c-Myc
Les inhibiteurs de c-Myc ciblent la protéine c-Myc, un facteur de transcription qui joue un rôle crucial dans la croissance cellulaire, la prolifération et l'apoptose. c-Myc régule l'expression de nombreux gènes impliqués dans le cycle cellulaire et est souvent surexprimé dans divers cancers, conduisant à une prolifération cellulaire incontrôlée et à la croissance tumorale. Inhiber c-Myc peut perturber ces processus, induisant un arrêt du cycle cellulaire et l'apoptose dans les cellules cancéreuses. Les inhibiteurs de c-Myc sont des outils importants dans la recherche sur le cancer et le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de c-Myc de haute qualité pour soutenir vos recherches en oncologie, régulation du cycle cellulaire et contrôle transcriptionnel.
76 produits trouvés pour "c-Myc"
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c-Myc inhibitor 5
DA3: Fluorescent c-Myc inhibitor, targets c-MYC G-quadruplex (K D 16 μM), selective, suppresses c-MYC expression.Formule :C30H46N12Couleur et forme :SolidMasse moléculaire :574.77c-Myc inhibitor 10
CAS :c-Myc inhibitor 10 enhances cell potency with improved permeability from methylated morpholine nitrogen.Formule :C28H38N6O3Couleur et forme :SolidMasse moléculaire :506.64Anticancer agent 84
CAS :Anticancer agent 84 inhibits c-MYC transcription by stabilizing G4 structures, aiding cancer research.Formule :C57H67N7O9Couleur et forme :SolidMasse moléculaire :994.18VGN50
VGN50 is a bioactive molecule that mimics the function of K-Rta, capable of downregulating MYC-mediated gene transcription. VGN50 exhibits antitumor activity.Formule :C121H218N46O32Masse moléculaire :2827.68453c-Myc inhibitor 13
c-Myc inhibitor13 (compound A6) is an inhibitor of c-MYC transcription. It selectively stabilizes c-MYCG4 and inhibits G4-related c-MYC transcription.Formule :C30H39N9OMasse moléculaire :541.32776CSI86
CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).Formule :C48H50F9N7O7SCouleur et forme :SolidMasse moléculaire :1040Cotylenin A
CAS :Cotylenin A is a phenanthraquinone compound that synergistically works with vitamin K2 to induce monocyte differentiation and growth arrest. It also inhibits c-Myc expression while inducing cyclin G2 expression in human leukemia HL-60 cells. Cotylenin A is applicable in acute myeloid leukemia research.Formule :C33H50O11Couleur et forme :SolidMasse moléculaire :622.744H122
H122 is a TEADPROTAC degrader effective in degrading TEAD1 with a DC50 of 3 nM, and it shows strong affinity for TEAD2, TEAD3, and TEAD4 with Ki values of 2.0, 3.6, and 1.6 nM, respectively. H122 also downregulates Myc expression and inhibits the growth of MSTO-211H and NCI-H226 cells, with IC50 values of 21.3 nM and 0.6 nM, respectively, demonstrating antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Formule :C45H45ClFN5O8Couleur et forme :SolidMasse moléculaire :838.319VPC-70063
CAS :VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Formule :C16H12F6N2SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :378.34Ref: TM-T60019
1mg49,00€5mg101,00€10mg152,00€25mg268,00€50mg385,00€100mg560,00€200mg790,00€1mL*10mM (DMSO)130,00€VTX-0811
VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-α/NF-κB and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.Couleur et forme :Odour LiquidKL4-219A
KL4-219A is a selective covalent degrader of the MYC, inhibiting MYC transcriptional activity and degrading MYC in a proteasome-dependent manner .Formule :C20H22N2O3SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :370.47PROTAC LZK-IN-1
CAS :PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.
Formule :C51H64F2N10O5SCouleur et forme :SolidMasse moléculaire :967.18c-Myc ligand 1
CAS :c-Mycligand 1 is a c-Myc inhibitor and functions as a ligand for target proteins in PROTAC (Proteolysis Targeting Chimeras). It is utilized in the synthesis of PROTAC c-Myc inhibitor 7.Formule :C13H10N2O2Masse moléculaire :226.23sAJM589
CAS :sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.Formule :C16H10N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.26IRES-C11
CAS :IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.Formule :C13H11Cl2NO4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :316.14Ref: TM-T40419
1mg94,00€5mg222,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.674,00€200mg2.242,00€1mL*10mM (DMSO)245,00€(S)-10-Hydroxycamptothecin
CAS :(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formule :C20H16N2O5Degré de pureté :99.09% - 99.81%Couleur et forme :SolidMasse moléculaire :364.35Agrimol B
CAS :1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Formule :C37H46O12Degré de pureté :99.06% - ≥95%Couleur et forme :SolidMasse moléculaire :682.75Saxagliptin
CAS :Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.Formule :C18H25N3O2Degré de pureté :99.17% - 99.95%Couleur et forme :SolidMasse moléculaire :315.41Mycro 3
CAS :Mycro 3 is potent and selective for c-Myc in whole cell assays.Formule :C24H17ClF2N6O4Degré de pureté :99.51% - 99.61%Couleur et forme :SolidMasse moléculaire :526.88Ref: TM-T4367
1mg50,00€5mg94,00€10mg165,00€25mg318,00€50mg452,00€100mg627,00€200mg845,00€1mL*10mM (DMSO)110,00€10074-G5
CAS :10074-G5 is an inhibitor of c-Myc-Max dimerization.Formule :C18H12N4O3Degré de pureté :99.51% - 99.94%Couleur et forme :SolidMasse moléculaire :332.31Ref: TM-T3686
2mg39,00€5mg59,00€10mg84,00€25mg135,00€50mg213,00€100mg375,00€200mg535,00€500mg853,00€1mL*10mM (DMSO)65,00€
