (compound 11) is a pyrimidine-derived CDK7 inhibitor for studying transcription-disrupted cancers.Formule :C24H26F3N6OPDegré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :502.47CDK7/12-IN-1
CAS :CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.Formule :C25H34N8OCouleur et forme :SolidMasse moléculaire :462.59DS96432529
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.Formule :C18H26N4O3SCouleur et forme :SoildMasse moléculaire :378.49Cdc7-IN-11
CAS :Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.Formule :C20H22F2N4O2SCouleur et forme :SolidMasse moléculaire :420.48CLK1/4-IN-1
CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.Formule :C18H14ClNO4SCouleur et forme :SolidMasse moléculaire :375.83CDK9-IN-13
CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.Formule :C27H35N5O2Couleur et forme :SolidMasse moléculaire :461.6CDK1-IN-3
CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.Formule :C28H25ClF3N5O2Couleur et forme :SolidMasse moléculaire :555.98CDK/HDAC-IN-1
CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.Formule :C20H18N4O4Couleur et forme :SolidMasse moléculaire :378.38CDK7-IN-33
CAS :CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.Formule :C29H36N6O4SCouleur et forme :SolidMasse moléculaire :564.699CDK8-IN-9
CDK8-IN-9, potent CDK8 inhibitor (IC50: 48.6 nM), curbs tumor growth, useful for colorectal cancer research.Couleur et forme :SolidYL-1-9
CAS :YL-1-9 is an inhibitor that prevents the degradation of p53 by MDM2 through tight binding to the crucial hydrophobic pocket of MDM2. It can induce cell cycle arrest and apoptosis in breast cancer cells [1].Formule :C22H23F3N2O3Couleur et forme :SolidMasse moléculaire :420.425CLK1/2-IN-1
CAS :CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.Formule :C21H20F3N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.42
