DYRK
Les inhibiteurs des kinases DYRK (kinase régulée par la phosphorylation de la tyrosine à double spécificité) sont des composés qui ciblent la famille des kinases DYRK, impliquées dans la régulation du cycle cellulaire, le développement neuronal et l'apoptose. Les kinases DYRK ont une double spécificité, ce qui signifie qu'elles peuvent phosphoryler à la fois des résidus de tyrosine et de sérine/thréonine. L'inhibition des kinases DYRK peut affecter divers processus cellulaires, notamment la progression du cycle cellulaire et la différenciation. Les inhibiteurs de DYRK sont des outils importants dans la recherche sur le cancer, les maladies neurodégénératives et la signalisation cellulaire. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs DYRK de haute qualité pour soutenir vos recherches sur le contrôle du cycle cellulaire, la neurobiologie et le développement thérapeutique.
48 produits trouvés pour "DYRK"
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BT173
CAS :<p>BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.</p>Formule :C18H12BrN3O2Degré de pureté :98.247%Couleur et forme :SolidMasse moléculaire :382.21AZ-Dyrk1B-33
CAS :<p>AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.</p>Formule :C19H16N4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :300.36GSK-626616
CAS :<p>GSK-626616: strong, oral DYRK3 inhibitor (IC50: 0.7 nM), affects DYRK family, may treat anemia.</p>Formule :C18H10Cl2N4OSDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :401.27Leucettine L41
CAS :<p>Leucettine L41 (LeucettineL41) is an inhibitor of DYRKs/CLKs, preferentially targeting DYRK1A, and inhibits DYRK2.</p>Formule :C17H13N3O3Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :307.3GNF2133
CAS :<p>GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.</p>Formule :C24H30N6O2Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :434.53CLK1-IN-3
CAS :<p>Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A.</p>Formule :C24H23FN6ODegré de pureté :98.46% - 99.76%Couleur et forme :SoildMasse moléculaire :430.48Protein kinase inhibitors 1 hydrochloride
CAS :<p>Protein Kinase Inhibitors 1 Hydrochloride effectively inhibits HIPK2, demonstrating high potency with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2,</p>Formule :C18H18ClN5O3SCouleur et forme :SolidMasse moléculaire :419.88Mirk-IN-1
CAS :<p>Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).</p>Formule :C23H17Cl2N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.32LDN-192960 hydrochloride
CAS :<p>LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.</p>Formule :C18H22Cl2N2O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.35Harmine
CAS :<p>Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.</p>Formule :C13H12N2ODegré de pureté :98.29% - 99.92%Couleur et forme :Off-White SolidMasse moléculaire :212.25Protein kinase inhibitors 1
CAS :<p>Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.</p>Formule :C18H17N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.42GNF4877
CAS :<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Formule :C25H27FN6O4Degré de pureté :98.68% - 99.40%Couleur et forme :SolidMasse moléculaire :494.52Harmine hydrochloride
CAS :<p>Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.</p>Formule :C13H13ClN2ODegré de pureté :99.61% - >99.99%Couleur et forme :Yellow To Slightly Green Crystalline PowderMasse moléculaire :248.71LDN-192960
CAS :<p>LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).</p>Formule :C18H20N2O2SDegré de pureté :98.01% - 99.51%Couleur et forme :SolidMasse moléculaire :328.43AZ191
CAS :<p>AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor.</p>Formule :C24H27N7ODegré de pureté :98.04% - 99.65%Couleur et forme :SolidMasse moléculaire :429.52ILK-IN-3
CAS :ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formule :C10H12N6ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :232.24GNF2133 hydrochloride
CAS :<p>GNF2133 hydrochloride: selective oral DYRK1A inhibitor (IC50: 0.0062 μM), boosts β-cell growth and insulin, potential for type 1 diabetes research.</p>Formule :C24H31ClN6O2Couleur et forme :SolidMasse moléculaire :471.02-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS :<p>2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.</p>Formule :C6H6N4ODegré de pureté :99.21% - 99.42%Couleur et forme :SolidMasse moléculaire :150.14ML167
CAS :<p>ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.</p>Formule :C19H17N3O3Degré de pureté :99.82% - >99.99%Couleur et forme :SolidMasse moléculaire :335.36ID-8
CAS :<p>ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.</p>Formule :C16H14N2O4Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :298.29FINDY
CAS :<p>FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.</p>Formule :C16H17NO2S2SiCouleur et forme :SolidMasse moléculaire :347.53Dyrk1A-IN-5
CAS :<p>Potent DYRK1A inhibitor with IC50s: 6 nM overall, 0.5 μM SF3B1, 2.1 μM tau phosphorylation. Useful for Down syndrome studies.</p>Formule :C16H9IN2O2Couleur et forme :SolidMasse moléculaire :388.16JH-XIV-68-3
CAS :<p>JH-XIV-68-3: Selective DYRK1A/B inhibitor; effective in HNSCC cell lines.</p>Formule :C21H17F3N8OCouleur et forme :SolidMasse moléculaire :454.41LDN-209929 dihydrochloride
CAS :<p>LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.</p>Formule :C17H19Cl3N2OSCouleur et forme :SolidMasse moléculaire :405.77Dyrk1A-IN-3
CAS :<p>Dyrk1A-IN-3 is a selective DYRK1A inhibitor with an IC50 of 76 nM, useful for neurodegenerative disease research.</p>Formule :C18H16N6Couleur et forme :SolidMasse moléculaire :316.36tBID
CAS :<p>tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM)</p>Formule :C11H3Br4N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.78AnnH31
CAS :<p>AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm the</p>Formule :C15H13N3ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :251.28DYRKi
CAS :<p>DYRKi is a nontoxic, DYRK1-selective inhibitor.</p>Formule :C20H13F3N4O2SCouleur et forme :SolidMasse moléculaire :430.4INDY
CAS :<p>INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.</p>Formule :C12H13NO2SDegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :235.3ProINDY
CAS :<p>ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.</p>Formule :C14H15NO3SDegré de pureté :97.19%Couleur et forme :SolidMasse moléculaire :277.34CLK-IN-T3
CAS :<p>CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.</p>Formule :C28H30N6O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :482.58YK-2-69
CAS :<p>YK-2-69 selectively blocks DYRK2 at Lys-231 and Lys-234, outperforming enzalutamide in prostate cancer treatment.</p>Formule :C25H27FN8OSDegré de pureté :98.61% - 99.64%Couleur et forme :SolidMasse moléculaire :506.6ML 315
CAS :<p>ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.</p>Formule :C18H13Cl2N3O2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :374.22DYRKs-IN-2
CAS :<p>DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.</p>Formule :C32H38ClN9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.16Dyrk1A-IN-8
CAS :<p>Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.</p>Formule :C17H21N3OCouleur et forme :SolidMasse moléculaire :283.37DYRKs-IN-1
CAS :<p>DYRKs-IN-1 has antitumor activity.</p>Formule :C30H30ClN7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :588.06DYRKs-IN-1 hydrochloride
CAS :<p>DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.</p>Formule :C30H31Cl2N7O4Couleur et forme :SolidMasse moléculaire :624.52Dyrk1A-IN-2
<p>Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.</p>Formule :C27H32N6O4Couleur et forme :SolidMasse moléculaire :504.58Norharmine
CAS :<p>Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.</p>Formule :C12H10N2OCouleur et forme :SolidMasse moléculaire :198.221Dyrk1A/α-synuclein-IN-1
<p>Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).</p>Formule :C20H21N5O3SCouleur et forme :SolidMasse moléculaire :411.48Dyrk1A-IN-4
CAS :<p>Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.</p>Formule :C14H13F3N6Couleur et forme :SolidMasse moléculaire :322.29Dyrk1A/α-synuclein-IN-2
<p>Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).</p>Formule :C21H16N4O4SCouleur et forme :SolidMasse moléculaire :420.44DYR530
CAS :<p>DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.</p>Formule :C23H24FN7Couleur et forme :SolidMasse moléculaire :417.48Dyrk1A-IN-11
CAS :<p>Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.</p>Formule :C23H23F5N8OCouleur et forme :SolidMasse moléculaire :522.47Dyrk1A-IN-1
<p>Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.</p>Formule :C23H20N4O3SCouleur et forme :SolidMasse moléculaire :432.49Dyrk1A/B-IN-1
<p>Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.</p>Formule :C21H17N3O2S2Couleur et forme :SolidMasse moléculaire :407.51Dyrk1A-IN-12
CAS :<p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>Formule :C22H16FN3O2SCouleur et forme :SolidMasse moléculaire :405.445DYRK1-IN-1
CAS :<p>DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.</p>Formule :C12H12N6Couleur et forme :SolidMasse moléculaire :240.26
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