ROCK
Les inhibiteurs de la protéine kinase associée à Rho (ROCK) ciblent les kinases ROCK, qui sont impliquées dans la régulation du cytosquelette, de la forme cellulaire et de la motilité. ROCK joue un rôle significatif dans le contrôle de la division cellulaire, notamment dans des processus tels que la cytokinèse. Inhiber ROCK peut entraîner des changements dans la dynamique du cycle cellulaire, la motilité cellulaire et l'apoptose, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer, la neurobiologie et les études cardiovasculaires. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de ROCK de haute qualité pour soutenir vos recherches en biologie cellulaire, dynamique du cytosquelette et mécanismes des maladies.
62 produits trouvés pour "ROCK".
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H-1152
CAS :H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).Formule :C16H21N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.42Y-33075
CAS :Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Formule :C16H16N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :280.32SB-772077B dihydrochloride
CAS :SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Formule :C15H20Cl2N8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.28CAY10746
CAS :CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Formule :C26H23N3O5Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :457.48Ref: TM-T36196
2mg34,00€5mg54,00€1mL*10mM (DMSO)54,00€10mg86,00€25mg172,00€50mg260,00€100mg411,00€200mg552,00€CID-5056270
CAS :CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphomaFormule :C17H13N3O3SDegré de pureté :99.6%Couleur et forme :White SolidMasse moléculaire :339.37Ref: TM-T23888
1mg110,00€5mg250,00€1mL*10mM (DMSO)253,00€10mg349,00€25mg515,00€50mg702,00€100mg928,00€200mg2.097,00€Rhodblock 6
CAS :Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Formule :C12H13N3ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :215.25Rho-Kinase-IN-1
CAS :Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Formule :C20H24N4SDegré de pureté :99.8%Couleur et forme :Yellow SolidMasse moléculaire :352.5Ref: TM-T12721
1mg71,00€1mL*10mM (DMSO)105,00€5mg138,00€10mg205,00€25mg358,00€50mg502,00€100mg665,00€200mg893,00€AS 1892802
CAS :AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.Formule :C20H19N3O2Degré de pureté :99.86%Couleur et forme :Yellow SolidMasse moléculaire :333.38Ref: TM-T22037
1mg49,00€5mg92,00€1mL*10mM (DMSO)109,00€10mg166,00€25mg358,00€50mg530,00€100mg758,00€200mg1.044,00€LX7101
CAS :LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Formule :C23H29N7O3Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :451.52ROCK2-IN-2
CAS :ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formule :C18H12N6OSDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :360.39Ref: TM-T12747
1mg50,00€5mg111,00€1mL*10mM (DMSO)136,00€10mg177,00€25mg304,00€50mg447,00€100mg692,00€200mg888,00€ROCK2-IN-6 hydrochloride
CAS :ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Formule :C26H22ClF2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.95Chroman 1
CAS :Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Formule :C24H28N4O4Degré de pureté :99.67% - 99.84%Couleur et forme :SolidMasse moléculaire :436.5Ref: TM-T14960
1mg73,00€5mg160,00€1mL*10mM (DMSO)173,00€10mg250,00€25mg430,00€50mg645,00€100mg888,00€ROCK-IN-7
CAS :ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formule :C17H17N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.4ROCK-IN-9
CAS :ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Formule :C20H20FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.4ROCK-IN-8
CAS :ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,Formule :C30H25FN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.61H-1152 dihydrochloride
CAS :H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Formule :C16H23Cl2N3O2SDegré de pureté :99.85%Couleur et forme :White SolidMasse moléculaire :392.34Ref: TM-T35328
1mg60,00€5mg135,00€1mL*10mM (DMSO)147,00€10mg215,00€25mg415,00€50mg655,00€100mg888,00€ROCK-IN-1
CAS :ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurologicalFormule :C20H18FN3ODegré de pureté :99.80%Couleur et forme :Yellow SolidMasse moléculaire :335.37ROCK-IN-11
CAS :ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.Formule :C22H20N4O4SCouleur et forme :SolidMasse moléculaire :436.484ROCK2-IN-12
CAS :ROCK2-IN-12 (Compound A25) is a selective inhibitor of ROCK2, exhibiting an IC50 of 7.0 nM for ROCK2, demonstrating greater efficacy compared to ROCK1 inhibition. It exerts potent anti-fibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. In a Bleomycin-induced mouse pulmonary fibrosis (PF) model, ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrosis progression. This compound is applicable in research on pulmonary diseases such as lung fibrosis.Formule :C23H18FN9OMasse moléculaire :455.46Rhodblock 1a
CAS :Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.Formule :C20H16N2O2Couleur et forme :SolidMasse moléculaire :316.353
