Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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ZXH-3-26
CAS :<p>ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.</p>Formule :C38H37ClN8O7SDegré de pureté :98.90% - 98.90%Couleur et forme :SolidMasse moléculaire :785.27pan-BET/BD2-IN-1
<p>Pan-BET/BD2-IN-1 (compound 6b) is a selective BET protein inhibitor with BRDT-1Ki of 1.05 μM and BRD4-1Ki of 0.68 μM. It effectively inhibits the growth of MM.1S cancer cells with an IC50 value of 2.6 μM.</p>Couleur et forme :Odour SolidGXH-II-052
<p>GXH-II-052: Potent BET inhibitor, binds BRD4/BRDT (Kd 0.6-28 nM), anti-proliferative, reduces c-Myc expression.</p>Formule :C62H76Cl2F2N14O11S2Couleur et forme :SolidMasse moléculaire :1366.39PRMT5-IN-11
CAS :<p>PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.</p>Formule :C13H17N5O4Couleur et forme :SolidMasse moléculaire :307.31PROTAC BET Degrader-1
CAS :<p>PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.</p>Formule :C44H45N11O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :871.9BBDDL2204
<p>BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.</p>Formule :C37H47N5O5SCouleur et forme :SolidMasse moléculaire :673.32979MNN-02-155
CAS :<p>MNN-02-155 is a bivalent molecular glue that can simultaneously interact with both p300/CBP and BCL6. It effectively induces the activation of BCL6-targeted reporter genes and promotes cell death. This compound is used in the research of diffuse large B-cell lymphoma (DLBCL).</p>Formule :C56H68ClF2N15O7Couleur et forme :SolidMasse moléculaire :1136.69dBET23
CAS :<p>dBET23 is a BRD4 degrader.</p>Formule :C43H45ClN8O9SCouleur et forme :SolidMasse moléculaire :885.38CDD-1102 HCl
<p>CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.</p>Formule :C32H31ClN6O3Degré de pureté :98.30%Couleur et forme :SoildMasse moléculaire :583.08PROTAC BRD9-binding moiety 1
CAS :<p>PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.</p>Formule :C23H25N3O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.59MZP-54
CAS :<p>MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)</p>Formule :C55H66ClN7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1036.67MT1
CAS :<p>MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).</p>Formule :C54H66Cl2N10O9S2Couleur et forme :SolidMasse moléculaire :1134.2JAK-IN-15
CAS :<p>JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).</p>Formule :C22H23FN4O3SCouleur et forme :SolidMasse moléculaire :442.51OARV-771
CAS :<p>OARV-771: VHL-based PROTAC targeting BET; DC50: Brd4-6nM, Brd2-1nM, Brd3-4nM; enhanced cell permeability.</p>Formule :C49H59ClN8O8S2Couleur et forme :SolidMasse moléculaire :987.62BRD4-IN-4
CAS :<p>BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line and</p>Formule :C17H18N2O3SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :330.4KDM4 ligand-1
<p>KDM4ligand-1 is a ligand targeting the protein (histone lysine demethylase KDM4) in PROTACs. It can be utilized for the synthesis of PROTACs.</p>Couleur et forme :Odour SolidPROTAC SMARCA2/4-degrader-25
<p>PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.</p>Formule :C44H50N10O9S2Couleur et forme :SolidMasse moléculaire :927.06(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS :<p>(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.</p>Formule :C41H46N6O6SCouleur et forme :SolidMasse moléculaire :750.91PROTAC BRD4 Degrader-10
CAS :<p>Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.</p>Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5AB3067
<p>AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)</p>Formule :C74H91ClFN11O17S2Couleur et forme :SolidMasse moléculaire :1525.16RX-37
CAS :<p>RX-37, a potent BET inhibitor (Ki: 3.2-24.7 nM for BRD2/3/4), selectively hinders growth in leukemia cells with MLL1 gene rearrangement.</p>Formule :C24H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.47PROTAC BRD4 Degrader-27
CAS :<p>PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2/BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.</p>Formule :C37H30F2N6O7Couleur et forme :SolidMasse moléculaire :708.67Uzansertib
CAS :<p>Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.</p>Formule :C26H26F3N5O3Couleur et forme :SolidMasse moléculaire :513.51PROTAC BRD4 Degrader-13
CAS :<p>PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.</p>Formule :C68H85F2N11O17P2S2Couleur et forme :SolidMasse moléculaire :1492.55α-Hydroxyglutaric Acid
CAS :<p>α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.</p>Formule :C5H8O5Couleur et forme :SolidMasse moléculaire :148.114DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Couleur et forme :Odour SolidTyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Couleur et forme :Odour SolidSAH-EZH2
CAS :<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Formule :C155H256N48O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3432.05TNKS-2-IN-2
CAS :<p>TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.</p>Formule :C26H23N3O6Degré de pureté :99.45%Couleur et forme :SoildMasse moléculaire :473.48Pumecitinib
CAS :<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Formule :C17H20N8O2SDegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :400.46R 8605
CAS :<p>R 8605 is a third-generation retinoid.</p>Formule :C22H27NO4Couleur et forme :SolidMasse moléculaire :369.45(S)-GNE-987
<p>(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).</p>Formule :C56H67F2N9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1096.31dBAZ2
<p>dBAZ2 is a pioneering PROTAC degrader targeting BAZ2A and BAZ2B, with DC50 values of 180 nM for BAZ2A and 250 nM for BAZ2B.</p>Formule :C54H64FN11O5S2Couleur et forme :SolidMasse moléculaire :1030.29NSC 370284
CAS :<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43KDM1A-IN-29
CAS :<p>KDM1A-IN-29 is a histone demethylase inhibitor.</p>Formule :C16H16ClN3O4SCouleur et forme :SoildMasse moléculaire :381.83HDAC6-IN-56
<p>HDAC6-IN-56 (compound 18d) is an inhibitor of HDAC6, with an IC50 of 1.3 nM. This compound can inhibit the S phase and induce apoptosis in HCT-116 colon cancer cells.</p>Formule :C25H27ClN4O4SCouleur et forme :SolidMasse moléculaire :514.14415Izilendustat
CAS :<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Formule :C22H28ClN3O4Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :433.93TYK2 activator-1
<p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>Formule :C23H21FN4O2Couleur et forme :SolidMasse moléculaire :404.16485GSK J5
CAS :<p>GSK J5: schistosome, helminth inhibitor; trematode insecticide; boosts schistosome death dose/time-wise.</p>Formule :C24H27N5O2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :417.5ZL0590
CAS :<p>ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.</p>Formule :C23H27F3N4O4SDegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :512.55Methylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Couleur et forme :Odour SolidSW2_110A
CAS :<p>SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.</p>Formule :C42H60N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.96SMARCA2 degrader-17
CAS :<p>SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.</p>Formule :C47H58N10O6SCouleur et forme :SolidMasse moléculaire :891.09CB1R/AMPK modulator 1
<p>Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.</p>Formule :C25H22Cl2N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.45PROTAC SMARCA2/4 degrader-36
CAS :<p>PROTACSMARCA2/4 degrader-36 (Compound 29) is a potent dual degrader targeting SMARCA2 and SMARCA4, exhibiting DC50 values of 0.22 nM and 0.85 nM, respectively. Additionally, PROTACSMARCA2/4 degrader-36 demonstrates antiproliferative activity.</p>Formule :C53H62ClN9O4SCouleur et forme :SolidMasse moléculaire :956.635E67-2
CAS :<p>E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.</p>Formule :C21H36N6O2Couleur et forme :SolidMasse moléculaire :404.559BAY-184
CAS :<p>BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.</p>Formule :C23H20N2O4SDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :420.48Lyngbyatoxin A
CAS :<p>Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as &quot;swimmers' itch&quot; in Hawaii.</p>Formule :C27H39N3O2Couleur et forme :SolidMasse moléculaire :437.62Eldocasiran
CAS :<p>Eldocasiran, a micro-RNA-193a-3p analogue, exhibits anticancer properties. It is utilized in cancer research [1].</p>Formule :C423H529N161O305P42Couleur et forme :SolidMasse moléculaire :14049.5JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidPF-04577806
CAS :<p>PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.</p>Formule :C26H37N7O3Couleur et forme :SolidMasse moléculaire :495.628iRucaparib-AP6
CAS :<p>iRucaparib-AP6: a specific, non-trapping PARP1 degrader; inhibits the enzyme's activity and scaffolding.</p>Formule :C46H55FN6O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :886.96PROTAC BRD4 Degrader-5
CAS :<p>PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.</p>Formule :C50H62ClN9O8S2Couleur et forme :SolidMasse moléculaire :1016.67PROTAC BET degrader-3
<p>PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.</p>Formule :C53H64N12O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1045.22PROTAC BRD4 Degrader-9
CAS :<p>PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.</p>Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.52-Methylquinazolin-4-ol
CAS :<p>Compound 1769-24-0 is a natural product for research related to life sciences. The catalog number is TPL0186 and the CAS number is 1769-24-0.</p>Formule :C9H8N2ODegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :160.17PROTAC BRD4 Degrader-32
<p>PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.</p>Formule :C42H42ClN5O5Couleur et forme :SolidMasse moléculaire :731.28745PROTAC SMARCA2/4-degrader-29
CAS :<p>PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.</p>Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95VinSpinIn
CAS :<p>VinSpinIn is a probe for the Spin family proteins.</p>Formule :C42H58N8O4Couleur et forme :SolidMasse moléculaire :738.98EP300/CBP ligand 2
<p>EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.</p>Formule :C20H18N6OCouleur et forme :SolidMasse moléculaire :358.4PROTAC SMARCA2/4-degrader-30
CAS :<p>Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.</p>Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95PRO-HD1
<p>PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50</p>Degré de pureté :98%Couleur et forme :Odour SolidBiguanide
CAS :<p>Biguanide can reduce oxidative stress in rats with hyperglycemia.</p>Formule :C2H7N5Couleur et forme :SolidMasse moléculaire :101.11Nicotinamide riboside tartrate
CAS :<p>NRT is an oral NAD+ precursor, boosts NAD+, activates SIRT1/3, provides vitamin B3, enhances metabolism, and may mitigate Alzheimer's.</p>Formule :C15H20N2O11Couleur et forme :SolidMasse moléculaire :404.33TAS-119
CAS :<p>TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95</p>Formule :C23H22Cl2FN5O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :506.36TAT-cyclo-CLLFVY
CAS :<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Formule :C111H188N42O24S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2559.1PROTAC SMARCA2/4-degrader-31
CAS :<p>PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.</p>Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61PRO-HD3
<p>PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].</p>Degré de pureté :98%Couleur et forme :Odour SolidEPZ-719
CAS :<p>EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.</p>Formule :C22H31FN4O3SCouleur et forme :SolidMasse moléculaire :450.57SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Formule :C45H62Cl3N7O8Couleur et forme :SolidMasse moléculaire :935.37MZP-55
CAS :<p>MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)</p>Formule :C57H70ClN7O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1080.73PROTAC SMARCA2/4-degrader-27
CAS :<p>PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.</p>Formule :C49H58FN9O6SCouleur et forme :SolidMasse moléculaire :920.11DS-103
<p>DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.</p>Formule :C28H33N5O3Couleur et forme :SolidMasse moléculaire :487.59PROTAC SMARCA2/4-degrader-26
<p>PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.</p>Formule :C38H47N9O5SCouleur et forme :SolidMasse moléculaire :741.9SIRT1/2/3-IN-1
CAS :<p>Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.</p>Formule :C46H63N9O8S2Couleur et forme :SolidMasse moléculaire :934.18HDAC6 ligand-3
<p>HDAC6ligand-3 serves as a ligand for HDAC6 and can be utilized as a target protein ligand in the synthesis of [PROTAC] HDAC6 degrader4.</p>Formule :C20H21N3O3Couleur et forme :SolidMasse moléculaire :351.399Antidiabetic agent 7
<p>Antidiabetic agent 7 (Compound 5m) functions as a potent hyperglycemia inhibitor. It effectively stimulates GLUT4 translocation in skeletal muscle cells by activating the AMPK-dependent pathway. Additionally, this compound is capable of reducing blood glucose levels and exhibits favorable pharmacokinetic properties. Antidiabetic agent 7 is suitable for research related to antihyperglycemic treatments.</p>Formule :C27H21Cl2N5O3Couleur et forme :SolidMasse moléculaire :534.39PRMT5 ligand 1
CAS :<p>PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.</p>Formule :C20H26N6O2Couleur et forme :SolidMasse moléculaire :382.459Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS :<p>Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.</p>Formule :C56H110N22O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1315.61JAK1/STAT3-IN-1
<p>JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).</p>Formule :C30H33FN4O3SCouleur et forme :SolidMasse moléculaire :548.67BRD4 degrader AT1
CAS :<p>BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.</p>Formule :C48H58ClN9O5S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :972.68TYD-68
<p>TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.</p>Couleur et forme :Odour SolidMS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Formule :C58H66ClF3N14O11S2Couleur et forme :SolidMasse moléculaire :1290.41175Thalidomide-NH-CBP/p300 ligand 2
CAS :<p>Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).</p>Formule :C48H57F2N11O6Couleur et forme :SolidMasse moléculaire :922.052Dihydrochlamydocin analog-1
CAS :<p>Dihydrochlamydocinanalog-1 (compound 2) is a Chlamydocin analog that inhibits the deacetylation of histone H4 peptides, with an IC50 of 30 nM.</p>Formule :C28H40N4O6Couleur et forme :SolidMasse moléculaire :528.64PROTAC HDAC6 degrader 4
<p>PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]</p>Formule :C39H42FN9O7Couleur et forme :SolidMasse moléculaire :767.81A-893
CAS :<p>A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .</p>Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54CARM1/IKZF3 ligand 1
<p>CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.</p>Formule :C27H35ClN6O3Couleur et forme :SolidMasse moléculaire :527.06SJ10542
CAS :<p>SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.</p>Formule :C41H46N12O5SCouleur et forme :SolidMasse moléculaire :818.95PROTAC CBP/P300 Degrader-1
CAS :<p>PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.</p>Formule :C46H53F2N11O6Couleur et forme :SolidMasse moléculaire :893.998HDAC11-IN-1
<p>HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.</p>Formule :C43H63F3N6O6S2Couleur et forme :SolidMasse moléculaire :881.12SIRT1-IN-1
CAS :<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Formule :C14H16N2ODegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :228.29(S,R,S)-AHPC-C5-COOH
CAS :<p>E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.</p>Formule :C29H42N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.73HDAC6 degrader-3
CAS :<p>HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.</p>Formule :C41H41F4N7O11Couleur et forme :SolidMasse moléculaire :883.8JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
<p>JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.</p>Formule :C43H51ClN8O3S2Couleur et forme :SolidMasse moléculaire :827.5BTR2004
<p>BTR2004 is a selective PROTAC degrader targeting the BET family (BRD2/3/4) proteins. It facilitates the formation of a ternary complex with BRD proteins and KLHL20, leading to ubiquitination and proteasomal degradation via the UPS pathway. BTR2004 shows potential for research in PC3 prostate cancer and MDA-MB-231 breast cancer cell lines.</p>Couleur et forme :Odour SolidFluorescein-NAD+
<p>Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.</p>Couleur et forme :SolidJAK3-IN-15
<p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>Couleur et forme :Odour SolidWDR5 ligand 2
CAS :<p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>Formule :C29H31F3N4O4Couleur et forme :SolidMasse moléculaire :556.576
