Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
SK-575
CAS :SK-575 is a potent PARP1-degrading agent effective against BRCA1/2 mutant cancers, even at low doses, and enhances tumor inhibition in mice.Formule :C47H53FN8O8Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :876.97ZEN-3862
CAS :ZEN-3862, a BET inhibitor, blocks BRD4(BD1) at 0.16 μM & BRD4(BD2) at 0.13 μM; usable in PROTACs for BRD4 degradation.Formule :C19H17FN2O3Degré de pureté :97.1%Couleur et forme :SolidMasse moléculaire :340.35OXFBD04
CAS :OXFBD04: Potent BRD4 inhibitor, IC50=166nM, acts on BET bromodomains; moderate CREBBP affinity; anti-cancer properties.Formule :C17H16N2O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :296.32Ref: TM-T12338
1mg52,00€2mg78,00€5mg115,00€1mL*10mM (DMSO)126,00€10mg182,00€25mg339,00€50mg505,00€100mg685,00€200mg944,00€KRH102140
CAS :KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.Formule :C25H24FNODegré de pureté :98.31% - 99.61%Couleur et forme :SolidMasse moléculaire :373.46ML192
CAS :ML192 (CID1434953) is a selective GPR55 ligand antagonist.Formule :C20H22N4O2SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :382.48Ref: TM-T33452
1mg34,00€5mg71,00€1mL*10mM (DMSO)92,00€10mg104,00€25mg172,00€50mg249,00€100mg350,00€200mg480,00€Bisaramil hydrochloride
CAS :Bisaramil hydrochloride (Bisaramil) is an antiarrhythmic compound that inhibits free radical production.Formule :C17H24Cl2N2O2Degré de pureté :98.64% - 99.48%Couleur et forme :SolidMasse moléculaire :359.29JAK1-IN-8
CAS :JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Formule :C22H23FN4O3SDegré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :442.51ACY-957
CAS :ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.Formule :C24H23N5OSDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :429.54Ref: TM-T10245
1mg90,00€2mg136,00€5mg230,00€1mL*10mM (DMSO)251,00€10mg281,00€25mg432,00€50mg612,00€100mg802,00€JAK-STAT-IN-1
CAS :JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formule :C21H21N5O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :375.42PARP10-IN-2
CAS :PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and
Formule :C14H10N2O2Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :238.24CPUY074020
CAS :CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.Formule :C25H28N4O2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :416.52Ref: TM-T10882
1mg71,00€5mg147,00€1mL*10mM (DMSO)159,00€10mg205,00€25mg319,00€50mg450,00€100mg587,00€200mg803,00€ZEN-2759
CAS :ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).Formule :C17H16N2O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :280.32PU139
CAS :PU139 is a novel inhibitor of histone acetyltransferase (HAT).Formule :C12H7FN2OSDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :246.26EB-47
CAS :EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).Formule :C24H27N9O6Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :537.53STS-E412
CAS :STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.Formule :C15H15ClN4O2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :318.76Raxofelast
CAS :Raxofelast (IRFI-016), a vitamin-like, hydrophilic antioxidant, mitigates ischemia-reperfusion in testis and may treat diabetic issues and atherosclerosis.Formule :C15H18O5Degré de pureté :99.74% - 99.97%Couleur et forme :SolidMasse moléculaire :278.3Butyzamide
CAS :Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.Formule :C29H32Cl2N2O5SDegré de pureté :99.39% - 99.83%Couleur et forme :SoildMasse moléculaire :591.55Ref: TM-T67894
1mg149,00€5mg253,00€1mL*10mM (DMSO)329,00€10mg371,00€25mg573,00€50mg862,00€100mg1.305,00€200mg1.755,00€DC-BPi-03
CAS :DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC 50 of 698.3 nM and a K d of 2.81 μM .Formule :C14H14N4O2SDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :302.35MS0124
CAS :MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
Formule :C20H29N5O3Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :387.48YLF-466D
CAS :YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.Formule :C29H20ClNO3Degré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :465.93Ref: TM-T13368
1mg34,00€5mg79,00€1mL*10mM (DMSO)82,00€10mg111,00€25mg188,00€50mg269,00€100mg371,00€200mg512,00€Procainamide
CAS :Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.Formule :C13H21N3ODegré de pureté :99.79% - 99.92%Couleur et forme :SolidMasse moléculaire :235.33BRD4 Inhibitor-20
CAS :BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity.
Formule :C18H18N2O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :358.41Chiauranib
CAS :Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47Ref: TM-T35570
1mg66,00€5mg144,00€1mL*10mM (DMSO)157,00€10mg245,00€25mg492,00€50mg710,00€100mg973,00€Flosequinan
CAS :Flosequinan is an arteriovenous vasodilator, which can effectively treat acute heart failure.Formule :C11H10FNO2SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :239.27Ref: TM-T31805
1mg175,00€1mL*10mM (DMSO)351,00€5mg394,00€10mg582,00€25mg888,00€50mg1.243,00€100mg1.674,00€500mg3.348,00€β-NF-JQ1
CAS :β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins.Formule :C45H42ClN5O6SDegré de pureté :97.58% - 99.15%Couleur et forme :SolidMasse moléculaire :816.36OUL232
CAS :OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.Formule :C10H10N4O2SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :250.28Butyrolactone 3
CAS :Butyrolactone 3 (MB-3) is a Gcn5 inhibitor with weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and can be used in cancer.Formule :C9H12O4Degré de pureté :98.99% - 99.5%Couleur et forme :SolidMasse moléculaire :184.19ZEN-3411
CAS :ZEN-3411 is an BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproducing BET proteins.Formule :C21H20N4O2Degré de pureté :97.51% - 98.84%Couleur et forme :SolidMasse moléculaire :360.41SS-208
CAS :SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.Formule :C13H11Cl2N3O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :344.15Izencitinib
CAS :Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Formule :C22H26N8Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :402.50Ref: TM-T35898
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg281,00€25mg567,00€50mg888,00€100mg1.431,00€200mg1.963,00€BRD2492
CAS :BRD2492 is an HDAC1 and HDAC2 inhibitor with antiproliferative activity, inhibits HDAC1/2 and induces apoptosis.Formule :C20H18N4O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :346.38PF-249
CAS :PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Formule :C17H16ClN3O3Degré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :345.78Ref: TM-T24626
1mg46,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg236,00€50mg344,00€100mg482,00€200mg662,00€BAY-299
CAS :BAY-299 inhibits BRPF2, TAF1, and TAF1L with IC50s of 67, 8, and 106 nM.Formule :C25H23N3O4Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :429.47DW14800
CAS :DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.Formule :C31H36N4O3Degré de pureté :99.55% - 99.68%Couleur et forme :SolidMasse moléculaire :512.64Ref: TM-T11131
1mg93,00€2mg123,00€5mg205,00€1mL*10mM (DMSO)233,00€10mg358,00€25mg680,00€50mg898,00€100mg1.341,00€AGI-24512
CAS :AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells inFormule :C24H24N4O2Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :400.47Ref: TM-T14141
1mg66,00€5mg145,00€1mL*10mM (DMSO)195,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€200mg982,00€NSC668394
CAS :NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.Formule :C17H12Br2N2O3Degré de pureté :99.29% - 99.29%Couleur et forme :SolidMasse moléculaire :452.1NT160
CAS :NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases.Formule :C21H21F3N4O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :418.41Ref: TM-T78709
1mg94,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg356,00€25mg715,00€50mg1.153,00€100mg1.783,00€EZH2-IN-14
CAS :EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.Formule :C31H39N7O2Couleur et forme :SolidMasse moléculaire :541.69QC6352
CAS :QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).Formule :C24H25N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.47GNE-049
CAS :GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.Formule :C27H32F2N6O2Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :510.58Amelparib
CAS :Amelparib (JPI-289) is an inhibitor of the poly-ADP-ribose polymerase.Formule :C19H25N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.42HDAC8-IN-4
CAS :HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].Formule :C17H14N2O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.44HDAC/HSP90-IN-3
CAS :HDAC/HSP90-IN-3, a dual inhibitor targeting fungal Hsp90 (IC50: 0.83 μM) & HDAC (IC50: 0.91 μM), counters azole-resistant C. albicans.Formule :C26H33N5O6Couleur et forme :SolidMasse moléculaire :511.57HDAC/BET-IN-1
CAS :HDAC/BET-IN-1 inhibits HDAC1 (IC50: 0.163 μM), HDAC6 (IC50: 0.067 μM), BRD4 (Ki: 0.076 μM), and fights leukemia.Formule :C29H40N4O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :604.71FHT-1204
CAS :FHT-1204 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) (IC50 ≤ 10 nM).Formule :C24H23N5O5S2Couleur et forme :SolidMasse moléculaire :525.6TCS HDAC6 20b
CAS :TCS HDAC6 20b (HDAC6-IN-7) is an HDAC6 inhibitor that blocks the growth of breast cancer cells and can be used in cancer research.Formule :C26H44N2O4SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :480.7GW814408X
CAS :GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formule :C19H16N6OMasse moléculaire :344.37PKC-θ inhibitor 1
CAS :PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)Formule :C17H15F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.32HDAC-IN-38
CAS :HDAC-IN-38: Potent HDAC1-3,5,6,8 inhibitor, boosts H3K14/H4K5 acetylation, elevates CBF, lessens cognitive decline & hippocampal atrophy.Formule :C27H28ClN3O2Couleur et forme :SolidMasse moléculaire :461.98Aurora kinase inhibitor-8
CAS :Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Formule :C30H29N7O3Couleur et forme :SolidMasse moléculaire :535.6PIM1-IN-1
CAS :PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Formule :C25H30N8O2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :474.56Ref: TM-T12474
10mgÀ demander1mL*10mM (DMSO)À demander1mg117,00€5mg281,00€25mg858,00€50mg1.341,00€100mg2.125,00€Tubulin/JAK2-IN-1
CAS :Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significantFormule :C22H20N6O3Couleur et forme :SolidMasse moléculaire :416.43HDAC6/HSP90-IN-1
CAS :HDAC6/HSP90-IN-1 is a potent dual inhibitor of HDAC6 and HSP90 with IC50s 4.3 nM & 46.8 nM, respectively; curbs PD-L1 and tumor growth in H1975 mice.Formule :C28H37N3O6Couleur et forme :SolidMasse moléculaire :511.61dBRD4-BD1
CAS :dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.Formule :C50H53F3N8O9Couleur et forme :SolidMasse moléculaire :967RK-0133114
RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54Sirtuin modulator 1
CAS :Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Formule :C31H32ClN5O2S2Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :606.2CAY10398
CAS :CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).Formule :C15H23N3O3Couleur et forme :SolidMasse moléculaire :293.367HIF-2α-IN-13
CAS :HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.Formule :C15H14ClF4NO2Couleur et forme :SolidMasse moléculaire :351.72UNC8153 TFA
CAS :UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating aFormule :C35H38F3N5O7Degré de pureté :96.44%Couleur et forme :SolidMasse moléculaire :697.7Demethyleneberberine chloride
CAS :Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-Formule :C19H18ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :359.8Bocodepsin
CAS :Bocodepsin (OKI-179) is a selective, orally active inhibitor of histone deacetylases (HDAC) with demonstrated antitumor efficacy.Formule :C26H39N5O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.75BY27
CAS :BY27 is a BET BD2 inhibitor with anticancer activity that inhibits BRD2, BRD3 and BRD4 and suppresses tumor growth.Formule :C22H21ClN6Degré de pureté :99.4% - 99.68%Couleur et forme :SolidMasse moléculaire :404.89JAK-IN-1
CAS :JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.Formule :C20H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.44JAK-IN-4
CAS :JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.Formule :C18H21N4Na2O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.341Bocodepsin hydrochloride
CAS :Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration.Formule :C26H40ClN5O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :618.21WAY-354574
CAS :WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].Formule :C20H23ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.93KPZ560
CAS :KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively.Formule :C26H21N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.61CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormule :C29H43Cl3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.04PF-06679142
CAS :PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Formule :C20H17F2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.35AMPK-IN-1
CAS :AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Formule :C24H18ClN3O3Couleur et forme :SolidMasse moléculaire :431.87HDAC6-IN-8
CAS :Compound 12C, with altered cap groups, shows wide-range enzyme inhibition; 9m and 9q target HDAC6 specifically.Formule :C23H17BrFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.32FHT-2344
CAS :FHT-2344, a SMARCA4/SMARCA2 ATPase inhibitor, exhibits anticancer activity with half-maximal inhibitory concentrations (IC 50 ) of 0.026 μM for SMARCA4 and 0.013 μM for SMARCA2, respectively [1].Formule :C23H24N6O5S2Couleur et forme :SolidMasse moléculaire :528.6Sirt2-IN-5
CAS :Sirt2-IN-5 is a potent inhibitor of SIRT2.Formule :C26H27Cl2N5O3Couleur et forme :SolidMasse moléculaire :528.43JAK kinase-IN-1
CAS :JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32Formule :C17H19F2N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.44PHD-IN-1
CAS :PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Formule :C24H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.49Vafidemstat
CAS :Vafidemstat (ORY-2001) is a lysine-histone demethylase (LSD1)/MAO-B inhibitor for the study of neurological disorders.Formule :C19H20N4O2Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :336.39NMS-P953
CAS :NMS-P953: JAK2 inhibitor, reduces tumor growth in SET-2 model, confirmed in vivo action, good pharmacokinetics and safety.Formule :C16H11ClF3N5OCouleur et forme :SolidMasse moléculaire :381.74JBI-589
CAS :JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.Formule :C29H28FN5OCouleur et forme :SolidMasse moléculaire :481.56CW 008
CAS :CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.Formule :C21H14F2N6O2Degré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :420.37CD235
CAS :CD235 is a structurally similar analog of CD161. CD161 is an orally bioavailable inhibitor of BET bromodomain.Formule :C26H20FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.47YM-08
CAS :YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formule :C19H17N3OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.49Ampkinone
CAS :Ampkinone is an indirect AMPK activator.Formule :C31H23NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.52KF21213
CAS :KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.Formule :C19H22N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.4KP-544
CAS :KP-544 is an agent of neurotrophin potentiator.Formule :C18H19ClN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.82Ginsenoside Rk1
CAS :Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :767.00PARP7-IN-16
CAS :PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.Formule :C25H26FN4NaO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.49GSK-3484862
CAS :Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Formule :C19H19N5OSDegré de pureté :99.87% - 99.963%Couleur et forme :SolidMasse moléculaire :365.45Ref: TM-T11469
1mg48,00€5mg113,00€10mg177,00€1mL*10mM (DMSO)203,00€25mg318,00€50mg485,00€100mg692,00€500mg1.395,00€MAK683-CH2CH2COOH
CAS :MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.Formule :C23H21FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.45HIF-2α-IN-6
CAS :HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].Formule :C15H13F4NO3SCouleur et forme :SolidMasse moléculaire :363.33MTDH-SND1 blocker 1
CAS :MTDH-SND1 Blocker 1 (Compound C26-A6) serves as an inhibitor targeting the MTDH-SND1 protein, effectively suppressing cancer metastasis [1].Formule :C14H13ClN4O3SCouleur et forme :SolidMasse moléculaire :352.8UNC7145
CAS :UNC6934 Negative Control (Axon 3591) is a chemically related compound that serves as a negative control for UNC6934, a potent and selective chemical probe that specifically targets the N-terminal PWWP (PWWP1) domain of NSD2.Formule :C24H23N5O4Couleur et forme :SolidMasse moléculaire :445.4705TRC160334 sodium
CAS :TRC160334 is a HIF hydroxylases inhibitor.Formule :C14H15N3O5SCouleur et forme :SolidMasse moléculaire :337.35MARK-IN-1
CAS :MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Formule :C22H23F2N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.53AAPK-25
CAS :AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formule :C21H13Cl2N3O2SDegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :442.32Ref: TM-T10215
1mg54,00€5mg118,00€1mL*10mM (DMSO)131,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€CBP/p300-IN-15
CAS :CBP/p300-IN-15 inhibits p300 (IC50: 2.5 nM) & CBP (28 nM), affects OVCAR-3 (EC50: 0.865 μM) & A2780 cells (2.71 μM) for ovarian cancer research.Formule :C26H28N4O5Couleur et forme :SolidMasse moléculaire :476.52GRK2 Inhibitor 2
CAS :GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Formule :C19H16N4O2Couleur et forme :SolidMasse moléculaire :332.36F-Amidine TFA
CAS :F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.Formule :C14H19FN4O2CF3COOHCouleur et forme :SolidMasse moléculaire :408.4Upadacitinib tartrate
CAS :Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.Formule :C21H33F3N6O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.521QL-1200186
CAS :QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFormule :C26H27N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.54DY-46-2
CAS :DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.Formule :C19H22N6O5SDegré de pureté :99.12% - 99.12%Couleur et forme :SolidMasse moléculaire :446.48(1s,4s)-Menin-MLL inhibitor-23
(1s,4s)-Menin-MLL Inhibitor-23, an enantiomer of Menin-MLL Inhibitor-23 (Example 99A), functions as an inhibitor of the menin-MLL interaction [1].Formule :C36H53FN6O4Couleur et forme :SolidMasse moléculaire :652.84VTX-27
CAS :VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Formule :C20H24ClFN6ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :418.9Ref: TM-T13314
1mg88,00€2mg118,00€1mL*10mM (DMSO)213,00€5mg230,00€10mg344,00€25mg532,00€50mg740,00€100mg982,00€HDAC6-IN-34
CAS :HDAC6-IN-34 (compound 21), an orally active, selective HDAC6 inhibitor, exhibits an IC50 of 18 nM. It enhances tubulin acetylation levels without impacting histone acetylation in cutaneous T-cell lymphoma cells and suppresses TNF-α secretion in LPS-stimulated macrophage cells. Furthermore, HDAC6-IN-34 demonstrates outstanding anti-arthritic efficacy in rats [1].Formule :C18H18F3N3O3Couleur et forme :SolidMasse moléculaire :381.35ARTD3/PARP3-IN-1
CAS :ARTD3/PARP3-IN-1 is a non-selective inhibitor targeting diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3)/PARP3 [1].Formule :C17H16N4O2Couleur et forme :SolidMasse moléculaire :308.33PHD2/HDACs-IN-1
CAS :PHD2/HDACs-IN-1: strong PHD2/HDAC inhibitor (IC50: 1.15-26.60 μM), low-toxicity, protects kidneys from cisplatin-induced AKI.Formule :C18H19N9O4Couleur et forme :SolidMasse moléculaire :425.4BRD-IN-3
CAS :BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ.Formule :C21H25N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.45DNMT-IN-3
CAS :DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].Formule :C37H39N7OCouleur et forme :SolidMasse moléculaire :597.75BRD4 Inhibitor-23
CAS :BRD4 Inhibitor-23: potent, oral, IC50: BRD4 BD-1 6.21 nM, BD-2 1.44 nM. See WO2022033542A1 Example 1.Formule :C22H19F2N3O4SCouleur et forme :SolidMasse moléculaire :459.47HL23
CAS :HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC).Formule :C44H44N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :712.83SRT3657
CAS :SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Formule :C40H54N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.97EPZ-030456
CAS :EPZ-030456 is an effective and selective inhibitor of the SMYD3.Formule :C28H34ClN5O4SCouleur et forme :SolidMasse moléculaire :572.12MS31
CAS :MS31 is a potent and highly affinity inhibitor of spindlin 1 (SPIN1).Formule :C20H27N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :341.45K-756
CAS :K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).
Formule :C24H27N5O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :433.5KDM4-IN-2
CAS :KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.Formule :C25H26N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.51CC-90005
CAS :CC-90005 is a potent, selective oral PKC-θ inhibitor with an IC50 of 8 nM, preferential over PKC-δ, and inhibits T cell activation.Formule :C21H27F2N7O2Couleur et forme :SolidMasse moléculaire :447.48GSK3368715 hydrochloride
CAS :GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.Formule :C20H38N4O2·HClCouleur et forme :SolidMasse moléculaire :403Compound SA91-0178
CAS :SA91-0178 (3-{[(1-methyl-2-oxo-1'-phenyl-1,2-dihydrospiro[indole-3,4'-piperidine]-5-carbonyl)amino]methyl}benzoic acid) is a specific METTL1 inhibitor and effectively alleviated tissue injury during septic inflammation.Formule :C28H27N3O4Masse moléculaire :469.54KDM2A/7A-IN-1
CAS :KDM2A/7A-IN-1 is a KDM2A/7A inhibitor with potential anti-tumour activity for the study of duodenal adenomas and ossifying fibromucoid tumours.Formule :C33H38N4ODegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :506.68MK-0626
CAS :MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Formule :C22H24F2N6O2Degré de pureté :99.47% - >99.99%Couleur et forme :SolidMasse moléculaire :442.46T-448 free base
CAS :T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).Formule :C17H20N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.43JAK2-IN-4
CAS :JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.Formule :C23H27N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.56PI3K/HDAC-IN-2
CAS :PI3K/HDAC-IN-2: dual inhibitor with IC50s - PI3Kα: 226nM, β: 279nM, γ: 467nM, δ: 29nM; HDAC1: 1.3nM. Selective to PI3Kδ/class I/IIb HDAC, anticancer.Formule :C23H23N7O4Couleur et forme :SolidMasse moléculaire :461.47Tankyrase-IN-5
CAS :Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitoryFormule :C17H18N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.34TC-A 2317 hydrochloride
CAS :TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Formule :C19H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.93Brepocitinib
CAS :Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Formule :C18H21F2N7ODegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :389.4Ref: TM-TQ0010
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg205,00€50mg371,00€100mg595,00€200mg833,00€PRMT5-IN-28
CAS :PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processesFormule :C18H19ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.82JAK-IN-5
CAS :JAK-IN-5 is a JAK inhibitor.Formule :C27H31FN6ODegré de pureté :98.1% - 99.37%Couleur et forme :SolidMasse moléculaire :474.57Ref: TM-T11710
1mg177,00€5mg370,00€1mL*10mM (DMSO)537,00€10mg552,00€25mg879,00€50mg1.189,00€100mg1.603,00€500mg3.205,00€XDM-CBP
CAS :XDM-CBP is an effective and selective CBP/p300 bromodomain inhibitor.Formule :C21H22N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.41JQKD82 dihydrochloride
CAS :JQKD82 (JADA82) dihydrochloride, a cell-permeable and selective inhibitor of KDM5, enhances H3K4me3 levels, making it effective for multiple myeloma research [1].Formule :C27H42Cl2N4O5Couleur et forme :SolidMasse moléculaire :573.55INCB059872 tosylate
CAS :INCB059872: potent, selective oral LSD1 inhibitor, increasing tumor-suppressor gene expression by promoting H3K4 and H3K9 methylation.Formule :C37H50N2O9S2Couleur et forme :SolidMasse moléculaire :730.932GSK737
CAS :GSK737 is a dual inhibitor of BRD4 BD1 and BD2, exhibiting pIC50 values of 5.3 and 7.3, respectively.Formule :C20H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :363.41PARP-2-IN-1
CAS :PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).Formule :C21H19F4N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.4ABBV-712
CAS :ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseasesFormule :C24H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.5KAT modulator-1
CAS :KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].Formule :C20H36O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.5FM-479
CAS :FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.
Formule :C25H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.523GSK2646264
CAS :GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.Formule :C24H26N2O2Couleur et forme :SolidMasse moléculaire :374.48JAK-IN-31
CAS :JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,Formule :C21H19N7O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.55PHD-IN-2
CAS :PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFormule :C26H27N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.54PRMT5-IN-29
CAS :PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].Formule :C18H20Cl3N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.74AGI-25696
CAS :AGI-25696 inhibits MATA2, blocking MTAP-deleted tumor growth, potential for cancer research.Formule :C27H18N4ODegré de pureté :98.40% - 99.74%Couleur et forme :SolidMasse moléculaire :414.46GSK-A
CAS :GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.Formule :C21H25N5O2Couleur et forme :SolidMasse moléculaire :379.46CBP/p300-IN-5
CAS :P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).Formule :C29H27F5N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :618.55Lepzacitinib
CAS :Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formule :C18H21N5O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :355.39Ref: TM-T78207
1mg50,00€5mg104,00€1mL*10mM (DMSO)114,00€10mg167,00€25mg340,00€50mg505,00€100mg712,00€200mg1.009,00€GSK217
CAS :GSK217 is a potent and selective inhibitor of the bromo and extraterminal domain (BET) second bromodomain (BD2) with high solubility, utilized in oncology andFormule :C20H20N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.41HSP70/SIRT2-IN-2
CAS :HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].Formule :C17H13N3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.5JG-2016
CAS :JG-2016, as a histone acetyltransferase 1 inhibitor, inhibits growth of human cancer cell lines and inhibits enzymatic activity in cellulose.Formule :C18H21ClN4O3Degré de pureté :99.00% - 99.37%Couleur et forme :SolidMasse moléculaire :376.84Ref: TM-T82008
1mg110,00€5mg268,00€1mL*10mM (DMSO)294,00€10mg432,00€25mg858,00€50mg1.378,00€100mg1.783,00€WM-586
CAS :WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.Formule :C20H20F3N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :467.47PRMT5-IN-25
CAS :PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1Formule :C24H21F3N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.46PARP7-IN-15
CAS :PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].Formule :C23H24F6N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.46QQN-00358
CAS :QQN-00358 is a novel potent and selective tankyrase (TNKS) inhibitor.Formule :C26H24F3N3O4Couleur et forme :SolidMasse moléculaire :499.48KDM5-C70
CAS :KDM5-C70 is an ethyl ester derivative of KDM5-C49.Formule :C17H28N4O3Degré de pureté :97.63% - 99.86%Couleur et forme :SolidMasse moléculaire :336.43Ref: TM-T15648
2mg42,00€5mg58,00€1mL*10mM (DMSO)70,00€10mg84,00€25mg133,00€50mg233,00€100mg464,00€200mg663,00€500mg1.018,00€Sirtuin-1 inhibitor 1
CAS :Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Formule :C20H17N3O2Degré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :331.37BRD7-IN-1
CAS :BRD7-IN-1, a BI7273 derivative, forms PROTAC VZ185, targeting BRD7/9 with DC50s of 4.5/1.8 nM via VHL ligand linkage.Formule :C22H28Cl2N4O3Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :467.39Ref: TM-T17697
1mg94,00€2mg137,00€5mg222,00€1mL*10mM (DMSO)227,00€10mg334,00€25mg602,00€50mg893,00€100mg1.243,00€200mg1.693,00€Pim-1 kinase inhibitor 5
CAS :Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Formule :C22H13Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.26Aurora Kinases-IN-4
CAS :Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Formule :C26H28N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.55Bavarostat
CAS :Bavarostat: brain-penetrant HDAC6 inhibitor; IC50=60nM; >80x selective for HDAC6; modulates tubulin over histone acetylation.Formule :C20H27FN2O2Couleur et forme :SolidMasse moléculaire :346.44JH-131e-153
CAS :JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈Formule :C22H38O5Couleur et forme :SolidMasse moléculaire :382.53Physachenolide C
CAS :Physachenolide C, a selective BET inhibitor, induces apoptosis and arrests the cell cycle at the G0-G1 phase, exhibiting antitumor activity [1].Formule :C30H40O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.63NMS-P515
CAS :NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity.Formule :C21H29N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.47KDM2B-IN-1
CAS :KDM2B-IN-1: Potent, specific KDM2B histone demethylase inhibitor for hyperproliferative disease research.Formule :C21H30N4O2SCouleur et forme :SolidMasse moléculaire :402.56GNE-955
CAS :GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Formule :C22H24N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.48GSK4028
CAS :GSK4028 is the enantiomeric negative control of GSK4027, a PCAF/GCN5 bromodomain chemical probe, with a pIC50 of 4.9 in a TR-FRET assay.Formule :C17H21BrN4OCouleur et forme :SolidMasse moléculaire :377.28TC-AC28
CAS :TC-AC28 is a novel potent and selective Brd2(2) ligand.Formule :C23H21N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.44(S,R)-CFT8634
CAS :(S,R)-CFT8634 is a selective and orally active BRD9 protein degrader with potential for researching BRD9-mediated disorders, such as abnormal cellularFormule :C37H45F3N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :710.79CBP/p300-IN-21
CAS :CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibitsFormule :C19H16ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.79PHD2-IN-1
CAS :PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].Formule :C21H23ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.88HIF-2α-IN-9
CAS :HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes withinFormule :C12H13F5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.35JAK-IN-26
CAS :JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormule :C22H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46Bromodomain inhibitor-12 (edisylate)
CAS :Bromodomain Inhibitor-12 Edisylate (example 303) serves as a bromodomain inhibitor applicable to autoimmune and inflammatory disease research [1].Formule :C30H44N4O11S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :700.82BET-IN-16
CAS :BET-IN-16 (Comp I), a bromodomain and extra-terminal (BET) inhibitor, demonstrates anticancer activity by impeding the growth of prostate cancer cells.Formule :C31H25N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.56BRD4 Inhibitor-28
CAS :BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55Formule :C23H21N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43Antitumor agent-101
CAS :Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM forFormule :C26H38N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :482.62MARK-IN-2
CAS :MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Formule :C18H18ClF2N5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.88SJ1461
CAS :SJ1461 is a potent, orally active inhibitor of the BET family, selectively targeting and inhibiting BRD2 (BD1), BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) withFormule :C21H18ClN7OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484SIRT5 inhibitor 7
CAS :SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.Formule :C28H32ClN7O3SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :582.12PIM-IN-2
CAS :PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Formule :C19H22N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.4GNE-207
CAS :GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM).Formule :C29H30N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.59SP-2-225
CAS :SP-2-225, a selective inhibitor of HDAC6, augments the production of cancer-associated antigens and enhances macrophage antigen cross-presentation to T cells,Formule :C28H34N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.58CBP-IN-1
CAS :CBP-IN-1 (compound 12) acts as a potent CBP inhibitor exhibiting an IC50 of 1.5 nM and additionally suppresses CBP BRET and BRD4(1) with IC50 values of 690 nMFormule :C27H33F2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.59Bisegliptin
CAS :Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.Formule :C18H26FN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.42FT895
CAS :FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.Formule :C16H15F3N4O2Degré de pureté :98.95% - >99.99%Couleur et forme :SolidMasse moléculaire :352.31Ref: TM-T11329
1mg92,00€5mg219,00€1mL*10mM (DMSO)241,00€10mg339,00€25mg570,00€50mg795,00€100mg1.108,00€MAT2A-IN-12
CAS :MAT2A Allosteric Inhibitor 2 is a potent, selective inhibitor exhibiting an IC50 of 5 nM and demonstrates nanomolar efficacy (IC50 = 5 μM) in proliferationFormule :C20H17NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.35Eleven-Nineteen-Leukemia Protein IN-2
CAS :Eleven-Nineteen-Leukemia Protein IN-2 (compound 23), an ENL inhibitor, exhibits an IC50 of 10.7 nM and is utilized for leukemia research [1].Formule :C22H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45LSD1-UM-109
CAS :LSD1-UM-109 is a highly potent and reversible inhibitor of LSD1, demonstrating an IC50 of 3.1 nM.Formule :C29H27FN6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :478.56Eleven-Nineteen-Leukemia Protein IN-3
CAS :ENL YEATS inhibitor Eleven-Nineteen-Leukemia Protein IN-3, IC50 15.4 nM, orally active, suppresses MYC, stabilizes ENL in vitro.Formule :C28H27N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.55PIM1-IN-4
CAS :PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Formule :C27H25BrCl2CuN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :663.88Tyk2-IN-9
CAS :Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.Formule :C20H17N9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.41PARP1-IN-7
CAS :PARP1-IN-7 functions as an anticancer agent by inhibiting poly(ADP-ribose) polymerase-1 (PARP1).Formule :C24H23N5OCouleur et forme :SolidMasse moléculaire :397.47MAT2A-IN-10
CAS :MAT2A-IN-10 (Compound 28), an orally active inhibitor of MAT2A, exhibits an IC50 of 26 nM and is utilized in cancer research [1].Formule :C27H24F2N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.51AMPK-α1β1γ1 activator 1
CAS :AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Formule :C25H24ClNO9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.91TCS 21311
CAS :TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formule :C27H25F3N4O4Degré de pureté :99.39% - ≥98%Couleur et forme :SolidMasse moléculaire :526.51Bromodomain inhibitor-12
CAS :Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].Formule :C28H38N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.63BET-IN-9
CAS :BET-IN-9 is a BET inhibitor[1].Formule :C22H24N4O3Couleur et forme :SolidMasse moléculaire :392.45Ro 32-0432 hydrochloride
CAS :Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.Formule :C28H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.55KT-531
CAS :KT-531 (KT531) is a highly potent and selective HDAC6 inhibitor with an IC50 value of 8.5 nM and is 39-fold more selective against other HDAC isoenzymes.Formule :C17H14F4N2O4SCouleur et forme :SolidMasse moléculaire :418.36AKB-6899
CAS :AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treatedFormule :C14H11FN2O4Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :290.25Nesuparib
CAS :Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.Formule :C23H24N6ODegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :400.48Ref: TM-T61932
1mg94,00€5mg200,00€1mL*10mM (DMSO)220,00€10mg319,00€25mg573,00€50mg782,00€100mg1.063,00€GSK761
GSK761 inhibits SP140 (IC50: 77.79 nM), hinders monocyte-to-macrophage differentiation, and prompts CD206+ regulatory macrophages.Formule :C40H46N4O4Couleur et forme :SolidMasse moléculaire :646.82A1B11
CAS :A1B11 is a selective SIRT2 inhibitor.Formule :C22H25N5OCouleur et forme :SolidMasse moléculaire :375.47Gö 7874
CAS :Gö 7874 is a potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC).Formule :C27H26N4O4Couleur et forme :SolidMasse moléculaire :470.52
