Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2553 produits trouvés pour "Chromatine/Épigénétique"
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Trichostatin A S-isomer
CAS :Trichostatin A S-isomer, a HDAC 1, 3, 4, 6, 10 inhibitor with IC50 ~20 nM, has wide-ranging epigenetic effects.Formule :C17H22N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.37Menin-MLL inhibitor 26
CAS :Menin-MLL inhibitor 26: Active reference, inhibits cell growth, used in leukemia research.Formule :C27H29F3N6O3SCouleur et forme :SolidMasse moléculaire :574.62HDAC/HSP90-IN-4
HDAC/HSP90-IN-4 inhibits HDAC (20 IC50=194nM, 26 IC50=360nM) & HSP90α (20 IC50=153nM, 26 IC50=77nM), affects cancer cell survival and invasion.Formule :C20H23N3O6Couleur et forme :SolidMasse moléculaire :401.15869HYDAMTIQ
CAS :HYDAMTIQ, a PARP-1/2 inhibitor (IC 50 : 29-38 nM), exhibits a range of pharmacological effects including anticancer, anti-inflammatory, and ischemic protective properties. It effectively reduces pulmonary PARP activity and alleviates symptoms such as allergen-induced cough and dyspnea while also diminishing bronchial hyperresponsiveness to methacholine. Moreover, HYDAMTIQ shows potent tumor suppressor activity in various cancers such as ovarian, breast, prostate, pancreatic, and glioblastoma multiforme. Demonstrating in vivo efficacy, HYDAMTIQ has been tested in animal models for conditions like cerebral ischemia, asthma, and cancer [1].Formule :C14H14N2O2SCouleur et forme :SolidMasse moléculaire :274.34TAF1 ligand 1
CAS :TAF1 ligand 1 is a TAF1 ligand. It can serve as a ligand for target proteins (Ligands for Target Protein for PROTAC) in the synthesis of PROTACs targeting TAF1, such as ZS3-046.Formule :C23H23N5O3Couleur et forme :SolidMasse moléculaire :417.46GSK852
GSK852 is a potent, second bromodomain (BD2)-selective, bromo and extra-terminal domain (BET) inhibitor with pIC50 of 7.9.Formule :C24H26N2O4Couleur et forme :SolidMasse moléculaire :406.47SRI-43265
CAS :SRI-43265 (compound 40) inhibits the dimerization of human antigen R protein (HuR), which is involved in cancer and inflammation pathogenesis [1].Formule :C19H20N6OCouleur et forme :SolidMasse moléculaire :348.4DS-9300
CAS :DS-9300, an orally administered potent and selective inhibitor of EP300/CBP HAT, exhibits a significant inhibitory activity with an IC50 value of 28 nM.Formule :C25H26F3N5O3Couleur et forme :SolidMasse moléculaire :501.50Sapintoxin D
CAS :Sapintoxin D is a fluorescent phorbol ester and selective activator of protein kinase C.Formule :C30H37NO8Couleur et forme :SolidMasse moléculaire :539.62GSK8814
CAS :GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan).Formule :C28H35F2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.61Tyk2-IN-15
CAS :Tyk2-IN-15 (Compound 97) is a selective inhibitor of tyrosine kinase 2 (Tyk2) with an IC50 value ≤ 10 nM for Tyk2-JH2. It is utilized in the research of inflammatory and autoimmune diseases [1].
Formule :C21H25F2N7OCouleur et forme :SolidMasse moléculaire :429.47Menin-MLL inhibitor 4
CAS :Menin-MLL inhibitor 4 has antitumor activity.Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction .Formule :C32H38FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.69PARP1-IN-29
CAS :PARP1-IN-29 is an orally active PARP-1 inhibitor with an IC50 of 6.3 nM. When labeled with [18F], PARP1-IN-29 can be utilized for positron emission tomography (PET) imaging, specifically targeting PARP-1 in tumors. This compound is useful in oncology and imaging studies, particularly for detecting PARP-1 activity in cancer.Formule :C18H16FN3O2Couleur et forme :SolidMasse moléculaire :325.34JAK1/TYK2-IN-3
JAK1/TYK2-IN-3, orally active, selectively inhibits TYK2 (IC50: 6 nM), JAK1 (37 nM), JAK2 (140 nM), JAK3 (362 nM), and has anti-inflammatory effects.Couleur et forme :SolidSIRT1-IN-5
CAS :SIRT1-IN-5 (215) is a modulator of NAD-dependent deacetylase SIRT1 with potential applications in cancer and cellular signaling research.Formule :C21H17N3O3SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :391.44LSD1-IN-18
LSD1-IN-18 inhibits LSD1 (Ki: 0.156 μM, KD: 0.075 μM), blocking THP-1 and MDA-MB-231 cell growth (IC50: 0.16, 0.21 μM).Formule :C31H40N6O2Couleur et forme :SolidMasse moléculaire :528.69CP-352664
CAS :CP-352664 is a JAK inhibitor with potency against JAK3, exhibiting an EC50 value of 210 nM. It holds potential for use in research related to organ transplant rejection and autoimmune diseases, such as rheumatoid arthritis.Formule :C18H18N4Couleur et forme :SolidMasse moléculaire :290.36JAK-IN-23
"JAK-IN-23: oral dual JAK/STAT & NF-κB inhibitor; JAK1 (IC50: 8.9 nM), JAK2 (15 nM), JAK3 (46.2 nM); for IBD research."Formule :C23H22Cl2N4OCouleur et forme :SolidMasse moléculaire :441.35TYK2 ligand 2
CAS :TYK2ligand 2 is the TYK2 ligand of PROTACTYD-68. TYD-68 is a highly potent and selective CRBN-recruiting TYK2 PROTAC degrader with a DC50 value of 0.42 nM.Formule :C24H20FN7O4Couleur et forme :SolidMasse moléculaire :489.458cis-4-Br-2,5-F2-PCPA
cis-4-Br-2,5-F2-PCPA (S1024) blocks LSD1/LSD2 (Ki: 94 nM/8.4 μM), hinders cancer stem cell growth, raises H3K4me2 in CCRF-CEM cells.Formule :C9H8BrF2NCouleur et forme :SolidMasse moléculaire :248.07
