Microtubules associés
Les inhibiteurs des protéines associées aux microtubules ciblent les protéines qui interagissent avec les microtubules, les composants structurels du cytosquelette de la cellule qui sont essentiels à la division cellulaire. Ces protéines régulent la stabilité et la dynamique des microtubules pendant la mitose. L'inhibition des protéines associées aux microtubules peut perturber la fonction des microtubules, entraînant un arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules cancéreuses à division rapide. Ces inhibiteurs sont largement utilisés dans la recherche sur le cancer et le développement de médicaments. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de protéines associées aux microtubules de haute qualité pour soutenir vos recherches sur la division cellulaire, la dynamique du cytosquelette et la thérapie contre le cancer.
262 produits trouvés pour "Microtubules associés"
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Tubulin inhibitor 8
CAS :<p>Tubulin inhibitor 8 blocks tubulin polymerization, stunts K562 cancer cell growth; IC50: 0.73 μM, 14 nM.</p>Formule :C21H14N2O3Degré de pureté :98.51% - 99.87%Couleur et forme :SolidMasse moléculaire :342.35TCS 2210
CAS :<p>TCS 2210 promotes neuronal differentiation in stem cells, boosting β-III tubulin and enolase markers.</p>Formule :C18H17N3O3Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :323.35CID-663143
CAS :<p>CID-663143 inhibits cancer cell growth and shows microtubule-binding activity.</p>Formule :C19H18N4O2SDegré de pureté :99.68% - 99.77%Couleur et forme :SolidMasse moléculaire :366.44LY3372689
CAS :<p>LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease.</p>Formule :C16H22FN5O3SDegré de pureté :99.43% - 99.53%Couleur et forme :SolidMasse moléculaire :383.44JH-VIII-157-02
CAS :<p>JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.</p>Formule :C28H27N5O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :465.55DM1-SMe
CAS :<p>DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in human cancer cells.</p>Formule :C36H50ClN3O10S2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :784.38SB-216
CAS :<p>SB-216, a potent anti-cancer compound, inhibits tubulin polymerization and curbs growth in various cancer cells.</p>Formule :C17H18N4O2Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :310.35Rosabulin
CAS :<p>v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency.</p>Formule :C22H16N4O2SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :400.45Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2
CAS :<p>Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau in</p>Formule :C38H65N11O9Couleur et forme :SolidMasse moléculaire :819.99Dolastatinol
CAS :<p>Dolastatinol, a synthetic analog of Dolastatin 10, serves as a potent low-nanomolar inhibitor of tubulin polymerization.</p>Formule :C43H70N6O7SCouleur et forme :SolidMasse moléculaire :815.12Valecobulin hydrochloride
CAS :<p>Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516.Cost-effective and quality-assured.</p>Formule :C26H29ClN6O5SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :573.06THK-5105
CAS :<p>THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.</p>Formule :C20H21FN2O2Couleur et forme :SolidMasse moléculaire :340.393,4',5-Trismethoxybenzophenone
CAS :<p>3,4',5-Trismethoxybenzophenone (compound 16a) is an effective inhibitor of tubulin assembly, demonstrating a half-maximal inhibitory concentration (IC 50) of 2.6 µM [1].</p>Formule :C16H16O4Couleur et forme :SolidMasse moléculaire :272.3ASN90
CAS :<p>ASN90 is a specific, orally active inhibitor of the O-GlcNAcase (OGA) enzyme, demonstrating an IC50 of 10.2 nM.</p>Formule :C17H21N5O3SCouleur et forme :SolidMasse moléculaire :375.45CNS-11
CAS :<p>CNS-11, a compound that disaggregates tau fibrils, is utilized in Alzheimer's disease (AD) research [1].</p>Formule :C25H21N3O2Couleur et forme :SolidMasse moléculaire :395.45KIF18A-IN-7
CAS :<p>KIF18A-IN-7 is an orally active inhibitor targeting KIF18A, demonstrating potent inhibition with an IC50 value of 9.4 nM against the microtubule-dependent</p>Formule :C27H35N3O5S2Couleur et forme :SoildMasse moléculaire :545.71Tubulin polymerization-IN-52
CAS :<p>Tubulin polymerization-IN-52 (compound SC23) effectively inhibits tubulin polymerization, exhibiting an IC50 value of 2.9 μM [1].</p>Formule :C21H18F3N5O3Couleur et forme :SolidMasse moléculaire :445.39JG-23
CAS :<p>JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) of</p>Formule :C19H16ClN3OS2Couleur et forme :SolidMasse moléculaire :401.93MK-6240
CAS :<p>MK-6240: A tau PET tracer with high specificity for NFTs binding.</p>Formule :C16H11FN4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :278.28Tubulin inhibitor 25
CAS :<p>Potent Tubulin inhibitor 25: IC50 0.98 μM, blocks HT29 cell growth, hinders cell migration & microtubule formation, anti-angiogenic.</p>Formule :C26H22O8Couleur et forme :SolidMasse moléculaire :462.45PBB3
CAS :<p>PBB3 is a tau-specific PET tracer.</p>Formule :C17H15N3OSCouleur et forme :SolidMasse moléculaire :309.39Oxaline
CAS :<p>Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].</p>Formule :C24H25N5O4Couleur et forme :SolidMasse moléculaire :447.49AMXI-5001 hydrochloride
<p>AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.</p>Formule :C25H21ClFN5O3Couleur et forme :SolidMasse moléculaire :493.92Lisavanbulin
CAS :<p>Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.</p>Formule :C26H29N9O3Couleur et forme :SolidMasse moléculaire :515.57EX05
CAS :<p>EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.</p>Formule :C26H30F2N4O5SCouleur et forme :SolidMasse moléculaire :548.60AM-9022
CAS :<p>AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].</p>Formule :C27H36F2N6O4SCouleur et forme :SolidMasse moléculaire :578.67TACC3 inhibitor 2
CAS :<p>TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.</p>Formule :C20H22FN5O2Couleur et forme :SolidMasse moléculaire :383.419Tubulin polymerization-IN-77
CAS :<p>Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.</p>Formule :C22H19BrF3NO7Couleur et forme :SolidMasse moléculaire :546.288Tubulin polymerization-IN-63
CAS :<p>Tubulin polymerization-IN-63 (compound 6) is an inhibitor of tubulin polymerization. It exhibits an IC50 value of 0.29 μM against MES-SA cells, making it suitable for use in cancer research.</p>Formule :C20H24ClCuN5O2SCouleur et forme :SolidMasse moléculaire :497.5TPI-287
CAS :<p>TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.</p>Formule :C46H63NO15Couleur et forme :SolidMasse moléculaire :869.99Monomethyl auristatin E intermediate-17
CAS :<p>MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).</p>Formule :C27H35NO7SMasse moléculaire :517.63Tubulin polymerization-IN-75
CAS :<p>Tubulin polymerization-IN-75 (Compound 6) is an inhibitor of tubulin polymerization, with an IC50 value of 30 μM. It effectively suppresses the proliferation of cancer cells Huh7 and 293T, demonstrating IC50 values of 14.3 μM and 13.8 μM, respectively.</p>Formule :C14H11NOCouleur et forme :SolidMasse moléculaire :209.243Tubulin polymerization-IN-33
<p>Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.</p>Formule :C27H28N2O6Couleur et forme :SolidMasse moléculaire :476.52Tubulin inhibitor 16
<p>Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].</p>Formule :C16H12FNO2Couleur et forme :SolidMasse moléculaire :269.27Tasidotin hydrochloride
CAS :<p>Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.</p>Formule :C32H59ClN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :643.30Icafolin-methyl
CAS :<p>Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.</p>Formule :C18H18F2N2O5Couleur et forme :SolidMasse moléculaire :380.343Tubulin polymerization-IN-32
<p>Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.</p>Formule :C29H30N2O7Couleur et forme :SolidMasse moléculaire :518.56Tubulin polymerization-IN-74
CAS :<p>Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.</p>Formule :C14H11NSCouleur et forme :SolidMasse moléculaire :225.309JC168
CAS :<p>JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.</p>Formule :C26H40O7Couleur et forme :SolidMasse moléculaire :464.592Myoseverin B
CAS :<p>Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.</p>Formule :C27H32N6O2Couleur et forme :SolidMasse moléculaire :472.582Antitubulin agent 1
<p>Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.</p>Formule :C21H19N3O3Couleur et forme :SolidMasse moléculaire :361.39Alfalone
CAS :<p>Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.</p>Formule :C17H14O5Couleur et forme :SolidMasse moléculaire :298.29TTBK1/2-IN-1
CAS :<p>TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.</p>Formule :C17H16N4OCouleur et forme :SolidMasse moléculaire :292.335Dictyostatin
CAS :<p>Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.</p>Formule :C32H52O6Couleur et forme :SolidMasse moléculaire :532.75AMG28
CAS :<p>AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.</p>Formule :C20H20N4OCouleur et forme :SolidMasse moléculaire :332.399Tubulin inhibitor 19
<p>Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.</p>Formule :C21H23NO5Couleur et forme :SolidMasse moléculaire :369.41Antitumor agent-200
CAS :<p>Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.</p>Formule :C19H21FN2O3SeCouleur et forme :SolidMasse moléculaire :423.34Tubulin inhibitor 22
<p>Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.</p>Formule :C20H17BrFNO4Couleur et forme :SolidMasse moléculaire :434.26Tubulin polymerization-IN-34
<p>"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."</p>Formule :C31H35N3O6Couleur et forme :SolidMasse moléculaire :545.63TTBK1/2-IN-3
CAS :<p>TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).</p>Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.426PM-060184
CAS :<p>PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.</p>Formule :C31H45N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.7Tubulin polymerization-IN-35
<p>Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.</p>Formule :C31H35N3O5Couleur et forme :SolidMasse moléculaire :529.63Tubulin polymerization-IN-8
CAS :<p>Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.</p>Formule :C21H24N4O4SCouleur et forme :SolidMasse moléculaire :428.5Epothilone E
CAS :<p>Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumor</p>Formule :C26H39NO7SCouleur et forme :SolidMasse moléculaire :509.66Tubulin inhibitor 15
<p>Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].</p>Formule :C16H12FNO2Couleur et forme :SolidMasse moléculaire :269.27Tubulin inhibitor 49
CAS :<p>Tubulin inhibitor 49 (Compound 18) is an inhibitor of tubulin polymerization with an IC50 of 48 μM. It disrupts the microtubule network of cells, causing cell cycle arrest in the G2 phase, and exhibits cytotoxicity with an IC50 of 8.8 μM in HeLa cells.</p>Formule :C18H14F3N3OSCouleur et forme :SolidMasse moléculaire :377.383Tau ligand-1
CAS :<p>Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.</p>Formule :C17H16FN3OCouleur et forme :SolidMasse moléculaire :297.327PROTAC α-synuclein degrader 6
CAS :<p>PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.</p>Formule :C37H39N5O9SMasse moléculaire :729.80Ombrabulin
CAS :<p>Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.</p>Formule :C21H26N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.44Tau tracer 2
CAS :<p>Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].</p>Formule :C15H9FN4Couleur et forme :SolidMasse moléculaire :264.263Cevipabulin fumarate
CAS :<p>Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).</p>Formule :C22H22ClF5N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.89
