CDK
Les inhibiteurs des kinases dépendantes des cyclines (CDK) sont des composés qui bloquent l'activité des CDK, un groupe de kinases protéiques qui régulent le cycle cellulaire, la transcription et d'autres processus cellulaires. Les CDK sont activées par leur liaison aux cyclines, et leur activité est cruciale pour la progression des cellules à travers les différentes phases du cycle cellulaire. Inhiber les CDK peut arrêter la division cellulaire, entraînant un arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules cancéreuses où les CDK sont souvent dysrégulées. Les inhibiteurs de CDK sont largement utilisés dans la recherche sur le cancer et ont un potentiel thérapeutique dans le traitement de divers cancers. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de CDK de haute qualité pour soutenir vos recherches sur le contrôle du cycle cellulaire, le cancer et le développement thérapeutique.
548 produits trouvés pour "CDK"
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SCH900776 (S-isomer)
CAS :SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formule :C15H18BrN7Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :376.25Ref: TM-T3700
1mg50,00€2mg66,00€5mg90,00€1mL*10mM (DMSO)108,00€10mg146,00€25mg250,00€50mg403,00€100mg593,00€BSJ-4-116
CAS :BSJ-4-116: potent, selective CDK12 PROTAC, IC50 = 6 nM; downregulates DDR genes, induces premature transcription termination.Formule :C40H49ClN8O8SDegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :837.38NSC23005 Sodium
CAS :NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.Formule :C13H16NNaO4SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :305.32BUR1
CAS :BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Formule :C16H17N5Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :279.34Abemaciclib
CAS :Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Formule :C27H32F2N8Degré de pureté :99.43% - 99.87%Couleur et forme :SolidMasse moléculaire :506.59NU6027
CAS :NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Formule :C11H17N5O2Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :251.29RGB-286638 free base
CAS :RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63Longdaysin
CAS :Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formule :C16H16F3N5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :335.332-Chloropyrazine
CAS :2-Chloropyrazine is used in chemical industry.Formule :C4H3ClN2Degré de pureté :98.98% - 99.89%Couleur et forme :Clear Colorless To Yellowish LiquidMasse moléculaire :114.53(E/Z)-Zotiraciclib
CAS :(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formule :C23H24N4ODegré de pureté :97.75% - 99.92%Couleur et forme :SolidMasse moléculaire :372.46Ref: TM-T21503
1mg43,00€2mg56,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg113,00€25mg200,00€50mg330,00€100mg480,00€Ro-3306
CAS :RO-3306: ATP-competitive CDK1 inhibitor, Ki 20 nM, >15x more selective than other human kinases.Formule :C18H13N3OS2Degré de pureté :97.67% - 99.79%Couleur et forme :SolidMasse moléculaire :351.45Atuveciclib
CAS :Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Formule :C18H18FN5O2SDegré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :387.43Ref: TM-T10464L
1mg84,00€2mg114,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg313,00€25mg580,00€50mg773,00€100mg1.063,00€BGG463
CAS :BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with an IC50 of 0.25 μM, 0.09 μM and 0.590 μM, respectively.Formule :C30H29F3N6O3Degré de pureté :98.21% - >99.99%Couleur et forme :SolidMasse moléculaire :578.58Ref: TM-T4618
1mg58,00€2mg82,00€5mg113,00€1mL*10mM (DMSO)145,00€10mg178,00€25mg333,00€50mg477,00€100mg692,00€PNU112455A hydrochloride
CAS :PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.Formule :C10H12ClN5O2SDegré de pureté :98.58% - 99.22%Couleur et forme :SolidMasse moléculaire :301.75Ref: TM-T8230
2mg44,00€5mg71,00€1mL*10mM (DMSO)79,00€10mg100,00€25mg172,00€50mg266,00€100mg434,00€500mg964,00€Ribociclib succinate hydrate
CAS :Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively).Formule :C27H38N8O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :570.651CAN508
CAS :CAN508: potent CDK9/T1 inhibitor; IC50 0.35 μM, Cdk2/E; Ki 13.3 μM, IC50 20 μM; 38x selective; antitumor.Formule :C9H10N6ODegré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :218.22SR-4835
CAS :SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (Formule :C21H20Cl2N10ODegré de pureté :98.09% - >99.99%Couleur et forme :SolidMasse moléculaire :499.36YKL-5-124
CAS :YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displaysFormule :C28H33N7O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :515.61Ref: TM-T22461
1mg82,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg222,00€25mg385,00€50mg560,00€100mg790,00€6-(Dimethylamino)purine
CAS :6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitorFormule :C7H9N5Degré de pureté :99.01% - 99.77%Couleur et forme :SolidMasse moléculaire :163.18CKI-7
CAS :CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Formule :C11H14Cl3N3O2SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :358.67Ref: TM-T19913
1mg73,00€5mg128,00€1mL*10mM (DMSO)140,00€10mg185,00€25mg299,00€50mg405,00€100mg545,00€CC-671
CAS :CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Formule :C28H28N6O4Degré de pureté :98.66% - 98.8%Couleur et forme :SolidMasse moléculaire :512.56Ref: TM-T4482
1mg50,00€5mg105,00€1mL*10mM (DMSO)120,00€10mg170,00€25mg340,00€50mg512,00€100mg733,00€500mg1.513,00€Milciclib
CAS :Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.Formule :C25H32N8ODegré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :460.57Ref: TM-T6081
1mg49,00€5mg101,00€1mL*10mM (DMSO)104,00€10mg168,00€25mg356,00€50mg572,00€100mg858,00€200mg1.153,00€Indirubin-3'-monoxime
CAS :Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Formule :C16H11N3O2Degré de pureté :99.55%Couleur et forme :Dark Red SolidMasse moléculaire :277.28THZ1 Hydrochloride
THZ1 Hydrochloride: selective covalent CDK7 inhibitor, IC50 of 3.2 nM; affects CDK12/13 & lowers MYC expression.Formule :C31H29Cl2N7O2Couleur et forme :SolidMasse moléculaire :602.51MSC2530818
CAS :MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).Formule :C18H17ClN4ODegré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :340.81Ref: TM-TQ0266
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg462,00€50mg692,00€100mg964,00€Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Formule :C25H31ClN6O2Couleur et forme :SolidMasse moléculaire :483.01PHA-767491 hydrochloride
CAS :PHA-767491 (CAY-10572) is a potent Cdc7/CDK9 inhibitor (IC50: 10/34 nM), selective against GSK3-β, CDK1/2, CDK5, MK2, CHK2, PLK1.Formule :C12H12ClN3ODegré de pureté :99.56% - 99.92%Couleur et forme :SolidMasse moléculaire :249.69LY3405105
CAS :LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Formule :C26H39N7O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :497.63LDC4297 hydrochloride
CAS :LDC4297 hydrochloride is a selective and potent CDK7 inhibitor with broad-spectrum antiviral activity, useful for research on viral infections.Formule :C23H29ClN8OCouleur et forme :SolidMasse moléculaire :468.98Voruciclib
CAS :Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Formule :C22H19ClF3NO5Degré de pureté :99.89% - 99.99%Couleur et forme :SolidMasse moléculaire :469.847BIO
CAS :7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Formule :C16H10BrN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :356.17Dinaciclib
CAS :Dinaciclib (SCH 727965) is a CDK inhibitor that selectively inhibits CDK1, CDK2, CDK5, and CDK9 (IC50 = 3/1/1/4 nM).Formule :C21H28N6O2Degré de pureté :98.21% - 99.75%Couleur et forme :SolidMasse moléculaire :396.49LY3143921
CAS :LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Formule :C16H12FN5OCouleur et forme :SolidMasse moléculaire :309.3JSH-150
CAS :JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Formule :C24H33ClN6O2SDegré de pureté :99.96% - 99.96%Couleur et forme :SolidMasse moléculaire :505.08Ribociclib
CAS :Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).Formule :C23H30N8ODegré de pureté :97.91% - >99.99%Couleur et forme :SolidMasse moléculaire :434.54Ref: TM-T6199
2mg43,00€5mg64,00€1mL*10mM (DMSO)69,00€10mg86,00€25mg97,00€50mg116,00€100mg168,00€500mg420,00€ON123300
CAS :ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Formule :C24H27N7ODegré de pureté :99.53% - 99.7%Couleur et forme :SolidMasse moléculaire :429.52BSJ-03-123
CAS :BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.Formule :C47H56N10O11Degré de pureté :97.78% - 99.38%Couleur et forme :SolidMasse moléculaire :937.01Ref: TM-T5395
1mg87,00€2mg113,00€5mg177,00€10mg259,00€25mg409,00€50mg560,00€100mg800,00€500mg1.611,00€FIT-039
CAS :FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Formule :C17H18FN3SDegré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :315.41Seliciclib
CAS :Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Formule :C19H26N6ODegré de pureté :97.15% - 99.89%Couleur et forme :White To Off-White SolidMasse moléculaire :354.45Flavopiridol hydrochloride
CAS :Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.Formule :C21H21Cl2NO5Degré de pureté :98.87% - 99.88%Couleur et forme :SolidMasse moléculaire :438.3(E/Z)-Zotiraciclib citrate
(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.Formule :C29H32N4O8Couleur et forme :SolidMasse moléculaire :564.59LDC-4297 HCl (1453834-21-3(free base))
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.
Formule :C23H29ClN8ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :469.02Senexin A
CAS :Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.Formule :C17H14N4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :274.32Ref: TM-T5673
1mg34,00€1mL*10mM (DMSO)71,00€5mg73,00€10mg94,00€25mg177,00€50mg323,00€100mg460,00€200mg622,00€AZD-5438
CAS :AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).Formule :C18H21N5O2SDegré de pureté :99.73% - 99.87%Couleur et forme :SolidMasse moléculaire :371.46PF-06873600
CAS :PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Formule :C20H27F2N5O4SDegré de pureté :98.77% - 99.55%Couleur et forme :SolidMasse moléculaire :471.52Ref: TM-T8463
1mg54,00€5mg114,00€1mL*10mM (DMSO)118,00€10mg178,00€25mg334,00€50mg557,00€100mg888,00€200mg1.198,00€DRB
CAS :DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)
Formule :C12H12Cl2N2O4Degré de pureté :99.46% - 99.83%Couleur et forme :White To Off-White Crystalline SolidMasse moléculaire :319.14CDK12-IN-5
CAS :CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.Formule :C18H15F5N8ODegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :454.36Ref: TM-T40290
1mg157,00€5mg378,00€1mL*10mM (DMSO)416,00€10mg612,00€25mg1.251,00€50mg1.972,00€100mg2.673,00€LSN2839567
CAS :LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.Formule :C25H28F2N8Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :478.54(R)-(+)-O-Demethylbuchenavianine
CAS :(R)-(+)-O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, >10 μM, >10 μM, and >10 μM, respectively.Formule :C21H21NO4Couleur et forme :SolidMasse moléculaire :351.40XL413
CAS :XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.Formule :C14H12ClN3O2Degré de pureté :98.40% - 99.94%Couleur et forme :SolidMasse moléculaire :289.72
