Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2242 produits trouvés pour "Chromatine/Épigénétique"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
PRMT5-IN-37
CAS :<p>PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.</p>Formule :C21H15F4N5O2Couleur et forme :SolidMasse moléculaire :445.37HYDAMTIQ
CAS :<p>HYDAMTIQ, a PARP-1/2 inhibitor (IC 50 : 29-38 nM), exhibits a range of pharmacological effects including anticancer, anti-inflammatory, and ischemic protective properties. It effectively reduces pulmonary PARP activity and alleviates symptoms such as allergen-induced cough and dyspnea while also diminishing bronchial hyperresponsiveness to methacholine. Moreover, HYDAMTIQ shows potent tumor suppressor activity in various cancers such as ovarian, breast, prostate, pancreatic, and glioblastoma multiforme. Demonstrating in vivo efficacy, HYDAMTIQ has been tested in animal models for conditions like cerebral ischemia, asthma, and cancer [1].</p>Formule :C14H14N2O2SCouleur et forme :SolidMasse moléculaire :274.34SRI-43265
CAS :<p>SRI-43265 (compound 40) inhibits the dimerization of human antigen R protein (HuR), which is involved in cancer and inflammation pathogenesis [1].</p>Formule :C19H20N6OCouleur et forme :SolidMasse moléculaire :348.4NVS-BPTF-1
CAS :<p>NVS-BPTF-1 is a specific inhibitor of bromodomain and PHD finger containing transcription factor (BPTF), exhibiting a dissociation constant (K_D) of 71 nM [1].</p>Formule :C26H28FN7O3SCouleur et forme :SolidMasse moléculaire :537.61NPC26
CAS :<p>NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.</p>Formule :C19H23N3O5S2Couleur et forme :SolidMasse moléculaire :437.533NSD2-PWWP1-IN-2
CAS :<p>NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.</p>Formule :C29H30N4Couleur et forme :SolidMasse moléculaire :434.575PRMT5-IN-49
CAS :<p>PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.</p>Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39BRD4 Inhibitor-33
CAS :<p>BRD4 Inhibitor-33 (example 13), a potent inhibitor of BRD4, is applicable in research related to both acute and chronic kidney diseases [1].</p>Formule :C24H20N4O2Couleur et forme :SolidMasse moléculaire :396.44PRMT5-IN-50
CAS :<p>PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.</p>Formule :C26H23F3N6OCouleur et forme :SolidMasse moléculaire :492.496BRD4-IN-7
CAS :<p>BRD4-IN-7, also known as compound 120, acts as a BRD4 inhibitor.</p>Formule :C29H24F2N4O3Couleur et forme :SolidMasse moléculaire :514.52MS8815
CAS :<p>MS8815 is a selective EZH2 PROTAC degrader with IC50 of 8.6 nM, used in triple-negative breast cancer research.</p>Formule :C65H87N9O8SCouleur et forme :SolidMasse moléculaire :1154.51HDAC-IN-27
<p>HDAC-IN-27 is a potent and orally active inhibitor of HDAC Class I (0.43 nM - 3.01 nM for HDAC1-3).</p>Formule :C20H22N4O2Couleur et forme :SolidMasse moléculaire :350.41HDAC6-IN-13
<p>HDAC6-IN-13: potent, selective HDAC6 inhibitor; oral; IC50=0.019μM; targets HDAC1/2/3; crosses blood-brain barrier; anti-inflammatory.</p>Formule :C23H22N4OCouleur et forme :SolidMasse moléculaire :370.45KDOAM-25 citrate
CAS :<p>KDOAM-25 citrate inhibits KDM5A/B/C/D (IC50: 71, 19, 69, 69 nM); boosts H3K4 methylation, hinders MM1S cell growth. [1]</p>Formule :C21H33N5O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.51MC2652
<p>MC2652, a potent LSD1 inhibitor, suppresses leukemia (MV4-11, NB4) and impedes prostate cancer (LNCaP) cell growth.</p>Formule :C22H20N2OCouleur et forme :SolidMasse moléculaire :328.41ROPA
CAS :<p>ROPA, a potent PKCalpha and PKCgamma activator, promotes tumor growth through PKC-activation.</p>Formule :C28H32O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.55LSD1-IN-13 hydrochloride
CAS :<p>LSD1-IN-13 hydrochloride (7e) is an oral LSD1 inhibitor (IC50: 24.43 nM), promoting differentiation in AML cell lines.</p>Formule :C23H30ClN3O2SCouleur et forme :SolidMasse moléculaire :448.02HIF-1/2α-IN-1
<p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>Formule :C17H16N6O4Couleur et forme :SolidMasse moléculaire :368.35CBP/p300-IN-2
CAS :<p>CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).</p>Formule :C27H29F2N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.56DCHC
CAS :<p>DCHC is an activator of SIRT1, but it does not induce SIRT1 expression. This compound can be utilized in studies related to mitochondrial damage.</p>Formule :C15H8Cl2O3Couleur et forme :SolidMasse moléculaire :307.128
