Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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SW155246
CAS :SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).Formule :C16H11ClN2O5SDegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :378.79SIRT5 inhibitor 5
CAS :SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.Formule :C21H14ClN3O3SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :423.87KP-302
CAS :KP-302 is a selective PAD inhibitor, reversing physical disability in multiple sclerosis (MS) mice and clearing T-cell infiltration in the brain.Formule :C20H23N5O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :365.43Ref: TM-T88080
1mg57,00€5mg120,00€10mg192,00€25mg394,00€50mg640,00€100mg1.018,00€200mg1.378,00€1mL*10mM (DMSO)133,00€Valemetostat tosylate
CAS :Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.Formule :C33H42ClN3O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :660.22GSK360A
CAS :GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.Formule :C17H17FN2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.33ZYJ-34c
CAS :ZYJ-34c is a potent oral antitumor activities histone deacetylase inhibitor (HDACi).Formule :C31H42N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :582.69LSD1-IN-5
CAS :LSD1-IN-5, a reversible LSD1 inhibitor, boosts H3K4me2 without affecting LSD1 expression; IC50: 121 nM.Formule :C15H13BrN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.18CM-579
CAS :CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.Formule :C29H40N4O3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :492.65Ref: TM-T10840L
1mg52,00€5mg90,00€10mg131,00€25mg207,00€50mg303,00€100mg447,00€1mL*10mM (DMSO)117,00€SIRT1-IN-3
CAS :SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1].Formule :C13H15BrN2OCouleur et forme :SolidMasse moléculaire :295.17Tripolin A
CAS :Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)Formule :C15H11NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :253.25LP99
CAS :LP99 is an epigenetic probe.Formule :C26H30ClN3O4SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :516.05Ref: TM-T15784
1mg43,00€5mg96,00€10mg145,00€25mg305,00€50mg442,00€100mgÀ demander1mL*10mM (DMSO)97,00€PRMT4-IN-1
CAS :PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].Formule :C23H28FN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.49BET bromodomain inhibitor 3
CAS :BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT.Formule :C18H17N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :339.35Angiogenesis agent 1
CAS :Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.Formule :C20H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.4Eleven-Nineteen-Leukemia Protein IN-1
CAS :ENL-IN-1: Potent ENL YEATS domain inhibitor with 14.5 nM IC50, enhances thermal stability in vitro.Formule :C27H33N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.6JAK-IN-30
CAS :JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50Formule :C19H26N8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.53JAK-IN-28
CAS :JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Formule :C20H18ClN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.86TM6089
CAS :TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.Formule :C13H14N4O3SDegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :306.34Ref: TM-T17105
1mg50,00€5mg109,00€10mg164,00€25mg285,00€50mg427,00€100mg623,00€200mg837,00€1mL*10mM (DMSO)116,00€EPZ032597
CAS :EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancerFormule :C20H23N7ODegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :377.44(2R/S)-6-PNG
CAS :(2R/S)-6-PNG (6-Prenylnaringenin) from hops is a natural histone deacetylase inhibitor that blocks T-type calcium channels reducing neurogenicity in mice.Formule :C20H20O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.37DC_C66
CAS :DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.Formule :C28H22NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.48AZD-1897
CAS :AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Formule :C18H23N3O3SDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :361.46M-110
CAS :M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Formule :C22H28ClN5O3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :445.94DDP-38003 dihydrochloride
CAS :DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).Formule :C21H28Cl2N4ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :423.38KDM5B-IN-3
CAS :KDM5B-IN-3 inhibits KDM5B/JARID1B with IC50 of 9.32 μM, useful in gastric cancer studies.Formule :C19H25ClN4O2Couleur et forme :SolidMasse moléculaire :376.88Guadecitabine sodium
CAS :Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .Formule :C18H24N9NaO10PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.407PBRM1-BD2-IN-1
CAS :PBRM1-BD2-IN-1: Selective PBRM1 inhibitor with Kd 0.7μM, IC50 0.2μM, useful in cancer research.Formule :C17H19ClN2OCouleur et forme :SolidMasse moléculaire :302.8PIM1-IN-7
CAS :PIM1-IN-7 inhibits PIM-1 (IC50: 0.67μM), toxic to HCT-116/MCF-7 cells (IC50: 42.9/7.68μM).Formule :C23H23N5OCouleur et forme :SolidMasse moléculaire :385.46MC-1353
CAS :MC-1353 is a potent, selective inhibitor of HDAC class I.Formule :C16H16N2O3Couleur et forme :SolidMasse moléculaire :284.31BRD4-BD1/2-IN-1
CAS :BRD4-BD1/2-IN-1 efficiently blocks BRD4 BD-1/2 under 100 nM IC50 (US20150148375A1, cmpd 5).Formule :C21H14F2N4O2Couleur et forme :SolidMasse moléculaire :392.36DC-BPi-11
CAS :DC-BPi-11 inhibits BPTF at IC50 698 nM and significantly reduces leukemia cell growth.Formule :C20H23N5O2SCouleur et forme :SolidMasse moléculaire :397.49EZH2-IN-11
CAS :EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.Formule :C28H36ClN3O5SCouleur et forme :SolidMasse moléculaire :562.12EZH2-IN-9
CAS :EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.Formule :C28H32ClF2N3O5SCouleur et forme :SolidMasse moléculaire :596.09NN-390
CAS :NN-390: selective HDAC6 inhibitor, IC50 9.8 μM, blood-brain barrier penetrant, potential for metastatic group 3 neural tube cancer research.Formule :C17H16F4N2O4SCouleur et forme :SolidMasse moléculaire :420.38AA-CW236
CAS :AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).Formule :C17H16ClF3N4O2Couleur et forme :SolidMasse moléculaire :400.78Antiproliferative agent-17
CAS :Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].Formule :C26H28N2OSCouleur et forme :SolidMasse moléculaire :416.58103D5R
CAS :103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.4AMPK activator 9
CAS :AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.Formule :C31H28F4N4O4Couleur et forme :SolidMasse moléculaire :596.57TYK2-IN-11
CAS :TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.Formule :C18H17N5O3SCouleur et forme :SolidMasse moléculaire :383.42AChE/HDAC-IN-1
CAS :COX-2-IN-23 (A10) inhibits AChE & HDAC (IC50s: 0.12 & 0.23 nM), has antioxidant/metal-binding traits, and is used in Alzheimer's research.Formule :C26H27ClN4O3Couleur et forme :SolidMasse moléculaire :478.97DNMT3A-IN-1
CAS :DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).Formule :C30H38N6O4Couleur et forme :SolidMasse moléculaire :546.66CAY10685
CAS :CAY10685, a CPTH2 analog with an alkyne for click reactions, inhibits NAT10 to study cancer-related chromatin changes.Formule :C17H16ClN3SDegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :329.85VE-465
CAS :VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.Formule :C22H28N8OSCouleur et forme :SolidMasse moléculaire :452.58BRD4 Inhibitor-25
BRD4 Inhibitor-25 blocks BRD4 (BD1: IC50 0.82 μM, BD2: 1.94 μM), induces cell death in ovarian cancer, used in cancer research.Formule :C29H27N5O6SCouleur et forme :SolidMasse moléculaire :573.62PRMT5-IN-17
CAS :PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.Formule :C26H33N7O2Couleur et forme :SolidMasse moléculaire :475.59J1038
CAS :J1038 is a novel Histone Deacetylase 8 (HDAC8) Inhibitor .Formule :C10H10N2O3SCouleur et forme :SolidMasse moléculaire :238.26HDAC8/BRPF1-IN-1
CAS :Compound 23a, dual HDAC8/BRPF1 inhibitor: IC50 HDAC8 = 443 nM, Kd BRPF1 = 67 nM; weak against HDAC1/6.Formule :C19H19N3O6SCouleur et forme :SolidMasse moléculaire :417.44IACS-9571 hydrochloride
CAS :IACS-9571 hydrochloride: potent TRIM24/BRPF1 inhibitor; IC50 = 8 nM (TRIM24); Kd = 31 nM (TRIM24), 14 nM (BRPF1).Formule :C32H43ClN4O8SCouleur et forme :SolidMasse moléculaire :679.22HDAC6-IN-14
HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1,Formule :C24H30FN3O4Couleur et forme :SolidMasse moléculaire :443.51SC-9
CAS :SC-9 is a protein kinase C activator.Formule :C22H24ClNO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.95BI-831266
CAS :BI-831266 is a potent and selective Aurora kinase B inhibitor.Formule :C27H38ClN7O2Couleur et forme :SolidMasse moléculaire :528.09HDAC-IN-41
CAS :HDAC-IN-41 is a selective class I HDAC inhibiting HDAC1, 2, & 3 with IC50: 0.62-1.46 µM; oral use; has NO-release.Formule :C20H22N4O6SCouleur et forme :SolidMasse moléculaire :446.48PARP11 inhibitor ITK7
CAS :ITK7 is a potent, selective PARP11 inhibitor with an IC50 of 14 nM, useful for cellular localization research.Formule :C17H14N4OSCouleur et forme :SolidMasse moléculaire :322.38HDAC1/MAO-B-IN-1
CAS :HDAC1/MAO-B-IN-1 is a selective Alzheimer’s research inhibitor with IC50s: HDAC1 (21.4 nM) & MAO-B (99 nM); crosses the blood-brain barrier.Formule :C18H17ClN2O2Couleur et forme :SolidMasse moléculaire :328.79Aurora kinase inhibitor-9
CAS :Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.Formule :C19H17Cl2N3O4SCouleur et forme :SolidMasse moléculaire :454.33BET-IN-7
CAS :BET-IN-7 is a potent BET inhibitor with a Ki of 12.27 μM and Kd of 89.3 μM, useful in sepsis research.Formule :C18H12ClN3OSCouleur et forme :SolidMasse moléculaire :353.83KDM2B-IN-4
CAS :KDM2B-IN-4, from patent WO2016112284A1 as 182b, is a potent KDM2B inhibitor used in cancer research.Formule :C24H28N2O2Couleur et forme :SolidMasse moléculaire :376.49Dihydro-5-azacytidine acetate
CAS :Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Formule :C10H18N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.27BETi-211
CAS :BETi-211 is a selective inhibitor BET bromodomain.Formule :C26H29N7O3Couleur et forme :SolidMasse moléculaire :487.55OUL245
CAS :OUL245: A selective PARP2 inhibitor (IC50=44nM), also inhibits other PARPs/TNKS (IC50=2.9-8.8μM).Formule :C8H5N3OSCouleur et forme :SolidMasse moléculaire :191.21HDAC6-IN-15
HDAC6-IN-15: selective HDAC6 inhibitor, IC50 of 38.2 nM, for cancer and neurodegenerative research.Formule :C25H28FFeN3O2Couleur et forme :SolidMasse moléculaire :477.35CYP51/HDAC-IN-1
CAS :Orally active CYP51/HDAC-IN-1 dual inhibitor targets virulence factors and resistance genes; effective against Candidiasis and Cryptococcal meningitis.Formule :C30H40F2N6O4Couleur et forme :SolidMasse moléculaire :586.67CBB1003
CAS :CBB1003 is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM).Formule :C25H31N9O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.57IND 1316
CAS :IND 1316 is an activator of AMP-activated protein kinase (AMPK).Formule :C22H17NO3Couleur et forme :SolidMasse moléculaire :343.38PKN1/2-IN-1
CAS :PKN1/2-IN-1 is a potent and selective PKN2 inhibitor, membrane permeability and anticancer.Protein kinase N proteins (PKN) are effectors of Rho GTPases.Formule :C14H15N3ODegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :241.29Ref: TM-T60339
2mg137,00€5mg222,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.674,00€1mL*10mM (DMSO)245,00€SMTIN-T140
CAS :SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Formule :C36H34BrClFN5OPDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :718.02HDAC-IN-28
CAS :HDAC-IN-28 is a novel inhibitor of HDAC that significantly inhibits tumour growth and metastasis.Formule :C23H26N4O4SCouleur et forme :SolidMasse moléculaire :454.54Y08175
CAS :Y08175, a CBP Bromodomain inhibitor, IC50: 37 nM (AlphaScreen), 178.15 nM (HTRF). Useful in prostate cancer research.Formule :C23H19FN4O5Couleur et forme :SolidMasse moléculaire :450.42CEP-8983
CAS :CEP-8983 is a PARP inhibitor potentially for the treatment of solid tumours.Formule :C18H14N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.32JS1310
CAS :JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.Formule :C23H22FN5O3Couleur et forme :SolidMasse moléculaire :435.45ARTD10/PARP10-IN-2
CAS :ARTD10/PARP10-IN-2: A potent, non-selective PARP inhibitor, IC50: ARTD10/PARP10 (2.0μM), ARTD1/PARP1 (9.7μM).Formule :C12H13N3O3Couleur et forme :SolidMasse moléculaire :247.25OHM1
CAS :OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53Formule :C24H42N6O5Couleur et forme :SolidMasse moléculaire :494.63PARP1-IN-11
CAS :PARP1-IN-11 is a potent PARP1 inhibitor (IC50=0.082 μM), also reducing PARP3, TNKS1, and TNKS2 activity.Formule :C16H12N2O4Couleur et forme :SolidMasse moléculaire :296.28SDR-04
CAS :SDR-04 inhibits BRD4-BD1 with high affinity, suppressing MV4;11 cancer cell growth as a BET inhibitor.Formule :C19H16N4O2Couleur et forme :SolidMasse moléculaire :332.36CP-690550A
CAS :Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.Formule :C15H21N5O2Couleur et forme :SolidMasse moléculaire :303.36ABT-472
CAS :ABT-472 is a novel PARP inhibitorFormule :C20H28N4O5Couleur et forme :SolidMasse moléculaire :404.46CBHA
CAS :m-Carboxycinnamic bishydroxamide: HDAC inhibitor, ID50 = 10 nM (HDAC1), 70 nM (HDAC3), induces apoptosis and tumor growth suppression.Formule :C10H10N2O4Couleur et forme :SolidMasse moléculaire :222.2CSV0C018875
CAS :CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].Formule :C18H17ClN2OCouleur et forme :SolidMasse moléculaire :312.79(2R,5S)-Ritlecitinib
CAS :(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].Formule :C15H19N5OCouleur et forme :SolidMasse moléculaire :285.34BRD4-BD1-IN-1
CAS :BRD4-BD1-IN-1 (Compound 9a) is a BRD4-BD1 inhibitor(IC50= 38.20 μM).Formule :C16H15BrN4O4Couleur et forme :SolidMasse moléculaire :407.22TP-238
CAS :"TP-238: Potent CECR2/BPTF dual probe; IC50: 30 nM/350 nM. Inhibits BRD9 (pIC50: 5.9); minimal activity on 338 other kinases."Formule :C22H30N6O3SCouleur et forme :SolidMasse moléculaire :458.58JAK1-IN-4
CAS :JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Formule :C26H32FN9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.59BRD4 Inhibitor-26
BRD4 Inhibitor-26: blocks BRD4 (BD1 and BD2) with IC50 of 0.82 μM & 1.94 μM; used in ovarian cancer research.Formule :C29H27N5O6SCouleur et forme :SolidMasse moléculaire :573.62CeMMEC2
CAS :CeMMEC2, a novel inhibitor of BRD4, binds both the first and the second bromodomain of BRD4.Formule :C14H19N5Couleur et forme :SolidMasse moléculaire :257.33HDAC6/8/BRPF1-IN-1
CAS :HDAC6/8/BRPF1-IN-1 is a cancer-research inhibitor for HDAC6, HDAC8, BRPF1 with IC50: 344-908 nM and Kd: 175.2 nM.Formule :C18H17N3O5SCouleur et forme :SolidMasse moléculaire :387.41Povorcitinib
CAS :Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).Formule :C23H22F5N7OCouleur et forme :SolidMasse moléculaire :507.469ART-IN-1
CAS :ART-IN-1 (compound 7) is a selective inhibitor of PARP with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1].Formule :C14H13NO2SCouleur et forme :SolidMasse moléculaire :259.32MAT2A-IN-7
CAS :MAT2A-IN-7 inhibits MAT2A in various cancers, especially MTAP-deficient cancer cells, with potential for research use.Formule :C17H13ClF3N3O2Couleur et forme :SolidMasse moléculaire :383.75SRTCX1003
CAS :SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.Formule :C23H23N5O3SCouleur et forme :SolidMasse moléculaire :449.53Aurora Kinases-IN-3
CAS :Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Formule :C20H16F3N3O4Couleur et forme :SolidMasse moléculaire :419.35PBRM1-BD2-IN-6
CAS :PBRM1-BD2-IN-6: potent PBRM1 inhibitor with 0.22 µM IC50, anti-cancer research potential.Formule :C16H15ClN2OCouleur et forme :SolidMasse moléculaire :286.76A2AAR/HDAC-IN-2
CAS :A2AAR/HDAC-IN-2: potent dual A2AAR/HDAC inhib., Ki 10.3 nM, IC50 18.5 nM, anti-tumor potential.Formule :C23H26N6O4Couleur et forme :SolidMasse moléculaire :450.49KCN1
CAS :KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.Formule :C26H27NO5SCouleur et forme :SolidMasse moléculaire :465.56SIRT2-IN-10
CAS :SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.Formule :C28H21N5OSCouleur et forme :SolidMasse moléculaire :475.56Trotabresib
CAS :Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.Formule :C21H21NO4SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :383.46Ref: TM-T36395
1mg92,00€5mg188,00€10mg311,00€25mg528,00€50mg755,00€100mg1.017,00€1mL*10mM (DMSO)215,00€GPI-15427
CAS :GPI-15427: a potent PARP-1 inhibitor, crosses the blood-brain barrier, boosts TMZ's effects on CNS tumors, and sensitizes cancer to radiotherapy.Formule :C20H20N4O2Couleur et forme :SolidMasse moléculaire :348.4CPI-1612
CAS :CPI-1612: Oral EP300/CBP HAT inhibitor, IC50 8.1 nM, has anticancer properties.Formule :C27H26N6OCouleur et forme :SolidMasse moléculaire :450.53ZLD2218
CAS :ZLD2218, a potent inhibitor of BRD4 with an IC50 value of 107 nM, has been demonstrated to mitigate kidney injury and fibrosis through extensive studies.Formule :C22H18N4OCouleur et forme :SolidMasse moléculaire :354.4BRM/BRG1 ATP Inhibitor-3
CAS :BRM/BRG1 ATP Inhibitor-3 targets BRM/BRG1 (IC50: 10.4/19.3 nM) for cancer/BAF disorder research.Formule :C26H25N5O2S2Couleur et forme :SolidMasse moléculaire :503.64PF-00956980
CAS :PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.Formule :C18H26N6OCouleur et forme :SolidMasse moléculaire :342.44
