Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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EP300/CBP ligand 2
EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.Formule :C20H18N6OCouleur et forme :SolidMasse moléculaire :358.4CBB1007 trihydrochloride (1379573-92-8 free base)
CAS :CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formule :C27H37Cl3N8O4Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :644.0Ref: TM-T10699L2
2mg131,00€5mg187,00€10mg283,00€50mg665,00€100mg1.034,00€200mgÀ demander500mgÀ demander1mL*10mM (DMSO)264,00€PROTAC SMARCA2/4-degrader-29
CAS :PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS :Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Formule :C56H110N22O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1315.61HIF-PHD-IN-4
HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.Couleur et forme :Odour SolidProtein Kinase C (19-36)
CAS :Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Formule :C93H159N35O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2151.48HDAC-IN-26
CAS :HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.Formule :C24H28FN5O3Couleur et forme :SolidMasse moléculaire :453.518Nicotinamide riboside malate
CAS :Orally active NAD+ booster, NR malate enhances metabolism, supports cognitive function, and is a vitamin B3 source.Formule :C15H20N2O10Couleur et forme :SolidMasse moléculaire :388.33JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).Formule :C30H33FN4O3SCouleur et forme :SolidMasse moléculaire :548.67PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formule :C55H60FN11O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1054.2CBP/p300-IN-8
CAS :CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.Formule :C27H31N3O4Couleur et forme :SolidMasse moléculaire :461.562GXH-II-052
GXH-II-052: Potent BET inhibitor, binds BRD4/BRDT (Kd 0.6-28 nM), anti-proliferative, reduces c-Myc expression.Formule :C62H76Cl2F2N14O11S2Couleur et forme :SolidMasse moléculaire :1366.39PROTAC SMARCA2/4 degrader-36
CAS :PROTACSMARCA2/4 degrader-36 (Compound 29) is a potent dual degrader targeting SMARCA2 and SMARCA4, exhibiting DC50 values of 0.22 nM and 0.85 nM, respectively. Additionally, PROTACSMARCA2/4 degrader-36 demonstrates antiproliferative activity.Formule :C53H62ClN9O4SCouleur et forme :SolidMasse moléculaire :956.635PROTAC BRD4 Degrader-30
PROTACBRD4 degrader-30 is an ISOX-DUAL-based PROTAC degrader, targeting BRD4 with an IC50 value of 65 nM. It is used in research studies related to c-Myc oncoproteins and the pathophysiology of cancer cells.Couleur et forme :Odour SolidHDAC6-IN-56
HDAC6-IN-56 (compound 18d) is an inhibitor of HDAC6, with an IC50 of 1.3 nM. This compound can inhibit the S phase and induce apoptosis in HCT-116 colon cancer cells.
Formule :C25H27ClN4O4SCouleur et forme :SolidMasse moléculaire :514.14415Barasertib
CAS :AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formule :C26H31FN7O6PDegré de pureté :99.92% - 99.97%Couleur et forme :SolidMasse moléculaire :587.54FTX-6058
CAS :FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.417Mersalyl
CAS :Mersalyl is an organic mercurial diuretic.Formule :C13H16HgNNaO6Couleur et forme :SolidMasse moléculaire :505.854UNC2399
CAS :UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC
Formule :C67H104N10O17SCouleur et forme :SolidMasse moléculaire :1353.68OKI-006
CAS :OKI-006 is an oral HDAC inhibitor with potential for cancer research, derived from largazole.Formule :C21H30N4O5S2Couleur et forme :SolidMasse moléculaire :482.62
