HSP
Les inhibiteurs des protéines de choc thermique (HSP) ciblent les HSP, une famille de chaperons moléculaires qui aident au repliement des protéines, à leur stabilité et à leur protection contre les dommages induits par le stress. Les HSP sont souvent surexprimées dans les cellules cancéreuses, les aidant à survivre dans des conditions stressantes telles que l'hypoxie et la chimiothérapie. Inhiber les HSP peut perturber ces mécanismes de protection, entraînant la mort cellulaire. Les inhibiteurs des HSP sont donc précieux dans la thérapie contre le cancer et la recherche sur les réponses au stress. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de HSP de haute qualité pour soutenir vos recherches sur l'homéostasie des protéines, les réponses au stress et l'oncologie.
201 produits trouvés pour "HSP".
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GRP78-IN-3
CAS :GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Formule :C17H18N4O2SDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :342.415Ethoxyquin
CAS :Produit contrôléEthoxyquin (Santoflex) is an antioxidant used in animal feeds.Formule :C14H19NODegré de pureté :97.15% - 98.73%Couleur et forme :Yellow LiquidMasse moléculaire :217.3068IPI-493
CAS :IPI-493 is a bioactive chemical.Formule :C28H39N3O8Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :545.62Novobiocin Sodium
CAS :Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Formule :C31H35N2NaO11Degré de pureté :98.46% - 99.51%Couleur et forme :SolidMasse moléculaire :634.61CC-99677
CAS :CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Formule :C22H20ClN5O3SDegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :469.944Arimoclomol maleate
CAS :Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Formule :C18H24ClN3O7Degré de pureté :99.44% - 99.98%Couleur et forme :SolidMasse moléculaire :429.852Col003
CAS :Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Formule :C14H11NO4Degré de pureté :99.03% - 99.96%Couleur et forme :SolidMasse moléculaire :257.2414Ref: TM-T10860
2mg44,00€5mg65,00€1mL*10mM (DMSO)65,00€10mg102,00€25mg205,00€50mg332,00€100mg513,00€200mg737,00€500mg1.107,00€Palmitic acid-13C2
CAS :13C-labeled Palmitic acid is a saturated fatty acid in animals/plants influencing GRP78 and CHOP in mouse cells.Formule :C16H32O2Masse moléculaire :258.415Palmitic acid-D4
CAS :Palmitic acid-D4 is the deuterated form of Palmitic acid. This compound is a long-chain saturated fatty acid commonly found in animals and plants. Palmitic acid (T2908) is known to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in murine granulosa cells.Formule :C16H32O2Masse moléculaire :260.45trans-Dehydrocurvularin
CAS :trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Formule :C16H18O5Couleur et forme :SolidMasse moléculaire :290.315Grp94-IN-3
Grp94-IN-3 (Compound 47) is a selective Grp94 ATP-competitive inhibitor with a dissociation constant (Kd) of 76 nM. It exhibits significantly lower affinity for Hsp90α, with a Kd of 9.17 μM. Grp94-IN-3 induces degradation of Integrin α2 (Integrinα2) in MDA-MB-231 cells and reduces intracellular accumulation of mutant myocilin in human trabecular meshwork cells. This compound is useful in research on metastatic cancers and open-angle glaucoma.Grp94 Inhibitor-2
Grp94 Inhibitor-2 (compound 23) is a cyclopropane analog that exhibits high affinity for Glucose Regulated Protein 94 (Grp94), with dissociation constants (Kd) of 0.48 µM for Grp94 and 0.65 µM for Hsp90α.Formule :C26H25ClFNO4Masse moléculaire :469.94NMS-E973
CAS :NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Formule :C22H22N4O7Degré de pureté :99.84%Couleur et forme :Yellow SolidMasse moléculaire :454.4327Ref: TM-T6609
2mg39,00€5mg60,00€1mL*10mM (DMSO)65,00€10mg101,00€25mg187,00€50mg294,00€100mg419,00€200mg589,00€TBPH
TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.Palmitic acid-13C sodium
CAS :13C-labeled Palmitic acid, a common long-chain fatty acid in flora/fauna, induces GRP78/CHOP in mouse cells.Formule :CC15H31NaO2Masse moléculaire :279.4HEMTAC WEE1 degrader-1
CAS :HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Formule :C57H71N15O6Couleur et forme :SolidMasse moléculaire :1062.27Shepherdin (79-87)
CAS :Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Formule :C41H64N12O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :949.09[Au(TPP)]Cl
CAS :[Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and exhibits anticancer properties.'Formule :C44H28AuClN4Masse moléculaire :845.14Hsp90β-IN-2
Hsp90β-IN-2 (Compound 16B) is a selective inhibitor of Hsp90β, with dissociation constants (KD) of 225 nM for Hsp90β and 73.32 μM for Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231, A549, and SKOV-3 cells, and is applicable in research on triple-negative breast cancer.JD-13
CAS :JD-13 is a selective GPR119 agonist; promotes insulin and GLP-1 release; glucose homeostasis; diabetes research tool.Formule :C25H32N4O3Degré de pureté :99.32% - 99.69%Couleur et forme :White SolidMasse moléculaire :436.56
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