CDK
Les inhibiteurs des kinases dépendantes des cyclines (CDK) sont des composés qui bloquent l'activité des CDK, un groupe de kinases protéiques qui régulent le cycle cellulaire, la transcription et d'autres processus cellulaires. Les CDK sont activées par leur liaison aux cyclines, et leur activité est cruciale pour la progression des cellules à travers les différentes phases du cycle cellulaire. Inhiber les CDK peut arrêter la division cellulaire, entraînant un arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules cancéreuses où les CDK sont souvent dysrégulées. Les inhibiteurs de CDK sont largement utilisés dans la recherche sur le cancer et ont un potentiel thérapeutique dans le traitement de divers cancers. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de CDK de haute qualité pour soutenir vos recherches sur le contrôle du cycle cellulaire, le cancer et le développement thérapeutique.
548 produits trouvés pour "CDK"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Crozbaciclib fumarate
CAS :Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.Formule :C32H34F2N6O4Couleur et forme :SolidMasse moléculaire :604.65EGFR/CDK2-IN-1
CAS :EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application inFormule :C19H12BrClO2Couleur et forme :SolidMasse moléculaire :387.65EGFR/HER2/CDK9-IN-3
CAS :EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.Formule :C24H21N3O4S2Couleur et forme :SolidMasse moléculaire :479.57PKC-9
CAS :PKC-9 is a PKC-zeta inhibitor 9.Formule :C25H25N7Couleur et forme :SolidMasse moléculaire :423.51CDK7-IN-15
CAS :CDK7-IN-15 (Compound 8) is an effective CDK7 inhibitor for studying cancers associated with transcriptional dysregulation.Formule :C21H24F4N6OSDegré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :484.51CDK7-IN-10
CAS :CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)Formule :C29H35N7O3Couleur et forme :SolidMasse moléculaire :529.63CDK7-IN-16
CAS :CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.Formule :C19H21F3N6O2SCouleur et forme :SolidMasse moléculaire :454.47CDK9-IN-14
CAS :CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.Formule :C21H23F2N3O4Couleur et forme :SolidMasse moléculaire :419.42Cdc7-IN-17
CAS :Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Formule :C13H15N5OSCouleur et forme :SolidMasse moléculaire :289.36K 00546
CAS :K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).Formule :C15H13F2N7O2S2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :425.44CDK8-IN-7
CAS :CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.Formule :C30H40N2Couleur et forme :SolidMasse moléculaire :428.65Cdc7-IN-15
CAS :Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].Formule :C12H14N4OSCouleur et forme :SolidMasse moléculaire :262.33CP681301
CAS :CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.Formule :C17H22N4OCouleur et forme :SolidMasse moléculaire :298.38P18IN003
CAS :P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion ofFormule :C17H16N2O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :296.32CDK5 inhibitor 20-223
CAS :CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.Formule :C19H19N3OCouleur et forme :SolidMasse moléculaire :305.37SNX2-1-108
CAS :SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.Formule :C21H16N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.38Metralindole
CAS :Metralindole is a reversible inhibitor of monoamine oxidase A (RIMA).Formule :C15H17N3OCouleur et forme :SolidMasse moléculaire :255.32Olomoucine II
CAS :Olomoucine II, a CDK inhibitor effective on Cdk1/2/4/7/9, also inhibits ERK2, ABCB1, and various virus replications, not effective on measles/influenza.Formule :C19H26N6O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :370.45SLM6
CAS :SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.Formule :C12H17N7O4Couleur et forme :SolidMasse moléculaire :323.31CDK9/10/GSK3β-IN-1
CAS :CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50Formule :C29H24ClN3O4SCouleur et forme :SolidMasse moléculaire :546.04SMAPP1
CAS :SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.Formule :C27H25N5O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :563.65SLK/STK10-IN-1
CAS :SLK/STK10-IN-1 is a selective and potent inhibitor of SLK and STK10 with potential antitumor activity.Formule :C17H13ClN2O3Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :328.75GW8510
CAS :GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Formule :C21H15N5O3S2Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :449.51β-catenin-IN-3
CAS :β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces theFormule :C19H20Br2N2OSCouleur et forme :SolidMasse moléculaire :484.25Alsterpaullone, 2-Cyanoethyl
CAS :Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β.Formule :C19H14N4O3Couleur et forme :SolidMasse moléculaire :346.34CDK-IN-10
CAS :CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Formule :C18H18N4O2Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :322.36Zotiraciclib HCl
CAS :Zotiraciclib (TG02/SB1317) is a CDK/JAK2/FLT3 inhibitor potentially treating Myc-overexpressing cancers, including glioblastoma.Formule :C23H26Cl2N4OCouleur et forme :SolidMasse moléculaire :445.388AG-012986
CAS :AG-012986: a selective CDK inhibitor with in vitro and in vivo antitumor effects; low IC50 in 14/18 cancer cell types; CAS# 486414-35-1.Formule :C22H23F2N5O2SCouleur et forme :SolidMasse moléculaire :459.51Aloisine B
CAS :Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.Formule :C15H14ClN3Degré de pureté :95.15%Couleur et forme :SolidMasse moléculaire :271.74Cdc7-IN-5
CAS :Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.Formule :C25H23N3O5Degré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :445.47Ref: TM-T10727
1mg90,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg356,00€25mg587,00€50mg802,00€100mg1.108,00€BS-181
CAS :BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.Formule :C22H32N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.53FN-1501
CAS :FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).Formule :C22H25N9ODegré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :431.49Ref: TM-T15335
1mg87,00€5mg177,00€1mL*10mM (DMSO)203,00€10mg295,00€25mg537,00€50mg807,00€100mg1.099,00€CDK8-IN-4
CAS :CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Formule :C20H18N4OCouleur et forme :SolidMasse moléculaire :330.38CDK12-IN-3
CAS :CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Formule :C23H28F2N8ODegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :470.52Cdc7-IN-1
CAS :Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Formule :C21H16ClN3O4Couleur et forme :SolidMasse moléculaire :409.82CLK1/2-IN-3
CAS :CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.Formule :C21H21N5O2Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :375.42CDK12-IN-E9
CAS :CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.Formule :C24H30N6O2Couleur et forme :SolidMasse moléculaire :434.53AS2863619 free base
CAS :AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.Formule :C16H12N8OCouleur et forme :SolidMasse moléculaire :332.32CLK1-IN-1
CAS :CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).Formule :C24H16FN5OCouleur et forme :SolidMasse moléculaire :409.42THZ1-R
CAS :THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.Formule :C31H30ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.07CDK8/19-IN-51
CAS :CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.Formule :C23H22N6O2Degré de pureté :98.65% - 99.62%Couleur et forme :SoildMasse moléculaire :414.46HTH-01-091
CAS :HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3,Formule :C26H28Cl2N4O2Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :499.43Ref: TM-T24152
1mg266,00€5mg655,00€1mL*10mM (DMSO)735,00€10mg888,00€25mg1.378,00€50mg1.783,00€100mg2.250,00€SJ572403
CAS :SJ572403 inhibits p27 protein, Kd 2.2 mM at D2 subdomain of p27-KID; useful in disordered protein disease research.Formule :C13H17N5O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :275.31Ref: TM-T16889
1mg39,00€5mg86,00€1mL*10mM (DMSO)92,00€10mg119,00€25mg231,00€50mg371,00€100mg537,00€200mg710,00€ML 315
CAS :ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.Formule :C18H13Cl2N3O2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :374.22CDK-IN-2
CAS :CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Formule :C18H19ClFN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :363.81Ref: TM-TQ0078
1mg38,00€2mg51,00€1mL*10mM (DMSO)92,00€5mg96,00€10mg138,00€25mg258,00€50mg376,00€100mg532,00€500mg1.063,00€dCeMM2
CAS :dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.Formule :C16H11ClN6OSDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :370.82Ref: TM-T61477
1mg34,00€5mg74,00€1mL*10mM (DMSO)104,00€10mg113,00€25mg236,00€50mg404,00€100mg600,00€500mg1.279,00€Abemaciclib metabolite M20
CAS :Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。Formule :C27H32F2N8ODegré de pureté :98.1% - 99.08%Couleur et forme :SolidMasse moléculaire :522.59DIF-3
CAS :DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Formule :C13H17ClO4Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :272.72Ref: TM-T60485
1mg96,00€1mL*10mM (DMSO)205,00€5mg222,00€10mg333,00€25mg557,00€50mg795,00€100mg1.071,00€500mg2.187,00€Cdc7-IN-7c
CAS :Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.Formule :C15H17N5OSDegré de pureté :98.19% - 99.22%Couleur et forme :SolidMasse moléculaire :315.39Ref: TM-T23867
1mg315,00€1mL*10mM (DMSO)600,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€SEL120-34A
CAS :SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Formule :C15H18Br2N4Degré de pureté :99.764% - 99.84%Couleur et forme :SolidMasse moléculaire :414.14Ref: TM-T10744
1mg612,00€5mg1.529,00€1mL*10mM (DMSO)1.835,00€10mg1.880,00€25mg2.178,00€50mg2.862,00€100mg3.870,00€
