Microtubules associés
Les inhibiteurs des protéines associées aux microtubules ciblent les protéines qui interagissent avec les microtubules, les composants structurels du cytosquelette de la cellule qui sont essentiels à la division cellulaire. Ces protéines régulent la stabilité et la dynamique des microtubules pendant la mitose. L'inhibition des protéines associées aux microtubules peut perturber la fonction des microtubules, entraînant un arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules cancéreuses à division rapide. Ces inhibiteurs sont largement utilisés dans la recherche sur le cancer et le développement de médicaments. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de protéines associées aux microtubules de haute qualité pour soutenir vos recherches sur la division cellulaire, la dynamique du cytosquelette et la thérapie contre le cancer.
262 produits trouvés pour "Microtubules associés"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
MAP4343
CAS :<p>Map4343, a 3-methyl ether pregnenolone derivative, binds MAP2, boosts tubulin polymerization, spurs neurite growth, and guards neurons.</p>Formule :C22H34O2Degré de pureté :97.024%Couleur et forme :SolidMasse moléculaire :330.5D-64131
CAS :<p>D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.</p>Formule :C16H13NO2Degré de pureté :99.48% - 99.67%Couleur et forme :SolidMasse moléculaire :251.28Soblidotin
CAS :<p>Soblidotin (TZT-1027) (Auristatin PE) is an inhibitor of tubulin polymerization. It is also a novel synthetic Dolastatin 10 derivative.</p>Formule :C39H67N5O6Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :701.98Parbendazole
CAS :<p>Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine.</p>Formule :C13H17N3O2Degré de pureté :99.60%Couleur et forme :Physical Description Crystals Or Fine White Powder (Ntp 1992)Masse moléculaire :247.29Suprafenacine
CAS :<p>Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that induces</p>Formule :C16H18N4ODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :282.34Spastazoline
CAS :<p>Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ).</p>Formule :C20H30N8Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :382.51Estramustine
CAS :<p>Estramustine (LEO-275), a nitrogen mustard-estradiol compound, treats prostate cancer and protects against radiation.</p>Formule :C23H31Cl2NO3Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :440.4Clanfenur
CAS :<p>Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity.</p>Formule :C16H15ClFN3O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :335.764-Isopropoxybenzoic acid
CAS :<p>4-Isopropoxybenzoic acid (AI3 12104) is a Centromere-Associated Protein E inhibitor.</p>Formule :C10H12O3Degré de pureté :99.88%Couleur et forme :White To Off-White PowderMasse moléculaire :180.2Vindesine sulfate
CAS :<p>Vindesine sulfate, a vinca alkaloid derived from vinblastine, binds to spindle microtubules, causing cell death.</p>Formule :C43H57N5O11SDegré de pureté :97.51%Couleur et forme :Amorphous SolidMasse moléculaire :852NQTrp
CAS :<p>NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects.</p>Formule :C21H16N2O4Degré de pureté :98.35%Couleur et forme :SolidMasse moléculaire :360.36ST-401
CAS :<p>ST-401, a microtubule-targeting agent (MTA), functions as a brain-penetrant microtubule (MT) assembly inhibitor. It disrupts microtubule (MT) function by gently and reversibly reducing MT assembly, which leads to mitotic delay and interphase cell death. ST-401 demonstrates potent antitumor activity.</p>Formule :C24H20N2OCouleur et forme :SolidMasse moléculaire :352.43Posdinemab
CAS :<p>Posdinemab, a humanized IgG1κ antibody, targets the microtubule-associated protein tau (MAPT) [1].</p>Couleur et forme :LiquidGosuranemab
CAS :<p>Gosuranemab (BMS-986168), a humanized IgG4 mAb, targets tau residues 15-22, and may aid in Alzheimer’s research.</p>Degré de pureté :95% - 95%Couleur et forme :Liquid4-Desacetylvinblastine hydrazide
CAS :<p>Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent.</p>Formule :C43H56N6O7Couleur et forme :SolidMasse moléculaire :768.94Semorinemab
CAS :<p>Semorinemab (RG6100) is a humanised monoclonal antibody targeting the N-terminal domain of tau protein with a Kd of 3.8 nM, suitable for Alzheimer's disease.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidTubulin polymerization-IN-2
CAS :<p>Tubulin-IN-2, anticancer β-tubulin binder, IC50 0.92 μM, effective against various cancers.</p>Formule :C17H12F2N2O2Couleur et forme :SolidMasse moléculaire :314.29Auristatin F
CAS :<p>Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.</p>Formule :C40H67N5O8Degré de pureté :98.41% - 99.25%Couleur et forme :SolidMasse moléculaire :745.99Aha1/Hsp90-IN-1
CAS :<p>Aha1/Hsp90-IN-1 (Compound 17) inhibits Aha1/Hsp90, preventing tau aggregation; IC50 = 3.32 μM.</p>Formule :C22H17F3N4O2Couleur et forme :SolidMasse moléculaire :426.39AM-5308
CAS :<p>AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.</p>Formule :C26H35N5O5SDegré de pureté :98.06% - 99.58%Couleur et forme :SolidMasse moléculaire :529.65Tau protein aggregation-IN-1
CAS :<p>Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disorders</p>Formule :C17H11BrN2O2Couleur et forme :SolidMasse moléculaire :355.19OSIP-486823
CAS :<p>OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.</p>Formule :C29H28FNO4Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :473.54IQTub4P
CAS :<p>IQTub4P is a potent inhibitor of microtubules. IQTub4P exhibits cytotoxicity in HeLa cells (EC50: 170 nM).</p>Formule :C19H18NNa2O8PCouleur et forme :SolidMasse moléculaire :465.305Tubulin polymerization-IN-42
CAS :<p>Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, inhibits tubulin polymerization and exhibits anti-cancer properties [1].</p>Formule :C22H21NO5Couleur et forme :SolidMasse moléculaire :379.41Alyssin
CAS :<p>Alyssin: sulforaphane analog, antioxidant; boosts Nrf2 and phase II enzymes in cancer cells; lowers PAH metabolism, reducing cancer risk in vitro.</p>Formule :C7H13NOS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :191.31Tubulozole
CAS :<p>Tubulozole blocks mitosis by inhibiting microtubule dynamics, leading to cell cycle arrest and apoptosis.</p>Formule :C23H23Cl2N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.42Sirt1/2-IN-1
CAS :<p>Sirt1/2-IN-1 inhibits SIRT1 (IC50: 1.81 μg/mL) and SIRT2 (2.10 μg/mL), less on SIRT3 (20.5 μg/mL), with anticancer properties.</p>Formule :C22H13ClN2OS2Couleur et forme :SolidMasse moléculaire :420.93Amphethinile
CAS :<p>Amphethinile is an anti-tubulin agent. The Ka of Amphethinile with tubulin is 1.3 μM.</p>Formule :C15H11N3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :265.33Microtubule inhibitor 3
CAS :<p>Compounds 17o and 17p with furan have IC50s of 14.0 and 2.9 nM, respectively, against NCI-H460 cancer cells.</p>Formule :C26H23FN4O3Couleur et forme :SolidMasse moléculaire :458.48Microtubule inhibitor 1
CAS :<p>Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity(IC50 = 9-16 nM, in cancer cells).</p>Formule :C21H19NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :333.38Anticancer agent 48
CAS :<p>Compound 48: broad-spectrum, anti-proliferative, inhibits microtubules, active in vivo, with potential for tumor research.</p>Formule :C26H25N3O4Couleur et forme :SolidMasse moléculaire :443.49Tubulin polymerization-IN-39
<p>Tubulin-IN-39 inhibits polymerization (IC50: 4.9 μM), blocks colchicine site, stops cancer growth.</p>Formule :C21H21N5O5Couleur et forme :SolidMasse moléculaire :423.42Tubulin inhibitor 28
CAS :<p>Compound 2g, a tubulin inhibitor with an IC50 of 1.2 μM, inhibits MCF-7 cell proliferation.</p>Formule :C12H8Br2S2Couleur et forme :SolidMasse moléculaire :376.13Tubulin inhibitor 7
CAS :<p>Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (</p>Formule :C21H14N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :358.35MT-7
CAS :<p>MT-7 is a tubulin polymerization inhibitor.</p>Formule :C22H17N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.39Anticancer agent 49
CAS :<p>Anticancer agent 49, also 69, hinders cell growth and microtubule aggregation, with potential in solid and blood cancer research.</p>Formule :C26H25N3O4Couleur et forme :SolidMasse moléculaire :443.49Tubulin polymerization-IN-19
CAS :<p>Tubulin aggregation-IN-19 (compound 4) is a potent tubulin aggregation inhibitor that has shown potential in breast cancer and drug-resistant colon cancer.</p>Formule :C25H25NO5Couleur et forme :SolidMasse moléculaire :419.47DJ101
CAS :<p>DJ101: A stable tubulin inhibitor that bypasses multidrug resistance efflux pumps.</p>Formule :C23H20N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.43Tubulin polymerization-IN-27
CAS :<p>Compound 5j inhibits tubulin polymerization, arrests cell cycle at G2/M phase, and induces apoptosis.</p>Formule :C22H20N2O2Couleur et forme :SolidMasse moléculaire :344.41MG-2119
CAS :<p>MG-2119 is a potent inhibitor of monomeric tau and α-syn aggregation and can be used to study neurological diseases.</p>Formule :C27H29N5O4Couleur et forme :SolidMasse moléculaire :487.55isoCA-4
CAS :<p>isoCA-4 is a Combretastatin A4 derivative. isoCA-4 is a tubulin polymerization inhibitor with anti-proliferative activities [1].</p>Formule :C18H20O5Couleur et forme :SolidMasse moléculaire :316.35Tubulin polymerization-IN-29
CAS :<p>Tubulin polymerization-IN-29 inhibits microtubule assembly, has anti-proliferative properties, and arrests HeLa cells at G2/M.</p>Formule :C25H20FNO6Couleur et forme :SolidMasse moléculaire :449.43BNC105P
CAS :<p>BNC105P, a prodrug VDA, converts to BNC105, blocks tubulin polymerization, disrupts tumor vessels, and evades P-glycoprotein resistance.</p>Formule :C20H21O10PCouleur et forme :SolidMasse moléculaire :452.3485Microtubule inhibitor 4
CAS :<p>Microtubule inhibitor 4 (Compound 2) blocks polymerization, toxic to HT-29 cells (IC50: 2.1 nM).</p>Formule :C25H23FN4O3Couleur et forme :SolidMasse moléculaire :446.47Tubulin inhibitor 27
CAS :<p>DYT-1 Tubulin inhibitor 27, IC50: 25.6 μM, hinders tubulin polymerization, displays anti-angiogenic and antitumor effects.</p>Formule :C21H19NO4Couleur et forme :SolidMasse moléculaire :349.38Tubulin polymerization-IN-21
CAS :<p>Tubulin polymerization-IN-21 disrupts microtubules, affects glucose metabolism, and has anticancer properties.</p>Formule :C30H29NO7Couleur et forme :SolidMasse moléculaire :515.55Tubulin polymerization-IN-10
CAS :<p>Tubulin polymerization-IN-10 inhibits tubulin polymerization with 4.25 μM IC50 and has anti-tumor properties.</p>Formule :C18H21NO6SCouleur et forme :SolidMasse moléculaire :379.43Neuroinflammatory-IN-3
CAS :<p>Neuroinflammatory-IN-3 is a potent tubulin inhibitor with anti-neuroinflammatory and antitumor properties.</p>Formule :C19H19ClO3Couleur et forme :SolidMasse moléculaire :330.81Tubulin polymerization-IN-36
CAS :<p>Tubulin polymerization-IN-36, a cancer research agent for lymphomas, inhibits tubulin at the colchicine site with IC50 of 2.8 µM.</p>Formule :C18H18N2O3Couleur et forme :SolidMasse moléculaire :310.35Tubulin polymerization-IN-16
CAS :<p>Compound 5g is a potent tubulin aggregation inhibitor, disrupting microtubules and causing G2/M arrest in SGC-7901 cells.</p>Formule :C24H27N5O5Couleur et forme :SolidMasse moléculaire :465.5
