Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2612 produits trouvés pour "Chromatine/Épigénétique"
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NMS-P953
CAS :NMS-P953: JAK2 inhibitor, reduces tumor growth in SET-2 model, confirmed in vivo action, good pharmacokinetics and safety.Formule :C16H11ClF3N5OCouleur et forme :SolidMasse moléculaire :381.74AMPK-IN-1
CAS :AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Formule :C24H18ClN3O3Couleur et forme :SolidMasse moléculaire :431.87PF-06679142
CAS :PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Formule :C20H17F2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.35Demethyleneberberine chloride
CAS :Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-Formule :C19H18ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :359.8JAK-IN-1
CAS :JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.Formule :C20H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.44BY27
CAS :BY27 is a BET BD2 inhibitor with anticancer activity that inhibits BRD2, BRD3 and BRD4 and suppresses tumor growth.Formule :C22H21ClN6Degré de pureté :99.4% - 99.68%Couleur et forme :SolidMasse moléculaire :404.89CAY10398
CAS :CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).Formule :C15H23N3O3Couleur et forme :SolidMasse moléculaire :293.367RK-0133114
RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54dBRD4-BD1
CAS :dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.Formule :C50H53F3N8O9Couleur et forme :SolidMasse moléculaire :967Tubulin/JAK2-IN-1
CAS :Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significantFormule :C22H20N6O3Couleur et forme :SolidMasse moléculaire :416.43GW814408X
CAS :GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formule :C19H16N6OMasse moléculaire :344.37Amelparib
CAS :Amelparib (JPI-289) is an inhibitor of the poly-ADP-ribose polymerase.Formule :C19H25N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.42EZH2-IN-14
CAS :EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.Formule :C31H39N7O2Couleur et forme :SolidMasse moléculaire :541.69EPZ011989 HCl(1598383-40-4 Free base)
CAS :EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.Formule :C35H51N5O4·HClCouleur et forme :SolidMasse moléculaire :642.27TCJL37
CAS :TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.Formule :C17H11ClF2N4O2Couleur et forme :SolidMasse moléculaire :376.74JAK-IN-17
"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."Formule :C33H38F2N6O8Couleur et forme :SolidMasse moléculaire :684.69JAK-IN-24
CAS :JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.Formule :C20H25N5O2Couleur et forme :SolidMasse moléculaire :367.44NSC756093
CAS :NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.Formule :C20H19NO4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :337.37Ref: TM-T24557
1mg47,00€5mg92,00€10mg157,00€25mg329,00€50mg490,00€100mg700,00€500mg1.406,00€1mL*10mM (DMSO)117,00€OM-1700
CAS :OM-1700 inhibits tankyrase 1 (IC50=127 nM) and 2 (IC50=14 nM); hinders colon cancer cell growth, COLO 320DM (GI50=650 nM).Formule :C25H23FN6O2Couleur et forme :SolidMasse moléculaire :458.49PRT543
CAS :PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.Formule :C17H17ClN4O4Couleur et forme :SolidMasse moléculaire :376.79Lin281632
CAS :Lin281632 is an inhibitor of RNA binding protein Lin28 and bromodomain. Lin281632 promotes mESC differentiation.Formule :C15H15N5ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :281.31Ref: TM-T27835
1mg34,00€5mg71,00€10mg101,00€25mg212,00€50mg340,00€100mg535,00€500mg1.144,00€1mL*10mM (DMSO)79,00€BRCA1-IN-2
CAS :BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.Formule :C26H33N4O7PDegré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :544.54PRMT5-IN-16
CAS :PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.Formule :C25H34N8O2Couleur et forme :SolidMasse moléculaire :478.591,2-Didecanoyl-sn-glycerol
CAS :GNN14490, a substrate for human pancreatic lipase, is utilized to create monomolecular films for enzyme assay studies.Formule :C23H44O5Couleur et forme :SolidMasse moléculaire :400.6GSK-2807 free base
CAS :GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.Formule :C19H32N8O5Couleur et forme :SolidMasse moléculaire :452.51ZL0420
CAS :ZL0420: Potent, selective BRD4 inhibitor, IC50 27 nM BD1 & 32 nM BD2.Formule :C16H16N4O2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :296.32MS023 trihydrochloride
CAS :MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.Formule :C17H28Cl3N3ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :396.78PARP7-probe-1
CAS :PARP7-probe-1: biotinylated, chemiluminescent PARP7 active site probe for research use.Formule :C36H49F3N8O5SCouleur et forme :SolidMasse moléculaire :762.89CBP/p300-IN-19
CAS :CBP/p300-IN-19 inhibits p300/CBP HAT (IC50: 1.4μM), less effective on PCAF/Myst3, shows anti-tumor properties.Formule :C30H27N3O3Couleur et forme :SolidMasse moléculaire :477.55Prolyl Hydroxylase inhibitor 1
CAS :Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).Formule :C19H18ClN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.83BATCP
CAS :BATCP is an inhibitor of histone deacetylases (HDAC) [1].Formule :C23H28F3N3O6Couleur et forme :SolidMasse moléculaire :499.487ZLN024
CAS :ZLN024 is an activator of AMPK allosteric.Formule :C13H13BrN2OSDegré de pureté :99.751%Couleur et forme :SolidMasse moléculaire :325.22Ref: TM-T13411
1mg93,00€5mg177,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)178,00€TNKS1/2-IN-1
CAS :TNKS1/2-IN-1: potent inhibitor for cancer, fibrosis research; pIC50 7.1-8.2.Formule :C26H23F4N3O4Couleur et forme :SolidMasse moléculaire :517.47SIRT6-IN-3
CAS :SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFormule :C21H30Br3ClN6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.73ZINC08792355
CAS :ZINC08792355 is a novel inhibitor of SIRT1.Formule :C31H24N4O3Couleur et forme :SolidMasse moléculaire :500.55RTS-V5
CAS :RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).Formule :C27H35N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.6Luteolin 7-sulfate
CAS :Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.Formule :C15H10O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.3AMPK activator 7
CAS :AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.Formule :C23H22F3N3O5Couleur et forme :SolidMasse moléculaire :477.43PARPYnD
CAS :PARPYnD: Photoaffinity PARP probe; inhibits PARP2, PARP1, PARP6 (IC50: 6, 38, 230 nM); tags PARP1/2 with N3 fluorescent probe.Formule :C34H31N9O3Couleur et forme :SolidMasse moléculaire :613.67I-BET762 carboxylic acid
CAS :I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).Formule :C20H17ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.83L-Moses
CAS :L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).Formule :C21H24N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.46ZINC08792229
CAS :ZINC08792229 is a novel inhibitor of SIRT1.Formule :C30H22N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.52HA-1004 dihydrochloride
CAS :HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel proteinFormule :C12H16ClN5O2SDegré de pureté :98%Couleur et forme :White Crystalline SolidMasse moléculaire :329.81MS67
CAS :MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14CBP/p300-IN-19 hydrochloride
CAS :CBP/p300-IN-19 HCl is a p300/CBP HAT inhibitor (IC50: p300 1.4 μM, CBP 2.2 μM) with antitumor properties.Formule :C30H28ClN3O3Couleur et forme :SolidMasse moléculaire :514.02Gö 7874
CAS :Gö 7874 is a potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC).Formule :C27H26N4O4Couleur et forme :SolidMasse moléculaire :470.52BChE/HDAC6-IN-1
CAS :BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6.Formule :C34H43N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :601.74Nesuparib
CAS :Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.Formule :C23H24N6ODegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :400.48Ref: TM-T61932
1mg94,00€5mg200,00€10mg319,00€25mg573,00€50mg782,00€100mg1.063,00€1mL*10mM (DMSO)220,00€AKB-6899
CAS :AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treatedFormule :C14H11FN2O4Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :290.25KT-531
CAS :KT-531 (KT531) is a highly potent and selective HDAC6 inhibitor with an IC50 value of 8.5 nM and is 39-fold more selective against other HDAC isoenzymes.Formule :C17H14F4N2O4SCouleur et forme :SolidMasse moléculaire :418.36KDM2A/7A-IN-1
CAS :KDM2A/7A-IN-1 is a KDM2A/7A inhibitor with potential anti-tumour activity for the study of duodenal adenomas and ossifying fibromucoid tumours.Formule :C33H38N4ODegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :506.68RK-701
CAS :RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54EPZ031686
CAS :EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.
Formule :C26H34ClF3N4O4SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :591.09AU-15330
CAS :AU-15330 is a proteolytic targeting chimera (PROTAC) that simultaneously targets SMARCA4, SMARCA2, and PBRM1 for degradation and exhibits cytotoxicity in H3.3K27M cells but not in H3 wild-type cells. Cost-effective and quality-assured.Formule :C39H49N9O5SDegré de pureté :98.21% - 99.62%Couleur et forme :SolidMasse moléculaire :755.93E7016
CAS :E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.
Formule :C20H19N3O3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :349.38PARP-1-IN-4
CAS :PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.Formule :C22H15Cl2N3O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :424.28HS94
CAS :HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.
Formule :C15H15N5O2SDegré de pureté :95.04%Couleur et forme :SolidMasse moléculaire :329.38KDM4-IN-4
CAS :KDM4-IN-4 is a KDM4 inhibitor with anticancer activity that inhibits the KDM4A-Tudor structural domain for cancer research.Formule :C16H23NODegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :245.36CPI-0610 carboxylic acid
CAS :CPI-0610 carboxylic acid is a selective BET protein inhibitor with potential anticancer effects.Formule :C20H15ClN2O3Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :366.8hRIO2 kinase ligand-1
CAS :hRIO2 kinase ligand-1 is a potent ligand for hRIO2 kinase (Kd: 520 nM).Formule :C17H14N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :262.31CCT129202
CAS :CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Formule :C23H25ClN8OSDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :497.02Piflufolastat
CAS :Piflufolastat (DCFPYL) is a PET imaging agent for prostate cancer PSMA.Formule :C18H23FN4O8Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :442.4Ref: TM-T31224
1mg54,00€5mg114,00€10mg178,00€25mg409,00€50mg708,00€100mg1.224,00€1mL*10mM (DMSO)138,00€JAK-IN-3
CAS :JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.Formule :C18H20N4O3Degré de pureté :98.04% - 98.19%Couleur et forme :SolidMasse moléculaire :340.38Ref: TM-T11704
1mg126,00€2mg178,00€5mg304,00€10mg492,00€25mg982,00€50mg1.558,00€100mg2.538,00€200mg3.402,00€1mL*10mM (DMSO)334,00€FHT-1015
CAS :FHT-1205 is a potent inhibitor (IC50 ≤ 10 nM) of SMARCA4/SMARCA2 ATPase (BRG1 and BRM).Formule :C25H25N5O4S3Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :555.69Ref: TM-T63925
1mg54,00€5mg114,00€10mg178,00€25mg356,00€50mg580,00€100mg888,00€1mL*10mM (DMSO)138,00€NPAS3-IN-1
CAS :NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.Formule :C10H5N3O2S3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :295.36JWG-071
CAS :JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.Formule :C34H44N8O3Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :612.77LY3295668
CAS :LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formule :C24H26ClF2N5O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :489.95CeMMEC1
CAS :CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).Formule :C19H16N2O4Degré de pureté :98.9% - 99.92%Couleur et forme :SolidMasse moléculaire :336.34PKC-IN-1
CAS :PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Formule :C25H37FN8O2Degré de pureté :98% - 98.79%Couleur et forme :SolidMasse moléculaire :500.61Y06137
CAS :Y06137, selective BET inhibitor, Kd 81 nM for BRD4(1), researched for castration-resistant prostate cancer treatment.Formule :C27H32N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :444.57PRMT5-IN-18
CAS :PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.Formule :C32H42N4O4Couleur et forme :SolidMasse moléculaire :546.70Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.Formule :C16H20N6OCouleur et forme :SolidMasse moléculaire :312.37HuR degrader 2
CAS :HuRdegrader 2 (Compound 3) is a molecular glue that targets and degrades the RNA-binding protein Hu antigen R (HuR), achieving 30% degradation at 0.1 μM. It inhibits the proliferation of Colo-205 cancer cells with an IC50 of ≤200 nM. HuRdegrader 2 also shows high affinity for cereblon with an HTRF ratio < 0.02.Formule :C20H15N3O3Masse moléculaire :345.35SIRT6 activator 2
CAS :SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Formule :C23H23N3O6Couleur et forme :SolidMasse moléculaire :437.45PFI-6-COOH
CAS :PFI-6-COOH (Compound 18) is a ligand for the eleven-nineteen leukemia (ENL) protein, and is utilized in the synthesis of the ENL PROTAC degrader MS41.Formule :C23H21N3O6Couleur et forme :SolidMasse moléculaire :435.43Octyl-α-hydroxyglutarate
CAS :Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.Formule :C13H24O5Masse moléculaire :260.33MRK-740-NC
CAS :MRK-740-NC is an inhibitor of the PRDM7/9 histone methyltransferase. Acting as the negative control compound for MRK-740, MRK-740-NC lacks inhibitory activity on PRDM7 and PRDM9 because the methylpyridine portion of MRK-740 is replaced with a phenyl group.Formule :C25H31N5O3Couleur et forme :SolidMasse moléculaire :449.55Menin-MLL inhibitor 26
CAS :Menin-MLL inhibitor 26: Active reference, inhibits cell growth, used in leukemia research.Formule :C27H29F3N6O3SCouleur et forme :SolidMasse moléculaire :574.62LNK01004
CAS :LNK01004 is a JAK inhibitor that exhibits potent inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50: ＜0.51 nM), and TYK2 (IC50: 1.0 nM). It can concurrently inhibit multiple cytokine-induced p-STAT signaling pathways and is applicable for research on diseases such as atopic dermatitis.Formule :C26H31N7O2Couleur et forme :SolidMasse moléculaire :473.57TK-129
TK-129: Oral KDM5B inhibitor, IC50=44 nM, low-toxicity, cardioprotective, aids in heart disease research.Formule :C15H23N5O2Couleur et forme :SolidMasse moléculaire :305.38Zavondemstat L-lysine
CAS :Zavondemstat (L-lysine) (QC8222; TACH 101) is an inhibitor of the histone lysine demethylase 4D (KDM4D) with antitumor properties.Formule :C32H43N5O5Masse moléculaire :577.71NSD2-PWWP1-IN-3
CAS :NSD2-PWWP1-IN-3 (compound 36) is an effective inhibitor of NSD2-PWWP1, with an IC50 value of 8.05 µM. It has potential applications in cancer research.Formule :C34H39N5O2Couleur et forme :SolidMasse moléculaire :549.706Bromodomain inhibitor-13
CAS :Bromodomain Inhibitor-13 (Compound 1), an analog of PFI-3, is a bromodomain-containing protein (BCP) inhibitor. It specifically targets the bromodomains of SMARCA2, SMARCA4, and the first and second bromodomains of PB1 [PB1(5) and PB1(2)], with dissociation constants (KD) of 37, 53, 30, and 190 nM, respectively.Formule :C21H22N4O2Couleur et forme :SolidMasse moléculaire :362.43Conophyllidine
CAS :Conophyllidine is a bisindole alkaloid and functions as a selective inhibitor of M2 polarization. It inhibits histone acetylation by targeting the histone acetyltransferase domain of the P300/CBP proteins. The IC50 of Conophyllidine for IL-4-induced arginase inhibition is 0.31 μM. This compound effectively induces tumor-associated macrophages (TAMs) to shift from an anti-inflammatory to an inflammatory state, thereby enhancing the recruitment and function of cytotoxic CD8+ T cells in the tumor microenvironment. Conophyllidine is useful for studying tumor-associated macrophages.Formule :C44H50N4O9Couleur et forme :SolidMasse moléculaire :778.89KMT9-IN-1
CAS :KMT9-IN-1 (Compound 8) is a KMT9 inhibitor and an ethyl ester prodrug of compound 7b. Inside cells, KMT9-IN-1 releases the active form 7b through the action of esterases. It specifically associates with the KMT9 target within cells, leading to a reduction in H4K12me1 levels. KMT9-IN-1 exhibits antitumor activity against colon cancer and can be employed in research on prostate cancer and hepatocellular carcinoma.Formule :C36H47ClFN7O5Couleur et forme :SolidMasse moléculaire :712.25TDI-015051
CAS :TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.Formule :C22H22FN5O4SCouleur et forme :SolidMasse moléculaire :471.505EED ligand 1
EED ligand 1: potent PRC2 inhibitor targeting EED subunit.Formule :C19H19FN8OCouleur et forme :SolidMasse moléculaire :394.41Protein kinase inhibitor 7
CAS :Protein kinase inhibitor 7 functions as an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). It impacts the autocrine motility factor (AMF) signaling pathway without affecting cell motility.Formule :C12H15N3O2SMasse moléculaire :265.33MDH1/2-IN-1
CAS :MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.Formule :C25H33NO4Couleur et forme :SolidMasse moléculaire :411.534ZL-28-6
CAS :ZL-28-6, a type I PRMT inhibitor (IC50: 18 nM), effectively targets CARM1 (a member of PRMT) within cells and is suitable for cancer research [1].Formule :C18H22Cl2N2OCouleur et forme :SolidMasse moléculaire :353.29Basroparib
CAS :Basroparib is an inhibitor of ribose polymerase (PARP) and has shown antitumour effects.Formule :C18H21F2N7O3Couleur et forme :SolidMasse moléculaire :421.4HDAC6-IN-51
CAS :HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.Formule :C24H24ClN5O3Couleur et forme :SolidMasse moléculaire :465.93AZ-3
CAS :AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).Formule :C20H28FN7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :385.48L-Moses dihydrochloride
L-Moses (L-45) dihydrochloride is the first, potent, selective p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor (Kd: 126 nM).Formule :C21H26Cl2N6Couleur et forme :SolidMasse moléculaire :433.38HDAC6-IN-59
CAS :HDAC6-IN-59 (Compound 38k) is a highly selective inhibitor of histone deacetylase 6 (HDAC6), with an IC50 of 3.12 nM and a 352-fold selectivity over HDAC1. It holds potential for research in esophageal cancer.Formule :C22H18ClN5O2Couleur et forme :SolidMasse moléculaire :419.86IOR-160
CAS :IOR-160 is a dual inhibitor of casein kinase 2 (CK2) and HDAC. It exhibits high selectivity for CK2 with an IC50 of 1.7 nM and demonstrates broad inhibitory activity against HDAC (HDAC1, 2, 3, and 6) with IC50 values of 3.3 nM, 24.0 nM, 3.9 nM, and 13.0 nM, respectively, while showing low activity against HDAC8. IOR-160 modulates critical cell signaling pathways by inhibiting AKT phosphorylation and increasing α-tubulin acetylation. The compound reduces tumor growth and burden through its dual inhibition of CK2/HDAC and is relevant for research on triple-negative breast cancer.Formule :C23H25F3N4O6Couleur et forme :SolidMasse moléculaire :510.46(Rac)-RG108
CAS :(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.Formule :C19H14N2O4Couleur et forme :SolidMasse moléculaire :334.326HbF inducer-1
HbF inducer-1 is a fetal hemoglobin inducer which is orally bioavailable.Formule :C18H19N3O3Couleur et forme :SolidMasse moléculaire :325.36HLCL-61
CAS :HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).Formule :C23H24N2OCouleur et forme :SolidMasse moléculaire :344.45KAT6A-IN-1
CAS :KAT6A-IN-1 (compound 5) is an inhibitor of KAT6A.Formule :C23H27N5O5SCouleur et forme :SolidMasse moléculaire :485.56
