c-Myc
Les inhibiteurs de c-Myc ciblent la protéine c-Myc, un facteur de transcription qui joue un rôle crucial dans la croissance cellulaire, la prolifération et l'apoptose. c-Myc régule l'expression de nombreux gènes impliqués dans le cycle cellulaire et est souvent surexprimé dans divers cancers, conduisant à une prolifération cellulaire incontrôlée et à la croissance tumorale. Inhiber c-Myc peut perturber ces processus, induisant un arrêt du cycle cellulaire et l'apoptose dans les cellules cancéreuses. Les inhibiteurs de c-Myc sont des outils importants dans la recherche sur le cancer et le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de c-Myc de haute qualité pour soutenir vos recherches en oncologie, régulation du cycle cellulaire et contrôle transcriptionnel.
69 produits trouvés pour "c-Myc"
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MYCi361
CAS :<p>MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).</p>Formule :C26H16ClF9N2O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :594.86MYCi975
CAS :<p>MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.</p>Formule :C25H16Cl2F6N2O2Degré de pureté :99.3% - 99.82%Couleur et forme :SolidMasse moléculaire :561.3Eragidomide
CAS :<p>Eragidomide (Cereblon modulator 1) is a CRBN E3 ligase modulator, specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.</p>Formule :C22H18ClF2N3O4Degré de pureté :97.51% - 99.63%Couleur et forme :SolidMasse moléculaire :461.85Ceramides Mixture
CAS :<p>Ceramides Mixture: endogenous, regulates cell cycle, growth, and telomerase activity, with hydroxy/non-hydroxy fatty acids.</p>Formule :C36H71NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.967APTO-253
CAS :<p>APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.</p>Formule :C22H14FN5Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :367.38MYCMI-6
CAS :<p>MYCMI-6 inhibits MYC:MAX, reduces tumor growth, triggers apoptosis, minimal side effects.</p>Formule :C20H19N7ODegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :373.41KJ Pyr 9
CAS :<p>KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).</p>Formule :C22H15N3O4Degré de pureté :99.56% - ≥98%Couleur et forme :SolidMasse moléculaire :385.37FIDAS-3
CAS :<p>FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities</p>Formule :C16H15F2NDegré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :259.29FIDAS-5
CAS :<p>FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Cost-effective and quality-assured.</p>Formule :C15H13ClFNDegré de pureté :97.66% - 98.3%Couleur et forme :SolidMasse moléculaire :261.72Saxagliptin hydrate
CAS :<p>Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).</p>Formule :C18H25N3O2·H2ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :333.43MYC-IN-2
CAS :<p>MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.</p>Formule :C25H17N3O2SCouleur et forme :SolidMasse moléculaire :423.49RA-V
<p>RA-V is a natural product that can be used as a reference standard.</p>Formule :C160H202N24O41Couleur et forme :SolidMasse moléculaire :3117.5c-Myc inhibitor 5
<p>DA3: Fluorescent c-Myc inhibitor, targets c-MYC G-quadruplex (K D 16 μM), selective, suppresses c-MYC expression.</p>Formule :C30H46N12Couleur et forme :SolidMasse moléculaire :574.77c-Myc inhibitor 10
CAS :<p>c-Myc inhibitor 10 enhances cell potency with improved permeability from methylated morpholine nitrogen.</p>Formule :C28H38N6O3Couleur et forme :SolidMasse moléculaire :506.64c-Myc inhibitor 12
<p>Compound 67h, also known as c-Myc inhibitor 12, is a potent inhibitor of c-Myc, exhibiting a pEC50 value of 6.4 [1].</p>Formule :C22H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.47MDEG-541
<p>MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1].</p>Formule :C35H38N4O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.76Anti-c-myc Antibody (9E10)
<p>Anti-c-myc Antibody (9E10) is a chimeric mouse IgG1 antibody targeting human c-myc.</p>Couleur et forme :Odour LiquidPROTAC MTP3 degrade-1
<p>PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.</p>Formule :C44H38N6O8Couleur et forme :SolidMasse moléculaire :778.27511Methylcarbamyl PAF C-8
<p>Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.</p>Couleur et forme :Odour Solidc-Myc inhibitor 11
<p>c-Myc inhibitor 11 (Compound 67e), a c-MYC inhibitor (p EC 50 : 6.4), exhibits high clearance, a moderate volume of distribution, and a short half-life in rat</p>Formule :C20H22N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.43CSI86
<p>CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).</p>Formule :C48H50F9N7O7SCouleur et forme :SolidMasse moléculaire :1040WBC100
CAS :<p>WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway</p>Formule :C25H33NO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.53Anticancer agent 263
<p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>Formule :C13H20N2O6Couleur et forme :SolidMasse moléculaire :300.308c-Myc inhibitor 7
CAS :<p>c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.</p>Formule :C35H30N6O5Couleur et forme :SoildMasse moléculaire :614.65Anticancer agent 84
CAS :<p>Anticancer agent 84 inhibits c-MYC transcription by stabilizing G4 structures, aiding cancer research.</p>Formule :C57H67N7O9Couleur et forme :SolidMasse moléculaire :994.18VGN50
<p>VGN50 is a bioactive molecule that mimics the function of K-Rta, capable of downregulating MYC-mediated gene transcription. VGN50 exhibits antitumor activity.</p>Formule :C121H218N46O32Masse moléculaire :2827.68453c-Myc inhibitor 13
<p>c-Myc inhibitor13 (compound A6) is an inhibitor of c-MYC transcription. It selectively stabilizes c-MYCG4 and inhibits G4-related c-MYC transcription.</p>Formule :C30H39N9OMasse moléculaire :541.32776Cotylenin A
CAS :<p>Cotylenin A is a phenanthraquinone compound that synergistically works with vitamin K2 to induce monocyte differentiation and growth arrest. It also inhibits c-Myc expression while inducing cyclin G2 expression in human leukemia HL-60 cells. Cotylenin A is applicable in acute myeloid leukemia research.</p>Formule :C33H50O11Couleur et forme :SolidMasse moléculaire :622.744H122
<p>H122 is a TEADPROTAC degrader effective in degrading TEAD1 with a DC50 of 3 nM, and it shows strong affinity for TEAD2, TEAD3, and TEAD4 with Ki values of 2.0, 3.6, and 1.6 nM, respectively. H122 also downregulates Myc expression and inhibits the growth of MSTO-211H and NCI-H226 cells, with IC50 values of 21.3 nM and 0.6 nM, respectively, demonstrating antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)</p>Formule :C45H45ClFN5O8Couleur et forme :SolidMasse moléculaire :838.319PROTAC LZK-IN-1
CAS :<p>PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.</p>Formule :C51H64F2N10O5SCouleur et forme :SolidMasse moléculaire :967.18KL4-219A
<p>KL4-219A is a selective covalent degrader of the MYC, inhibiting MYC transcriptional activity and degrading MYC in a proteasome-dependent manner .</p>Formule :C20H24N2O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :356.48VPC-70063
CAS :<p>VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.</p>Formule :C16H12F6N2SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :378.34sAJM589
CAS :<p>sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.</p>Formule :C16H10N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.26IRES-C11
CAS :<p>IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.</p>Formule :C13H11Cl2NO4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :316.14Mycro 3
CAS :<p>Mycro 3 is potent and selective for c-Myc in whole cell assays.</p>Formule :C24H17ClF2N6O4Degré de pureté :99.51% - 99.61%Couleur et forme :SolidMasse moléculaire :526.88Saxagliptin
CAS :<p>Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.</p>Formule :C18H25N3O2Degré de pureté :99.17% - 99.95%Couleur et forme :SolidMasse moléculaire :315.41(S)-10-Hydroxycamptothecin
CAS :<p>(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.</p>Formule :C20H16N2O5Degré de pureté :99.09% - 99.81%Couleur et forme :SolidMasse moléculaire :364.35Mollugin
CAS :<p>Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.</p>Formule :C17H16O4Degré de pureté :99.87% - ≥95%Couleur et forme :SolidMasse moléculaire :284.31ML327
CAS :<p>ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).</p>Formule :C19H18N4O4Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :366.3710074-G5
CAS :<p>10074-G5 is an inhibitor of c-Myc-Max dimerization.</p>Formule :C18H12N4O3Degré de pureté :99.51% - 99.67%Couleur et forme :SolidMasse moléculaire :332.31NNK
CAS :<p>NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.Cost-effective and quality-assured.</p>Formule :C10H13N3O2Degré de pureté :99.63% - 99.92%Couleur et forme :SolidMasse moléculaire :207.23Lusianthridin
CAS :<p>Lusianthridin is a natural product from Dendrobium venustum.</p>Formule :C15H14O3Degré de pureté :98.49%Couleur et forme :SolidMasse moléculaire :242.27Agrimol B
CAS :<p>1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.</p>Formule :C37H46O12Degré de pureté :99.06% - ≥95%Couleur et forme :SolidMasse moléculaire :682.7510058-F4
CAS :<p>10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.</p>Formule :C12H11NOS2Degré de pureté :98% - 99.87%Couleur et forme :SolidMasse moléculaire :249.35APTO-253 HCl
CAS :<p>APTO-253 (LOR-253/LT-253) is a small-molecule MTF-1 inhibitor with antitumor properties, reducing cyclin D1, hypoxia, and angiogenesis gene expression.</p>Formule :C22H15ClFN5Couleur et forme :SolidMasse moléculaire :403.8410074-A4
CAS :<p>10074-A4 is a c-Myc binding compound that associates with c-Myc370–409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features from</p>Formule :C18H14Cl2N2O3SDegré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :409.29Artemisitene
CAS :<p>Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.</p>Formule :C15H20O5Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :280.32NY2267
CAS :<p>NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl</p>Formule :C38H43N3O6Degré de pureté :99.16% - 99.27%Couleur et forme :SolidMasse moléculaire :637.76Idarubicin hydrochloride
CAS :<p>Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).</p>Formule :C26H27NO9·HClDegré de pureté :98.91% - 99.96%Couleur et forme :SolidMasse moléculaire :533.95BTYNB
CAS :<p>BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1. MDK6620 downregulates β-TrCP1 mRNA and reduces activation of NF-κB.</p>Formule :C12H9BrN2OSDegré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :309.18EN4
CAS :<p>EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.</p>Formule :C25H24N2O4Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :416.47PARL Protein, Human, Recombinant (Myc)
<p>Required for the control of apoptosis during postnatal growth.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :37.8 kDa (predicted)ACOX1 Protein, Mouse, Recombinant (Myc)
<p>Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :76.2 kDa (predicted)2-5A-dependent Rnase Protein, Human, Recombinant (Myc)
<p>2-5A-dependent Rnase Protein, Human, Recombinant (Myc) is expressed in E.</p>Degré de pureté :85% - 85%Couleur et forme :Lyophilized PowderMasse moléculaire :85.1 kDa (predicted)c-Myc inhibitor 9
CAS :<p>c-Myc inhibitor 9 (compound 332) with logEC50 ≥6, suppresses tumors in mice, useful for cancer research.</p>Formule :C27H31N5OSCouleur et forme :SolidMasse moléculaire :473.63RK-9123016
CAS :<p>RK-9123016 is a SIRT2 inhibitor.</p>Formule :C16H18N6O3SDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :374.42FUBP1-IN-2
CAS :<p>FUBP1-IN-2 hinders FUBP1, affects c-Myc and p21 expression, and depletes polyamines.</p>Formule :C26H26ClN3O4Couleur et forme :SolidMasse moléculaire :479.96KSI-3716
CAS :<p>KSI-3716 is a c-Myc inhibitor, a bladder chemotherapy agent that blocks the formation of complexes between c-MYC/MAX and target gene promoters.</p>Formule :C17H11BrCl2N2O2Degré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :426.09BI8622
CAS :<p>BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.</p>Formule :C25H26N6ODegré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :426.51VPC-70619
CAS :<p>VPC-70619: Oral, selective N-Myc inhibitor; blocks cancer growth by hindering N-Myc-Max/DNA binding; well-absorbed.</p>Formule :C16H8ClF3N4OCouleur et forme :SolidMasse moléculaire :364.71c-Myc inhibitor 8
CAS :<p>c-Myc inhibitor 8 suppresses cell growth in various cancers and is used in research.</p>Formule :C19H12BrClF3NO3S2Couleur et forme :SolidMasse moléculaire :538.79m-Se3
CAS :<p>m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].</p>Formule :C29H23IN2SeDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :605.37SYHA1815
CAS :<p>SYHA1815, an orally active RET inhibitor (IC50=0.9 nmol/L), demonstrates antitumor activity. It exhibits greater selectivity for RET over KDR (IC50=15.9 nmol/L). SYHA1815 operates by downregulating c-Myc, arresting the G1 cell cycle, and inhibiting RET-driven cell proliferation.</p>Formule :C27H26ClF4N5OCouleur et forme :SolidMasse moléculaire :547.98KI-CDK9d-32
CAS :<p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>Formule :C39H45N9O4Couleur et forme :SolidMasse moléculaire :703.83c-Myc inhibitor 4
<p>Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.</p>Formule :C26H33FN6O3Couleur et forme :SolidMasse moléculaire :496.58BRD4 Inhibitor-40
CAS :<p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>Formule :C27H32N8OCouleur et forme :SolidMasse moléculaire :484.596MY05
CAS :<p>MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).</p>Formule :C19H11ClN4OCouleur et forme :SolidMasse moléculaire :346.77JY-3-094
CAS :<p>JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.</p>Formule :C13H8N4O5Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :300.23β-catenin-IN-8
CAS :<p>β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.</p>Formule :C15H12ClN3O2SCouleur et forme :SolidMasse moléculaire :333.79
