Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2573 produits trouvés pour "Chromatine/Épigénétique"
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(3S,4R)-Tofacitinib
CAS :(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).Formule :C16H20N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.37LSD1-IN-13 hydrochloride
CAS :LSD1-IN-13 hydrochloride (7e) is an oral LSD1 inhibitor (IC50: 24.43 nM), promoting differentiation in AML cell lines.Formule :C23H30ClN3O2SCouleur et forme :SolidMasse moléculaire :448.02PARP1-IN-30
CAS :PARP1-IN-30 is a specific and effective PARP1 inhibitor with cytotoxic properties. It precisely inhibits PARP1 in tumor cells lacking breast cancer 1 protein (BRCA1) or BRCA2. PARP1-IN-30 holds potential for use in cancer research.Formule :C14H12ClNO4SCouleur et forme :SolidMasse moléculaire :325.77AMI-408
CAS :AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.Formule :C20H13Cl2N6NaO5SCouleur et forme :SolidMasse moléculaire :543.32Purinostat
CAS :Purinostat is a selective inhibitor of HDACI/IIb with potential anti-leukemic properties. Its mesylate form, Purinostat mesylate, is effective at inhibiting the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDACI/IIb, impacting several crucial factors for leukemia stem cell (LSC) survival, such as c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Additionally, Purinostat mesylate enhances glutamate metabolism in LSCs by increasing GLS1.Formule :C23H26N10O3Couleur et forme :SolidMasse moléculaire :490.518LSD1-IN-15
LSD1-IN-15 inhibits LSD1, MAO-A/B with IC50s: 0.149, 0.028, 0.327 μM; arrests LNCaP cancer cell growth, IC50 9.9 μM.Formule :C22H20N2OCouleur et forme :SolidMasse moléculaire :328.41MC3138
CAS :MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Formule :C25H25NO6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :435.47BRD-7880
CAS :BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.Formule :C32H38N4O7Couleur et forme :SolidMasse moléculaire :590.67P300-IN-4
P300-IN-4 (compound 6) is a histone acetyltransferase p300 inhibitor with an IC50 value of 12.2 μM.Formule :C29H28ClIN4O5Couleur et forme :SolidMasse moléculaire :674.91Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Formule :C28H46N8O6SCouleur et forme :SolidMasse moléculaire :622.78(rac)-Talazoparib
CAS :(rac)-Talazoparib ((rac)-BMN-673) (Compound 47) is an orally active inhibitor of PARP1/2, with Ki values of 1.2 nM and 0.87 nM, respectively. It inhibits cellular PARylation at an EC50 of 2.51 nM. This compound leads to the accumulation of DNA damage and suppresses the proliferation of BRCA1/2-mutated MX-1 and Capan-1 cells, with IC50 values of 0.3 nM and 5 nM, respectively. Additionally, (rac)-Talazoparib exhibits antitumor activity in mouse models.Formule :C19H14F2N6OCouleur et forme :SolidMasse moléculaire :380.351SIRT6 activator 2
CAS :SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Formule :C23H23N3O6Couleur et forme :SolidMasse moléculaire :437.45PARP7-IN-23
CAS :PARP7-IN-23 (compound 56) is a potent PARP7 inhibitor with an EC50 of 0.915 nM for pSTAT1 in NCI-H1373 cells, indicating its potential for cancer research.
Formule :C27H22F7N5O3Couleur et forme :SolidMasse moléculaire :597.484BSI-401
CAS :BSI-401 is an oral inhibitor of PARP-1. It can inhibit pancreatic cancer either when used alone or in synergy with Oxaliplatin.Formule :C9H4INO4Couleur et forme :SolidMasse moléculaire :317.037BET/Aurora kinase-IN-1
CAS :BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.Formule :C25H30FN7OCouleur et forme :SolidMasse moléculaire :463.55HDAC-IN-87
CAS :HDAC-IN-87 (Compound XII6) is a non-selective HDAC inhibitor with pIC50 values of 6.9 for HDAC4 and 5.8 for HDAC6. It exhibits fungicidal activity against P. sorghi and P. pachyrhizi. The acute oral LD50 in both male and female rats is greater than 500 mg/kg.Formule :C13H7F5N4O2SCouleur et forme :SolidMasse moléculaire :378.277PHD2-IN-4
CAS :PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.Formule :C21H19N5O3Couleur et forme :SolidMasse moléculaire :389.407SIRT-IN-6
CAS :SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.
Formule :C7H4ClN3OSCouleur et forme :SolidMasse moléculaire :213.644GNE-886
CAS :GNE-886 has a wide range of applications in life science related research.Formule :C28H30N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.59CM-414
CAS :CM-414: HDAC/PDE5 inhibitor, targeting Alzheimer’s, IC50s: PDE5 (60 nM), HDAC1/2/3/6. Reduces Aβ, pTau in mice, boosts cognition.Formule :C23H29N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.51
