Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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SIRT5 inhibitor 8
CAS :SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Formule :C22H25ClN8O2SDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :501PRO-HD2
PRO-HD2 is a selective, PROTAC-based degrader of HDAC6 [1].Degré de pureté :98%Couleur et forme :Odour SolidSIRT5 inhibitor 9
CAS :SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formule :C24H29ClN8O4SDegré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :561.06SIRT1-IN-1
CAS :SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formule :C14H16N2ODegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :228.29Ref: TM-T9648
1mg92,00€5mg192,00€10mg295,00€25mg505,00€50mg708,00€100mg964,00€200mg1.288,00€1mL*10mM (DMSO)195,00€HAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Formule :C60H69N17O11SCouleur et forme :SolidMasse moléculaire :1236.36PARP/EZH2-IN-1
CAS :PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.Formule :C43H41FN8O5Couleur et forme :SolidMasse moléculaire :768.85PROTAC HDAC6 degrader 3
PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]Formule :C46H56F2N10O9SCouleur et forme :SolidMasse moléculaire :963.06RMM23
RMM23 is an inhibitor that targets PfBDP1, exhibiting a Kd of 1.24 μM. In vitro, it shows EC50 values of 18 μM against the 3D7 wild-type strain, 14 μM against the NF54 wild-type strain, and 20 μM against the multidrug-resistant K1 strain during the blood stage.Couleur et forme :Odour SolidSphingosine (d14:1)
CAS :Sphingosine (d14:1) boosts N. rileyi fungus growth, inhibits PKC, and reduces CHO cell proliferation; found in various sea creatures.Formule :C14H29NO2Couleur et forme :SolidMasse moléculaire :243.39SJ988497
CAS :SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Formule :C36H36N10O5Couleur et forme :SolidMasse moléculaire :688.74UNC6349 (Ket2)
UNC6349 (Ket2), a ligand containing diethyllysine (Ket2), effectively binds to wild-type CBX5 with a dissociation constant (K D) of 3.2 μM [1].Formule :C41H57N7O11Couleur et forme :SolidMasse moléculaire :823.93NCT-TFP
CAS :NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors[1].Formule :C41H34F4N2O5Couleur et forme :SolidMasse moléculaire :710.71RX-37
CAS :RX-37, a potent BET inhibitor (Ki: 3.2-24.7 nM for BRD2/3/4), selectively hinders growth in leukemia cells with MLL1 gene rearrangement.Formule :C24H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.47MS479
MS479 is a BRD4 PROTAC degrader that binds with high affinity to BRD4-BD2 and GLP (BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM). It effectively reduces the protein levels of BRD4 short isoforms. By directly binding to its substrate GLP, MS479 recruits the E3 ligase SPOP as a bridging protein. Additionally, MS479 can be utilized to inhibit the proliferation of colorectal cancer cells.Couleur et forme :Odour SolidCAY10591
CAS :SIRT1 activated by CAY10591, mimics caloric restriction, extends lifespan, inhibits apoptosis, suppresses TNF-α, and promotes fat mobilization.
Formule :C20H25N5O2Couleur et forme :SolidMasse moléculaire :367.44HIF-1 inhibitor-5
HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1Formule :C28H35NO5Couleur et forme :SolidMasse moléculaire :465.58FHD-286
CAS :FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia.Formule :C24H30N6O6S2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :562.66Ref: TM-T9749
1mg144,00€5mg283,00€10mg454,00€25mg615,00€50mg777,00€100mg1.064,00€1mL*10mM (DMSO)359,00€Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Couleur et forme :Odour SolidZSNI-21
ZSNI-21 is a dual inhibitor targeting ADAM17 and HDAC2. It effectively suppresses the proliferation of Bel-7402 cells and exhibits significant anti-metastatic properties against HCC-LM3 cells, making it a promising candidate for hepatocellular carcinoma (HCC) research.Formule :C26H25N3O5Couleur et forme :SolidMasse moléculaire :459.49ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Couleur et forme :Odour Solid
