CDK
Les inhibiteurs des kinases dépendantes des cyclines (CDK) sont des composés qui bloquent l'activité des CDK, un groupe de kinases protéiques qui régulent le cycle cellulaire, la transcription et d'autres processus cellulaires. Les CDK sont activées par leur liaison aux cyclines, et leur activité est cruciale pour la progression des cellules à travers les différentes phases du cycle cellulaire. Inhiber les CDK peut arrêter la division cellulaire, entraînant un arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules cancéreuses où les CDK sont souvent dysrégulées. Les inhibiteurs de CDK sont largement utilisés dans la recherche sur le cancer et ont un potentiel thérapeutique dans le traitement de divers cancers. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de CDK de haute qualité pour soutenir vos recherches sur le contrôle du cycle cellulaire, le cancer et le développement thérapeutique.
500 produits trouvés pour "CDK"
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AMG 925
CAS :<p>AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.</p>Formule :C26H29N7O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :471.55CID44216842
CAS :<p>CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.</p>Formule :C22H20BrN3O3SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :486.38CVT-313
CAS :<p>CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.</p>Formule :C20H28N6O3Degré de pureté :97.46% - 97.97%Couleur et forme :SolidMasse moléculaire :400.47GSK 3 Inhibitor IX
CAS :<p>GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.</p>Formule :C16H10BrN3O2Degré de pureté :98% - 99.72%Couleur et forme :SolidMasse moléculaire :356.17Purvalanol B
CAS :<p>Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)</p>Formule :C20H25ClN6O3Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :432.9Palbociclib monohydrochloride
CAS :<p>Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinases</p>Formule :C24H29N7O2·HClDegré de pureté :99.73% - >99.99%Couleur et forme :SolidMasse moléculaire :483.99Toyocamycin
CAS :<p>Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (</p>Formule :C12H13N5O4Degré de pureté :98.1% - 98.17%Couleur et forme :SolidMasse moléculaire :291.26Wogonin
CAS :<p>Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.</p>Formule :C16H12O5Degré de pureté :98% - 99.8%Couleur et forme :Yellow CrystalMasse moléculaire :284.26Palbociclib Isethionate
CAS :<p>Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。</p>Formule :C24H29N7O2·C2H6O4SDegré de pureté :99.01% - 99.27%Couleur et forme :SolidMasse moléculaire :573.66SU9516
CAS :<p>SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.</p>Formule :C13H11N3O2Degré de pureté :99.34% - 99.87%Couleur et forme :SolidMasse moléculaire :241.25BI-1347
CAS :<p>BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.</p>Formule :C22H20N4ODegré de pureté :96.7% - 99.63%Couleur et forme :SolidMasse moléculaire :356.42SRI-29329
CAS :<p>SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).</p>Formule :C20H26ClN7Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :399.92NSC23005
CAS :<p>NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).</p>Formule :C13H17NO4SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :283.34AT7519
CAS :<p>AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.</p>Formule :C16H17Cl2N5O2Degré de pureté :98.88% - 99.65%Couleur et forme :SolidMasse moléculaire :382.24(E/Z)-TG003
CAS :<p>(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.</p>Formule :C13H15NO2SDegré de pureté :98% - 99.04%Couleur et forme :SolidMasse moléculaire :249.33TP-353
CAS :<p>TP-353 (EOS-61973) is a CDK7 inhibitor.</p>Formule :C35H30FNO3Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :531.62Trilaciclib
CAS :<p>Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. enhances antitumour immunity.</p>Formule :C24H30N8ODegré de pureté :99.624%Couleur et forme :SolidMasse moléculaire :446.55AZ5576
CAS :<p>AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].</p>Formule :C21H24FN3O3Degré de pureté :99.88%Couleur et forme :SoildMasse moléculaire :385.43CDK12-IN-5
CAS :<p>CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.</p>Formule :C18H15F5N8ODegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :454.36LSN2839567
CAS :<p>LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.</p>Formule :C25H28F2N8Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :478.54(R)-(+)-O-Demethylbuchenavianine
CAS :<p>(R)-(+)-O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, >10 μM, >10 μM, and >10 μM, respectively.</p>Formule :C21H21NO4Couleur et forme :SolidMasse moléculaire :351.40Riviciclib hydrochloride
CAS :<p>Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.</p>Formule :C21H20ClNO5·HClDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :438.3XL413
CAS :<p>XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.</p>Formule :C14H12ClN3O2Degré de pureté :98.40% - >99.99%Couleur et forme :SolidMasse moléculaire :289.72MFH290
CAS :<p>MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.</p>Formule :C26H31N5O3S2Couleur et forme :SolidMasse moléculaire :525.69CDK2-IN-13
CAS :<p>CDK2-IN-13: Potent CDK2 inhibitor, arrests cell cycle, induces apoptosis, IC50=12 µM, used in cancer research.</p>Formule :C13H12ClN5Couleur et forme :SoildMasse moléculaire :273.72CDK8-IN-4
CAS :<p>CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).</p>Formule :C20H18N4OCouleur et forme :SolidMasse moléculaire :330.38CDK12-IN-3
CAS :<p>CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.</p>Formule :C23H28F2N8ODegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :470.52Cdc7-IN-5
CAS :<p>Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.</p>Formule :C25H23N3O5Degré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :445.47Cdc7-IN-9
CAS :<p>Cdc7-IN-9 can be used for the research of cancer which is a potent inhibitor of Cdc7 [1].</p>Formule :C15H17N5OSCouleur et forme :SolidMasse moléculaire :315.39SNX2-1-108
CAS :<p>SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.</p>Formule :C21H16N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.38Metralindole HCl
CAS :<p>Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.</p>Formule :C15H18ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :291.78CDK7-IN-15
CAS :<p>CDK7-IN-15, a pyrimidine-based potent CDK7 inhibitor, shows promise for various cancers with defective transcription.</p>Formule :C21H24F4N6OSCouleur et forme :SolidMasse moléculaire :484.51BAY-958
CAS :<p>BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.</p>Formule :C17H16FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.4EGFR/CDK2-IN-1
CAS :<p>EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application in</p>Formule :C19H12BrClO2Couleur et forme :SolidMasse moléculaire :387.65CDK7-IN-10
CAS :<p>CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)</p>Formule :C29H35N7O3Couleur et forme :SolidMasse moléculaire :529.63CDK7-IN-16
CAS :<p>CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.</p>Formule :C19H21F3N6O2SCouleur et forme :SolidMasse moléculaire :454.47Ipivivint
CAS :<p>Ipivivint: orally active, potent CLK inhibitor; hinders CLK1, CLK2, & CLK3; curbs Wnt signaling & SRSF phosphorylation for cancer research.</p>Formule :C26H21FN8Couleur et forme :SolidMasse moléculaire :464.5NSC 693868
CAS :<p>CDKs and GSK-3 inhibitor</p>Formule :C9H7N5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :185.19Atuveciclib S-Enantiomer
CAS :<p>Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.</p>Formule :C18H18FN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43CDK8-IN-6
CAS :<p>CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers.</p>Formule :C26H37ClN2Couleur et forme :SolidMasse moléculaire :413.04CDK4/6-IN-14
CAS :<p>CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, >60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.</p>Formule :C24H27ClFN7OCouleur et forme :SolidMasse moléculaire :483.97KH-CB19
CAS :<p>KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).</p>Formule :C15H13Cl2N3O2Couleur et forme :SolidMasse moléculaire :338.19Cdc7-IN-14
CAS :<p>Cdc7-IN-14 (compound 82) is a potent CDC7 inhibitor with an IC50 < 1 nM, promising for cancer research.</p>Formule :C18H20N4O2SCouleur et forme :SolidMasse moléculaire :356.44CDK9-IN-15
CAS :<p>CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.</p>Formule :C16H11N3OSDegré de pureté :97.24%Couleur et forme :SolidMasse moléculaire :293.34CDK-IN-10
CAS :<p>CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.</p>Formule :C18H18N4O2Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :322.36CLK1-IN-2
<p>CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.</p>Formule :C16H12Cl2N2O2SCouleur et forme :SolidMasse moléculaire :367.25XIE18-6
CAS :<p>XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.</p>Formule :C18H15NO6SDegré de pureté :99.712%Couleur et forme :SolidMasse moléculaire :373.38NSC 625987
CAS :<p>Cyclin-dependent kinase (cdk) 4 inhibitor</p>Formule :C15H13NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :271.33ARN22089
CAS :<p>ARN22089 is an oral active CDC42 GTPase interaction inhibitor that blocks tumour growth in BRAF mutant mouse melanoma models and PDXs in vivo.</p>Formule :C23H27N5Degré de pureté :98.37%Couleur et forme :SolidMasse moléculaire :373.49CDK8/19-IN-51
CAS :<p>CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.</p>Formule :C23H22N6O2Degré de pureté :98.65% - 99.62%Couleur et forme :SoildMasse moléculaire :414.46
