PLK
Les inhibiteurs des kinases Polo-like (PLK) ciblent les PLK, une famille de kinases sérine/thréonine essentielles à différentes étapes de la division cellulaire, y compris l'entrée en mitose, l'assemblage du fuseau et la cytokinèse. Les PLK sont cruciales pour l'exécution correcte du cycle cellulaire, et leur dérégulation est souvent associée au cancer. Inhiber les PLK peut induire un arrêt du cycle cellulaire et l'apoptose dans les cellules cancéreuses, ce qui rend ces inhibiteurs importants dans la recherche et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de PLK de haute qualité pour soutenir vos recherches sur la mitose, le contrôle du cycle cellulaire et l'oncologie.
29 produits trouvés pour "PLK".
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PROTAC PLK1 Degrader-3
CAS :PROTACPLK1 Degrader-3 (Compound DD-1) is a PLK1 PROTAC degrader that operates via the N-deglycosylation pathway, with a dissociation constant (Kd) of 2.2 μM. Its cell permeability is limited, requiring higher concentrations to achieve a notable degradation effect. PROTACPLK1 Degrader-3 is applicable in research on non-small cell lung cancer.Formule :C102H196N57O23PMasse moléculaire :2620.04PLK1-IN-12
PLK1-IN-12 is a highly selective, orally active PLK1 inhibitor with an IC50 of 20 nM. It demonstrates greater selectivity for PLK1 over PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM). PLK1-IN-12 exhibits anticancer efficacy across a wide range of cell lines and is applicable to anti-leukemia research.Couleur et forme :Odour SolidRP-1664
CAS :RP-1664,PLK4 inhibitor (IC50=3 nM). Disrupts centriole biogenesis. Antitumor activity in breast cancer, neuroblastoma.Formule :C23H24F2N8O2SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :514.55PLK1-IN-14
PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor with an IC50 of 22.61 pM for PLK1, and an IC50 of 0.09 nM for inhibiting the proliferation of DU-145 prostate cancer cells. It is applicable in prostate cancer research.Couleur et forme :Odour SolidSP27
CAS :SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].Formule :C40H40F2N12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :806.82PLK1 Protein, Human, Recombinant (His)
PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Degré de pureté :96.8%Couleur et forme :Lyophilized PowderMasse moléculaire :70.5 kDa (predicted); 66 kDa (reducing conditions)PLK1 Protein, Mouse, Recombinant (His)
PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :70.6 kDa (predicted); 65 kDa (reducing conditions)Poloxime
CAS :Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.Formule :C10H13NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :179.22GSK461364
CAS :GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Formule :C27H28F3N5O2SDegré de pureté :99% - 99.93%Couleur et forme :SolidMasse moléculaire :543.604Poloxin
CAS :Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).Formule :C18H19NO3Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :297.3484SBE13
CAS :SBE13 is a highly selective PLK1 inhibitor (IC₅₀=200 pM), a type II inhibitor with anti-tumor activity.Formule :C24H27ClN2O4Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :442.9355-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS :5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Formule :C8H13N3SDegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :183.274HMN-214
CAS :HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Formule :C22H20N2O5SDegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :424.47TAK-960
CAS :TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.Formule :C27H34F3N7O3Degré de pureté :97.06%Couleur et forme :White SolidMasse moléculaire :561.5992Ro3280
CAS :Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Formule :C27H35F2N7O3Degré de pureté :97.76% - >99.99%Couleur et forme :SolidMasse moléculaire :543.6087MLN0905
CAS :MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).Formule :C24H25F3N6SDegré de pureté :98% - 99.92%Couleur et forme :Yellow SolidMasse moléculaire :486.556(1E)-CFI-400437 dihydrochloride
CAS :(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.Formule :C29H30Cl2N6O2Degré de pureté :97.08%Couleur et forme :Orange SolidMasse moléculaire :565.493HMN-176
CAS :HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).Formule :C20H18N2O4SDegré de pureté :98.92% - 98.99%Couleur et forme :SolidMasse moléculaire :382.433PLK1-IN-9
CAS :PLK1-IN-9 (Compound M2), a polo-like kinase 1 (PLK1) inhibitor, targets the PLK proteins modified with peptides 1010pT, cdc25c, and PBIP, exhibiting IC50 values of 1.6, 0.8, and 1.4 μM, respectively. This compound effectively inhibits the proliferation of various cancer cell lines including HeLa, HL60, SNU387/499, and HepG2, demonstrating cytotoxic effects and inducing apoptosis. Additionally, PLK1-IN-9 has been shown to suppress tumor growth in a HepG2 xenograft mouse model.Formule :C12H7F3N4O2Masse moléculaire :296.2048Centrinone-B
CAS :Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Formule :C27H27F2N7O5S2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :631.67
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