Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2612 produits trouvés pour "Chromatine/Épigénétique"
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AB3067
AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)Formule :C74H91ClFN11O17S2Couleur et forme :SolidMasse moléculaire :1525.16PROTAC BET Degrader-1
CAS :PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.Formule :C44H45N11O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :871.9PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.Formule :C38H47N9O5SCouleur et forme :SolidMasse moléculaire :741.9ZXH-3-26
CAS :ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.Formule :C38H37ClN8O7SDegré de pureté :98.90% - 98.90%Couleur et forme :SolidMasse moléculaire :785.27PRMT5-IN-12
CAS :PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.Formule :C27H30F3N7O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :669.7TO-1187
TO-1187 is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It enhances the ubiquitination and subsequent degradation of HDAC6, making it useful for research in hematological malignancies and solid tumors.Couleur et forme :Odour SolidPep2m, myristoylated
CAS :Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Formule :C63H118N18O14SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1383.8TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Formule :C23H21FN4O2Couleur et forme :SolidMasse moléculaire :404.16485TAT-cyclo-CLLFVY
CAS :Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formule :C111H188N42O24S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2559.1Sirtuin modulator 5
CAS :Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.Formule :C24H23N3O4Couleur et forme :SolidMasse moléculaire :417.46ZMF-23
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis andFormule :C22H23Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.36PROTAC BRD4 Degrader-15
CAS :PROTAC BRD4 Degrader-15 targets von Hippel-Lindau and BRD4 with IC50s 7.2/8.1 nM and degrades BRD4 in cancer cells.Formule :C57H62F2N10O10S2Couleur et forme :SolidMasse moléculaire :1149.3PROTAC MPS1 degrader 1
PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase)Formule :C41H46N12O7Couleur et forme :SolidMasse moléculaire :818.88HDAC-IN-26
CAS :HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.Formule :C24H28FN5O3Couleur et forme :SolidMasse moléculaire :453.518JQ1-TCO
CAS :JQ1-TCO, a BET inhibitor derivative, enables click chemistry for molecular probing in vivo and in vitro.Formule :C31H37ClN6O3SCouleur et forme :SolidMasse moléculaire :609.18HDAC1/2-IN-3
CAS :HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively.Formule :C24H25N5OSCouleur et forme :SolidMasse moléculaire :431.56CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Couleur et forme :SolidBBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Formule :C37H47N5O5SCouleur et forme :SolidMasse moléculaire :673.32979CPI-1328
CAS :CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.Formule :C28H36ClN3O4SCouleur et forme :SolidMasse moléculaire :546.12GSK3735967
CAS :GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62PROTAC BRD4 Degrader-13
CAS :PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Formule :C68H85F2N11O17P2S2Couleur et forme :SolidMasse moléculaire :1492.55PARP1-IN-6
CAS :PARP1-IN-6, a dual-function inhibitor, targets both tubulin and PARP-1, demonstrating inhibitory concentration (IC50) values of 0.94 μM for tubulin and 0.48 μMFormule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.27MRTX9768 hydrochloride
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.Couleur et forme :SolidJMJD6 inhibitor WL12
CAS :WL12 (ZINC6733033): First-in-class JMJD6 inhibitor; halts JMJD6-dependent cervical/liver cancer cell growth.
Formule :C16H11N3O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :277.28PROTAC TYK2 degradation agent1
CAS :PROTAC TYK2 Agent1 selectively degrades TYK2, with a 14 nM DC50, for autoimmune research.Formule :C55H69N13O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1056.28PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formule :C50H58FN11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :960.13PRO-HD1
PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50Degré de pureté :98%Couleur et forme :Odour SolidMS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formule :C15H26Cl2N2ODegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :321.28PKC β pseudosubstrate
CAS :Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Formule :C177H294N62O38S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3994.84Foenumoside B
CAS :Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotesFormule :C60H96O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1217.39Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS :Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].Formule :C34H43N3O7Couleur et forme :SolidMasse moléculaire :605.72BAY-184
CAS :BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.Formule :C23H20N2O4SDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :420.48PROTAC BRD4 Degrader-28
PROTAC BRD4 Degrader-28 (Compound 4) is a PROTAC degrader specifically targeting BRD4, and it holds potential for cancer research.Formule :C38H36ClN7O8SCouleur et forme :SolidMasse moléculaire :786.25TYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Couleur et forme :Odour SolidPF-03622905
CAS :PF-03622905: potent ATP-competitive PKC inhibitor, IC50: 5.6-74.1 nM for PKCα/βI/βII/γ/θ, high specificity for PKC.Formule :C24H35N7O3Couleur et forme :SolidMasse moléculaire :469.59Ep300/CREBBP-IN-3
CAS :Ep300/CREBBP-IN-3 inhibits Ep300 & CREBBP (IC50: 0.056 & 0.095 μM respectively); potential for cancer research.Formule :C26H25F4N5O3Couleur et forme :SolidMasse moléculaire :531.50dBRD9
CAS :dBRD9 is a PROTAC.Formule :C40H45N7O10Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :783.83Ref: TM-T31221
1mg129,00€5mg311,00€10mg502,00€25mg874,00€50mg1.320,00€100mg1.833,00€1mL*10mM (DMSO)434,00€A-893
CAS :A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.Formule :C53H64N12O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1045.22PF-04577806
CAS :PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.Formule :C26H37N7O3Couleur et forme :SolidMasse moléculaire :495.628Lyngbyatoxin A
CAS :Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as "swimmers' itch" in Hawaii.
Formule :C27H39N3O2Couleur et forme :SolidMasse moléculaire :437.62BRD4 degrader AT1
CAS :BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.Formule :C48H58ClN9O5S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :972.68Pumecitinib
CAS :Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Formule :C17H20N8O2SDegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :400.46BRD3067
CAS :BRD3067, a Tubacin derivative, inhibits HDAC6 (IC50 15 nM) and acts as a negative control for Tubacin A, showing anticancer and anti-inflammatory effects.Formule :C21H23N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.43iRucaparib-AP6
CAS :iRucaparib-AP6: a specific, non-trapping PARP1 degrader; inhibits the enzyme's activity and scaffolding.Formule :C46H55FN6O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :886.96SRG-II-19F
SRG-II-19F is a BRDT BD1 degrader, useful for studying ClpC2's impact on ClpC1P1P2 protease.Formule :C80H109ClN16O14SCouleur et forme :SolidMasse moléculaire :1586.34Go6976
CAS :Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.Formule :C24H18N4ODegré de pureté :95.89%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :378.43JPS016
CAS :JPS016: benzamide VHL E3-ligase PROTAC, degrades HDAC1/2, triggers apoptosis in HCT116 cells.Formule :C48H63N7O8SCouleur et forme :SolidMasse moléculaire :898.12PROTAC CBP/P300 Degrader-1
CAS :PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.Formule :C46H53F2N11O6Couleur et forme :SolidMasse moléculaire :893.998AZ'9567
AZ9567 is a potent MAT2A inhibitor. It demonstrates antiproliferative activity against MTAPKO HCT116 cells, with a pIC50 of 8.9.Formule :C24H19F2N5O2Masse moléculaire :447.15068JB300
CAS :JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formule :C43H45ClFN7O10SCouleur et forme :SolidMasse moléculaire :906.375XYD198
XYD198 (Compound 14h) is an orally active degrader of CBP/p300. It inhibits the CBP/p300 bromodomain with an IC50 of 213.5 nM and exhibits antitumor activity against acute myeloid leukemia.Formule :C54H49F2N11O7Masse moléculaire :1001.37845XF067-68
CAS :XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14(S)-GNE-987
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).Formule :C56H67F2N9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1096.31MACTIDE-V
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.Formule :C109H156N22O27S2Couleur et forme :SolidMasse moléculaire :2269.09517PRO-HD3
PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].Degré de pureté :98%Couleur et forme :Odour SolidKB02-JQ1
CAS :KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.Formule :C38H43Cl2N7O6SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :796.77MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Couleur et forme :Odour SolidNSC 370284
CAS :NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43ZL0590
CAS :ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.Formule :C23H27F3N4O4SDegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :512.55Ref: TM-T60072
1mg71,00€5mg152,00€10mg222,00€25mg401,00€50mg602,00€100mg887,00€1mL*10mM (DMSO)167,00€Echinomycin
CAS :Echinomycin (Quinomycin A) is a quinoxaline antibiotic and a DNA-intercalating peptide that inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity.Formule :C51H64N12O12S2Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :1101.26CPI-268456
CAS :CPI-268456 is a compound which has bioactive.Formule :C20H15Cl2N3O2Couleur et forme :SolidMasse moléculaire :400.26Axl-IN-16
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptorFormule :C14H19ClO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.75Antitumor agent-170
Antitumor agent-170 (Compound C6) inhibits PD-1/PD-L1 interaction and PARP7 with IC50 values of 0.342 μM and 7.05 nM, respectively. It shows high affinity for human PD-L1, with a Ki of 9.31 nM, and can restore T cell function while increasing IFN-γ secretion. In mouse models, Antitumor agent-170 exhibits antitumor effects against melanoma and demonstrates favorable pharmacokinetic properties.Formule :C59H69ClF3N11O9Masse moléculaire :1167.49204SNIPER(BRD)-1
CAS :SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.Formule :C53H66ClN9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1056.73NP213
CAS :NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).Formule :C42H84N28O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1093.3Namoline
CAS :Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.Formule :C10H3ClF3NO4Couleur et forme :SolidMasse moléculaire :293.58SYY-B085-1
CAS :SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor.Formule :C27H23F4N5O4Couleur et forme :SolidMasse moléculaire :557.506Vanicoside A
CAS :Vanicoside A is a protein kinase C( PKC ) inhibitor from Polygonum pensylvanicum [1] .Formule :C51H50O21Couleur et forme :SolidMasse moléculaire :998.93HIF-1 α (556-574)
CAS :HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.Formule :C101H150D2N20O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2254.6Myelin Basic Protein
CAS :Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Formule :C60H103N21O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1390.59Methylation Compound Library
xnum methylation-related compounds that can be used for high-throughput and high-content screening.Couleur et forme :Odour SolidRef: TM-L3510
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPRMT5-IN-11
CAS :PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.Formule :C13H17N5O4Couleur et forme :SolidMasse moléculaire :307.31GSK040
CAS :GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.Formule :C29H34N4O4Couleur et forme :SolidMasse moléculaire :502.6SMD-3040 TFA
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.Degré de pureté :98%Couleur et forme :Odour SolidBiguanide
CAS :Biguanide can reduce oxidative stress in rats with hyperglycemia.Formule :C2H7N5Couleur et forme :SolidMasse moléculaire :101.11PROTAC BRD4 Degrader-19
CAS :PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utilityFormule :C44H38N8O5S2Couleur et forme :SolidMasse moléculaire :822.95NPC-15437 dihydrochloride
CAS :NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.Formule :C25H52Cl2N4O2Couleur et forme :SolidMasse moléculaire :511.62BRD7-IN-1 free base
CAS :BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.Formule :C22H26N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.47NF-κB/HIF-1α-IN-1
NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.Formule :C24H27N7O4Couleur et forme :SolidMasse moléculaire :477.212452-PADQZ hydrochloride
CAS :2-PADQZ hydrochloride shows antiviral activity and targets influenza A virus RNA promoter.Formule :C15H21ClN4O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :324.81Tubulin/HDAC-IN-3
Tubulin/HDAC-IN-3 (compound 12a) serves as a potent dual inhibitor of tubulin polymerization and HDAC1/8, exhibiting IC50 values of 5.4 μM for tubulinFormule :C28H28N2O10Couleur et forme :SolidMasse moléculaire :552.53MNK/PIM-IN-1
CAS :MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.Formule :C27H27FN6O2Couleur et forme :SolidMasse moléculaire :486.5512-Methylquinazolin-4-ol
CAS :Compound 1769-24-0 is a natural product for research related to life sciences. The catalog number is TPL0186 and the CAS number is 1769-24-0.Formule :C9H8N2ODegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :160.17HDAC-IN-68 hydrochloride
HDAC-IN-68 (hydrochloride) (Compound 29) is an HDACs inhibitor with an IC50 value of 0.04 μM and induces microtubule fragmentation by activating katanin, a microtubule-severing protein. It is applicable in cancer research.Formule :C27H25ClN8O6Masse moléculaire :592.15856AS2553627
CAS :AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38PROTAC BRD4 Degrader-32
PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.Formule :C42H42ClN5O5Couleur et forme :SolidMasse moléculaire :731.28745JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L3700
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderCBP/p300-IN-8
CAS :CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.Formule :C27H31N3O4Couleur et forme :SolidMasse moléculaire :461.562PROTAC BRD4 Degrader-5
CAS :PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.Formule :C50H62ClN9O8S2Couleur et forme :SolidMasse moléculaire :1016.67SW2_152F
SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.Formule :C45H62Cl3N7O8Couleur et forme :SolidMasse moléculaire :935.373β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS :3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.
Formule :C30H52O4Couleur et forme :SolidMasse moléculaire :476.742Uzansertib
CAS :Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.Formule :C26H26F3N5O3Couleur et forme :SolidMasse moléculaire :513.51PROTAC BRD4 Degrader-10
CAS :Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5BRD4-IN-4
CAS :BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line andFormule :C17H18N2O3SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :330.4Hyp-dBET1
Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.Couleur et forme :Odour SolidHDAC6-IN-53
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.Couleur et forme :Odour SolidPROTAC MPS1 degrader 2
PROTAC MPS1 Degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 values of 42.0, 2.1, and 154.0 nM respectively. It is utilized in the research of acute myeloid leukemia.Formule :C41H41N11O8SCouleur et forme :SolidMasse moléculaire :847.90
