CDK
Les inhibiteurs des kinases dépendantes des cyclines (CDK) sont des composés qui bloquent l'activité des CDK, un groupe de kinases protéiques qui régulent le cycle cellulaire, la transcription et d'autres processus cellulaires. Les CDK sont activées par leur liaison aux cyclines, et leur activité est cruciale pour la progression des cellules à travers les différentes phases du cycle cellulaire. Inhiber les CDK peut arrêter la division cellulaire, entraînant un arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules cancéreuses où les CDK sont souvent dysrégulées. Les inhibiteurs de CDK sont largement utilisés dans la recherche sur le cancer et ont un potentiel thérapeutique dans le traitement de divers cancers. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de CDK de haute qualité pour soutenir vos recherches sur le contrôle du cycle cellulaire, le cancer et le développement thérapeutique.
548 produits trouvés pour "CDK"
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Milciclib
CAS :Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.Formule :C25H32N8ODegré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :460.57Ref: TM-T6081
1mg49,00€5mg101,00€1mL*10mM (DMSO)104,00€10mg168,00€25mg356,00€50mg572,00€100mg858,00€200mg1.153,00€NVP-LCQ195
CAS :NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Formule :C17H19Cl2N5O4SDegré de pureté :99.56% - 99.85%Couleur et forme :SolidMasse moléculaire :460.33Ref: TM-TQ0068
1mg46,00€5mg92,00€1mL*10mM (DMSO)94,00€10mg138,00€25mg255,00€50mg374,00€100mg533,00€200mg705,00€(E/Z)-Zotiraciclib citrate
(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.Formule :C29H32N4O8Couleur et forme :SolidMasse moléculaire :564.59LY3177833
CAS :LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Formule :C16H12FN5ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :309.3Ref: TM-T7810
1mg38,00€5mg80,00€1mL*10mM (DMSO)87,00€10mg109,00€25mg212,00€50mg318,00€100mg477,00€200mg677,00€LDC4297 hydrochloride
CAS :LDC4297 hydrochloride is a selective and potent CDK7 inhibitor with broad-spectrum antiviral activity, useful for research on viral infections.Formule :C23H29ClN8OCouleur et forme :SolidMasse moléculaire :468.987BIO
CAS :7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Formule :C16H10BrN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :356.17BS-181 dihydrochloride
CAS :BS-181 dihydrochloride: Potent CDK7 inhibitor (IC50: 21 nM), less effective on CDK2/5/9, no impact on CDK1/4/6, halts cancer cell growth, triggers apoptosis.Formule :C22H34Cl2N6Couleur et forme :SolidMasse moléculaire :453.46Abemaciclib methanesulfonate
CAS :Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
Formule :C27H32F2N8·CH4O3SDegré de pureté :98.69% - 99.44%Couleur et forme :SolidMasse moléculaire :602.7HQ461
CAS :HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Formule :C15H15N5OS2Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :345.44Ref: TM-T9849
1mg43,00€2mg56,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg144,00€25mg319,00€50mg537,00€100mg767,00€500mg1.558,00€2-Chloropyrazine
CAS :2-Chloropyrazine is used in chemical industry.Formule :C4H3ClN2Degré de pureté :98.98% - 99.89%Couleur et forme :Clear Colorless To Yellowish LiquidMasse moléculaire :114.53RGB-286638 free base
CAS :RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63SR-4835
CAS :SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (Formule :C21H20Cl2N10ODegré de pureté :98.09% - >99.99%Couleur et forme :SolidMasse moléculaire :499.36LDC-4297 HCl (1453834-21-3(free base))
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.Formule :C23H29ClN8ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :469.02LY3405105
CAS :LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Formule :C26H39N7O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :497.63FIT-039
CAS :FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Formule :C17H18FN3SDegré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :315.41Indirubin-3′-oxime
CAS :Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Formule :C16H11N3O2Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :277.28Ref: TM-T9138
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg120,00€25mg236,00€50mg356,00€100mg532,00€200mg772,00€Fadraciclib
CAS :Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Formule :C21H31N7ODegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :397.52Ref: TM-TQ0053
1mg42,00€2mg55,00€1mL*10mM (DMSO)87,00€5mg88,00€10mg145,00€25mg260,00€50mg414,00€100mg583,00€MSC2530818
CAS :MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).Formule :C18H17ClN4ODegré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :340.81Ref: TM-TQ0266
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg462,00€50mg692,00€100mg964,00€Senexin A
CAS :Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.Formule :C17H14N4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :274.32Ref: TM-T5673
1mg34,00€1mL*10mM (DMSO)71,00€5mg73,00€10mg94,00€25mg177,00€50mg323,00€100mg460,00€200mg622,00€Aminopurvalanol A
CAS :Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1Formule :C19H26ClN7ODegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :403.91Ref: TM-T22260
2mg39,00€5mg60,00€1mL*10mM (DMSO)62,00€10mg92,00€25mg173,00€50mg269,00€100mg389,00€200mg555,00€KB-0742 dihydrochloride
CAS :KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Formule :C16H27Cl2N5Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :360.33Ref: TM-T9446
1mg90,00€2mg136,00€5mg222,00€1mL*10mM (DMSO)235,00€10mg358,00€25mg597,00€50mg850,00€100mg1.153,00€Amantadine
CAS :Amantadine (1-Aminoadamantane), an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release and blocks dopamine reuptake.Formule :C10H17NDegré de pureté :99.73% - 99.94%Couleur et forme :Hexakistetrahedral Crystals By Sublimation SolidMasse moléculaire :151.25ON123300
CAS :ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Formule :C24H27N7ODegré de pureté :99.53% - 99.7%Couleur et forme :SolidMasse moléculaire :429.52Ribociclib
CAS :Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).Formule :C23H30N8ODegré de pureté :97.91% - >99.99%Couleur et forme :SolidMasse moléculaire :434.54Ref: TM-T6199
2mg43,00€5mg64,00€1mL*10mM (DMSO)69,00€10mg86,00€25mg97,00€50mg116,00€100mg168,00€500mg420,00€PHA-767491
CAS :PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Formule :C12H11N3ODegré de pureté :99.49% - >99.99%Couleur et forme :SolidMasse moléculaire :213.24Ref: TM-T6206
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg64,00€25mg92,00€50mg138,00€100mg197,00€200mg295,00€Desmethylglycitein
CAS :Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFormule :C15H10O5Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :270.24ON-013100
CAS :ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Formule :C19H22O7SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :394.44Ref: TM-T16391
1mg48,00€1mL*10mM (DMSO)60,00€5mg71,00€10mg100,00€25mg172,00€50mg268,00€100mg404,00€200mg570,00€Dalpiciclib
CAS :Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.Formule :C25H30N6O2Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :446.54LY3143921
CAS :LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Formule :C16H12FN5OCouleur et forme :SolidMasse moléculaire :309.3CKI-7
CAS :CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Formule :C11H14Cl3N3O2SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :358.67Ref: TM-T19913
1mg73,00€5mg128,00€1mL*10mM (DMSO)140,00€10mg185,00€25mg299,00€50mg405,00€100mg545,00€SCH900776 (S-isomer)
CAS :SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formule :C15H18BrN7Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :376.25Ref: TM-T3700
1mg50,00€2mg66,00€5mg90,00€1mL*10mM (DMSO)108,00€10mg146,00€25mg250,00€50mg403,00€100mg593,00€Cucurbitacin E
CAS :Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Formule :C32H44O8Degré de pureté :98.88% - 99.87%Couleur et forme :SolidMasse moléculaire :556.69Ref: TM-T5S1467
1mg56,00€5mg109,00€1mL*10mM (DMSO)133,00€10mg168,00€25mg284,00€50mg423,00€100mg610,00€BUR1
CAS :BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Formule :C16H17N5Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :279.34BGG463
CAS :BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with an IC50 of 0.25 μM, 0.09 μM and 0.590 μM, respectively.Formule :C30H29F3N6O3Degré de pureté :98.21% - >99.99%Couleur et forme :SolidMasse moléculaire :578.58Ref: TM-T4618
1mg58,00€2mg82,00€5mg113,00€1mL*10mM (DMSO)145,00€10mg178,00€25mg333,00€50mg477,00€100mg692,00€CC-671
CAS :CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Formule :C28H28N6O4Degré de pureté :98.66% - 98.8%Couleur et forme :SolidMasse moléculaire :512.56Ref: TM-T4482
1mg50,00€5mg105,00€1mL*10mM (DMSO)120,00€10mg170,00€25mg340,00€50mg512,00€100mg733,00€500mg1.513,00€AG-494
CAS :AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Formule :C16H12N2O3Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :280.28SCH900776
CAS :SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Formule :C15H18BrN7Degré de pureté :96.69% - 99.6%Couleur et forme :SolidMasse moléculaire :376.25MLS-573151
CAS :MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Formule :C21H19N3O2SDegré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :377.46Ref: TM-T22106
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg86,00€25mg161,00€50mg245,00€100mg363,00€200mg515,00€Purvalanol A
CAS :Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.Formule :C19H25ClN6ODegré de pureté :98.13% - 99.68%Couleur et forme :PowderMasse moléculaire :388.89NU2058
CAS :NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.Formule :C12H17N5ODegré de pureté :99.34% - 99.92%Couleur et forme :SolidMasse moléculaire :247.3Ref: TM-T3186
10mg39,00€1mL*10mM (DMSO)44,00€25mg73,00€50mg101,00€100mg152,00€200mg219,00€500mg358,00€TC11
CAS :TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosisFormule :C20H22N2O2Degré de pureté :97.86%Couleur et forme :SolidMasse moléculaire :322.4LY2857785
CAS :LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).Formule :C26H36N6ODegré de pureté :99.68%Couleur et forme :Solid PowderMasse moléculaire :448.6Ref: TM-TQ0060
1mg50,00€2mg71,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg170,00€25mg334,00€50mg537,00€100mg863,00€SNS-032
CAS :SNS-032 (BMS-387032) is a selective inhibitor of CDK2 and is 10- and 20-fold selective over CDK1/CDK4. SNS-032 is sensitive to CDK7/9, and no effect on CDK6.Formule :C17H24N4O2S2Degré de pureté :98.27% - 99.91%Couleur et forme :SolidMasse moléculaire :380.53Ref: TM-T6049
5mg48,00€1mL*10mM (DMSO)50,00€10mg63,00€25mg92,00€50mg124,00€100mg202,00€200mg299,00€500mg504,00€PF-562271 hydrochloride
CAS :PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.Formule :C21H20F3N7O3SHClDegré de pureté :97.08%Couleur et forme :SolidMasse moléculaire :543.95SEL120-34A HCl
CAS :SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectivelyFormule :C15H19Br2ClN4Degré de pureté :98.13% - 98.47%Couleur et forme :SolidMasse moléculaire :450.6AZD-5597
CAS :AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent
Formule :C23H28FN7ODegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :437.51AS2863619
CAS :AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formule :C16H14Cl2N8ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :405.24Ref: TM-T8378
1mg124,00€2mg170,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg409,00€25mg677,00€50mg954,00€100mg1.288,00€PHA-767491 hydrochloride
CAS :PHA-767491 (CAY-10572) is a potent Cdc7/CDK9 inhibitor (IC50: 10/34 nM), selective against GSK3-β, CDK1/2, CDK5, MK2, CHK2, PLK1.Formule :C12H12ClN3ODegré de pureté :99.56% - 99.92%Couleur et forme :SolidMasse moléculaire :249.696-(Dimethylamino)purine
CAS :6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitorFormule :C7H9N5Degré de pureté :99.01% - 99.77%Couleur et forme :SolidMasse moléculaire :163.18LDC000067
CAS :LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.Formule :C18H18N4O3SDegré de pureté :98.08% - 99.07%Couleur et forme :SolidMasse moléculaire :370.43
