
Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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SK-575
CAS :SK-575 is a potent PARP1-degrading agent effective against BRCA1/2 mutant cancers, even at low doses, and enhances tumor inhibition in mice.Formule :C47H53FN8O8Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :876.97ZEN-3862
CAS :ZEN-3862, a BET inhibitor, blocks BRD4(BD1) at 0.16 μM & BRD4(BD2) at 0.13 μM; usable in PROTACs for BRD4 degradation.Formule :C19H17FN2O3Degré de pureté :97.1%Couleur et forme :SolidMasse moléculaire :340.35OXFBD04
CAS :OXFBD04: Potent BRD4 inhibitor, IC50=166nM, acts on BET bromodomains; moderate CREBBP affinity; anti-cancer properties.Formule :C17H16N2O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :296.32Ref: TM-T12338
1mg52,00€2mg78,00€5mg115,00€10mg182,00€25mg339,00€50mg505,00€100mg685,00€200mg944,00€1mL*10mM (DMSO)126,00€KRH102140
CAS :KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.Formule :C25H24FNODegré de pureté :98.31% - 99.61%Couleur et forme :SolidMasse moléculaire :373.46ML192
CAS :ML192 (CID1434953) is a selective GPR55 ligand antagonist.Formule :C20H22N4O2SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :382.48Ref: TM-T33452
1mg34,00€5mg71,00€10mg104,00€25mg172,00€50mg249,00€100mg350,00€200mg480,00€1mL*10mM (DMSO)92,00€Bisaramil hydrochloride
CAS :Bisaramil hydrochloride (Bisaramil) is an antiarrhythmic compound that inhibits free radical production.Formule :C17H24Cl2N2O2Degré de pureté :98.64% - 99.48%Couleur et forme :SolidMasse moléculaire :359.29JAK1-IN-8
CAS :JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Formule :C22H23FN4O3SDegré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :442.51ACY-957
CAS :ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.Formule :C24H23N5OSDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :429.54Ref: TM-T10245
1mg90,00€2mg136,00€5mg230,00€10mg281,00€25mg432,00€50mg612,00€100mg802,00€1mL*10mM (DMSO)251,00€JAK-STAT-IN-1
CAS :JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formule :C21H21N5O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :375.42PARP10-IN-2
CAS :PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and
Formule :C14H10N2O2Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :238.24CPUY074020
CAS :CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.Formule :C25H28N4O2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :416.52Ref: TM-T10882
1mg71,00€5mg147,00€10mg205,00€25mg319,00€50mg450,00€100mg587,00€200mg803,00€1mL*10mM (DMSO)159,00€ZEN-2759
CAS :ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).Formule :C17H16N2O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :280.32PU139
CAS :PU139 is a novel inhibitor of histone acetyltransferase (HAT).Formule :C12H7FN2OSDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :246.26EB-47
CAS :EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).Formule :C24H27N9O6Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :537.53STS-E412
CAS :STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.Formule :C15H15ClN4O2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :318.76Raxofelast
CAS :Raxofelast (IRFI-016), a vitamin-like, hydrophilic antioxidant, mitigates ischemia-reperfusion in testis and may treat diabetic issues and atherosclerosis.Formule :C15H18O5Degré de pureté :99.74% - 99.97%Couleur et forme :SolidMasse moléculaire :278.3Butyzamide
CAS :Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.Formule :C29H32Cl2N2O5SDegré de pureté :99.39% - 99.83%Couleur et forme :SoildMasse moléculaire :591.55Ref: TM-T67894
1mg149,00€5mg253,00€10mg371,00€25mg573,00€50mg862,00€100mg1.305,00€200mg1.755,00€1mL*10mM (DMSO)329,00€DC-BPi-03
CAS :DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC 50 of 698.3 nM and a K d of 2.81 μM .Formule :C14H14N4O2SDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :302.35MS0124
CAS :MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
Formule :C20H29N5O3Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :387.48YLF-466D
CAS :YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.Formule :C29H20ClNO3Degré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :465.93Ref: TM-T13368
1mg34,00€5mg79,00€10mg111,00€25mg188,00€50mg269,00€100mg371,00€200mg512,00€1mL*10mM (DMSO)82,00€Procainamide
CAS :Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.Formule :C13H21N3ODegré de pureté :99.79% - 99.92%Couleur et forme :SolidMasse moléculaire :235.33BRD4 Inhibitor-20
CAS :BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity.
Formule :C18H18N2O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :358.41Chiauranib
CAS :Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47Ref: TM-T35570
1mg66,00€5mg144,00€10mg245,00€25mg492,00€50mg710,00€100mg973,00€1mL*10mM (DMSO)157,00€Flosequinan
CAS :Flosequinan is an arteriovenous vasodilator, which can effectively treat acute heart failure.Formule :C11H10FNO2SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :239.27Ref: TM-T31805
1mg175,00€5mg394,00€10mg582,00€25mg888,00€50mg1.243,00€100mg1.674,00€500mg3.348,00€1mL*10mM (DMSO)351,00€β-NF-JQ1
CAS :β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins.Formule :C45H42ClN5O6SDegré de pureté :97.58% - 99.15%Couleur et forme :SolidMasse moléculaire :816.36OUL232
CAS :OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.Formule :C10H10N4O2SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :250.28Butyrolactone 3
CAS :Butyrolactone 3 (MB-3) is a Gcn5 inhibitor with weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and can be used in cancer.Formule :C9H12O4Degré de pureté :98.99% - 99.5%Couleur et forme :SolidMasse moléculaire :184.19ZEN-3411
CAS :ZEN-3411 is an BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproducing BET proteins.Formule :C21H20N4O2Degré de pureté :97.51% - 98.84%Couleur et forme :SolidMasse moléculaire :360.41SS-208
CAS :SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.Formule :C13H11Cl2N3O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :344.15Izencitinib
CAS :Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Formule :C22H26N8Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :402.50Ref: TM-T35898
1mg84,00€5mg177,00€10mg281,00€25mg567,00€50mg888,00€100mg1.431,00€200mg1.963,00€1mL*10mM (DMSO)195,00€BRD2492
CAS :BRD2492 is an HDAC1 and HDAC2 inhibitor with antiproliferative activity, inhibits HDAC1/2 and induces apoptosis.Formule :C20H18N4O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :346.38PF-249
CAS :PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Formule :C17H16ClN3O3Degré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :345.78Ref: TM-T24626
1mg46,00€5mg92,00€10mg147,00€25mg236,00€50mg344,00€100mg482,00€200mg662,00€1mL*10mM (DMSO)100,00€BAY-299
CAS :BAY-299 inhibits BRPF2, TAF1, and TAF1L with IC50s of 67, 8, and 106 nM.Formule :C25H23N3O4Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :429.47DW14800
CAS :DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.Formule :C31H36N4O3Degré de pureté :99.55% - 99.68%Couleur et forme :SolidMasse moléculaire :512.64Ref: TM-T11131
1mg93,00€2mg123,00€5mg205,00€10mg358,00€25mg680,00€50mg898,00€100mg1.341,00€1mL*10mM (DMSO)233,00€AGI-24512
CAS :AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells inFormule :C24H24N4O2Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :400.47Ref: TM-T14141
1mg66,00€5mg145,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€200mg982,00€1mL*10mM (DMSO)195,00€NSC668394
CAS :NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.Formule :C17H12Br2N2O3Degré de pureté :99.29% - 99.29%Couleur et forme :SolidMasse moléculaire :452.1NT160
CAS :NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases.Formule :C21H21F3N4O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :418.41Ref: TM-T78709
1mg94,00€5mg222,00€10mg356,00€25mg715,00€50mg1.153,00€100mg1.783,00€1mL*10mM (DMSO)245,00€EZH2-IN-14
CAS :EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.Formule :C31H39N7O2Couleur et forme :SolidMasse moléculaire :541.69QC6352
CAS :QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).Formule :C24H25N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.47GNE-049
CAS :GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.Formule :C27H32F2N6O2Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :510.58Amelparib
CAS :Amelparib (JPI-289) is an inhibitor of the poly-ADP-ribose polymerase.Formule :C19H25N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.42HDAC8-IN-4
CAS :HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].Formule :C17H14N2O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.44HDAC/HSP90-IN-3
CAS :HDAC/HSP90-IN-3, a dual inhibitor targeting fungal Hsp90 (IC50: 0.83 μM) & HDAC (IC50: 0.91 μM), counters azole-resistant C. albicans.Formule :C26H33N5O6Couleur et forme :SolidMasse moléculaire :511.57HDAC/BET-IN-1
CAS :HDAC/BET-IN-1 inhibits HDAC1 (IC50: 0.163 μM), HDAC6 (IC50: 0.067 μM), BRD4 (Ki: 0.076 μM), and fights leukemia.Formule :C29H40N4O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :604.71FHT-1204
CAS :FHT-1204 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) (IC50 ≤ 10 nM).Formule :C24H23N5O5S2Couleur et forme :SolidMasse moléculaire :525.6TCS HDAC6 20b
CAS :TCS HDAC6 20b (HDAC6-IN-7) is an HDAC6 inhibitor that blocks the growth of breast cancer cells and can be used in cancer research.Formule :C26H44N2O4SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :480.7GW814408X
CAS :GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formule :C19H16N6OMasse moléculaire :344.37PKC-θ inhibitor 1
CAS :PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)Formule :C17H15F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.32HDAC-IN-38
CAS :HDAC-IN-38: Potent HDAC1-3,5,6,8 inhibitor, boosts H3K14/H4K5 acetylation, elevates CBF, lessens cognitive decline & hippocampal atrophy.Formule :C27H28ClN3O2Couleur et forme :SolidMasse moléculaire :461.98Aurora kinase inhibitor-8
CAS :Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Formule :C30H29N7O3Couleur et forme :SolidMasse moléculaire :535.6PIM1-IN-1
CAS :PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Formule :C25H30N8O2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :474.56Ref: TM-T12474
1mg117,00€5mg281,00€10mgÀ demander25mg858,00€50mg1.341,00€100mg2.125,00€1mL*10mM (DMSO)À demanderTubulin/JAK2-IN-1
CAS :Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significantFormule :C22H20N6O3Couleur et forme :SolidMasse moléculaire :416.43HDAC6/HSP90-IN-1
CAS :HDAC6/HSP90-IN-1 is a potent dual inhibitor of HDAC6 and HSP90 with IC50s 4.3 nM & 46.8 nM, respectively; curbs PD-L1 and tumor growth in H1975 mice.Formule :C28H37N3O6Couleur et forme :SolidMasse moléculaire :511.61dBRD4-BD1
CAS :dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.Formule :C50H53F3N8O9Couleur et forme :SolidMasse moléculaire :967RK-0133114
RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54Sirtuin modulator 1
CAS :Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Formule :C31H32ClN5O2S2Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :606.2CAY10398
CAS :CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).Formule :C15H23N3O3Couleur et forme :SolidMasse moléculaire :293.367HIF-2α-IN-13
CAS :HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.Formule :C15H14ClF4NO2Couleur et forme :SolidMasse moléculaire :351.72UNC8153 TFA
CAS :UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating aFormule :C35H38F3N5O7Degré de pureté :96.44%Couleur et forme :SolidMasse moléculaire :697.7Demethyleneberberine chloride
CAS :Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-Formule :C19H18ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :359.8Bocodepsin
CAS :Bocodepsin (OKI-179) is a selective, orally active inhibitor of histone deacetylases (HDAC) with demonstrated antitumor efficacy.Formule :C26H39N5O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.75BY27
CAS :BY27 is a BET BD2 inhibitor with anticancer activity that inhibits BRD2, BRD3 and BRD4 and suppresses tumor growth.Formule :C22H21ClN6Degré de pureté :99.4% - 99.68%Couleur et forme :SolidMasse moléculaire :404.89JAK-IN-1
CAS :JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.Formule :C20H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.44JAK-IN-4
CAS :JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.Formule :C18H21N4Na2O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.341Bocodepsin hydrochloride
CAS :Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration.Formule :C26H40ClN5O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :618.21WAY-354574
CAS :WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].Formule :C20H23ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.93KPZ560
CAS :KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively.Formule :C26H21N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.61CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormule :C29H43Cl3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.04PF-06679142
CAS :PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Formule :C20H17F2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.35AMPK-IN-1
CAS :AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Formule :C24H18ClN3O3Couleur et forme :SolidMasse moléculaire :431.87HDAC6-IN-8
CAS :Compound 12C, with altered cap groups, shows wide-range enzyme inhibition; 9m and 9q target HDAC6 specifically.Formule :C23H17BrFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.32FHT-2344
CAS :FHT-2344, a SMARCA4/SMARCA2 ATPase inhibitor, exhibits anticancer activity with half-maximal inhibitory concentrations (IC 50 ) of 0.026 μM for SMARCA4 and 0.013 μM for SMARCA2, respectively [1].Formule :C23H24N6O5S2Couleur et forme :SolidMasse moléculaire :528.6Sirt2-IN-5
CAS :Sirt2-IN-5 is a potent inhibitor of SIRT2.Formule :C26H27Cl2N5O3Couleur et forme :SolidMasse moléculaire :528.43JAK kinase-IN-1
CAS :JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32Formule :C17H19F2N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.44PHD-IN-1
CAS :PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Formule :C24H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.49Vafidemstat
CAS :Vafidemstat (ORY-2001) is a lysine-histone demethylase (LSD1)/MAO-B inhibitor for the study of neurological disorders.Formule :C19H20N4O2Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :336.39NMS-P953
CAS :NMS-P953: JAK2 inhibitor, reduces tumor growth in SET-2 model, confirmed in vivo action, good pharmacokinetics and safety.Formule :C16H11ClF3N5OCouleur et forme :SolidMasse moléculaire :381.74JBI-589
CAS :JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.Formule :C29H28FN5OCouleur et forme :SolidMasse moléculaire :481.56CW 008
CAS :CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.Formule :C21H14F2N6O2Degré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :420.37CD235
CAS :CD235 is a structurally similar analog of CD161. CD161 is an orally bioavailable inhibitor of BET bromodomain.Formule :C26H20FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.47YM-08
CAS :YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formule :C19H17N3OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.49Ampkinone
CAS :Ampkinone is an indirect AMPK activator.Formule :C31H23NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.52KF21213
CAS :KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.Formule :C19H22N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.4KP-544
CAS :KP-544 is an agent of neurotrophin potentiator.Formule :C18H19ClN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.82Ginsenoside Rk1
CAS :Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :767.00PARP7-IN-16
CAS :PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.Formule :C25H26FN4NaO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.49GSK-3484862
CAS :Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Formule :C19H19N5OSDegré de pureté :99.87% - 99.963%Couleur et forme :SolidMasse moléculaire :365.45Ref: TM-T11469
1mg48,00€5mg113,00€10mg177,00€25mg318,00€50mg485,00€100mg692,00€500mg1.395,00€1mL*10mM (DMSO)203,00€MAK683-CH2CH2COOH
CAS :MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.Formule :C23H21FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.45HIF-2α-IN-6
CAS :HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].Formule :C15H13F4NO3SCouleur et forme :SolidMasse moléculaire :363.33MTDH-SND1 blocker 1
CAS :MTDH-SND1 Blocker 1 (Compound C26-A6) serves as an inhibitor targeting the MTDH-SND1 protein, effectively suppressing cancer metastasis [1].Formule :C14H13ClN4O3SCouleur et forme :SolidMasse moléculaire :352.8UNC7145
CAS :UNC6934 Negative Control (Axon 3591) is a chemically related compound that serves as a negative control for UNC6934, a potent and selective chemical probe that specifically targets the N-terminal PWWP (PWWP1) domain of NSD2.Formule :C24H23N5O4Couleur et forme :SolidMasse moléculaire :445.4705TRC160334 sodium
CAS :TRC160334 is a HIF hydroxylases inhibitor.Formule :C14H15N3O5SCouleur et forme :SolidMasse moléculaire :337.35MARK-IN-1
CAS :MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Formule :C22H23F2N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.53AAPK-25
CAS :AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formule :C21H13Cl2N3O2SDegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :442.32Ref: TM-T10215
1mg54,00€5mg118,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€1mL*10mM (DMSO)131,00€CBP/p300-IN-15
CAS :CBP/p300-IN-15 inhibits p300 (IC50: 2.5 nM) & CBP (28 nM), affects OVCAR-3 (EC50: 0.865 μM) & A2780 cells (2.71 μM) for ovarian cancer research.Formule :C26H28N4O5Couleur et forme :SolidMasse moléculaire :476.52GRK2 Inhibitor 2
CAS :GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Formule :C19H16N4O2Couleur et forme :SolidMasse moléculaire :332.36F-Amidine TFA
CAS :F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.Formule :C14H19FN4O2CF3COOHCouleur et forme :SolidMasse moléculaire :408.4Upadacitinib tartrate
CAS :Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.Formule :C21H33F3N6O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.521QL-1200186
CAS :QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFormule :C26H27N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.54DY-46-2
CAS :DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.Formule :C19H22N6O5SDegré de pureté :99.12% - 99.12%Couleur et forme :SolidMasse moléculaire :446.48

