c-Myc
Les inhibiteurs de c-Myc ciblent la protéine c-Myc, un facteur de transcription qui joue un rôle crucial dans la croissance cellulaire, la prolifération et l'apoptose. c-Myc régule l'expression de nombreux gènes impliqués dans le cycle cellulaire et est souvent surexprimé dans divers cancers, conduisant à une prolifération cellulaire incontrôlée et à la croissance tumorale. Inhiber c-Myc peut perturber ces processus, induisant un arrêt du cycle cellulaire et l'apoptose dans les cellules cancéreuses. Les inhibiteurs de c-Myc sont des outils importants dans la recherche sur le cancer et le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de c-Myc de haute qualité pour soutenir vos recherches en oncologie, régulation du cycle cellulaire et contrôle transcriptionnel.
76 produits trouvés pour "c-Myc"
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Eragidomide
CAS :Eragidomide (Cereblon modulator 1) is a CRBN E3 ligase modulator, specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.Formule :C22H18ClF2N3O4Degré de pureté :97.51% - 99.63%Couleur et forme :SolidMasse moléculaire :461.85Ref: TM-T10765
1mg38,00€5mg82,00€10mg133,00€25mg269,00€50mg442,00€100mg595,00€200mg802,00€1mL*10mM (DMSO)84,00€Saxagliptin hydrate
CAS :Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).Formule :C18H25N3O2·H2ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :333.43MYCi975
CAS :MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.Formule :C25H16Cl2F6N2O2Degré de pureté :99.3% - 99.82%Couleur et forme :SolidMasse moléculaire :561.3FIDAS-5
CAS :FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Cost-effective and quality-assured.Formule :C15H13ClFNDegré de pureté :98.3% - 99.17%Couleur et forme :SolidMasse moléculaire :261.72Ref: TM-T11285
1mg59,00€2mg85,00€5mg116,00€10mg187,00€25mg331,00€50mg512,00€100mg740,00€500mg1.415,00€MYCi361
CAS :MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).Formule :C26H16ClF9N2O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :594.86MYCMI-6
CAS :MYCMI-6 inhibits MYC:MAX, reduces tumor growth, triggers apoptosis, minimal side effects.Formule :C20H19N7ODegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :373.41Ref: TM-T12134
1mg71,00€5mg152,00€10mg222,00€25mg358,00€50mg512,00€100mg707,00€200mg973,00€500mg1.431,00€Ceramides Mixture
CAS :Ceramides Mixture: endogenous, regulates cell cycle, growth, and telomerase activity, with hydroxy/non-hydroxy fatty acids.Formule :C36H71NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.967KJ Pyr 9
CAS :KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).Formule :C22H15N3O4Degré de pureté :99.56% - ≥98%Couleur et forme :SolidMasse moléculaire :385.37Ref: TM-T15665
2mg37,00€5mg54,00€10mg77,00€25mg138,00€50mg264,00€100mg482,00€200mg647,00€500mg1.009,00€1mL*10mM (DMSO)59,00€FIDAS-3
CAS :FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activitiesFormule :C16H15F2NDegré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :259.29Ref: TM-T11284
5mg49,00€10mg73,00€25mg127,00€50mg182,00€100mg264,00€200mg354,00€1mL*10mM (DMSO)48,00€APTO-253
CAS :APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.Formule :C22H14FN5Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :367.38Ref: TM-T10352
1mg40,00€2mg52,00€5mg75,00€10mg96,00€25mg170,00€50mg255,00€100mg371,00€1mL*10mM (DMSO)84,00€WBC100
CAS :WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathwayFormule :C25H33NO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.53MDEG-541
MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1].Formule :C35H38N4O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.76PROTAC MTP3 degrade-1
PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.Formule :C44H38N6O8Couleur et forme :SolidMasse moléculaire :778.27511Methylcarbamyl PAF C-8
Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.Couleur et forme :Odour Solidc-Myc inhibitor 11
c-Myc inhibitor 11 (Compound 67e), a c-MYC inhibitor (p EC 50 : 6.4), exhibits high clearance, a moderate volume of distribution, and a short half-life in ratFormule :C20H22N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.43c-Myc inhibitor 12
Compound 67h, also known as c-Myc inhibitor 12, is a potent inhibitor of c-Myc, exhibiting a pEC50 value of 6.4 [1].Formule :C22H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.47Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Formule :C13H20N2O6Couleur et forme :SolidMasse moléculaire :300.308c-Myc inhibitor 7
CAS :c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.Formule :C35H30N6O5Couleur et forme :SoildMasse moléculaire :614.65MYC-IN-2
CAS :MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.Formule :C25H17N3O2SCouleur et forme :SolidMasse moléculaire :423.49RA-V
RA-V is a natural product that can be used as a reference standard.Formule :C160H202N24O41Couleur et forme :SolidMasse moléculaire :3117.5c-Myc inhibitor 5
DA3: Fluorescent c-Myc inhibitor, targets c-MYC G-quadruplex (K D 16 μM), selective, suppresses c-MYC expression.Formule :C30H46N12Couleur et forme :SolidMasse moléculaire :574.77c-Myc inhibitor 10
CAS :c-Myc inhibitor 10 enhances cell potency with improved permeability from methylated morpholine nitrogen.Formule :C28H38N6O3Couleur et forme :SolidMasse moléculaire :506.64Anticancer agent 84
CAS :Anticancer agent 84 inhibits c-MYC transcription by stabilizing G4 structures, aiding cancer research.Formule :C57H67N7O9Couleur et forme :SolidMasse moléculaire :994.18VGN50
VGN50 is a bioactive molecule that mimics the function of K-Rta, capable of downregulating MYC-mediated gene transcription. VGN50 exhibits antitumor activity.Formule :C121H218N46O32Masse moléculaire :2827.68453c-Myc inhibitor 13
c-Myc inhibitor13 (compound A6) is an inhibitor of c-MYC transcription. It selectively stabilizes c-MYCG4 and inhibits G4-related c-MYC transcription.Formule :C30H39N9OMasse moléculaire :541.32776CSI86
CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).Formule :C48H50F9N7O7SCouleur et forme :SolidMasse moléculaire :1040Cotylenin A
CAS :Cotylenin A is a phenanthraquinone compound that synergistically works with vitamin K2 to induce monocyte differentiation and growth arrest. It also inhibits c-Myc expression while inducing cyclin G2 expression in human leukemia HL-60 cells. Cotylenin A is applicable in acute myeloid leukemia research.Formule :C33H50O11Couleur et forme :SolidMasse moléculaire :622.744H122
H122 is a TEADPROTAC degrader effective in degrading TEAD1 with a DC50 of 3 nM, and it shows strong affinity for TEAD2, TEAD3, and TEAD4 with Ki values of 2.0, 3.6, and 1.6 nM, respectively. H122 also downregulates Myc expression and inhibits the growth of MSTO-211H and NCI-H226 cells, with IC50 values of 21.3 nM and 0.6 nM, respectively, demonstrating antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Formule :C45H45ClFN5O8Couleur et forme :SolidMasse moléculaire :838.319VPC-70063
CAS :VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Formule :C16H12F6N2SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :378.34Ref: TM-T60019
1mg49,00€5mg101,00€10mg152,00€25mg268,00€50mg385,00€100mg560,00€200mg790,00€1mL*10mM (DMSO)130,00€VTX-0811
VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-α/NF-κB and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.Couleur et forme :Odour LiquidKL4-219A
KL4-219A is a selective covalent degrader of the MYC, inhibiting MYC transcriptional activity and degrading MYC in a proteasome-dependent manner .Formule :C20H22N2O3SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :370.47PROTAC LZK-IN-1
CAS :PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.
Formule :C51H64F2N10O5SCouleur et forme :SolidMasse moléculaire :967.18c-Myc ligand 1
CAS :c-Mycligand 1 is a c-Myc inhibitor and functions as a ligand for target proteins in PROTAC (Proteolysis Targeting Chimeras). It is utilized in the synthesis of PROTAC c-Myc inhibitor 7.Formule :C13H10N2O2Masse moléculaire :226.23sAJM589
CAS :sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.Formule :C16H10N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.26IRES-C11
CAS :IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.Formule :C13H11Cl2NO4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :316.14Ref: TM-T40419
1mg94,00€5mg222,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.674,00€200mg2.242,00€1mL*10mM (DMSO)245,00€(S)-10-Hydroxycamptothecin
CAS :(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formule :C20H16N2O5Degré de pureté :99.09% - 99.81%Couleur et forme :SolidMasse moléculaire :364.35Agrimol B
CAS :1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Formule :C37H46O12Degré de pureté :99.06% - ≥95%Couleur et forme :SolidMasse moléculaire :682.75Saxagliptin
CAS :Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.Formule :C18H25N3O2Degré de pureté :99.17% - 99.95%Couleur et forme :SolidMasse moléculaire :315.41Mycro 3
CAS :Mycro 3 is potent and selective for c-Myc in whole cell assays.Formule :C24H17ClF2N6O4Degré de pureté :99.51% - 99.61%Couleur et forme :SolidMasse moléculaire :526.88Ref: TM-T4367
1mg50,00€5mg94,00€10mg165,00€25mg318,00€50mg452,00€100mg627,00€200mg845,00€1mL*10mM (DMSO)110,00€10074-G5
CAS :10074-G5 is an inhibitor of c-Myc-Max dimerization.Formule :C18H12N4O3Degré de pureté :99.51% - 99.94%Couleur et forme :SolidMasse moléculaire :332.31Ref: TM-T3686
2mg39,00€5mg59,00€10mg84,00€25mg135,00€50mg213,00€100mg375,00€200mg535,00€500mg853,00€1mL*10mM (DMSO)65,00€ML327
CAS :ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).Formule :C19H18N4O4Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :366.37Ref: TM-T4252
1mg47,00€2mg62,00€5mg92,00€10mg137,00€25mg222,00€50mg356,00€100mg612,00€200mg850,00€1mL*10mM (DMSO)101,00€Lusianthridin
CAS :Lusianthridin is a natural product from Dendrobium venustum.Formule :C15H14O3Degré de pureté :98.49%Couleur et forme :SolidMasse moléculaire :242.27NNK
CAS :NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.Cost-effective and quality-assured.Formule :C10H13N3O2Degré de pureté :99.63% - 99.92%Couleur et forme :SolidMasse moléculaire :207.23Ref: TM-T20533
5mg57,00€10mg90,00€25mg150,00€50mg215,00€100mg260,00€200mg385,00€500mg617,00€1mL*10mM (DMSO)62,00€10058-F4
CAS :10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.Formule :C12H11NOS2Degré de pureté :98% - 99.87%Couleur et forme :SolidMasse moléculaire :249.35APTO-253 HCl
CAS :APTO-253 (LOR-253/LT-253) is a small-molecule MTF-1 inhibitor with antitumor properties, reducing cyclin D1, hypoxia, and angiogenesis gene expression.Formule :C22H15ClFN5Couleur et forme :SolidMasse moléculaire :403.8410074-A4
CAS :10074-A4 is a c-Myc binding compound that associates with c-Myc370–409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features fromFormule :C18H14Cl2N2O3SDegré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :409.29Ref: TM-T9628
1mg56,00€2mg80,00€5mg114,00€10mg177,00€25mg318,00€50mg454,00€100mg627,00€200mg845,00€1mL*10mM (DMSO)101,00€Artemisitene
CAS :Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.Formule :C15H20O5Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :280.32Ref: TM-T21065
1mg95,00€5mg187,00€10mg329,00€25mg560,00€50mg800,00€100mg1.103,00€1mL*10mM (DMSO)281,00€NY2267
CAS :NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFormule :C38H43N3O6Degré de pureté :99.16% - 99.27%Couleur et forme :SolidMasse moléculaire :637.76BTYNB
CAS :BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1. MDK6620 downregulates β-TrCP1 mRNA and reduces activation of NF-κB.Formule :C12H9BrN2OSDegré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :309.18Idarubicin hydrochloride
CAS :Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formule :C26H27NO9·HClDegré de pureté :98.91% - 99.96%Couleur et forme :SolidMasse moléculaire :533.95
