Wee1
Les inhibiteurs de Wee1 ciblent la kinase Wee1, un régulateur clé du point de contrôle G2/M dans le cycle cellulaire. Wee1 contrôle le moment de la mitose en inhibant les kinases dépendantes des cyclines (CDK) pour empêcher une entrée prématurée en mitose. L'inhibition de Wee1 peut entraîner l'abolition du point de contrôle G2/M, forçant les cellules avec de l'ADN endommagé à entrer prématurément en mitose, ce qui entraîne souvent la mort cellulaire. Cela rend les inhibiteurs de Wee1 particulièrement utiles en thérapie contre le cancer, notamment en combinaison avec des agents endommageant l'ADN. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de Wee1 de haute qualité pour soutenir vos recherches sur le contrôle du cycle cellulaire, la réponse aux dommages de l'ADN et le traitement du cancer.
15 produits trouvés pour "Wee1"
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PKMYT1-IN-4
PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.Formule :C19H15F3N4O2Couleur et forme :SolidMasse moléculaire :388.34PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Formule :C24H26FN5O2Couleur et forme :SolidMasse moléculaire :435.49ZN-c3
CAS :<p>Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties. Cost-effective and quality-assured.</p>Formule :C29H34N8O2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :526.63WEE1-IN-6
CAS :<p>WEE1-IN-6 (compound 110) is an orally active inhibitor of WEE1, displaying a DC50 value of ≤ 100 nM. This compound effectively inhibits cell proliferation [1].</p>Formule :C45H52FN11O4Couleur et forme :SolidMasse moléculaire :829.96PD 407824
CAS :<p>PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).</p>Formule :C20H12N2O3Degré de pureté :98.02%Couleur et forme :SolidMasse moléculaire :328.32WEE1-IN-3
CAS :<p>WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.</p>Formule :C28H31N7O2Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :497.59Adavosertib
CAS :<p>Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.</p>Formule :C27H32N8O2Degré de pureté :98.65% - 99.86%Couleur et forme :SolidMasse moléculaire :500.6PD0166285
CAS :<p>PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.</p>Formule :C26H27Cl2N5O2Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :512.43RP-6306
CAS :<p>Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.</p>Formule :C18H20N4O2Degré de pureté :98.41% - 99.28%Couleur et forme :SolidMasse moléculaire :324.38PKMYT1-IN-9
CAS :<p>PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.</p>Formule :C17H14FN5OCouleur et forme :SolidMasse moléculaire :323.324WEE1 degrader 1
<p>WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.</p>Formule :C30H31N5O3Couleur et forme :SolidMasse moléculaire :509.6WEE1-IN-11
CAS :WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Formule :C26H29FN8OS2Couleur et forme :SolidMasse moléculaire :552.69WEE1/PKMYT1-IN-1
CAS :<p>WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.</p>Formule :C16H16N4O3Couleur et forme :SolidMasse moléculaire :312.323WEE1-IN-10
CAS :<p>WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.</p>Formule :C28H30Cl2N8ODegré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :565.5PKMYT1-IN-2
CAS :<p>PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].</p>Formule :C22H19N5O2Couleur et forme :SolidMasse moléculaire :385.42
