HSP
Les inhibiteurs des protéines de choc thermique (HSP) ciblent les HSP, une famille de chaperons moléculaires qui aident au repliement des protéines, à leur stabilité et à leur protection contre les dommages induits par le stress. Les HSP sont souvent surexprimées dans les cellules cancéreuses, les aidant à survivre dans des conditions stressantes telles que l'hypoxie et la chimiothérapie. Inhiber les HSP peut perturber ces mécanismes de protection, entraînant la mort cellulaire. Les inhibiteurs des HSP sont donc précieux dans la thérapie contre le cancer et la recherche sur les réponses au stress. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de HSP de haute qualité pour soutenir vos recherches sur l'homéostasie des protéines, les réponses au stress et l'oncologie.
197 produits trouvés pour "HSP".
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GRP78-IN-3
CAS :GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Formule :C17H18N4O2SDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :342.415IPI-493
CAS :IPI-493 is a bioactive chemical.Formule :C28H39N3O8Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :545.62CC-99677
CAS :CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Formule :C22H20ClN5O3SDegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :469.944Col003
CAS :Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Formule :C14H11NO4Degré de pureté :99.03% - 99.96%Couleur et forme :SolidMasse moléculaire :257.2414Novobiocin Sodium
CAS :Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Formule :C31H35N2NaO11Degré de pureté :99% - 99.51%Couleur et forme :SolidMasse moléculaire :634.6062Ethoxyquin
CAS :Produit contrôléEthoxyquin (Santoflex) is an antioxidant used in animal feeds.Formule :C14H19NODegré de pureté :97.15% - 98.73%Couleur et forme :Yellow LiquidMasse moléculaire :217.3068Arimoclomol maleate
CAS :Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Formule :C18H24ClN3O7Degré de pureté :99.44% - 99.98%Couleur et forme :SolidMasse moléculaire :429.852Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Formule :C34H49F3N4O10Couleur et forme :SolidMasse moléculaire :730.34008Hsp90β-IN-2
Hsp90β-IN-2 (Compound 16B) is a selective inhibitor of Hsp90β, with dissociation constants (KD) of 225 nM for Hsp90β and 73.32 μM for Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231, A549, and SKOV-3 cells, and is applicable in research on triple-negative breast cancer.Cemdomespib
CAS :Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.Formule :C24H30FNO6Couleur et forme :SolidMasse moléculaire :447.5TBPH
TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.3-Phenyltoxoflavin
CAS :3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Formule :C13H11N5O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :269.2587NMS-E973
CAS :NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Formule :C22H22N4O7Degré de pureté :99.84%Couleur et forme :Yellow SolidMasse moléculaire :454.4327[Au(TPP)]Cl
CAS :[Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and exhibits anticancer properties.'Formule :C44H28AuClN4Masse moléculaire :845.14JG-258
CAS :JG-258 is an inactive negative control for Hsp70 inhibitors [1] .Formule :C20H22ClN3OS3Couleur et forme :SolidMasse moléculaire :452.06trans-Dehydrocurvularin
CAS :trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Formule :C16H18O5Couleur et forme :SolidMasse moléculaire :290.315Grp94 Inhibitor-2
Grp94 Inhibitor-2 (compound 23) is a cyclopropane analog that exhibits high affinity for Glucose Regulated Protein 94 (Grp94), with dissociation constants (Kd) of 0.48 µM for Grp94 and 0.65 µM for Hsp90α.Formule :C26H25ClFNO4Masse moléculaire :469.946BrCaQ-C10-TPP
6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.Formule :C45H47Br2N2O3PCouleur et forme :SolidMasse moléculaire :854.65HEMTAC WEE1 degrader-1
CAS :HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Formule :C57H71N15O6Couleur et forme :SolidMasse moléculaire :1062.27Grp94-IN-3
Grp94-IN-3 (Compound 47) is a selective Grp94 ATP-competitive inhibitor with a dissociation constant (Kd) of 76 nM. It exhibits significantly lower affinity for Hsp90α, with a Kd of 9.17 μM. Grp94-IN-3 induces degradation of Integrin α2 (Integrinα2) in MDA-MB-231 cells and reduces intracellular accumulation of mutant myocilin in human trabecular meshwork cells. This compound is useful in research on metastatic cancers and open-angle glaucoma.
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