Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2615 produits trouvés pour "Chromatine/Épigénétique"
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Sirtuin modulator 5
CAS :Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.Formule :C24H23N3O4Couleur et forme :SolidMasse moléculaire :417.46SMARCA2 degrader-17
CAS :SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.Formule :C47H58N10O6SCouleur et forme :SolidMasse moléculaire :891.09PROTAC BRD4 Degrader-13
CAS :PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Formule :C68H85F2N11O17P2S2Couleur et forme :SolidMasse moléculaire :1492.55Biguanide
CAS :Biguanide can reduce oxidative stress in rats with hyperglycemia.Formule :C2H7N5Couleur et forme :SolidMasse moléculaire :101.11TAS-119
CAS :TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formule :C23H22Cl2FN5O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :506.36Ref: TM-T34787
1mg97,00€5mg235,00€1mL*10mM (DMSO)261,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€PROTAC SMARCA2/4-degrader-29
CAS :PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95HDAC6-IN-56
HDAC6-IN-56 (compound 18d) is an inhibitor of HDAC6, with an IC50 of 1.3 nM. This compound can inhibit the S phase and induce apoptosis in HCT-116 colon cancer cells.
Formule :C25H27ClN4O4SCouleur et forme :SolidMasse moléculaire :514.14415EP300/CBP ligand 2
EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.Formule :C20H18N6OCouleur et forme :SolidMasse moléculaire :358.4PIM-IN-1
CAS :PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).Formule :C15H18ClFN4OCouleur et forme :SolidMasse moléculaire :324.78PROTAC BRD4 Degrader-32
PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.Formule :C42H42ClN5O5Couleur et forme :SolidMasse moléculaire :731.28745PROTAC SMARCA2/4-degrader-30
CAS :Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95KDM4 ligand-1
KDM4ligand-1 is a ligand targeting the protein (histone lysine demethylase KDM4) in PROTACs. It can be utilized for the synthesis of PROTACs.Couleur et forme :Odour SolidSIRT1-IN-1
CAS :SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formule :C14H16N2ODegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :228.29Ref: TM-T9648
1mg92,00€5mg192,00€1mL*10mM (DMSO)195,00€10mg295,00€25mg505,00€50mg708,00€100mg964,00€200mg1.288,00€Thalidomide-NH-CBP/p300 ligand 2
CAS :Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).Formule :C48H57F2N11O6Couleur et forme :SolidMasse moléculaire :922.052PROTAC SMARCA2/4-degrader-31
CAS :PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95VinSpinIn
CAS :VinSpinIn is a probe for the Spin family proteins.Formule :C42H58N8O4Couleur et forme :SolidMasse moléculaire :738.98CPI-268456
CAS :CPI-268456 is a compound which has bioactive.Formule :C20H15Cl2N3O2Couleur et forme :SolidMasse moléculaire :400.26AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61Nicotinamide riboside tartrate
CAS :NRT is an oral NAD+ precursor, boosts NAD+, activates SIRT1/3, provides vitamin B3, enhances metabolism, and may mitigate Alzheimer's.Formule :C15H20N2O11Couleur et forme :SolidMasse moléculaire :404.33PROTAC SMARCA2/4-degrader-27
CAS :PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.Formule :C49H58FN9O6SCouleur et forme :SolidMasse moléculaire :920.11
