Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2612 produits trouvés pour "Chromatine/Épigénétique"
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MI-1481
CAS :MI-1481: potent MML1 inhibitor, IC50 3.6 nM; disrupts menin-MLL1, active in MLL leukemia.Formule :C29H30F3N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :597.65lirucitinib
CAS :Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.Formule :C16H25N5OSCouleur et forme :SolidMasse moléculaire :335.468Aurora A inhibitor 1
CAS :Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)Formule :C25H28ClF2N5O2Couleur et forme :SolidMasse moléculaire :503.97Balanol
CAS :Balanol is an ATP-competitive Protein Kinase C and Protein Kinase A inhibitor.Formule :C28H26N2O10Couleur et forme :SolidMasse moléculaire :550.51Dot1L-IN-1
CAS :The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.Formule :C32H36ClN9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.21KAT6A-IN-2
CAS :KAT6A-IN-2 (compound 7) is an inhibitor of KAT6A.Formule :C23H29N5O5SCouleur et forme :SolidMasse moléculaire :487.57ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Formule :C19H22N4O3SCouleur et forme :SolidMasse moléculaire :386.47PARP1/2-IN-4
CAS :PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.Formule :C23H30FN5O6Couleur et forme :SolidMasse moléculaire :491.51G-631
CAS :G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.Formule :C19H22F2N6O3Couleur et forme :SolidMasse moléculaire :420.41XP-524
CAS :XP-524: BET & EP300 inhibitor, suppresses KRAS tumors in vivo, targets PDAC, boosts immune response.Formule :C30H28N6O3SCouleur et forme :SolidMasse moléculaire :552.65CP-352664
CAS :CP-352664 is a JAK inhibitor with potency against JAK3, exhibiting an EC50 value of 210 nM. It holds potential for use in research related to organ transplant rejection and autoimmune diseases, such as rheumatoid arthritis.Formule :C18H18N4Couleur et forme :SolidMasse moléculaire :290.36RU-0415529
CAS :RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.Formule :C21H29N3O4SCouleur et forme :SolidMasse moléculaire :419.538LSD1-IN-22
LSD1-IN-22: potent LSD1 inhibitor, K_i 98 nM, curbs cancer cell growth.Formule :C9H8BrF2NCouleur et forme :SolidMasse moléculaire :248.07BRD4 D1-IN-2
BRD4 D1-IN-2 (compound 26), a BRD4 D1 inhibitor, IC50 <0.092 μM, 15 nM affinity, >500x selectivity over BRD2 D1/BRD4 D2.Formule :C33H39F3N6OCouleur et forme :SolidMasse moléculaire :592.7AJI-214
CAS :AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD).Formule :C17H13ClFN5OCouleur et forme :SolidMasse moléculaire :357.77SMARCA2-IN-2
CAS :Compound I-25, also known as SMARCA2-IN-2, is a SMARCA2 inhibitor (IC 50: 101-500 μM) with applications in cancer research.Formule :C16H17N3Couleur et forme :SolidMasse moléculaire :251.33SGC-BRDVIII-NC
CAS :SGC-BRDVIII-NC (Compound 35) serves as a negative control for the SMARCA2/4 and PB1 bromodomain (BRD) inhibitors. The binding ability of the protein-ligand is completely eliminated in SGC-BRDVIII-NC through the methylation of the phenolic hydroxyl group. This compound is applicable for research in adipogenesis.Formule :C20H27N5O3Couleur et forme :SolidMasse moléculaire :385.46rel-A-395 hydrochloride
CAS :rel-A-395 hydrochloride is the relative configuration of A-395 hydrochloride. A-395 is an antagonist of protein-protein interactions within the polycomb repressive complex 2 (PRC2). It inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 value of 18 nM.Formule :C26H36ClFN4O2SCouleur et forme :SolidMasse moléculaire :523.11SGC6870N
CAS :SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.Formule :C23H21BrN2O2SMasse moléculaire :469.39BET-IN-1
BET-IN-1 is a potent inhibitor of BET, exhibiting good brain permeability and a reasonable metabolic stability.Formule :C23H24ClFN4O3SCouleur et forme :SolidMasse moléculaire :490.98QCA570
CAS :QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).Formule :C39H33N7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :695.79LSD1-IN-15
LSD1-IN-15 inhibits LSD1, MAO-A/B with IC50s: 0.149, 0.028, 0.327 μM; arrests LNCaP cancer cell growth, IC50 9.9 μM.Formule :C22H20N2OCouleur et forme :SolidMasse moléculaire :328.41JAK2 JH2 binder-1
CAS :JAK2 JH2 binder-1: potent, selective, Ki=37.1 nM, potential for studying myeloproliferative neoplasms.Formule :C29H25N7O6SCouleur et forme :SolidMasse moléculaire :599.62CEE321
CAS :CEE321 is an effective pan-JAK inhibitor with an IC50 of 54 nM. It effectively inhibits biomarkers associated with atopic dermatitis.Formule :C18H16ClN5OCouleur et forme :SolidMasse moléculaire :353.806PRMT5-IN-50
CAS :PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.Formule :C26H23F3N6OCouleur et forme :SolidMasse moléculaire :492.496DS79932728
CAS :DS79932728 is an orally active inhibitor of G9a and GLP, with IC50 values of 12.6 nM and 75.7 nM, respectively. It induces the production of γ-globin, thereby increasing fetal hemoglobin (HbF) levels. In cynomolgus monkey models, DS79932728 enhances the proportion of F-reticulocytes (F-rets) and shows good oral absorption characteristics.Formule :C19H25N3OCouleur et forme :SolidMasse moléculaire :311.421PAD-IN-2
CAS :PAD-IN-2, potent PAD4 inhibitor, IC50 <1 μM; targets autoimmune/cancer disorders.Formule :C27H28ClN5O2Couleur et forme :SolidMasse moléculaire :490CCW 28-3
CAS :CCW 28-3 is a novel potent covalent BRD4 degrader, degrading BRD4 in a proteasome- and RNF4-dependent manner without inhibiting RNF4 autoubiquitination activityFormule :C44H42Cl2N6O4SCouleur et forme :SolidMasse moléculaire :821.81Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12PRMT5-IN-3
CAS :PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells.Formule :C22H23F3N4O3Couleur et forme :SolidMasse moléculaire :448.44Dioleyl phosphatidylserine
CAS :Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.Formule :C42H78NO10PCouleur et forme :SolidMasse moléculaire :788.04MS8511
CAS :MS8511: Selective, irreversible G9a/GLP inhibitor. IC50: 100 nM (G9a), 140 nM (GLP). Lowers H3K9me2, anti-proliferative. Useful in cancer/AD/PWS research.Formule :C28H41N5O3Couleur et forme :SolidMasse moléculaire :495.665-Ph-IAA-AM
5-Ph-IAA-AM, eggshell-permeable analog of 5-Ph-IAA, boosts protein degradation in embryos, useful for studying proteins in C. elegans.Formule :C19H17NO4Couleur et forme :SolidMasse moléculaire :323.34AMPTX-1
CAS :AMPTX-1 is a molecular glue functioning as a potent, selective, and reversible covalent degrader of BRD9 by recruiting it to the E3 ligase DCAF16.Formule :C42H53N5O4Couleur et forme :SolidMasse moléculaire :691.901PKCiota-IN-1
CAS :PKCiota-IN-1: Strong PKC-ι inhibitor (IC50=2.7 nM); also blocks PKC-α/ε (IC50s=45/450 nM).Formule :C25H22FN5OCouleur et forme :SolidMasse moléculaire :427.47(1-Nitroethene-1,2-diyl)dibenzene
CAS :(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.Formule :C14H11NO2Couleur et forme :SolidMasse moléculaire :225.24BRD4 D1-IN-1
BRD4 D1-IN-1 selectively inhibits BRD4 D1 (IC50 <0.092 μM, Kd 18 nM) with >500-fold specificity versus D2.Formule :C32H37F3N6OCouleur et forme :SolidMasse moléculaire :578.67(Rac)-Nanatinostat
CAS :(Rac)-Nanatinostat ((Rac)-CHR-3996, example 44) is a potent HDAC inhibitor with an IC50 of less than 330 nM. It exhibits anticancer properties, effectively inhibiting the growth of HeLa, U937, and HUT cells.Formule :C20H19FN6O2Couleur et forme :SolidMasse moléculaire :394.402BRD4-IN-7
CAS :BRD4-IN-7, also known as compound 120, acts as a BRD4 inhibitor.Formule :C29H24F2N4O3Couleur et forme :SolidMasse moléculaire :514.52HDAC-IN-47
HDAC-IN-47: Oral HDAC inhibitor (IC50: 19.75-302.73 nM for HDAC1-8), blocks G2/M, inhibits autophagy, triggers apoptosis, anti-cancer in vivo.Formule :C17H20BrN3O4Couleur et forme :SolidMasse moléculaire :410.26NVS-BPTF-1
CAS :NVS-BPTF-1 is a specific inhibitor of bromodomain and PHD finger containing transcription factor (BPTF), exhibiting a dissociation constant (K_D) of 71 nM [1].Formule :C26H28FN7O3SCouleur et forme :SolidMasse moléculaire :537.61LSD1/2-IN-4
LSD1/2-IN-4, a PCPA derivative, inhibits LSD1 (Ki 0.11 μM) & LSD2 (Ki 130 μM), potentially useful in T-cell leukemia research.Formule :C9H8BrF2NCouleur et forme :SolidMasse moléculaire :248.07Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Formule :C28H46N8O6SCouleur et forme :SolidMasse moléculaire :622.78PRMT5-IN-32
CAS :PRMT5-IN-32, an inhibitor of PRMT5, inhibits HCT116 cell proliferation with an IC50 of 0.13 μM [1].Formule :C27H21F4N5O2Couleur et forme :SolidMasse moléculaire :523.48SARS-CoV-2 nsp14-IN-1
SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.Formule :C20H20N6O5SCouleur et forme :SolidMasse moléculaire :456.48(2R)-Octyl-α-hydroxyglutarate sodium
CAS :(Sodium) (2R)-Octyl-α-hydroxyglutarate is the sodium salt variant of (2R)-Octyl-α-hydroxyglutarate, which has been shown to possess anti-inflammatory properties [1].Formule :C13H23NaO5Couleur et forme :SolidMasse moléculaire :282.31EBET-590
CAS :EBET-590 is a BET inhibitor utilized in cancer research.Formule :C26H26N4O3Masse moléculaire :442.51Ten01
Ten01 exhibits a 5.0 nM inhibition of JAK1 kinase.Formule :C18H20F6N4OCouleur et forme :SolidMasse moléculaire :422.37PARP-1-IN-1
PARP-1-IN-1: Selective, oral PARP-1 inhibitor with 0.96 nM IC50; well-tolerated and effective in single-dose MDA-MB-436 model.Formule :C23H25FN4OCouleur et forme :SolidMasse moléculaire :392.47NSD2-PWWP1-IN-2
CAS :NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.Formule :C29H30N4Couleur et forme :SolidMasse moléculaire :434.575MAO A/HDAC-IN-1
MAO A/HDAC-IN-1 is an effective monoamine oxidase A (MAO A) and HDAC dual inhibitor, which can be used for glioma research.Formule :C21H24ClN3O3Couleur et forme :SolidMasse moléculaire :401.89PRMT5-IN-49
CAS :PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39JAK3-IN-7
CAS :JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction afterFormule :C17H20N6ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :324.38BRD4 Inhibitor-33
CAS :BRD4 Inhibitor-33 (example 13), a potent inhibitor of BRD4, is applicable in research related to both acute and chronic kidney diseases [1].Formule :C24H20N4O2Couleur et forme :SolidMasse moléculaire :396.44Enzomenib
CAS :Enzomenib (DSP5336), a menin protein inhibitor encoded by the multiple endocrine neoplasia (MEN) gene, blocks the interaction between menin protein and mixed lineage leukemia (MLL) fusion proteins. This compound is utilized in researching hematological malignancies.Formule :C33H43FN6O3Couleur et forme :SolidMasse moléculaire :590.73PARP-1/HDAC-IN-1
CAS :PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.Formule :C22H18N4O4Degré de pureté :95.94%Couleur et forme :SolidMasse moléculaire :402.4ATR kinase-IN-2
CAS :ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.Formule :C24H29F2N9O2Couleur et forme :SolidMasse moléculaire :513.54Azaphilone-9
CAS :AZA-9 inhibits cancer growth by blocking HuR-ARE RNA binding; IC50=1.2μM.Formule :C21H23BrO5Couleur et forme :SolidMasse moléculaire :435.31PF-06263276
CAS :PF-06263276 selectively inhibits pan-JAK with IC50: JAK1 (2.2 nM), JAK2 (23.1 nM), JAK3 (59.9 nM), TYK2 (29.7 nM).Formule :C31H31FN8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.63BET-IN-6
CAS :BET-IN-6: Potent BRD2/4 inhibitor and ligand for PROTAC BRD2/BRD4 degrader-1 synthesis.Formule :C22H20N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.47HIF-2α-IN-7
CAS :HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.Formule :C18H9F6NO2Couleur et forme :SolidMasse moléculaire :385.26JAK1/TYK2-IN-3
JAK1/TYK2-IN-3, orally active, selectively inhibits TYK2 (IC50: 6 nM), JAK1 (37 nM), JAK2 (140 nM), JAK3 (362 nM), and has anti-inflammatory effects.Couleur et forme :SolidBPTF-IN-BZ1
CAS :BPTF-IN-BZ1 is a BPTF inhibitor that possesses a high potency with a Kd of 6.3 nM.Formule :C13H15ClN4OCouleur et forme :SolidMasse moléculaire :278.74MC2652
MC2652, a potent LSD1 inhibitor, suppresses leukemia (MV4-11, NB4) and impedes prostate cancer (LNCaP) cell growth.Formule :C22H20N2OCouleur et forme :SolidMasse moléculaire :328.41MTL-CEBPA
MTL-CEPBA is a small activating RNA that targets C/EBPα upregulation and exhibits anti-inflammatory and anti-cancer effects.Couleur et forme :SolidROPA
CAS :ROPA, a potent PKCalpha and PKCgamma activator, promotes tumor growth through PKC-activation.Formule :C28H32O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.55GSK8814
CAS :GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan).Formule :C28H35F2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.61AMI-408
CAS :AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.Formule :C20H13Cl2N6NaO5SCouleur et forme :SolidMasse moléculaire :543.32ER272
CAS :ER272 is a natural PKC activator, inducing hippocampal neurogenesis.Formule :C24H34O6Couleur et forme :SolidMasse moléculaire :418.52PARP14 inhibitor 2
CAS :PARP14 inhibitor2 (Compound 3) is an orally active and highly selective PARP14 inhibitor with an IC50 value of less than 30 nM. It effectively inhibits the mono ADP-ribosyltransferase activity of PARP14 and modulates IFN-γ and IL-4 signaling, thereby reversing pro-tumor macrophage polarization and suppressing anti-tumor inflammatory responses. PARP14 inhibitor2 holds potential for research in PARP14-related conditions such as tumors, atopic dermatitis, and autoimmune diseases.Formule :C25H32FN3O4SCouleur et forme :SolidMasse moléculaire :489.60OM-153
CAS :OM-153 blocks tankyrase 1 (IC50: 13 nM) and 2 (IC50: 2 nM), stifling WNT signaling and COLO 320DM cell growth.Formule :C28H24FN7O2Couleur et forme :SolidMasse moléculaire :509.53MU1656
CAS :MU1656 is a selective inhibitor of histone methyltransferase DOT1L, which significantly inhibits cancer cell proliferation in hematological malignancies.Formule :C32H45N7O2Degré de pureté :96.92%Couleur et forme :SolidMasse moléculaire :559.75Tyk2-IN-10
CAS :Tyk2-IN-10 acts as an inhibitor of the Tyrosine Kinase 2 (Tyk2)-mediated signaling pathway, which plays a role in inflammation regulation.Formule :C25H27N5O3Couleur et forme :SolidMasse moléculaire :445.51WW437
WW437 is a histone deacetylase (HDAC) inhibitor that exhibits potent anti-breast cancer activity both in vitro and in vivo.Formule :C23H27N5O4Couleur et forme :SolidMasse moléculaire :437.49Purinostat
CAS :Purinostat is a selective inhibitor of HDACI/IIb with potential anti-leukemic properties. Its mesylate form, Purinostat mesylate, is effective at inhibiting the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDACI/IIb, impacting several crucial factors for leukemia stem cell (LSC) survival, such as c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Additionally, Purinostat mesylate enhances glutamate metabolism in LSCs by increasing GLS1.Formule :C23H26N10O3Couleur et forme :SolidMasse moléculaire :490.518HDAC11-IN-2
CAS :HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.Formule :C25H35N3O3Couleur et forme :SolidMasse moléculaire :425.564PAD2-IN-1 hydrochloride
PAD2-IN-1 hydrochloride: potent, selective PAD2 inhibitor; 95x less on PAD4, 79x less on PAD3; benzimidazole derivative.Formule :C25H30ClFN6O3Couleur et forme :SolidMasse moléculaire :517BRD4-IN-9
CAS :BRD4-IN-9, an orally active BRD4 inhibitor, demonstrates a potent IC50 of 9.4 nM. In a murine melanoma xenograft model, it effectively inhibits tumor growth.Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.46LSD1-IN-13 hydrochloride
CAS :LSD1-IN-13 hydrochloride (7e) is an oral LSD1 inhibitor (IC50: 24.43 nM), promoting differentiation in AML cell lines.Formule :C23H30ClN3O2SCouleur et forme :SolidMasse moléculaire :448.02YLIU-4-105-1
CAS :YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Formule :C32H34F3N7O2Couleur et forme :SolidMasse moléculaire :605.65Tyk2-IN-15
CAS :Tyk2-IN-15 (Compound 97) is a selective inhibitor of tyrosine kinase 2 (Tyk2) with an IC50 value ≤ 10 nM for Tyk2-JH2. It is utilized in the research of inflammatory and autoimmune diseases [1].Formule :C21H25F2N7OCouleur et forme :SolidMasse moléculaire :429.47SIRT1-IN-5
CAS :SIRT1-IN-5 (215) is a modulator of NAD-dependent deacetylase SIRT1 with potential applications in cancer and cellular signaling research.Formule :C21H17N3O3SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :391.44PRMT5-IN-48
CAS :PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).Formule :C30H37N5O3Couleur et forme :SolidMasse moléculaire :515.646GNE-886
CAS :GNE-886 has a wide range of applications in life science related research.Formule :C28H30N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.59PARP7-IN-23
CAS :PARP7-IN-23 (compound 56) is a potent PARP7 inhibitor with an EC50 of 0.915 nM for pSTAT1 in NCI-H1373 cells, indicating its potential for cancer research.
Formule :C27H22F7N5O3Couleur et forme :SolidMasse moléculaire :597.48415:0 PG sodium
CAS :15:0 PG sodium serves as an activator for the Protein Kinase C family and is an anionic phospholipid located in the membranes of mitochondria and microsomes. It plays a crucial role in the composition of pulmonary surfactants, especially within the membrane of the pulmonary lamellar bodies.Formule :C36H70NaO10PCouleur et forme :SolidMasse moléculaire :716.90XP5
XP5 is an oral HDAC6 inhibitor, potent against cancer cells, including YCC3/7 (IC50=31 nM to 2.31 μM).Formule :C19H25N3O5SCouleur et forme :SolidMasse moléculaire :407.48TD034
CAS :TD034 is a selective, reversible, non-covalent inhibitor of HDAC11, with an IC50 of 5.1 nM and a Ki of 1.5 nM. It does not inhibit other HDACs or sirtuins. TD034 inhibits the desuccinylation of SHMT2 (a substrate of HDAC11) and lowers YAP1 levels by inhibiting HDAC11. TD034 is applicable for lung cancer research.Formule :C45H64N4O6Couleur et forme :SolidMasse moléculaire :757.01Aurora B inhibitor 1
CAS :Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Formule :C25H26ClF2N7O2Degré de pureté :98.37%Couleur et forme :SolidMasse moléculaire :529.97PARP14 inhibitor 1
CAS :PARP14 inhibitor1 (compound Q22) is a selective inhibitor of PARP14 with an IC50 of 5.52 nM. It also exhibits anti-inflammatory properties and has a half-life of 182 minutes in mouse liver microsomes. This compound is applicable for atopic dermatitis research.
Formule :C23H27FN4O3Couleur et forme :SolidMasse moléculaire :426.484AJI-100
CAS :AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).Formule :C17H14FN5OCouleur et forme :SolidMasse moléculaire :323.32HDAC6-IN-12
HDAC6-IN-12 is a potent inhibitor of HDAC6 that binds in the DNA chain, causing DNA damage and exhibiting anticancer effects that can be used in cancer researchFormule :C24H39F2N3O5Couleur et forme :SolidMasse moléculaire :487.58HIF-2α-IN-5
CAS :HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].Formule :C15H12F4O3S2Couleur et forme :SolidMasse moléculaire :380.38WIZ degrader 1
CAS :WIZ degrader 1 (Compound 141) is a degrader of the wide-interval zinc-finger motif (WIZ) with an AC50 of 2 nM. It can induce the expression of fetal hemoglobin (HbF), exhibiting an EC50 value of 6 mM. WIZ degrader 1 is used in the research of genetic blood disorders.Formule :C25H33F2N5O2Masse moléculaire :473.56Trichostatin A S-isomer
CAS :Trichostatin A S-isomer, a HDAC 1, 3, 4, 6, 10 inhibitor with IC50 ~20 nM, has wide-ranging epigenetic effects.Formule :C17H22N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.37HIF-1α-IN-5
HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.Formule :C16H15N3O2Couleur et forme :SolidMasse moléculaire :281.31TY-011
CAS :TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Formule :C18H16ClN5Couleur et forme :SolidMasse moléculaire :337.81XY153
XY153 (8l) is a BD2 selective BET inhibitor targeting BRD4, 3 & 2 with IC50s: 0.79, 5.31 & 5.09 nM, useful in acute myeloid leukemia & cancer research.Formule :C33H34FN3O4Couleur et forme :SolidMasse moléculaire :555.64DDO-3055
CAS :DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.Formule :C17H13ClN2O5Couleur et forme :SolidMasse moléculaire :360.749Ad-JQ1
CAS :Ad-JQ1 (Compound 16) is a Target Protein Ligand-Linker Conjugate incorporating a BRD4 ligand and a PROTAC linker capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACβ-NF-JQ1.Formule :C37H47ClN6O4SCouleur et forme :SolidMasse moléculaire :707.33
