Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2612 produits trouvés pour "Chromatine/Épigénétique"
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Deferoxamine Mesylate
CAS :Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Formule :C26H52N6O11SDegré de pureté :94.68% - 99.8%Couleur et forme :SolidMasse moléculaire :656.79Ilginatinib
CAS :Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.Formule :C21H20FN7Degré de pureté :98.4% - 99.01%Couleur et forme :SolidMasse moléculaire :389.43Ref: TM-T12266
1mg60,00€5mg131,00€10mg177,00€25mg259,00€50mg371,00€100mg532,00€200mg705,00€1mL*10mM (DMSO)126,00€BMS-986158
CAS :BMS-986158: BET inhibitor, IC50 of 6.6 nM in SCLC, 5 nM in TNBC cells.Formule :C30H33N5O2Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :495.62Ref: TM-T14685
1mg87,00€5mg259,00€10mg465,00€25mg745,00€50mg1.026,00€100mg1.388,00€1mL*10mM (DMSO)283,00€FIDAS-5
CAS :FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Cost-effective and quality-assured.Formule :C15H13ClFNDegré de pureté :98.3% - 99.17%Couleur et forme :SolidMasse moléculaire :261.72Ref: TM-T11285
1mg56,00€2mg80,00€5mg110,00€10mg177,00€25mg314,00€50mg485,00€100mg700,00€500mg1.341,00€1-Naphthohydroxamic acid
CAS :1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1Formule :C11H9NO2Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :187.19Ref: TM-T13996
5mg33,00€10mg60,00€25mg108,00€50mg200,00€100mg299,00€200mg430,00€1mL*10mM (DMSO)38,00€Hydroxycitric acid tripotassium hydrate
CAS :Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.Formule :C6H7K3O8Degré de pureté :99.85%Couleur et forme :White Solid CrystallineMasse moléculaire :324.41LIN28 inhibitor LI71
CAS :LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.Formule :C21H21NO3Degré de pureté :95.88%Couleur et forme :SolidMasse moléculaire :335.4Ref: TM-T11850
1mg107,00€5mg255,00€10mg414,00€25mg745,00€50mg1.063,00€100mg1.459,00€1mL*10mM (DMSO)341,00€Fenbendazole
CAS :Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.Formule :C15H13N3O2SDegré de pureté :99.74%Couleur et forme :White To Yellowish PowderMasse moléculaire :299.35VTP50469
CAS :VTP50469 is a highly selective and orally active small molecule inhibitor of the Menin-MLL protein-protein interaction.Cost-effective and quality-assured.Formule :C32H47FN6O4SDegré de pureté :98.31% - 99.55%Couleur et forme :SolidMasse moléculaire :630.82Ref: TM-T13336
1mg164,00€5mg334,00€10mg401,00€25mg560,00€50mg715,00€100mg964,00€1mL*10mM (DMSO)465,00€T-3775440 hydrochloride
CAS :T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).Formule :C18H23ClN4ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :346.85Ref: TM-T13055
1mg92,00€2mg118,00€5mg192,00€10mg289,00€25mg485,00€50mg663,00€100mg893,00€1mL*10mM (DMSO)212,00€ODM-207
CAS :ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.Formule :C22H21N3O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :375.42Ref: TM-T10521
1mg44,00€5mg92,00€10mg133,00€25mg235,00€50mg339,00€100mg480,00€200mg660,00€1mL*10mM (DMSO)90,00€Oltipraz
CAS :Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.Formule :C8H6N2S3Degré de pureté :98.79% - 99.77%Couleur et forme :SolidMasse moléculaire :226.34MS31 trihydrochloride (2366264-12-0 free base)
MS31 trihydrochloride (2366264-12-0 free base) is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitorFormule :C20H30Cl3N3O2Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :450.83Ref: TM-T12111L
1mg185,00€5mg369,00€10mg542,00€25mg867,00€50mg1.153,00€100mg1.584,00€1mL*10mM (DMSO)379,00€Curcumin
CAS :Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity.Formule :C21H20O6Degré de pureté :95% - 98.98%Couleur et forme :Orange-Yellow Crystal Powder; Gives Brownish-Red Color With Alkali; Light-Yellow Color With Acids Physical Description Orange-Yellow Needles (Ntp 1992)Masse moléculaire :368.38Ilginatinib hydrochloride
CAS :Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Formule :C21H21ClFN7Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :425.89Ref: TM-T12266L2
1mg70,00€5mg150,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€200mg973,00€1mL*10mM (DMSO)166,00€N-(3-Aminopropyl)cyclohexylamine
CAS :N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.Formule :C9H20N2Degré de pureté :98.05% - 98.82%Couleur et forme :Pale Yellow Clear LiquidMasse moléculaire :156.2685Nefiracetam
CAS :Nefiracetam (DM9384), in Phase 2 trials, enhances GABA, choline, monoamine systems, and treats Ro 5-4864 convulsions.Formule :C14H18N2O2Degré de pureté :97.37%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :246.3Indoprofen
CAS :Indoprofen ((±)-Indoprofe) is a non-steroidal anti-inflammatory drug.Formule :C17H15NO3Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :281.31Minocycline hydrochloride
CAS :Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Formule :C23H28ClN3O7Degré de pureté :99.28% - >99.99%Couleur et forme :Bright Yellow-Orange Amorphous Solid Crystalline YellowMasse moléculaire :493.94JAK2 Inhibitor V
CAS :JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Formule :C23H24N2ODegré de pureté :98.36% - 99.15%Couleur et forme :SolidMasse moléculaire :344.45Ref: TM-T3042
2mg37,00€5mg54,00€10mg80,00€25mg148,00€50mg259,00€100mg477,00€500mg1.063,00€1mL*10mM (DMSO)59,00€MAT2A inhibitor 2
CAS :MAT2A inhibitor 2 is an inhibitor of methionine adenosyltransferase 2A (MAT2A).Formule :C18H24ClN3O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :365.85MS402
CAS :MS402 is a novel BD1-selective BET BrD inhibitor.Formule :C20H19ClN2O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :370.83iso-Azalansta
CAS :(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Formule :C22H24ClN3O2SDegré de pureté :99.53% - 99.89%Couleur et forme :SoildMasse moléculaire :429.96Amifostine
CAS :Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Formule :C5H15N2O3PSDegré de pureté :99.59%Couleur et forme :White SolidMasse moléculaire :214.22Miltefosine
CAS :Miltefosine (HePC), effective oral drug for both visceral and cutaneous leishmaniasis, in clinical trials worldwide.Formule :C21H46NO4PDegré de pureté :98% - 99.94%Couleur et forme :White To Off-White PowderMasse moléculaire :407.57Fluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Couleur et forme :Solid(R)-SKBG-1
CAS :(R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNAFormule :C22H26ClN3O6SDegré de pureté :97.25%Couleur et forme :SolidMasse moléculaire :495.98SJ10542
CAS :SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formule :C41H46N12O5SCouleur et forme :SolidMasse moléculaire :818.95AUR1545
CAS :AUR1545 is a selective KAT2A/KAT2B degradator, inhibitory against AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.Formule :C41H50BrN9O5Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :828.8FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Couleur et forme :LiquidCARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formule :C27H35ClN6O3Couleur et forme :SolidMasse moléculaire :527.06PROTAC BRD4 Degrader-5
CAS :PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.Formule :C50H62ClN9O8S2Couleur et forme :SolidMasse moléculaire :1016.67TCIP3
CAS :TCIP3 is a bivalent molecular glue (molecular glue) that can simultaneously bind to both p300/CBP and BCL6. It redirects p300 and CBP to activate programmed cell death genes, which are typically repressed by the oncogenic driver BCL6. TCIP3 is useful for studying diffuse large B-cell lymphoma (DLBCL) and is not toxic to untransformed tonsil lymphocytes or fibroblasts.Formule :C58H71ClF2N16O7Couleur et forme :SolidMasse moléculaire :1177.74PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Couleur et forme :Odour SolidProtein Kinase C (19-31)
CAS :Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.Formule :C67H118N26O16Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :1543.82PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]Formule :C39H42FN9O7Couleur et forme :SolidMasse moléculaire :767.81PROTAC BRD4 Degrader-10
CAS :Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5UNC10142
UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.Formule :C33H52N6O3Couleur et forme :SolidMasse moléculaire :580.8CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Couleur et forme :SolidHDAC1-IN-9
HDAC1-IN-9 (13c) is an HDAC1 inhibitor. It inhibits the HDAC1 enzyme with an IC50 value of 1.07 µM. This compound exhibits the strongest antiproliferative activity against HT-29 (human colon adenocarcinoma cells), with an IC50 of 1.78 μM. In HCT-116 (human colon cancer cells), HDAC1-IN-9 significantly induces apoptosis. Additionally, HDAC1-IN-9 possesses antiangiogenic properties, reducing the expression levels of VEGFR-2 and phosphorylated VEGFR-2 (pVEGFR-2) by approximately 80%.Formule :C17H17N3O3Couleur et forme :SolidMasse moléculaire :311.34NP213
CAS :NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).Formule :C42H84N28O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1093.3HDAC6-IN-53
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.Couleur et forme :Odour SolidSAMS
CAS :SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).Formule :C74H131N29O18S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1779.15SMD-3236
CAS :SMD-3236 is a PRAOTAC degrader targeting SMARCA2, designed using SMARCA ligand and VHL-1 ligand, and exhibits prolonged anti-tumor activity in vivo. SMARCA2 acts as a synthetic lethal target in cancer cells lacking SMARCA4, with SMD-3236 showing 2000-fold selectivity for SMARCA2 over SMARCA4, having a DC50 of less than 1 nM and a Dmax of over 95%. In the human cancer xenograft models deficient in SMARCA4, notably the H838 model, SMD-3236 effectively induces loss of SMARCA2 in tumor tissue while sparing the SMARCA4 protein, thereby inhibiting tumor growth. The compound consists of a target protein ligand (red part) SMI-1074, a PROTAC linker (black part) (trans-4-Ethynylcyclohexyl)methyl methanesulfonate, and an E3 ligase ligand (blue part) SMARCA2 ligand-14, forming the E3LigaseLigand-linker Conjugate 159.Formule :C61H75ClN10O5SCouleur et forme :SolidMasse moléculaire :1095.83ZL0590
CAS :ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.Formule :C23H27F3N4O4SDegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :512.55Ref: TM-T60072
1mg71,00€5mg152,00€10mg222,00€25mg401,00€50mg602,00€100mg887,00€1mL*10mM (DMSO)167,00€KDM1A-IN-29
CAS :KDM1A-IN-29 is a histone demethylase inhibitor.
Formule :C16H16ClN3O4SCouleur et forme :SoildMasse moléculaire :381.833β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS :3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.
Formule :C30H52O4Couleur et forme :SolidMasse moléculaire :476.742DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Couleur et forme :Odour SolidCBP/p300-IN-8
CAS :CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.Formule :C27H31N3O4Couleur et forme :SolidMasse moléculaire :461.562Hyp-dBET1
Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.Couleur et forme :Odour SolidMenin-KMT2A-IN-1
Menin–KMT2A-IN-1 (Compound 20) is an inhibitor of menin–KMT2A, binding to menin with an IC50 of 8 nM, and disrupting the interaction between menin and lysine methyltransferase 2A (KMT2A). It inhibits hERG channels with an IC50 of 65 μM and suppresses MV4-11 cells with an IC50 of 74 nM. Furthermore, Menin–KMT2A-IN-1 exhibits favorable pharmacokinetic properties in CD-1 mice, with an oral bioavailability of 74%.Formule :C28H35FN6O3Couleur et forme :SolidMasse moléculaire :522.61Uzansertib
CAS :Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.Formule :C26H26F3N5O3Couleur et forme :SolidMasse moléculaire :513.51Pumecitinib
CAS :Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Formule :C17H20N8O2SDegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :400.46SMD-3040 TFA
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.Degré de pureté :98%Couleur et forme :Odour SolidPROTAC BRD4 Degrader-19
CAS :PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utilityFormule :C44H38N8O5S2Couleur et forme :SolidMasse moléculaire :822.95GSK040
CAS :GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.Formule :C29H34N4O4Couleur et forme :SolidMasse moléculaire :502.6GSK8573
CAS :GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).Formule :C20H21NO3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :323.39Vanicoside A
CAS :Vanicoside A is a protein kinase C( PKC ) inhibitor from Polygonum pensylvanicum [1] .Formule :C51H50O21Couleur et forme :SolidMasse moléculaire :998.93MZP-54
CAS :MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Formule :C55H66ClN7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1036.67HIF-1 α (556-574)
CAS :HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.Formule :C101H150D2N20O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2254.6TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Couleur et forme :Odour SolidNamoline
CAS :Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.Formule :C10H3ClF3NO4Couleur et forme :SolidMasse moléculaire :293.58BRD7-IN-1 free base
CAS :BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.Formule :C22H26N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.47KB02-JQ1
CAS :KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.Formule :C38H43Cl2N7O6SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :796.77NSC 370284
CAS :NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Couleur et forme :Odour SolidCDD-1102 HCl
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.Formule :C32H31ClN6O3Degré de pureté :98.30%Couleur et forme :SoildMasse moléculaire :583.08Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Couleur et forme :Odour SolidPRO-HD3
PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].Degré de pureté :98%Couleur et forme :Odour SolidAxl-IN-16
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptorFormule :C14H19ClO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.75XF067-68
CAS :XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14JB300
CAS :JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formule :C43H45ClFN7O10SCouleur et forme :SolidMasse moléculaire :906.375SNIPER(BRD)-1
CAS :SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.Formule :C53H66ClN9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1056.73PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.Formule :C53H64N12O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1045.22PROTAC SMARCA2/4-degrader-28
CAS :PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formule :C54H68ClN9O11S2Couleur et forme :SolidMasse moléculaire :1118.75PF-04577806
CAS :PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.Formule :C26H37N7O3Couleur et forme :SolidMasse moléculaire :495.628MNK/PIM-IN-1
CAS :MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.Formule :C27H27FN6O2Couleur et forme :SolidMasse moléculaire :486.551HDAC11-IN-1
HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.Formule :C43H63F3N6O6S2Couleur et forme :SolidMasse moléculaire :881.12VinSpinIn
CAS :VinSpinIn is a probe for the Spin family proteins.Formule :C42H58N8O4Couleur et forme :SolidMasse moléculaire :738.98R 8605
CAS :R 8605 is a third-generation retinoid.Formule :C22H27NO4Couleur et forme :SolidMasse moléculaire :369.45GSK3735967
CAS :GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62GNE-987
CAS :GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.Formule :C56H67F2N9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1096.31ZMF-23
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis andFormule :C22H23Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.36HDAC6 ligand-3
HDAC6ligand-3 serves as a ligand for HDAC6 and can be utilized as a target protein ligand in the synthesis of [PROTAC] HDAC6 degrader4.Formule :C20H21N3O3Couleur et forme :SolidMasse moléculaire :351.399HIV-1 protease-IN-10
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) andFormule :C23H40O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.56TAT-cyclo-CLLFVY
CAS :Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formule :C111H188N42O24S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2559.1Sirtuin modulator 5
CAS :Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.Formule :C24H23N3O4Couleur et forme :SolidMasse moléculaire :417.46SR-0813
CAS :SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9.Formule :C25H32N6O3SDegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :496.62Ref: TM-T40229
1mg39,00€5mg86,00€10mg124,00€25mg253,00€50mg384,00€100mg532,00€200mg705,00€1mL*10mM (DMSO)94,00€MAK-683 hydrochloride
CAS :MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formule :C20H18ClFN6ODegré de pureté :97.02% - >99.99%Couleur et forme :SolidMasse moléculaire :412.85PROTAC BET Degrader-1
CAS :PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.Formule :C44H45N11O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :871.9MRS2698
CAS :MRS2698: potent P2Y2 agonist, EC50 8 nM, >300x selectivity over P2Y4/P2Y6.Formule :C9H16N3O13P3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.22HSP90/LSD1-IN-1
HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.Couleur et forme :Odour SolidOkicenone
CAS :Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.
Formule :C15H14O4Couleur et forme :SolidMasse moléculaire :258.27BAY-184
CAS :BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.Formule :C23H20N2O4SDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :420.48Lyngbyatoxin A
CAS :Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as "swimmers' itch" in Hawaii.
Formule :C27H39N3O2Couleur et forme :SolidMasse moléculaire :437.62HIF1-IN-3
CAS :HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFormule :C26H24N2O3Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :412.48PROTAC BRD4 Degrader-13
CAS :PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Formule :C68H85F2N11O17P2S2Couleur et forme :SolidMasse moléculaire :1492.55MS33
CAS :MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formule :C64H84F3N11O7SCouleur et forme :SolidMasse moléculaire :1208.5MNN-02-155
CAS :MNN-02-155 is a bivalent molecular glue that can simultaneously interact with both p300/CBP and BCL6. It effectively induces the activation of BCL6-targeted reporter genes and promotes cell death. This compound is used in the research of diffuse large B-cell lymphoma (DLBCL).Formule :C56H68ClF2N15O7Couleur et forme :SolidMasse moléculaire :1136.69DS-103
DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.Formule :C28H33N5O3Couleur et forme :SolidMasse moléculaire :487.59
