Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2612 produits trouvés pour "Chromatine/Épigénétique"
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SRT3657
CAS :SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Formule :C40H54N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.97MS31
CAS :MS31 is a potent and highly affinity inhibitor of spindlin 1 (SPIN1).Formule :C20H27N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :341.45KDM4-IN-2
CAS :KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.Formule :C25H26N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.51MK-0626
CAS :MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Formule :C22H24F2N6O2Degré de pureté :99.47% - >99.99%Couleur et forme :SolidMasse moléculaire :442.46JAK2-IN-4
CAS :JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.Formule :C23H27N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.56Tankyrase-IN-5
CAS :Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitoryFormule :C17H18N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.34Brepocitinib
CAS :Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Formule :C18H21F2N7ODegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :389.4Ref: TM-TQ0010
1mg34,00€2mg46,00€5mg66,00€10mg99,00€25mg205,00€50mg371,00€100mg595,00€200mg833,00€1mL*10mM (DMSO)73,00€PRMT5-IN-28
CAS :PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processesFormule :C18H19ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.82JAK-IN-5
CAS :JAK-IN-5 is a JAK inhibitor.Formule :C27H31FN6ODegré de pureté :98.1% - 99.37%Couleur et forme :SolidMasse moléculaire :474.57Ref: TM-T11710
1mg177,00€5mg370,00€10mg552,00€25mg879,00€50mg1.189,00€100mg1.603,00€500mg3.205,00€1mL*10mM (DMSO)537,00€XDM-CBP
CAS :XDM-CBP is an effective and selective CBP/p300 bromodomain inhibitor.Formule :C21H22N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.41PHD-IN-2
CAS :PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFormule :C26H27N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.54PRMT5-IN-29
CAS :PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].Formule :C18H20Cl3N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.74CBP/p300-IN-5
CAS :P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).Formule :C29H27F5N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :618.55HSP70/SIRT2-IN-2
CAS :HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].Formule :C17H13N3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.5PRMT5-IN-25
CAS :PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1Formule :C24H21F3N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.46PARP7-IN-15
CAS :PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].Formule :C23H24F6N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.46QQN-00358
CAS :QQN-00358 is a novel potent and selective tankyrase (TNKS) inhibitor.Formule :C26H24F3N3O4Couleur et forme :SolidMasse moléculaire :499.48KDM5-C70
CAS :KDM5-C70 is an ethyl ester derivative of KDM5-C49.Formule :C17H28N4O3Degré de pureté :97.63% - 99.86%Couleur et forme :SolidMasse moléculaire :336.43Ref: TM-T15648
2mg42,00€5mg58,00€10mg84,00€25mg133,00€50mg233,00€100mg464,00€200mg663,00€500mg1.018,00€1mL*10mM (DMSO)70,00€Sirtuin-1 inhibitor 1
CAS :Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Formule :C20H17N3O2Degré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :331.37BRD7-IN-1
CAS :BRD7-IN-1, a BI7273 derivative, forms PROTAC VZ185, targeting BRD7/9 with DC50s of 4.5/1.8 nM via VHL ligand linkage.Formule :C22H28Cl2N4O3Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :467.39Ref: TM-T17697
1mg94,00€2mg137,00€5mg222,00€10mg334,00€25mg602,00€50mg893,00€100mg1.243,00€200mg1.693,00€1mL*10mM (DMSO)227,00€Pim-1 kinase inhibitor 5
CAS :Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Formule :C22H13Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.26Aurora Kinases-IN-4
CAS :Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Formule :C26H28N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.55Physachenolide C
CAS :Physachenolide C, a selective BET inhibitor, induces apoptosis and arrests the cell cycle at the G0-G1 phase, exhibiting antitumor activity [1].Formule :C30H40O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.63NMS-P515
CAS :NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity.Formule :C21H29N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.47GNE-955
CAS :GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Formule :C22H24N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.48PHD2-IN-1
CAS :PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].Formule :C21H23ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.88BET-IN-16
CAS :BET-IN-16 (Comp I), a bromodomain and extra-terminal (BET) inhibitor, demonstrates anticancer activity by impeding the growth of prostate cancer cells.Formule :C31H25N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.56JAK-IN-26
CAS :JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormule :C22H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46Antitumor agent-101
CAS :Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM forFormule :C26H38N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :482.62SJ1461
CAS :SJ1461 is a potent, orally active inhibitor of the BET family, selectively targeting and inhibiting BRD2 (BD1), BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) withFormule :C21H18ClN7OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484PIM-IN-2
CAS :PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Formule :C19H22N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.4SIRT5 inhibitor 7
CAS :SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.Formule :C28H32ClN7O3SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :582.12CBP-IN-1
CAS :CBP-IN-1 (compound 12) acts as a potent CBP inhibitor exhibiting an IC50 of 1.5 nM and additionally suppresses CBP BRET and BRD4(1) with IC50 values of 690 nMFormule :C27H33F2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.59GNE-207
CAS :GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM).Formule :C29H30N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.59Eleven-Nineteen-Leukemia Protein IN-2
CAS :Eleven-Nineteen-Leukemia Protein IN-2 (compound 23), an ENL inhibitor, exhibits an IC50 of 10.7 nM and is utilized for leukemia research [1].Formule :C22H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45Bisegliptin
CAS :Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.Formule :C18H26FN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.42FT895
CAS :FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.Formule :C16H15F3N4O2Degré de pureté :98.95% - >99.99%Couleur et forme :SolidMasse moléculaire :352.31Ref: TM-T11329
1mg97,00€5mg230,00€10mg359,00€25mg602,00€50mg838,00€100mg1.169,00€1mL*10mM (DMSO)255,00€LSD1-UM-109
CAS :LSD1-UM-109 is a highly potent and reversible inhibitor of LSD1, demonstrating an IC50 of 3.1 nM.Formule :C29H27FN6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :478.56Bromodomain inhibitor-12
CAS :Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].Formule :C28H38N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.63Tyk2-IN-9
CAS :Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.Formule :C20H17N9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.41PARP1-IN-7
CAS :PARP1-IN-7 functions as an anticancer agent by inhibiting poly(ADP-ribose) polymerase-1 (PARP1).Formule :C24H23N5OCouleur et forme :SolidMasse moléculaire :397.47AMPK-α1β1γ1 activator 1
CAS :AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Formule :C25H24ClNO9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.91Ro 32-0432 hydrochloride
CAS :Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.Formule :C28H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.55MAT2A-IN-10
CAS :MAT2A-IN-10 (Compound 28), an orally active inhibitor of MAT2A, exhibits an IC50 of 26 nM and is utilized in cancer research [1].Formule :C27H24F2N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.51BET-IN-9
CAS :BET-IN-9 is a BET inhibitor[1].Formule :C22H24N4O3Couleur et forme :SolidMasse moléculaire :392.45PIM1-IN-4
CAS :PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Formule :C27H25BrCl2CuN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :663.88Eleven-Nineteen-Leukemia Protein IN-3
CAS :ENL YEATS inhibitor Eleven-Nineteen-Leukemia Protein IN-3, IC50 15.4 nM, orally active, suppresses MYC, stabilizes ENL in vitro.Formule :C28H27N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.55MAT2A-IN-12
CAS :MAT2A Allosteric Inhibitor 2 is a potent, selective inhibitor exhibiting an IC50 of 5 nM and demonstrates nanomolar efficacy (IC50 = 5 μM) in proliferationFormule :C20H17NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.35SP-2-225
CAS :SP-2-225, a selective inhibitor of HDAC6, augments the production of cancer-associated antigens and enhances macrophage antigen cross-presentation to T cells,Formule :C28H34N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.58BRD4 Inhibitor-28
CAS :BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55Formule :C23H21N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43MARK-IN-2
CAS :MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Formule :C18H18ClF2N5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.88Bromodomain inhibitor-12 (edisylate)
CAS :Bromodomain Inhibitor-12 Edisylate (example 303) serves as a bromodomain inhibitor applicable to autoimmune and inflammatory disease research [1].Formule :C30H44N4O11S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :700.82HIF-2α-IN-9
CAS :HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes withinFormule :C12H13F5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.35CBP/p300-IN-21
CAS :CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibitsFormule :C19H16ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.79(S,R)-CFT8634
CAS :(S,R)-CFT8634 is a selective and orally active BRD9 protein degrader with potential for researching BRD9-mediated disorders, such as abnormal cellularFormule :C37H45F3N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :710.79TC-AC28
CAS :TC-AC28 is a novel potent and selective Brd2(2) ligand.Formule :C23H21N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.44GSK4028
CAS :GSK4028 is the enantiomeric negative control of GSK4027, a PCAF/GCN5 bromodomain chemical probe, with a pIC50 of 4.9 in a TR-FRET assay.Formule :C17H21BrN4OCouleur et forme :SolidMasse moléculaire :377.28KDM2B-IN-1
CAS :KDM2B-IN-1: Potent, specific KDM2B histone demethylase inhibitor for hyperproliferative disease research.Formule :C21H30N4O2SCouleur et forme :SolidMasse moléculaire :402.56JH-131e-153
CAS :JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈Formule :C22H38O5Couleur et forme :SolidMasse moléculaire :382.53Bavarostat
CAS :Bavarostat: brain-penetrant HDAC6 inhibitor; IC50=60nM; >80x selective for HDAC6; modulates tubulin over histone acetylation.Formule :C20H27FN2O2Couleur et forme :SolidMasse moléculaire :346.44WM-586
CAS :WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.Formule :C20H20F3N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :467.47JG-2016
CAS :JG-2016, as a histone acetyltransferase 1 inhibitor, inhibits growth of human cancer cell lines and inhibits enzymatic activity in cellulose.Formule :C18H21ClN4O3Degré de pureté :99.00% - 99.37%Couleur et forme :SolidMasse moléculaire :376.84Ref: TM-T82008
1mg110,00€5mg268,00€10mg432,00€25mg858,00€50mg1.378,00€100mg1.783,00€1mL*10mM (DMSO)294,00€GSK217
CAS :GSK217 is a potent and selective inhibitor of the bromo and extraterminal domain (BET) second bromodomain (BD2) with high solubility, utilized in oncology andFormule :C20H20N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.41Lepzacitinib
CAS :Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formule :C18H21N5O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :355.39Ref: TM-T78207
1mg50,00€5mg104,00€10mg167,00€25mg340,00€50mg505,00€100mg712,00€200mg1.009,00€1mL*10mM (DMSO)114,00€GSK-A
CAS :GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.Formule :C21H25N5O2Couleur et forme :SolidMasse moléculaire :379.46AGI-25696
CAS :AGI-25696 inhibits MATA2, blocking MTAP-deleted tumor growth, potential for cancer research.Formule :C27H18N4ODegré de pureté :98.40% - 99.74%Couleur et forme :SolidMasse moléculaire :414.46JAK-IN-31
CAS :JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,Formule :C21H19N7O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.55GSK2646264
CAS :GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.Formule :C24H26N2O2Couleur et forme :SolidMasse moléculaire :374.48FM-479
CAS :FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.
Formule :C25H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.523ABBV-712
CAS :ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseasesFormule :C24H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.5KAT modulator-1
CAS :KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].Formule :C20H36O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.5GSK737
CAS :GSK737 is a dual inhibitor of BRD4 BD1 and BD2, exhibiting pIC50 values of 5.3 and 7.3, respectively.Formule :C20H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :363.41PARP-2-IN-1
CAS :PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).Formule :C21H19F4N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.4INCB059872 tosylate
CAS :INCB059872: potent, selective oral LSD1 inhibitor, increasing tumor-suppressor gene expression by promoting H3K4 and H3K9 methylation.Formule :C37H50N2O9S2Couleur et forme :SolidMasse moléculaire :730.932JQKD82 dihydrochloride
CAS :JQKD82 (JADA82) dihydrochloride, a cell-permeable and selective inhibitor of KDM5, enhances H3K4me3 levels, making it effective for multiple myeloma research [1].Formule :C27H42Cl2N4O5Couleur et forme :SolidMasse moléculaire :573.55TC-A 2317 hydrochloride
CAS :TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Formule :C19H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.93PI3K/HDAC-IN-2
CAS :PI3K/HDAC-IN-2: dual inhibitor with IC50s - PI3Kα: 226nM, β: 279nM, γ: 467nM, δ: 29nM; HDAC1: 1.3nM. Selective to PI3Kδ/class I/IIb HDAC, anticancer.Formule :C23H23N7O4Couleur et forme :SolidMasse moléculaire :461.47T-448 free base
CAS :T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).Formule :C17H20N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.43K-756
CAS :K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).
Formule :C24H27N5O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :433.5Compound SA91-0178
CAS :SA91-0178 (3-{[(1-methyl-2-oxo-1'-phenyl-1,2-dihydrospiro[indole-3,4'-piperidine]-5-carbonyl)amino]methyl}benzoic acid) is a specific METTL1 inhibitor and effectively alleviated tissue injury during septic inflammation.Formule :C28H27N3O4Masse moléculaire :469.54GSK3368715 hydrochloride
CAS :GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.Formule :C20H38N4O2·HClCouleur et forme :SolidMasse moléculaire :403CC-90005
CAS :CC-90005 is a potent, selective oral PKC-θ inhibitor with an IC50 of 8 nM, preferential over PKC-δ, and inhibits T cell activation.Formule :C21H27F2N7O2Couleur et forme :SolidMasse moléculaire :447.48HL23
CAS :HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC).Formule :C44H44N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :712.83BRD4 Inhibitor-23
CAS :BRD4 Inhibitor-23: potent, oral, IC50: BRD4 BD-1 6.21 nM, BD-2 1.44 nM. See WO2022033542A1 Example 1.Formule :C22H19F2N3O4SCouleur et forme :SolidMasse moléculaire :459.47ARTD3/PARP3-IN-1
CAS :ARTD3/PARP3-IN-1 is a non-selective inhibitor targeting diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3)/PARP3 [1].Formule :C17H16N4O2Couleur et forme :SolidMasse moléculaire :308.33DY-46-2
CAS :DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.Formule :C19H22N6O5SDegré de pureté :99.12% - 99.12%Couleur et forme :SolidMasse moléculaire :446.48QL-1200186
CAS :QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFormule :C26H27N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.54F-Amidine TFA
CAS :F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.Formule :C14H19FN4O2CF3COOHCouleur et forme :SolidMasse moléculaire :408.4GRK2 Inhibitor 2
CAS :GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Formule :C19H16N4O2Couleur et forme :SolidMasse moléculaire :332.36AAPK-25
CAS :AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formule :C21H13Cl2N3O2SDegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :442.32Ref: TM-T10215
1mg54,00€5mg118,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€1mL*10mM (DMSO)131,00€HIF-2α-IN-6
CAS :HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].Formule :C15H13F4NO3SCouleur et forme :SolidMasse moléculaire :363.33TRC160334 sodium
CAS :TRC160334 is a HIF hydroxylases inhibitor.Formule :C14H15N3O5SCouleur et forme :SolidMasse moléculaire :337.35UNC7145
CAS :UNC6934 Negative Control (Axon 3591) is a chemically related compound that serves as a negative control for UNC6934, a potent and selective chemical probe that specifically targets the N-terminal PWWP (PWWP1) domain of NSD2.Formule :C24H23N5O4Couleur et forme :SolidMasse moléculaire :445.4705MTDH-SND1 blocker 1
CAS :MTDH-SND1 Blocker 1 (Compound C26-A6) serves as an inhibitor targeting the MTDH-SND1 protein, effectively suppressing cancer metastasis [1].Formule :C14H13ClN4O3SCouleur et forme :SolidMasse moléculaire :352.8Ginsenoside Rk1
CAS :Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :767.00KP-544
CAS :KP-544 is an agent of neurotrophin potentiator.Formule :C18H19ClN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.82Ampkinone
CAS :Ampkinone is an indirect AMPK activator.Formule :C31H23NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.52CW 008
CAS :CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.Formule :C21H14F2N6O2Degré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :420.37JBI-589
CAS :JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.Formule :C29H28FN5OCouleur et forme :SolidMasse moléculaire :481.56JAK kinase-IN-1
CAS :JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32Formule :C17H19F2N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.44
