Microtubules associés
Les inhibiteurs des protéines associées aux microtubules ciblent les protéines qui interagissent avec les microtubules, les composants structurels du cytosquelette de la cellule qui sont essentiels à la division cellulaire. Ces protéines régulent la stabilité et la dynamique des microtubules pendant la mitose. L'inhibition des protéines associées aux microtubules peut perturber la fonction des microtubules, entraînant un arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules cancéreuses à division rapide. Ces inhibiteurs sont largement utilisés dans la recherche sur le cancer et le développement de médicaments. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de protéines associées aux microtubules de haute qualité pour soutenir vos recherches sur la division cellulaire, la dynamique du cytosquelette et la thérapie contre le cancer.
262 produits trouvés pour "Microtubules associés"
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O-GlcNAcase-IN-4
CAS :<p>O-GlcNAcase-IN-4, an inhibitor from patent WO2018140299A1, may aid in neurodegenerative disease research.</p>Formule :C16H22FN5O3SCouleur et forme :SolidMasse moléculaire :383.44Tubulin polymerization-IN-18
CAS :<p>Tubulin aggregation-IN-18 (compound 3) is a potent tubulin aggregation inhibitor with potential for breast cancer and drug-resistant colon cancer studies.</p>Formule :C25H25NO6Couleur et forme :SolidMasse moléculaire :435.47Synstab A
CAS :<p>Synstab A is a microtubule stabilizer.</p>Formule :C15H13BrCl3N3O3SCouleur et forme :SolidMasse moléculaire :501.61Microtubule inhibitor 7
CAS :<p>Compounds 17o and 17p have IC50s of 14.0 nM and 2.9 nM respectively, in NCI-H460 cancer cells, showing potent activity.</p>Formule :C25H19FN2O5Couleur et forme :SolidMasse moléculaire :446.43(S)-Dolaphenine hydrochloride
CAS :<p>(S)-Dolaphenine hydrochloride is a useful componet of compound synthesis.</p>Formule :C11H13ClN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :240.75Deox B 7,4
CAS :<p>Deox B 7,4 is a reversible microtubule inhibitor that acts by increasing lysosomal V-ATPase activity and lysosome acidity.</p>Formule :C18H18O5Couleur et forme :SolidMasse moléculaire :314.33Tubulin polymerization-IN-30
CAS :<p>Compound 6e inhibits tubulin polymerization, disrupts microtubules, halts G2/M phase, and targets HeLa, SGC-7901, A549 with low IC50.</p>Formule :C22H25N5O3Couleur et forme :SolidMasse moléculaire :407.47Tubulin inhibitor 29
CAS :<p>Compound 3c, a tubulin inhibitor, blocks assembly at colchicine site with IC50 of 1.2 μM; anti-proliferative IC50 7.5 μM in MCF-7 cells.</p>Formule :C12H8F2O2S2Couleur et forme :SolidMasse moléculaire :286.32Microtubule inhibitor 6
CAS :<p>Compound 17o inhibits microtubules, toxic to NCI-H460, BxPC-3, HT-29 cells (IC50: 14.0, 6.6, 7.0 nM), blocks polymerization.</p>Formule :C24H19FN2O5Couleur et forme :SolidMasse moléculaire :434.42Tubulin inhibitor 31
<p>Tubulin inhibitor 31: potent with 4 µM IC50, anti-proliferative, inhibits HUVEC migration.</p>Formule :C22H19NO2Couleur et forme :SolidMasse moléculaire :329.39Tubulin polymerization-IN-7
CAS :<p>Tubulin aggregation-IN-7 is a potent tubulin aggregation inhibitor that has shown research potential for cancer diseases.</p>Formule :C28H24N4O6SCouleur et forme :SolidMasse moléculaire :544.58Anticancer agent 60
CAS :<p>Anticancer agent 60 hinders HepG2 cell growth with IC50 of 4.13 μM and suppresses tumors in HepG2 mouse model.</p>Formule :C27H33N5O4SCouleur et forme :SolidMasse moléculaire :523.65SB26019
CAS :<p>SB26019: Potent anti-neuroinflammation; inhibits NF-κB via α-tubulin monomers preventing p65 translocation.</p>Formule :C24H20O4Couleur et forme :SolidMasse moléculaire :372.41AMXI-5001
CAS :<p>AMXI-5001: potent oral parp1/2 inhibitor, blocks microtubules, strong anti-cancer effects, lower IC50s, and can shrink large tumors.</p>Formule :C25H20FN5O3Couleur et forme :SolidMasse moléculaire :457.46Tubulin inhibitor 20
CAS :<p>Tubulin inhibitor 20 (compound 1) shows the potential for the cancer research that is a potent tubulin inhibitor [1].</p>Formule :C19H18O4Couleur et forme :SolidMasse moléculaire :310.34Tubulin inhibitor 26
CAS :<p>Compound 3c, a potent indazole-based tubulin inhibitor, halts G2/M phase and induces apoptosis in various cancers without weight loss in mice.</p>Formule :C17H19N3O3Couleur et forme :SolidMasse moléculaire :313.35Microtubule inhibitor 5
CAS :<p>Compound 17f, a potent microtubule inhibitor, shows strong cytotoxicity in NCI-H460 cells with an IC50 of 154.5 nM and high cell permeability.</p>Formule :C22H15FN2O4Couleur et forme :SolidMasse moléculaire :390.36Tubulin polymerization-IN-37
CAS :<p>Tubulin polymerization-IN-37 inhibits tubulin polymerization at the colchicine site (IC50: 2.3 μΜ), potentially aiding lymphoma research.</p>Formule :C19H20N2O4Couleur et forme :SolidMasse moléculaire :340.37THK-5117
CAS :<p>THK-5117, a tau PET probe, has a high tau fibril affinity (Ki 10.5 nM) and binds well to AD brain aggregates.</p>Formule :C19H19FN2O2Couleur et forme :SolidMasse moléculaire :326.36OXi8007
CAS :<p>OXi8007, a water-soluble prodrug for OXi8006, disrupts vasculature and exhibits strong cytotoxicity against DU-145 cancer cells.</p>Formule :C26H24NNa2O10PCouleur et forme :SolidMasse moléculaire :587.428Hydromethylthionine HBr
CAS :<p>Hydromethylthionine (LMTM/Leucomethylene Blue) inhibits tau in Alzheimer's/frontotemporal dementia and improves brain function.</p>Formule :C16H21Br2N3SCouleur et forme :SolidMasse moléculaire :447.233(R)-TTBK1-IN-1
CAS :<p>(R)-TTBK1-IN-1: potent, selective brain-penetrant TTBK1 inhibitor, studies Alzheimer’s & tauopathies.</p>Formule :C18H19N5O2Couleur et forme :SolidMasse moléculaire :337.38Tubulin polymerization-IN-25
CAS :<p>Tubulin polymerization-IN-25 inhibits tubulin (IC50: 1.11 μM) & FTase (IC50: 0.39 μM), and is cytotoxic to cancer cells, halting growth.</p>Formule :C24H18N2O3SCouleur et forme :SolidMasse moléculaire :414.48Tubulin polymerization-IN-15
CAS :<p>Tubulin polymerization-IN-15 (compound 4) is a highly effective inhibitor of tubulin polymerization, with significant potential in cancer research [1].</p>Formule :C18H17N3O4Couleur et forme :SolidMasse moléculaire :339.35Tubulin polymerization-IN-20
CAS :<p>Tubulin aggregation-IN-20, a potent inhibitor, may be studied for breast and drug-resistant colon cancers.</p>Formule :C25H24FNO5Couleur et forme :SolidMasse moléculaire :437.46Tubulin inhibitor 18
CAS :<p>"Tubulin inhibitor 18 (5j), a potent chalcone, uniquely structured for cancer research."</p>Formule :C22H26O5Couleur et forme :SolidMasse moléculaire :370.44Tubulin/MMP-IN-1
<p>Tubulin/MMP-IN-1 inhibits tubulin, MMP, and cancer cell growth; disrupts cell cycles and induces apoptosis.</p>Formule :C38H44NO9PCouleur et forme :SolidMasse moléculaire :689.73Tubulin inhibitor 12
CAS :<p>New tubulin inhibitor 12 (Hit 9); potent anti-cancer agent; IC50=25.3 μM; strong anti-tumor effect.</p>Formule :C24H20N2OCouleur et forme :SolidMasse moléculaire :352.43Tau tracer 1
CAS :<p>Tau tracer 1 is a radiopharmaceutical for imaging Tau aggregates linked to neurodegenerative disease diagnosis.</p>Formule :C34H23N5O2Couleur et forme :SolidMasse moléculaire :533.591Iso-Fludelone
CAS :<p>Iso-Fludelone: a stable, soluble, potent, 3rd-gen epothilone B inhibiting cell division and inducing apoptosis, with low toxicity.</p>Formule :C27H36F3NO6Couleur et forme :SolidMasse moléculaire :527.57KIF18A-IN-4
CAS :<p>KIF18A-IN-4: Non-competitive KIF18A inhibitor, IC50 6.16 μM, targets mitotic kinesins/kinases, anti-tumor.</p>Formule :C22H27N3O3SCouleur et forme :SolidMasse moléculaire :413.53Antitumor agent-68
CAS :<p>Potent Antitumor-68 inhibits tubulin, IC50: 3.6μM HeLa, 3.8μM MCF-7; also scavenges ROS/DPPH dose-dependently.</p>Formule :C17H11NO2Couleur et forme :SolidMasse moléculaire :261.27Antitumor agent-71
CAS :<p>Antitumor Agent-71 inhibits tubulin aggregation; IC50 of 3.98-15.70 μM against cancer cells.</p>Formule :C26H31N5O4SCouleur et forme :SolidMasse moléculaire :509.62IDT
CAS :<p>IDT, an oral TNFα modulator, changes neutrophil levels, boosts cognition, and reduces tau/amyloid in 3xTgAD mice.</p>Formule :C8H5NS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :179.26DHNQ
CAS :<p>DHNQ is a novel inhibitor of the PI3K enzyme activity and transcriptional as well as translational expression levels in colorectal cancer (CRC).</p>Formule :C18H14N2OCouleur et forme :SolidMasse moléculaire :274.32D011-2120
CAS :<p>D011-2120: Antiviral that blocks microtubule growth, disrupts Golgi, and hinders viral egress.</p>Formule :C17H15NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :281.31DAT1
CAS :<p>DAT1 is an antimitotic and antiangiogenic that acts by binding to the colchicine binding site of tubulin.</p>Formule :C17H15N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :325.38Acodazole
CAS :<p>Acodazole is a synthetic imidazoquinoline. It has antimicrobial and antineoplastic properties. It also has been shown to treat arrhythmias.</p>Formule :C20H19N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.4Acodazole hydrochloride
CAS :<p>Acodazole hydrochloride: synthetic imidazoquinoline with antineoplastic activity; disrupts DNA replication by intercalation.</p>Formule :C20H20ClN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.86LDN-193665
CAS :LDN-193665 is a potent inhibitor of tau kinase. It acts by targeting CDK5/p25 and GSK3β.Formule :C15H11FN4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :314.34GF 15
CAS :<p>GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.</p>Formule :C23H21ClO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.86TOK-8801
CAS :<p>TOK-8801 is a dihydroimidazole thiazole carboxamide with immunomodulatory activity.</p>Formule :C17H21N3OSDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :315.43Mivobulin
CAS :<p>Mivobulin is an inhibitor of tubulin .</p>Formule :C17H19N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :325.37S-methyl DM1
CAS :<p>S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.</p>Formule :C36H50ClN3O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :752.31Cevipabulin
CAS :<p>Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell</p>Formule :C18H18ClF5N6ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :464.82Tau-aggregation and neuroinflammation-IN-1
CAS :<p>Potent tau aggregate inhibitor, anti-inflammatory, low cytotoxicity, reverses memory impairment in rats.</p>Formule :C25H20N2O7Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :460.44CCB02
CAS :CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity.Formule :C14H9N3ODegré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :235.24S516
CAS :<p>S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.</p>Formule :C21H19N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.47Sabeluzole
CAS :<p>Sabeluzole (R-58735) has antiepileptic and cognitive enhancing properties and may be used in the study of Alzheimer's disease.</p>Formule :C22H26FN3O2SDegré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :415.52Erbulozole
CAS :<p>Erbulozole (R 55104) is a synthetic microtubule inhibitor with anti-invasive activity that induces Wernicke's encephalopathy-like neurotoxicity.</p>Formule :C24H27N3O5SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :469.55
