HSP
Les inhibiteurs des protéines de choc thermique (HSP) ciblent les HSP, une famille de chaperons moléculaires qui aident au repliement des protéines, à leur stabilité et à leur protection contre les dommages induits par le stress. Les HSP sont souvent surexprimées dans les cellules cancéreuses, les aidant à survivre dans des conditions stressantes telles que l'hypoxie et la chimiothérapie. Inhiber les HSP peut perturber ces mécanismes de protection, entraînant la mort cellulaire. Les inhibiteurs des HSP sont donc précieux dans la thérapie contre le cancer et la recherche sur les réponses au stress. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de HSP de haute qualité pour soutenir vos recherches sur l'homéostasie des protéines, les réponses au stress et l'oncologie.
169 produits trouvés pour "HSP"
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KW-2478
CAS :<p>KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.</p>Formule :C30H42N2O9Degré de pureté :98.68% - 99.52%Couleur et forme :SolidMasse moléculaire :574.66Alvespimycin
CAS :<p>Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.</p>Formule :C32H48N4O8Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :616.75Calenduloside E
CAS :<p>Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by</p>Formule :C36H56O9Degré de pureté :96.16% - 98.99%Couleur et forme :SolidMasse moléculaire :632.8217-AEP-GA
CAS :<p>17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.</p>Formule :C34H50N4O8Degré de pureté :97.77% - 99.56%Couleur et forme :SolidMasse moléculaire :642.78Retaspimycin Hydrochloride
CAS :<p>Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).</p>Formule :C31H46ClN3O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :624.17Bimoclomol
CAS :<p>Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.</p>Formule :C14H20ClN3O2Couleur et forme :SolidMasse moléculaire :297.78CH5138303
CAS :<p>CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.</p>Formule :C19H18ClN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.9AMP-PCP
CAS :<p>AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.</p>Formule :C11H18N5O12P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.21JG-48
CAS :<p>JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells.</p>Formule :C20H16F3N3OS2Couleur et forme :SolidMasse moléculaire :435.49Hsp90-IN-15
CAS :<p>Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.</p>Formule :C23H27F3N4Couleur et forme :SolidMasse moléculaire :416.48CCT251236
CAS :<p>CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.</p>Formule :C32H32N4O5Degré de pureté :98.82% - 99.89%Couleur et forme :SolidMasse moléculaire :552.62HSP90-IN-12
CAS :<p>VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.</p>Formule :C25H36O4Couleur et forme :SolidMasse moléculaire :400.55YM-01 Tosylate
CAS :<p>YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.</p>Formule :C27H27N3O4S3Couleur et forme :SolidMasse moléculaire :553.72Displurigen
CAS :<p>Displurigen is an inhibitor of ATPase activity of HSP70.</p>Formule :C15H10O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :286.3Malonganenone A
CAS :<p>Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.</p>Formule :C26H38N4O2Couleur et forme :SolidMasse moléculaire :438.616BrCaQ
CAS :<p>6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.</p>Formule :C18H15BrN2O3Couleur et forme :SolidMasse moléculaire :387.23HSP90-IN-22
CAS :<p>HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in</p>Formule :C25H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.53PU3
CAS :<p>PU3 is an inhibitor of Hsp90.</p>Formule :C19H25N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.43SEW84
CAS :<p>SEW84, an Aha1-stimulated Hsp90 inhibitor, has an IC50 of 0.3 μM, aiding protein deposition disease research.</p>Formule :C19H14F4N4OSCouleur et forme :SolidMasse moléculaire :422.4HSP90-IN-14
CAS :<p>HSP90-IN-14 inhibits Hsp90 (Kd=0.26 μM) and fights influenza A/H3N2, A/H1N1, B with EC50 of 2.6, 3.9, 17 μM in MDCK cells.</p>Formule :C14H8Cl2N4O4SCouleur et forme :SolidMasse moléculaire :399.21CH5164840
CAS :<p>CH5164840: strong HSP90 blocker; excels in NSCLC treatment; boosts erlotinib efficacy on EGFR-mutant tumors.</p>Formule :C19H23N5O2SCouleur et forme :SolidMasse moléculaire :385.48Hsp90-Cdc37-IN-1
CAS :<p>Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.</p>Formule :C43H57FN2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :748.99Vibsanin A
CAS :<p>Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.</p>Formule :C25H38O4Couleur et forme :SolidMasse moléculaire :402.57YM-1
CAS :<p>YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.</p>Formule :C20H20ClN3OS2Couleur et forme :SolidMasse moléculaire :417.98BIIB028
CAS :<p>BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.</p>Formule :C19H21ClN5O5PCouleur et forme :SolidMasse moléculaire :465.83Retaspimycin
CAS :<p>Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).</p>Formule :C31H45N3O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.7KUNB31
CAS :<p>KUNB31 is a potent and selective inhibitor of Hsp90β.</p>Formule :C19H18N2O3Couleur et forme :SolidMasse moléculaire :322.36HSP90-IN-20
CAS :<p>HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.</p>Formule :C26H32N4O4Couleur et forme :SolidMasse moléculaire :464.56Hsp90-IN-17
CAS :<p>Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.</p>Formule :C21H20N4O7Couleur et forme :SolidMasse moléculaire :440.41Heat Shock Protein Inhibitor II
CAS :<p>Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.</p>Formule :C12H11NO3Couleur et forme :SolidMasse moléculaire :217.22SW02
CAS :<p>SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).</p>Formule :C19H23BrN2O5Couleur et forme :SolidMasse moléculaire :439.3PU24FCl
CAS :<p>PU24FCl is a specific inhibitor of tumor Hsp90.</p>Formule :C20H21ClFN5O3Couleur et forme :SolidMasse moléculaire :433.86BMS-358233
CAS :<p>BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.</p>Formule :C25H25ClN6O2SCouleur et forme :SolidMasse moléculaire :509.02EC 144
CAS :<p>EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.</p>Formule :C21H24ClN5O2Couleur et forme :SolidMasse moléculaire :413.9MPC-3100
CAS :<p>MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].</p>Formule :C22H25BrN6O4SCouleur et forme :SolidMasse moléculaire :549.44Iroxanadine
CAS :<p>Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in</p>Formule :C14H20N4ODegré de pureté :98.04% - 99.04%Couleur et forme :SolidMasse moléculaire :260.33AMP-PCP disodium
CAS :<p>AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.</p>Formule :C11H16N5Na2O12P3Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :549.17SNX0723
CAS :<p>SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.</p>Formule :C22H26FN3O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :399.46Arimoclomol
CAS :<p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>Formule :C14H20ClN3O3Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :313.78JG-231
CAS :<p>JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.</p>Formule :C22H18BrCl2N3OS4Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :619.47KU-177
CAS :<p>KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.</p>Formule :C27H23NO8Degré de pureté :96.92% - 98.54%Couleur et forme :SolidMasse moléculaire :489.47HSP90-IN-29
CAS :<p>HSP90-IN-29 (Compound 13), a benzoxazole derivative, serves as a potent and selective HSP-90 inhibitor, exhibiting a low IC50 value of 30 nM. This compound demonstrates significant antitumor activity [1].</p>Formule :C19H20ClN3O4Couleur et forme :SolidMasse moléculaire :389.83GRP78-IN-2
CAS :<p>GRP78-IN-2 inhibits surface GRP78, showing anti-angiogenic and anti-cancer properties, sparing normal cells.</p>Formule :C29H29NO6Couleur et forme :SolidMasse moléculaire :487.54HSP90-IN-27
CAS :<p>HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].</p>Formule :C18H21N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.44Flavokawain 1i
CAS :<p>Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties.</p>Formule :C21H18O4Couleur et forme :SolidMasse moléculaire :334.37MAO A/HSP90-IN-2
CAS :<p>MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.</p>Formule :C25H31ClN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.98HSP70/SIRT2-IN-2
CAS :<p>HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].</p>Formule :C17H13N3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.5Colletofragarone A2
CAS :<p>Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.</p>Formule :C22H26O6Couleur et forme :SolidMasse moléculaire :386.44YM-08
CAS :<p>YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].</p>Formule :C19H17N3OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.49HSP90-IN-19
CAS :<p>HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.</p>Formule :C29H38O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.61
