Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2612 produits trouvés pour "Chromatine/Épigénétique"
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HSP90/LSD1-IN-1
HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.Couleur et forme :Odour SolidPIM-IN-1
CAS :PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).Formule :C15H18ClFN4OCouleur et forme :SolidMasse moléculaire :324.78DS-103
DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.Formule :C28H33N5O3Couleur et forme :SolidMasse moléculaire :487.59CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Couleur et forme :SolidPim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Couleur et forme :Odour SolidPOI ligand 1
POI ligand 1 serves as a template for the non-selective HDAC inhibitor Vorinostat. It functions as a target protein ligand (PROTAC target protein ligand) in the creation of PROTAC HDAC degraders with anti-tumor properties. Additionally, POI ligand 1 is utilized in the synthesis of FF2049.Formule :C14H21N3O3Couleur et forme :SolidMasse moléculaire :279.335PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Couleur et forme :Odour SolidUNC10142
UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.Formule :C33H52N6O3Couleur et forme :SolidMasse moléculaire :580.8EPZ020411 2HCl (1700663-41-7(free base))
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).Formule :C25H40Cl2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.51pan-BET/BD2-IN-1
Pan-BET/BD2-IN-1 (compound 6b) is a selective BET protein inhibitor with BRDT-1Ki of 1.05 μM and BRD4-1Ki of 0.68 μM. It effectively inhibits the growth of MM.1S cancer cells with an IC50 value of 2.6 μM.Couleur et forme :Odour SolidBI01826025
BI01826025 (pArg-JQ1), a BRDT BD1 bromodomain PROTAC degrader, tests ClpC2's effect on ClpC1P1P2 protease.Formule :C31H42ClN10O7PSCouleur et forme :SolidMasse moléculaire :765.22TP-472N
CAS :TP-472N serves as a negative control probe for TP-472, which is a specific and effective BRD7/9 probe.Formule :C19H18N2O2Couleur et forme :SolidMasse moléculaire :306.36PARP1-IN-6
CAS :PARP1-IN-6, a dual-function inhibitor, targets both tubulin and PARP-1, demonstrating inhibitory concentration (IC50) values of 0.94 μM for tubulin and 0.48 μMFormule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.27Adenosine receptor modulator 1
Adenosine receptor modulator 1 acts as an inducer of collagen VII (C7). It enhances the expression of COL7A1 mRNA in donor-derived keratinocytes and, in synergy with Gentamicin, increases the overall levels of C7.Formule :C25H28N6O3Couleur et forme :SolidMasse moléculaire :460.53XF056-132
CAS :XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .Formule :C51H57F4N9O7SCouleur et forme :SolidMasse moléculaire :1016.11BTR2004
BTR2004 is a selective PROTAC degrader targeting the BET family (BRD2/3/4) proteins. It facilitates the formation of a ternary complex with BRD proteins and KLHL20, leading to ubiquitination and proteasomal degradation via the UPS pathway. BTR2004 shows potential for research in PC3 prostate cancer and MDA-MB-231 breast cancer cell lines.Couleur et forme :Odour SolidTazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS :Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].Formule :C34H43N3O7Couleur et forme :SolidMasse moléculaire :605.72JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Couleur et forme :Odour SolidMT1
CAS :MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).Formule :C54H66Cl2N10O9S2Couleur et forme :SolidMasse moléculaire :1134.2SAMβA TFA
SAMβA TFA, a selective antagonist of Mfn1-βIIPKC association conjugated to the cell permeable peptide TAT47-57, is a rationally designed inhibitor that improvesFormule :C50H73N17O16·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1168.22 (free acid)
