Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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POI ligand 1
POI ligand 1 serves as a template for the non-selective HDAC inhibitor Vorinostat. It functions as a target protein ligand (PROTAC target protein ligand) in the creation of PROTAC HDAC degraders with anti-tumor properties. Additionally, POI ligand 1 is utilized in the synthesis of FF2049.Formule :C14H21N3O3Couleur et forme :SolidMasse moléculaire :279.335SJ1008030
CAS :SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.
Formule :C42H43N13O7SCouleur et forme :SolidMasse moléculaire :873.94PROTAC MPS1 degrader 2
PROTAC MPS1 Degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 values of 42.0, 2.1, and 154.0 nM respectively. It is utilized in the research of acute myeloid leukemia.Formule :C41H41N11O8SCouleur et forme :SolidMasse moléculaire :847.90Malantide
CAS :Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Formule :C72H124N22O21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1633.89HDAC-IN-26
CAS :HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.Formule :C24H28FN5O3Couleur et forme :SolidMasse moléculaire :453.518ZIP
CAS :Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Formule :C90H154N30O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1928.4ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Couleur et forme :Odour SolidBisindolylmaleimide XI hydrochloride
CAS :Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is an orally active pan-PKC inhibitor that inhibits PKCα, PKCβI, PKCβII, and PKCγ.Formule :C28H29ClN4O2Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :489.01MZP-55
CAS :MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)Formule :C57H70ClN7O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1080.73GSK232
CAS :GSK232 is a highly selective and cellularly penetrant inhibitor of CECR2 with outstanding physicochemical properties.Formule :C21H27ClN6O3SCouleur et forme :SolidMasse moléculaire :479.0PROTAC SMARCA2/4-degrader-27
CAS :PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.Formule :C49H58FN9O6SCouleur et forme :SolidMasse moléculaire :920.11SGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Formule :C41H47ClN6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.37ZSNI-21
ZSNI-21 is a dual inhibitor targeting ADAM17 and HDAC2. It effectively suppresses the proliferation of Bel-7402 cells and exhibits significant anti-metastatic properties against HCC-LM3 cells, making it a promising candidate for hepatocellular carcinoma (HCC) research.Formule :C26H25N3O5Couleur et forme :SolidMasse moléculaire :459.49Delcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Formule :C122H203N45O36S2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :2940.33Ref: TM-T11740L
1mg166,00€2mg213,00€5mg313,00€10mg442,00€25mg642,00€50mg880,00€100mg1.179,00€200mg1.594,00€PARP/EZH2-IN-2
PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.Formule :C33H31N7O3Masse moléculaire :573.24884TP-472N
CAS :TP-472N serves as a negative control probe for TP-472, which is a specific and effective BRD7/9 probe.Formule :C19H18N2O2Couleur et forme :SolidMasse moléculaire :306.36HDAC11-IN-1
HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.Formule :C43H63F3N6O6S2Couleur et forme :SolidMasse moléculaire :881.12PARP1-IN-6
CAS :PARP1-IN-6, a dual-function inhibitor, targets both tubulin and PARP-1, demonstrating inhibitory concentration (IC50) values of 0.94 μM for tubulin and 0.48 μMFormule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.27AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61Dihydrochlamydocin analog-1
CAS :Dihydrochlamydocinanalog-1 (compound 2) is a Chlamydocin analog that inhibits the deacetylation of histone H4 peptides, with an IC50 of 30 nM.Formule :C28H40N4O6Couleur et forme :SolidMasse moléculaire :528.64SIRT1/2/3-IN-1
CAS :Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.Formule :C46H63N9O8S2Couleur et forme :SolidMasse moléculaire :934.18CARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formule :C27H35ClN6O3Couleur et forme :SolidMasse moléculaire :527.06PROTAC BRD4 Degrader-7
CAS :PROTAC BRD4 Degrader-7, from patent WO2020055976A1, has IC50 of 15.5 nM (BD1) & 12.3 nM (BD2).Formule :C26H29N5O2SCouleur et forme :SolidMasse moléculaire :475.61GSK023
GSK023 (compound 31) is a selective chemical probe that targets the BET BD1 domain.Formule :C29H39N5O2Masse moléculaire :489.31038TNKS-2-IN-2
CAS :TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Formule :C26H23N3O6Degré de pureté :99.45%Couleur et forme :SoildMasse moléculaire :473.48NF-κB/HIF-1α-IN-1
NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.Formule :C24H27N7O4Couleur et forme :SolidMasse moléculaire :477.21245PRMT5-IN-41
CAS :PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM.Formule :C22H16F5N5O2Couleur et forme :SolidMasse moléculaire :477.39SAMβA TFA
SAMβA TFA, a selective antagonist of Mfn1-βIIPKC association conjugated to the cell permeable peptide TAT47-57, is a rationally designed inhibitor that improvesFormule :C50H73N17O16·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1168.22 (free acid)BRD4 Inhibitor-27
CAS :BRD4 Inhibitor-27 is a potent BRD4 inhibitor that inhibits BRD4 BD1 and BRD4 BD2 with IC50s of 9.6 and 11.3 μM, respectively.BRD4 Inhibitor-27 has anticancer
Formule :C16H13F3N6Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :346.31Antitumor agent-170
Antitumor agent-170 (Compound C6) inhibits PD-1/PD-L1 interaction and PARP7 with IC50 values of 0.342 μM and 7.05 nM, respectively. It shows high affinity for human PD-L1, with a Ki of 9.31 nM, and can restore T cell function while increasing IFN-γ secretion. In mouse models, Antitumor agent-170 exhibits antitumor effects against melanoma and demonstrates favorable pharmacokinetic properties.Formule :C59H69ClF3N11O9Masse moléculaire :1167.49204Ep300/CREBBP-IN-8
CAS :Ep300/CREBBP-IN-8, IC50: 0.014/0.018 μM, potent Ep300/CREBBP inhibitor, oral, for cancer research.Formule :C25H27F2N5O3Couleur et forme :SolidMasse moléculaire :483.51OKI-006
CAS :OKI-006 is an oral HDAC inhibitor with potential for cancer research, derived from largazole.Formule :C21H30N4O5S2Couleur et forme :SolidMasse moléculaire :482.62BRD4 Inhibitor-16
BRD4 Inhibitor-16 (Compound 4) is a potent suppressor of BRD4 linked to cancer, aiding in research of BRD4-related treatments.Formule :C42H43N7O8SCouleur et forme :SolidMasse moléculaire :805.9KDM4 ligand-1
KDM4ligand-1 is a ligand targeting the protein (histone lysine demethylase KDM4) in PROTACs. It can be utilized for the synthesis of PROTACs.Couleur et forme :Odour SolidHD-TAC7
CAS :HD-TAC7 is a PROTAC degrader targeting HDAC, with IC50 values of 3.6/4.2/1.1 μM for HDAC1/HDAC2/HDAC3. It can reduce the expression of NF-κB p65.Formule :C33H32FN7O7Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :657.65PROTAC SMARCA2/4-degrader-30
CAS :Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95(+)-JQ-1-aldehyde
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].Couleur et forme :SolidGpC Methyltransferase
GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.LH168
LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.Formule :C29H31F3N6O2SCouleur et forme :SolidMasse moléculaire :584.66Nicotinamide riboside tartrate
CAS :NRT is an oral NAD+ precursor, boosts NAD+, activates SIRT1/3, provides vitamin B3, enhances metabolism, and may mitigate Alzheimer's.Formule :C15H20N2O11Couleur et forme :SolidMasse moléculaire :404.33dBET23
CAS :dBET23 is a BRD4 degrader.Formule :C43H45ClN8O9SCouleur et forme :SolidMasse moléculaire :885.38EP300/CBP ligand 2
EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.Formule :C20H18N6OCouleur et forme :SolidMasse moléculaire :358.4EPZ-719
CAS :EPZ-719 is a selective and orally available SETD2 inhibitor (IC50 = 0.005 μM), with anti-cancer activity, and can be used for hematological malignancies.Formule :C22H31FN4O3SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :450.57Ref: TM-T40318
1mg177,00€5mg385,00€10mg618,00€25mg1.305,00€50mg2.088,00€100mg5.670,00€1mL*10mM (DMSO)383,00€PRMT1-IN-1
CAS :PRMT1-IN-1 is a PRMT1 inhibitor.
Formule :C20H7Br6NO5Couleur et forme :SolidMasse moléculaire :820.702DDO-2093
CAS :DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.Formule :C29H37ClFN9O3Couleur et forme :SolidMasse moléculaire :614.12PROTAC SMARCA2/4-degrader-29
CAS :PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95ACBI2
CAS :ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer research.Formule :C56H68BrFN8O5SCouleur et forme :SolidMasse moléculaire :1064.16UNC6349 (Ket2)
UNC6349 (Ket2), a ligand containing diethyllysine (Ket2), effectively binds to wild-type CBX5 with a dissociation constant (K D) of 3.2 μM [1].Formule :C41H57N7O11Couleur et forme :SolidMasse moléculaire :823.93Sphingosine (d14:1)
CAS :Sphingosine (d14:1) boosts N. rileyi fungus growth, inhibits PKC, and reduces CHO cell proliferation; found in various sea creatures.Formule :C14H29NO2Couleur et forme :SolidMasse moléculaire :243.39HIF-PHD-IN-4
HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.Couleur et forme :Odour SolidTAS-119
CAS :TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formule :C23H22Cl2FN5O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :506.36Ref: TM-T34787
1mg97,00€5mg235,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€1mL*10mM (DMSO)261,00€Protein Kinase C (19-36)
CAS :Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Formule :C93H159N35O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2151.48HAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Formule :C60H69N17O11SCouleur et forme :SolidMasse moléculaire :1236.36SMARCA2 degrader-17
CAS :SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.Formule :C47H58N10O6SCouleur et forme :SolidMasse moléculaire :891.09MACTIDE-V
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.Formule :C109H156N22O27S2Couleur et forme :SolidMasse moléculaire :2269.09517Nicotinamide riboside malate
CAS :Orally active NAD+ booster, NR malate enhances metabolism, supports cognitive function, and is a vitamin B3 source.Formule :C15H20N2O10Couleur et forme :SolidMasse moléculaire :388.33PIM-IN-1
CAS :PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).Formule :C15H18ClFN4OCouleur et forme :SolidMasse moléculaire :324.78HSP90-IN-30
HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.Formule :C20H39B12N4O2Masse moléculaire :499.41897JAK1/TYK2-IN-1
CAS :JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).Formule :C18H20F3N7OCouleur et forme :SolidMasse moléculaire :407.401PROTAC BRD4 Degrader-1
CAS :PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).Formule :C40H37N9O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.78FTX-6058 hydrochloride
CAS :FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Formule :C22H19ClFN5O2Couleur et forme :SolidMasse moléculaire :439.87(rel)-Tranylcypromine D5 hydrochloride
CAS :(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.Formule :C9H12ClNDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :174.682PROTAC_ERRα
CAS :PROTAC_ERRα is a potent, selective degrader of ERRα, efficiently facilitating its proteasomal degradation.Formule :C46H47F3N6O9S2Couleur et forme :SolidMasse moléculaire :949.03GXH-II-052
GXH-II-052: Potent BET inhibitor, binds BRD4/BRDT (Kd 0.6-28 nM), anti-proliferative, reduces c-Myc expression.Formule :C62H76Cl2F2N14O11S2Couleur et forme :SolidMasse moléculaire :1366.39C 21
CAS :PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Formule :C90H161ClN36O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2166.94PROTAC BRD4 Degrader-27
CAS :PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2/BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.Formule :C37H30F2N6O7Couleur et forme :SolidMasse moléculaire :708.67Kiss2 peptide
CAS :Kiss2 peptide functions as a positive regulator of reproductive behavior. In COS-7 cells, it binds to its homologous G-protein coupled receptor Kiss2R (GPR54), activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).Formule :C63H84N16O12Masse moléculaire :1257.44Cath-L-dBET1
Cath-L-dBET1 is a PROTAC degrader targeting BRD4. It has an IC50 value of 2.8 μM in MDA-MB-231 cells. Activated by cathepsin L (Cath-L), Cath-L-dBET1 recruits E3 ubiquitin ligase to degrade BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable for antitumor research.Couleur et forme :Odour Solid7-oxo Staurosporine
CAS :Antibiotic 7-oxo Staurosporine from S. platensis blocks various kinases, induces G2/M arrest in K562 cells, is cytotoxic, and impedes mycelial growth.Formule :C28H24N4O4Couleur et forme :SolidMasse moléculaire :480.51PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]Formule :C39H42FN9O7Couleur et forme :SolidMasse moléculaire :767.81UNC6864 (Kei)
UNC6864, an ethylisopropyllysine-containing ligand, exhibits binding affinity to wild-type CBX5, demonstrating a dissociation constant (K D) of 3.3 μM.Formule :C42H59N7O11Couleur et forme :SolidMasse moléculaire :837.96DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Couleur et forme :Odour SolidPRMT5-IN-11
CAS :PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.Formule :C13H17N5O4Couleur et forme :SolidMasse moléculaire :307.31Foenumoside B
CAS :Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotesFormule :C60H96O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1217.39BBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Formule :C37H47N5O5SCouleur et forme :SolidMasse moléculaire :673.32979Mersalyl
CAS :Mersalyl is an organic mercurial diuretic.Formule :C13H16HgNNaO6Couleur et forme :SolidMasse moléculaire :505.854JMJD6 inhibitor WL12
CAS :WL12 (ZINC6733033): First-in-class JMJD6 inhibitor; halts JMJD6-dependent cervical/liver cancer cell growth.
Formule :C16H11N3O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :277.28I-BET432
I-BET432, a BET inhibitor, blocks BRD4 BD1/BD2 (pIC50: 7.5/7.2), is oral, and targets cancer/inflammation.Formule :C18H21N3O3Couleur et forme :SolidMasse moléculaire :327.38E67-2
CAS :E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Formule :C21H36N6O2Couleur et forme :SolidMasse moléculaire :404.559NPC-15437 dihydrochloride
CAS :NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.Formule :C25H52Cl2N4O2Couleur et forme :SolidMasse moléculaire :511.62TO-1187
TO-1187 is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It enhances the ubiquitination and subsequent degradation of HDAC6, making it useful for research in hematological malignancies and solid tumors.Couleur et forme :Odour SolidPROTAC BRD2/BRD4 degrader-1
Compound 15: Potent PROTAC, selectively degrades BRD4/BRD2, has low toxicity, and is built of a BET inhibitor, linker, and CRBN ligand.Formule :C39H38N6O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :766.82Y16524
Y16524 is a potent inhibitor of the CBP/p300 bromodomain (CBP/p300bromodomain) with an IC50 value of 0.01 μM. It shows potential for research in acute myeloid leukemia (AML).Formule :C30H34ClN5O4Couleur et forme :SolidMasse moléculaire :564.075PROTAC BRD9-binding moiety 1
CAS :PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.Formule :C23H25N3O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.59BET-IN-25
BET-IN-25 (compound 7) is an orally bioactive inhibitor targeting the bromodomains BD1 and BD2, with IC50 values of 0.18 μM and 9.2 μM, respectively.Formule :C19H25N5O4SMasse moléculaire :419.16273HDAC8-IN-6
HDAC8-IN-6 (compound 3) is a potent inhibitor of HDAC8 with an IC50 of 5.1 μM and exhibits cytotoxicity.
Formule :C19H18IN3O2Masse moléculaire :447.04437XF056-132
CAS :XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .Formule :C51H57F4N9O7SCouleur et forme :SolidMasse moléculaire :1016.11PROTAC BET Degrader-10
CAS :PROTAC BET Degrader-10 targets and degrades BRD4 with a DC50 of 49 nM, using Cereblon ligands.Formule :C39H39ClN8O6SCouleur et forme :SolidMasse moléculaire :783.3Ref: TM-T39374
5mg225,00€10mg359,00€25mg672,00€50mg999,00€100mg1.485,00€200mgÀ demander500mgÀ demander1mL*10mM (DMSO)309,00€CW-3308
CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.Formule :C45H48N6O8Couleur et forme :SolidMasse moléculaire :800.9PROTAC BRD4-DCAF1 degrader-1
CAS :PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.Formule :C60H64Cl2F2N8O9SCouleur et forme :SolidMasse moléculaire :1182.17JAK-IN-15
CAS :JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Formule :C22H23FN4O3SCouleur et forme :SolidMasse moléculaire :442.51OARV-771
CAS :OARV-771: VHL-based PROTAC targeting BET; DC50: Brd4-6nM, Brd2-1nM, Brd3-4nM; enhanced cell permeability.Formule :C49H59ClN8O8S2Couleur et forme :SolidMasse moléculaire :987.62Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS :Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Formule :C56H110N22O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1315.61SW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).Formule :C44H64N6O9Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :821.01Pep2m, myristoylated
CAS :Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Formule :C63H118N18O14SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1383.8Biotinylated-JQ1
CAS :Biotin-JQ1 is a bromodomain BRD4 binder; inhibits MM1.S cell growth with EC50 of 0.4μM.Formule :C39H53ClN8O6S2Couleur et forme :SolidMasse moléculaire :829.47FHD-609
CAS :FHD-609 is an effective BRD9 inhibitor and PROTAC degrader, depleting the SS18-SSX fusion protein, and can be used for the study of synovial sarcoma (SS).Formule :C47H56N8O6Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :829Ref: TM-T75135
1mg69,00€5mg147,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€1mL*10mM (DMSO)207,00€EEDi-5273
CAS :EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.Formule :C26H22F4N6O2Couleur et forme :SolidMasse moléculaire :526.496Echinomycin
CAS :Echinomycin (Quinomycin A) is a quinoxaline antibiotic and a DNA-intercalating peptide that inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity.Formule :C51H64N12O12S2Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :1101.26
